The study was designed to determine the analgesic, anti-inflammatory, anti-diarrheal, antimicrobi... more The study was designed to determine the analgesic, anti-inflammatory, anti-diarrheal, antimicrobial activities and presence of phytochemical constituents of ethanolic extract of Grewia hirsute (EGH) Vahl. Analgesic property was investigated by acetic acid, hot plate, and formalin induced writhing method, anti-inflammatory activity was assessed by xylin generated ear edema and carrageenan-induced edema in rat paw, anti-diarrheal study was conducted by castor oil and testing of gut motility using barium sulfate (BaSO 4) and anti-microbial activity was assessed by disc diffusion method. In hot plate method, 250 mg/kg b.w. disclosed higher percentage latency elongation. In acetic acid-induced analgesia, percentage of writhing inhibition for 250 and 500 mg/kg b.w doses of plant extract and standard drug were 55%, 70% and 84% respectively. At later phase, 250, 500 mg/kg b.w doses of extract and standard drug showed 66.01%, 76.3% and 82.608% writhing inhibition individually in analgesia induced by formalin. In xylin-induced ear edema, 500 mg/kg b.w. dose showed noticeable inhibition (59.79%) than 250 mg/kg b.w. (48.18%). In carrageenan method, EGH demonstrated significant (p < 0.001) inhibition activity as 40.67%, 53.11% and 62.03% for 250 and 500 mg/kg b.w. dose and standard drug respectively. In castor oil-induced diarrhea, the percentage inhibition of defection for 250 and 500 mg/kg b.w. dose were 41.67% and 59.72%, respectively, whereas in gut motility test, 500 mg/kg b.w. dose showed remarkable (30.45%) depletion of BaSO 4 transit. The tested plant extract have potential analgesic, anti-inflammatory, anti-diarrhoeal and antimicrobial properties which may conclude the extract as a potential source of phytomedicine.
Journal of Agribusiness and Rural Development, 2010
Dans le présent article il est indiqué les caracteristiques agricoles de la République de Guinée ... more Dans le présent article il est indiqué les caracteristiques agricoles de la République de Guinée comme facteur déterminant de son économie. L'analyse concerne les conditions pedo-climatiques de la Guinée, sa situation géographique, demographique, économique, mais aussi les aspects culturels et juridiques de la vie paysanne de ce pays de l'Afrique de l'Ouest. L'accent a été mis également sur les difficultés que rencontre l'agriculture guinéenne tout en soulignant les voies et moyens á suivre pour développer cette agriculture.
The study was designed to determine the analgesic, anti-inflammatory, anti-diarrheal, antimicrobi... more The study was designed to determine the analgesic, anti-inflammatory, anti-diarrheal, antimicrobial activities and presence of phytochemical constituents of ethanolic extract of Grewia hirsute (EGH) Vahl. Analgesic property was investigated by acetic acid, hot plate, and formalin induced writhing method, anti-inflammatory activity was assessed by xylin generated ear edema and carrageenan-induced edema in rat paw, anti-diarrheal study was conducted by castor oil and testing of gut motility using barium sulfate (BaSO 4) and anti-microbial activity was assessed by disc diffusion method. In hot plate method, 250 mg/kg b.w. disclosed higher percentage latency elongation. In acetic acid-induced analgesia, percentage of writhing inhibition for 250 and 500 mg/kg b.w doses of plant extract and standard drug were 55%, 70% and 84% respectively. At later phase, 250, 500 mg/kg b.w doses of extract and standard drug showed 66.01%, 76.3% and 82.608% writhing inhibition individually in analgesia induced by formalin. In xylin-induced ear edema, 500 mg/kg b.w. dose showed noticeable inhibition (59.79%) than 250 mg/kg b.w. (48.18%). In carrageenan method, EGH demonstrated significant (p < 0.001) inhibition activity as 40.67%, 53.11% and 62.03% for 250 and 500 mg/kg b.w. dose and standard drug respectively. In castor oil-induced diarrhea, the percentage inhibition of defection for 250 and 500 mg/kg b.w. dose were 41.67% and 59.72%, respectively, whereas in gut motility test, 500 mg/kg b.w. dose showed remarkable (30.45%) depletion of BaSO 4 transit. The tested plant extract have potential analgesic, anti-inflammatory, anti-diarrhoeal and antimicrobial properties which may conclude the extract as a potential source of phytomedicine.
Journal of Agribusiness and Rural Development, 2010
Dans le présent article il est indiqué les caracteristiques agricoles de la République de Guinée ... more Dans le présent article il est indiqué les caracteristiques agricoles de la République de Guinée comme facteur déterminant de son économie. L'analyse concerne les conditions pedo-climatiques de la Guinée, sa situation géographique, demographique, économique, mais aussi les aspects culturels et juridiques de la vie paysanne de ce pays de l'Afrique de l'Ouest. L'accent a été mis également sur les difficultés que rencontre l'agriculture guinéenne tout en soulignant les voies et moyens á suivre pour développer cette agriculture.
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