Papers by prabhat shankar
Journal of advanced zoology, 2024
Journal of advanced zoology, Mar 11, 2024
Toxicology International
Arsenic (As) is an environmental toxin distributed in groundwater which is presently a global con... more Arsenic (As) is an environmental toxin distributed in groundwater which is presently a global concern. The present study aimed to investigate the efficacy of SCEE in the mitigation of arsenic-induced hepato-renal dysfunction and oxidative stress in rats. Thirty male Charles foster rats (140-160 g) were randomly assigned into three groups. Group I (n = 6) - Control, Group II (n = 6) - SCEE control was administrated with 600 mg kg-1 body weight daily for 60 days and the last Group III (n = 24) was As-treated at 8 mg kg-1 body weight daily for 90 days. Subsequently, Group III was further divided into three subgroups. The subgroup I (n = 6) was immediately sacrificed to observe the arsenic-induced toxicity. Subgroup II (n = 6) was kept on a normal diet for 60 days for auto recovery. Subgroup III (n = 6) was administrated orally by SCEE at 600 mg kg-1 body weight daily for 60 days to decipher the therapeutic potential against arsenic-induced toxicity. The experimental exposure reveals va...
Journal of advanced zoology, Mar 11, 2024
The presence of arsenic (As) metalloid in groundwater poses serious threat to human and animal's ... more The presence of arsenic (As) metalloid in groundwater poses serious threat to human and animal's health. Approx. 300 million people of about 105 countries in the world are affected due to arsenite poisoning. Except mitigation there is no such mode by which the population can be prevented from being exposed to arsenic. Elaeocarpus sphaericus (E. sphaericus) is widely used in the folk medicine system for the treatment of various diseases. Hence, present study aimed to investigate the Bio-remedial Impact of ESSE against As-Induced Nephrotoxicity in Charles foster rats. Male twenty-four rats (weighing 160 ± 20 g) were randomly assigned into two groups, where Group-I (n=6) rats were used as control. Group-II (n=18) rats were treated with sodium arsenite at 8 mg/Kg body weight for 90 days daily and then further divided into three subgroups. SubGroup I (n=6); rats were sacrificed and data were collected, SubGroup II (n=6); rats were left for 60 days for auto recovery (as As-pre-treated group), and SubGroup II (n=6); rats were administrated with E. sphaericus at 20mg/kg body weight for 60 days. After the completion of entire experimental dose all the control and treatment group were sacrificed to evaluate the various parameters. As-Induced rats had Significant (p<0.0001) alteration in haematological parameters. As-Induced serum levels of urea, uric acid, creatinine and albumin had significant (p<0.0001) alteration. Level of MDA and BUN were significantly (p<0001) increased. However, ESSE administration significantly reduced the adverse effect related to test of nephrological functions, MDA level significantly (p<0.0001) reduced. Dose dependent ESSE administration combat As-Induced toxicity and significantly (P<0.0001) normalise the level of haematological parameters. Hence, the study concluded that E. sphaericus seed might be used as a nutritional supplement to combat the arsenic led toxicity among the exposed population.
The extremely hazardous trace metal arsenic is ubiquitous in the Earth’s crust contaminating grou... more The extremely hazardous trace metal arsenic is ubiquitous in the Earth’s crust contaminating groundwater globally. The present study was conducted to evaluate the arsenic-induced hepato-nephro alterations, enzymatic inhibition and neurobehavioral instability and in Charles foster rats. Rats were divided into four groups (n = 6; each) weighing with 160 ± 20 g. The group I (control) received arsenic free distilled water and remaining three treatment group (group II − 5 mg kg− 1 body weight, group III; 8mg kg− 1 body weight and group IV; 12mg kg− 1 body weight) were treated with Sodium arsenite (NaAsO2) in combination with distilled water for 90 days. This experimental exposure reveals severe haematological, biochemical and histopathological changes along with neuro-behavioural disorders. The presence of arsenic in blood were analysed through Graphite Furnace Atomic Absorption Spectrophotometer (GF-AAS). Compare to control group the analysed level of arsenic is too high in blood. The s...
Environmental Arsenic in a Changing World, 2019
Arsenic contamination in the groundwater is a serious and widespread global public health problem... more Arsenic contamination in the groundwater is a serious and widespread global public health problem and India is one of the highly arsenic exposed country with maximum impact in the Ganga-Meghna-Brahmaputra (GMB) plains. A total of 18 districts out of 38 districts of the state of Bihar are highly affected with groundwater arsenic poisoning. Gyaspur-Mahaji village (a flood plain region of river Ganga) of Patna district was under taken for the study on the basis of large number of skin and breast cancer cases along with typical symptoms of arsenicosis diagnosed in Mahavir Cancer Institute and Research Centre, Patna. The study deals with the survey of the entire village with groundwater and blood arsenic estimation with special attention to know the health status of the arsenic exposed population. The study revealed high arsenic concentration in the groundwater in the village. Arsenic in the blood samples indicates biomarker for chronic arsenic exposure. The overall health status of the village people was very poor but the most unfortunate part was the appearance of skin cancer and breast cancer in many of the arsenic exposed population of this village. Although the number of such persons was few, it was still alarming as more persons may be impacted if they continue to drink arsenic contaminated water in future.
Doxorubicin is one of the important antitumor agents having a variety of therapeutic potency agai... more Doxorubicin is one of the important antitumor agents having a variety of therapeutic potency against variety of human tumors including soft tissue sarcoma, breast cancer, small cell carcinoma of the lung and acute leukemias. immune system and heart. Whenever this drug is used on cancer patients, its toxicity acts on immune system of the patients by depressing the bone marrow. an import chemotherapy is still obscure. In present investigation to evaluate the efficacy of Ashwagandha against Rats. After administration of Doxorubicin @ 5 mg/kg b.w. Intraperitoneal (I.P.) to rats marked reduction in When Ashwagandha (300mg/kg b.w.) admi continued for 21 days ((21 days was counted from the first exposure of Doxorubicin)) then significant increase in findings of present investigation showed that immunity marrow depression.
International Journal of Environmental Research and Public Health, 2020
Chronic exposure to groundwater containing elevated concentrations of geogenic contaminants such ... more Chronic exposure to groundwater containing elevated concentrations of geogenic contaminants such as arsenic (As) and uranium (U) can lead to detrimental health impacts. In this study, we have undertaken a groundwater survey of representative sites across all districts of the State of Bihar, in the Middle Gangetic Plain of north-eastern India. The aim is to characterize the inorganic major and trace element aqueous geochemistry in groundwater sources widely used for drinking in Bihar, with a particular focus on the spatial distribution and associated geochemical controls on groundwater As and U. Concentrations of As and U are highly heterogeneous across Bihar, exceeding (provisional) guideline values in ~16% and 7% of samples (n = 273), respectively. The strongly inverse correlation between As and U is consistent with the contrasting redox controls on As and U mobility. High As is associated with Fe, Mn, lower Eh and is depth-dependent; in contrast, high U is associated with HCO3−, N...
International Journal of Advanced Research, 2017
At least nine of the 16 districts of the state of West Bengal, India, have arsenic concentrations... more At least nine of the 16 districts of the state of West Bengal, India, have arsenic concentrations in groundwater &amp;gt; 0.05 mg/l, the current USEPA maximum contaminant level (MCL) for drinking water. Ingestion of contaminated groundwater has affected about 10 million inhabitants of ...
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Papers by prabhat shankar