An effort was made to study the effect of hygrothermal ageing at varying interval of time on the ... more An effort was made to study the effect of hygrothermal ageing at varying interval of time on the interphase of the fiber reinforced polymer composites. Silane-coated glass fibres and epoxy as matrix were used to fabricate the micro-composite. Absorbance peaks of OH stretching bands were focused to study the curing mechanism of epoxy matrix and effect of hygrothermal exposure at the interphase of the micro-composite by FTIR imaging. The DSC was carried out to monitor the glass transition temperature of hygrothermally aged samples after each interval. The FTIR results shows existence of gradient in degree of curing from the interphase to the bulk matrix and with the increase in aging time the water absorption increases at the interphase leading to improvement in the adhesion initially, as it is reflected in the results obtained with DSC analysis i.e increases in glass transition temperature with the aging time was reported. Obtained improved results may be attributed to moisture induc...
The aim of present study is to assess the refractive error among the students of age group 9 to 1... more The aim of present study is to assess the refractive error among the students of age group 9 to 16 years with the help of Snellen's E-chart.
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Prostate cancer (PCa), the most frequently diagnosed malignancy in men is associated with signifi... more Prostate cancer (PCa), the most frequently diagnosed malignancy in men is associated with significant mortality and morbidity. Therefore, demand exists for the identification of potential biomarkers for patient stratification according to prognostic risks and the mechanisms involved in cancer development and progression to avoid over/under treatment of patients and prevent relapse. Quantitative proteomic mass spectrometry profiling and gene enrichment analysis of TGF-β induced-EMT in human Prostate androgen-dependent (LNCaP) and androgen-independent (PC-3) adenocarcinoma cell lines was performed to investigate proteomics involved in Prostate carcinogenesis and their effect onto the survival of PCa patients. Amongst 1,795 proteins, which were analyzed, 474 proteins were significantly deregulated. These proteins contributed to apoptosis, gluconeogenesis, transcriptional regulation, RNA splicing, cell cycle, and MAPK cascade and hence indicating the crucial roles of these proteins in PCa initiation and progression. We have identified a panel of six proteins viz., GOT1, HNRNPA2B1, MAPK1, PAK2, UBE2N, and YWHAB, which contribute to cancer development, and the transition of PCa from androgen dependent to independent stages. The prognostic values of identified proteins were evaluated using UALCAN, GEPIA, and HPA datasets. The results demonstrate the utility of SWATH-LC-MS/MS for understanding the proteomics involved in EMT transition of PCa and identification of clinically relevant proteomic biomarkers.
Facilitating the process of wound healing and effective treatment of wounds remains a serious cha... more Facilitating the process of wound healing and effective treatment of wounds remains a serious challenge in healthcare. Wound dressing materials play a major role in the protection of wounds and in accelerating the natural healing process. In the present study, novel core/shell (c/s) nanofibrous mats of poly(vinyl pyrrolidone)‑iodine (PVPI) and polycaprolactone (PCL) were fabricated using a co-axial electrospinning process followed by their surface modification with poly-l-lysine. The developed nanofibrous mats were extensively characterized for their physicochemical properties using various analytical techniques. The core/shell structure of the PVP-I/PCL nanofibers was confirmed using TEM analysis. The PVP-I release studies showed an initial burst phase followed by a sustained release pattern of PVP-I over a period of 30 days. The developed nanofibers exhibited higher BSA and fibrinogen adsorption as compared to pristine PCL. Cytotoxicity studies using MTT assay demonstrated that the PVP-I/PCL (c/s) nanofibers were cytocompatible at optimized PVP-I concentration (3 wt%). The PCL-poly-l-lysine and PVP-I/PCL-poly-l-lysine nanofibers exhibited higher cell viability (24.2% and 21.4% higher at day 7) when compared to uncoated PCL and PVP-I/PCL nanofibers. The PVP-I/PCL nanofibers showed excellent antimicrobial activity against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria. The inflammatory response of Mouse RAW 264.7 macrophage cells towards the nanofibers was studied using RT-PCR. It revealed that the pro-inflammatory cytokines (TNF-α and IL-1β) were significantly upregulated on PCL nanofibers, while their expression was comparatively lower on poly-l-lysine coated PCL or PVP-I/PCL(c/s) nanofibers. Overall, the study highlights the ability of poly-l-lysine coated PVP-I/PCL (c/s) nanofibers as potential wound dressing materials effectively facilitating the early stage wound healing and repair process by virtue of their selective modulation of inflammation, cell adhesion and antimicrobial properties.
