Papers by oguntope sobajo
New Microbes and New Infections
New Microbes and New Infections, 2020
Methicillin-resistant Staphylococcus aureus (MRSA) is an increasingly prevalent pathogen. We stud... more Methicillin-resistant Staphylococcus aureus (MRSA) is an increasingly prevalent pathogen. We studied the prevalence of MRSA and its association with vaginitis during pregnancy. Bacteriological investigations of high vaginal swabs of 350 healthy pregnant women attending antenatal clinics were carried out. Staphylococci were isolated from high vaginal swabs of 135 of the women. The staphylococcal isolates were resistant to multiple antibiotics. The PCR amplification of DNA of 20 selected isolates yielded six possessing the mecA gene and 13 the blaZ gene. MRSA possessing both the mecA and blaZ genes were isolated from subjects who reported vaginal discharge and itching.
Mediterranean Journal of Nutrition and Metabolism, 2016
BACKGROUND: The prevalence of diabetes mellitus continues to increase alarmingly in spite of year... more BACKGROUND: The prevalence of diabetes mellitus continues to increase alarmingly in spite of years of intensive research. The need to explore alternative therapy such dietary and phytotherapy has been gaining attention in the management/treatment of diabetes mellitus. OBJECTIVE: The present research work was carried out to investigate the biochemical indices in the liver and kidney of alloxan-induced diabetic rats fed with Artocarpus altilis fruit based-diet. METHODS: Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg) in albino rats. A total of thirty two albino rats (Rattus norvegicus) were grouped into four; control (non-diabetic rat), diabetic untreated rats, diabetic rats administered with metformin daily and diabetic rats fed with Artocarpus altilis fruit based-diet groups. Biochemical indices in the serum, liver and kidney were determined. RESULTS: The results shows significant (P < 0.05) decrease in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, bilirubin, urea, creatinine and lipid peroxidation of diabetic fed with Artocarpus altilis fruit based-diet. Also diabetic rats fed with Artocarpus altilis fruit based-diet demonstrated significant increase (p < 0.05) in albumin and total protein concentrations as well as antioxidant enzymes activities when compared with diabetic untreated rats and diabetic rats administered with metformin daily. CONCLUSION: The results obtained in this study demonstrated that consumption of Artocarpus altilis fruit based-diet may ameliorate the liver and kidney function indices of alloxan-induced diabetic rats.
Journal of Immunoassay and Immunochemistry
Rhizomes of Curcuma longa (Turmeric) purchased from local farmers in Ado Ekiti, Nigeria, were ana... more Rhizomes of Curcuma longa (Turmeric) purchased from local farmers in Ado Ekiti, Nigeria, were analysed for their nutritional, phytochemical and antimicrobial properties as well as the bioactive constituents of its essential oil. The dried rhizomes were found to be rich in energy, protein, carbohydrate and fat, with high concentrations of Ca2+, Fe2+, K-, PO42- and ascorbic acid but low levels of Zn2+, thiamine, niacin and riboflavin. Quantitative phytochemical analyses revealed high concentrations of alkaloids, tannins and saponins, moderate level of oxalate with low level of phytates and no detectable cyanogenic glycosides. Qualitative phytochemical analyses of the extracts of C. longa indicated that alkaloids, tannins and phenols were present in the acetone, methanol and ethanol extracts and saponin only in the ethanolic extract; while none of the tested phytochemicals were detected in the chloroform extract. Identification of the bio-active components of C. longa oil using GC-MS s...
ABUAD International Journal of Natural and Applied Sciences, 2021
Extracts and isolated compounds of Allium sativum (garlic) have been found to be of health benefi... more Extracts and isolated compounds of Allium sativum (garlic) have been found to be of health benefit. The study was aimed at assessing the effects of crude garlic extracts on urinopathogens of pregnant women, as well as to compare the antibacterial and genetic profiles of Nigerian indigenous and exotic varieties of garlic. Biodata and urine samples were collected from two hundred (200) healthy pregnant women attending antenatal clinics. The urine samples were subjected to urinalysis and bacteriological investigations. The subjects were 20 - 43 (31.03 ± 1.46) years old, with modal age 25-30 years. Urinalysis of subjects’ urine samples showed no nitrituria, haematuria and bilirubinuria. However, glucosuria (1.5%), ketonuria (3%), leukocyturia (15%) and proteinuria (24%) were detected. Bacterial loads of the urine samples range from 0 to 1100 (with mean value of 315.72) cfU/mL, an indication of non-urinary tract infection bacteriuria. Bacteria isolated from the urine samples were: Escher...
Investment in Africa over the past year with regards to SARS-CoV-2 genotyping has led to a massiv... more Investment in Africa over the past year with regards to SARS-CoV-2 genotyping has led to a massive increase in the number of sequences, exceeding 100,000 genomes generated to track the pandemic on the continent. Our results show an increase in the number of African countries able to sequence within their own borders, coupled with a decrease in sequencing turnaround time. Findings from this genomic surveillance underscores the heterogeneous nature of the pandemic but we observe repeated dissemination of SARS-CoV-2 variants within the continent. Sustained investment for genomic surveillance in Africa is needed as the virus continues to evolve, particularly in the low vaccination landscape. These investments are very crucial for preparedness and response for future pathogen outbreaks.One-Sentence SummaryExpanding Africa SARS-CoV-2 sequencing capacity in a fast evolving pandemic.
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Papers by oguntope sobajo