Accumulating evidence have suggested that some microRNAs are aberrantly expressed in prostate can... more Accumulating evidence have suggested that some microRNAs are aberrantly expressed in prostate cancer. In our previous work, we had identified a panel of four differentially expressed microRNAs in prostate cancer. In the present study, we have investigated common molecular targets of this panel of miRNAs (DEMs) and key hub genes that can serve as potential candidate biomarkers in the pathogenesis and progression of prostate cancer. A joint bioinformatics approach was employed to identify differentially expressed genes (DEGs) in prostate cancer. Gene enrichment analysis followed by the protein-protein interaction (PPI) network construction and selection of hub genes was further performed using String and Cytoscape, respectively. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the identified hub genes was conducted using the Database for Annotation, Visualization and Integrated Discovery (DAVID) tool. In total, 496 genes were identified to be common targets of DEMs in prostate cancer and 13 key hub genes were identified from three modules of the PPI network of the DEGs. Further top five genes viz Rhoa, PI3KCA, CDC42, MAPK3, TP53 were used for Enrichment analysis which revealed their association with vital cellular and functional pathways in prostate cancer indicating their potential as candidate biomarkers in prostate cancer.
Antimicrobial electrospun nonwoven Eudragit L-100 nanofibrous mats containing Moxifloxacin hydroc... more Antimicrobial electrospun nonwoven Eudragit L-100 nanofibrous mats containing Moxifloxacin hydrochloride (MOX-HCL) were fabricated for fast dissolving drug delivery systems (DDSs) associated with wound infection. The morphological characterization of nanofibers using ESEM revealed that the average diameter of non woven nanofibrous mats ranges 200-600 nm. The nanofiber showed cylindrical shape with crack on the surface. Differential scanning calorimetric (DSC) and Wide Angle X-ray diffraction (WAXRD) demonstrate that the drug exists in an amorphous state in the nanofibers. Nanofibrous mats were also tested for mechanical strength, contact angle, swelling assay, haemolysis and disintegration test. In vitro disintegration tests demonstrated that the dissolution of Eudragit L-100 fiber mats was within 25 sec which was higher compared to the pure drug. The Eudragit nanofibers showed pH-dependent drug release profiles, with slow release at pH 1.2 and burst release (around 30 sec) at pH 6.8. The in-vitro quantitative and qualitative antimicrobial assay showed that the developed Eudragit L-100 nanofibrous mats with MOX-HCL concentration of 1%, 5% and 15 wt % exhibited antibacterial activities against both gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacteria. The in-vitro cytotoxicity assay using mouse fibroblast NIH/3T3 cells demonstrated significant biocompatibility of nanofiber mats. As per the results of biological evaluation, Eudragit L-100 nanofibrous mats with 1wt% MOX-HCL could be a suitable substrate for biomedical applications. Eudragit L-100 nanofibrous mats containing Moxifloxacin hydrochloride (MOX-HCL) showed immediate DDSs for localized drug release in the wound infection at slightly acidic or alkaline conditions where faster drug release rate is required for wound healing.
/5). All the patients did not assume any antidyslipidemic treatment. Mean sphygmomanometric blood... more /5). All the patients did not assume any antidyslipidemic treatment. Mean sphygmomanometric blood pressure was: 150ϩ/-19/90ϩ/-10 mmHg; mean PP was: 60ϩ/-15 mm Hg and heart rate: 72ϩ/-12 beats/ min. Total-cholesterol, HDL-cholesterol, Triglicerides and LDL-cholesterol were: 225ϩ/-37 mg/dl, 56ϩ/-15 mg/dl, 143ϩ/-61 mg/dl and 140ϩ/-34 mg/dl, respectively. A significant correlation was observed between PP and LDL-cholesterol (linear regression analysis; rϭ 0.21, pϽ.02), whereas the correlation between PP and Total-cholesterol, and between PP and HDL-cholesterol did not reach a statistical significance (rϭ 0.17, pϭ.07; rϭ-0.13, pϭ.18, respectively). In conclusion, in the population studied of resistant hypertensive patients, the correlation found between pulse pressure and LDL-cholesterol suggests that, in presence of persistently elevated blood pressure, plasma lipids may influence the vascular stiffness, expressed by pulse pressure values. Possibly, the vascular alterations linked to dyslipidemia may account for resistence versus pharmacological therapy.
Prostate cancer (PCa) is the second most common malignancy amongst men worldwide. Under PCa maint... more Prostate cancer (PCa) is the second most common malignancy amongst men worldwide. Under PCa maintenance therapy drugs acting as antagonists/partial agonists of hormone receptors against the prostate tissue are used in clinical practices. Prominent drugs being Cyproterone acetate, Flutamide, Bicalutamide, they not only cause acute and long-term toxicity, but also develops drug resistance among patients. Our focus has been on phytochemicals which do not exhibit any cytotoxicity and have significant androgen receptor (AR) inhibition activity. As Protein- Ligand interactions play a key role in structure based drug design, so by using molecular docking, we screened 803 phytochemicals and investigated their binding affinity against AR. The three dimensional (3D) structure of AR was retrieved from Protein Data Bank, and docked with 3D Pubchem structures of 803 phytochemicals using Argus Lab. Molecular docking and drug likeness studies were made using ADMET properties while Lipinski's r...
Background: Overall, the incidence of colorectal cancer appears to be stable or diminishing. Howe... more Background: Overall, the incidence of colorectal cancer appears to be stable or diminishing. However, based on our regional cancer institute's datas, we have observed the increasing incidence of colorectal cancer in patients ≤40 age. The aim of this study was to verify the rising trend, clinico-pathological features and survival in colorectal cancer in patients ≤40,in comparison to patients >40 age. Materials and methods: A retrospective study was conducted to review all patients≤ 40 age and more than 40 year of age separatly with a diagnosis of colorectal cancer from January 2004 to December 2012. Results: Young patients were 24.17% of total 1096 colorectal cases. In young patients 60.37% were male and 39.63% were female. 9% young had family history & only 8% had history of alcohol intake. Onset of symptoms to reaching diagnosis period is longer in younger patients.(Range 3 months to 1 year in young, while 1 months to 6 months in older). Higher pathological T stage was seen in the younger age group when compared with patients above 40 years. Also the younger age group showed more advanced N stage when compared with patients above 40 years. With final TNM staging, in younger age group 66% were in stage IV and 30% were in stage III. Eighty percent of all young cancer deaths were within 22 months (from 8months to 22 months). Conclusion: Above results show the aggressive nature and late diagnosis of carcinoma colorectal in young. These data highlight a need for thorough evaluation of young with colorectal symptoms and in high risk population, also life style modification agenda by Govt .or non Govt. organization.
Epithelial-mesenchymal transition (EMT) is a plastic transition in tumor progression during which... more Epithelial-mesenchymal transition (EMT) is a plastic transition in tumor progression during which cancer cells undergo dramatic changes acquiring highly invasive properties. Transforming growth factor-β (TGF-β) is an inducer of EMT in epithelial cells and is obligatory for acquiring invasive phenotype in carcinoma. TGF-β plays a vital role in metastasis and tumorigenesis in prostate cancer, and mutations in the components of Wnt signaling pathways are associated with various kinds of cancers including prostate cancer. The purpose of this study was to identify alterations in Wnt signaling pathway components involved during prostate cancer progression and to determine the effect of quercetin on TGF-βinduced EMT in prostate cancer (PC-3) cell line. The expression of epithelial and mesenchymal markers and the components of Wnt signaling pathway were evaluated by real-time polymerase chain reaction. It was observed that quercetin prevented TGF-β-induced expression of vimentin and Ncadherin and increased the expression of E-cadherin in PC-3 cells, thus preventing TGF-β-induced EMT. Furthermore, the relative expression of Twist, Snail, and Slug showed that quercetin significantly decreased TGF-β-induced expression of Twist, Snail, and Slug. In the present study, the expression of epithelial markers were found to be upregulated in naive state and downregulated in induced state whereas the mesenchymal markers were found to be downregulated in naive state and upregulated in induced state. Thus, our study concludes that quercetin may prevent prostate cancer metastasis by regulating the components of Wnt pathway.
The last twenty years of economic reforms have demonstrated that growth is a necessary but not su... more The last twenty years of economic reforms have demonstrated that growth is a necessary but not sufficient condition for sustained poverty reduction. Sustainable poverty reduction needs access. Access comes from the 3Es (Education, Employability and Employment). This paper attempts to explore how privatization in vocational education can impact the quality and scale of vocational skills development in India. The paper formulates tangible ideas that will enable formulation of scalable mechanisms in overcoming the challenges that the vocational training organizations currently face. It also discusses issues of access, quality, efficiency and value of vocational education across various sectors, education qualifications and age groups.
Globally Prostate Cancer is the second most commonly diagnosed and sixth leading cause of Cancer... more Globally Prostate Cancer is the second most commonly diagnosed and sixth leading cause of Cancer mortalities in men worldwide but currently there is no cure for metastatic castration-resistant prostate cancer (CRPC). Chemoresistance and metastasis are the main causes of treatment resistance and mortality in Prostate Cancer patients. Although several advances have been made to control yet there is an urgent need to investigate the mechanisms and pathways for chemoresistance and prostate cancer (PCa) metastasis. Cancer stem cells (CSCs), a sub-population of cancer cells characterised by self-renewal and tumor initiation, have gained intense attention as they not only play a crucial role in cancer relapse but also contribute substantially to chemoresistance. Contributing to the role of CSCs are the miRNAs which are known key regulators of the posttranscriptional regulation of genes involved in a wide array of biological processes including tumorigenesis. The altered expressions of miR...
Patient-reported outcomes (PROs) might detect more toxic effects of radiotherapy than do clinicia... more Patient-reported outcomes (PROs) might detect more toxic effects of radiotherapy than do clinician-reported outcomes. We did a quality of life (QoL) substudy to assess PROs up to 24 months after conventionally fractionated or hypofractionated radiotherapy in the Conventional or Hypofractionated High Dose Intensity Modulated Radiotherapy in Prostate Cancer (CHHiP) trial. The CHHiP trial is a randomised, non-inferiority phase 3 trial done in 71 centres, of which 57 UK hospitals took part in the QoL substudy. Men with localised prostate cancer who were undergoing radiotherapy were eligible for trial entry if they had histologically confirmed T1b-T3aN0M0 prostate cancer, an estimated risk of seminal vesicle involvement less than 30%, prostate-specific antigen concentration less than 30 ng/mL, and a WHO performance status of 0 or 1. Participants were randomly assigned (1:1:1) to receive a standard fractionation schedule of 74 Gy in 37 fractions or one of two hypofractionated schedules: 6...
Pelvic bone metastasis from transitional cell carcinoma of the urinary bladder. ... There are no ... more Pelvic bone metastasis from transitional cell carcinoma of the urinary bladder. ... There are no files associated with this item. ... Items in IMSEAR Digital Repository are protected by copyright, with all rights reserved, unless otherwise indicated. ... Index Medicus for South-...
The Journal of Obstetrics and Gynecology of India, 2014
Satyanarayan is a second year Resident in the Department of Radiation Oncology. He always self st... more Satyanarayan is a second year Resident in the Department of Radiation Oncology. He always self starter, disciplined, confident and goal oriented. He have a keen interest in the area of publication as author as well reviewer and this has been resulted in several publications in indexed journals and conferences (National and International)
An effort was made to study the effect of hygrothermal ageing at varying interval of time on the ... more An effort was made to study the effect of hygrothermal ageing at varying interval of time on the interphase of the fiber reinforced polymer composites. Silane-coated glass fibres and epoxy as matrix were used to fabricate the micro-composite. Absorbance peaks of OH stretching bands were focused to study the curing mechanism of epoxy matrix and effect of hygrothermal exposure at the interphase of the micro-composite by FTIR imaging. The DSC was carried out to monitor the glass transition temperature of hygrothermally aged samples after each interval. The FTIR results shows existence of gradient in degree of curing from the interphase to the bulk matrix and with the increase in aging time the water absorption increases at the interphase leading to improvement in the adhesion initially, as it is reflected in the results obtained with DSC analysis i.e increases in glass transition temperature with the aging time was reported. Obtained improved results may be attributed to moisture induc...
The aim of present study is to assess the refractive error among the students of age group 9 to 1... more The aim of present study is to assess the refractive error among the students of age group 9 to 16 years with the help of Snellen's E-chart.
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Prostate cancer (PCa), the most frequently diagnosed malignancy in men is associated with signifi... more Prostate cancer (PCa), the most frequently diagnosed malignancy in men is associated with significant mortality and morbidity. Therefore, demand exists for the identification of potential biomarkers for patient stratification according to prognostic risks and the mechanisms involved in cancer development and progression to avoid over/under treatment of patients and prevent relapse. Quantitative proteomic mass spectrometry profiling and gene enrichment analysis of TGF-β induced-EMT in human Prostate androgen-dependent (LNCaP) and androgen-independent (PC-3) adenocarcinoma cell lines was performed to investigate proteomics involved in Prostate carcinogenesis and their effect onto the survival of PCa patients. Amongst 1,795 proteins, which were analyzed, 474 proteins were significantly deregulated. These proteins contributed to apoptosis, gluconeogenesis, transcriptional regulation, RNA splicing, cell cycle, and MAPK cascade and hence indicating the crucial roles of these proteins in PCa initiation and progression. We have identified a panel of six proteins viz., GOT1, HNRNPA2B1, MAPK1, PAK2, UBE2N, and YWHAB, which contribute to cancer development, and the transition of PCa from androgen dependent to independent stages. The prognostic values of identified proteins were evaluated using UALCAN, GEPIA, and HPA datasets. The results demonstrate the utility of SWATH-LC-MS/MS for understanding the proteomics involved in EMT transition of PCa and identification of clinically relevant proteomic biomarkers.
Facilitating the process of wound healing and effective treatment of wounds remains a serious cha... more Facilitating the process of wound healing and effective treatment of wounds remains a serious challenge in healthcare. Wound dressing materials play a major role in the protection of wounds and in accelerating the natural healing process. In the present study, novel core/shell (c/s) nanofibrous mats of poly(vinyl pyrrolidone)‑iodine (PVPI) and polycaprolactone (PCL) were fabricated using a co-axial electrospinning process followed by their surface modification with poly-l-lysine. The developed nanofibrous mats were extensively characterized for their physicochemical properties using various analytical techniques. The core/shell structure of the PVP-I/PCL nanofibers was confirmed using TEM analysis. The PVP-I release studies showed an initial burst phase followed by a sustained release pattern of PVP-I over a period of 30 days. The developed nanofibers exhibited higher BSA and fibrinogen adsorption as compared to pristine PCL. Cytotoxicity studies using MTT assay demonstrated that the PVP-I/PCL (c/s) nanofibers were cytocompatible at optimized PVP-I concentration (3 wt%). The PCL-poly-l-lysine and PVP-I/PCL-poly-l-lysine nanofibers exhibited higher cell viability (24.2% and 21.4% higher at day 7) when compared to uncoated PCL and PVP-I/PCL nanofibers. The PVP-I/PCL nanofibers showed excellent antimicrobial activity against both Gram-positive (S. aureus) and Gram-negative (E. coli) bacteria. The inflammatory response of Mouse RAW 264.7 macrophage cells towards the nanofibers was studied using RT-PCR. It revealed that the pro-inflammatory cytokines (TNF-α and IL-1β) were significantly upregulated on PCL nanofibers, while their expression was comparatively lower on poly-l-lysine coated PCL or PVP-I/PCL(c/s) nanofibers. Overall, the study highlights the ability of poly-l-lysine coated PVP-I/PCL (c/s) nanofibers as potential wound dressing materials effectively facilitating the early stage wound healing and repair process by virtue of their selective modulation of inflammation, cell adhesion and antimicrobial properties.
Accumulating evidence have suggested that some microRNAs are aberrantly expressed in prostate can... more Accumulating evidence have suggested that some microRNAs are aberrantly expressed in prostate cancer. In our previous work, we had identified a panel of four differentially expressed microRNAs in prostate cancer. In the present study, we have investigated common molecular targets of this panel of miRNAs (DEMs) and key hub genes that can serve as potential candidate biomarkers in the pathogenesis and progression of prostate cancer. A joint bioinformatics approach was employed to identify differentially expressed genes (DEGs) in prostate cancer. Gene enrichment analysis followed by the protein-protein interaction (PPI) network construction and selection of hub genes was further performed using String and Cytoscape, respectively. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the identified hub genes was conducted using the Database for Annotation, Visualization and Integrated Discovery (DAVID) tool. In total, 496 genes were identified to be common targets of DEMs in prostate cancer and 13 key hub genes were identified from three modules of the PPI network of the DEGs. Further top five genes viz Rhoa, PI3KCA, CDC42, MAPK3, TP53 were used for Enrichment analysis which revealed their association with vital cellular and functional pathways in prostate cancer indicating their potential as candidate biomarkers in prostate cancer.
Antimicrobial electrospun nonwoven Eudragit L-100 nanofibrous mats containing Moxifloxacin hydroc... more Antimicrobial electrospun nonwoven Eudragit L-100 nanofibrous mats containing Moxifloxacin hydrochloride (MOX-HCL) were fabricated for fast dissolving drug delivery systems (DDSs) associated with wound infection. The morphological characterization of nanofibers using ESEM revealed that the average diameter of non woven nanofibrous mats ranges 200-600 nm. The nanofiber showed cylindrical shape with crack on the surface. Differential scanning calorimetric (DSC) and Wide Angle X-ray diffraction (WAXRD) demonstrate that the drug exists in an amorphous state in the nanofibers. Nanofibrous mats were also tested for mechanical strength, contact angle, swelling assay, haemolysis and disintegration test. In vitro disintegration tests demonstrated that the dissolution of Eudragit L-100 fiber mats was within 25 sec which was higher compared to the pure drug. The Eudragit nanofibers showed pH-dependent drug release profiles, with slow release at pH 1.2 and burst release (around 30 sec) at pH 6.8. The in-vitro quantitative and qualitative antimicrobial assay showed that the developed Eudragit L-100 nanofibrous mats with MOX-HCL concentration of 1%, 5% and 15 wt % exhibited antibacterial activities against both gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacteria. The in-vitro cytotoxicity assay using mouse fibroblast NIH/3T3 cells demonstrated significant biocompatibility of nanofiber mats. As per the results of biological evaluation, Eudragit L-100 nanofibrous mats with 1wt% MOX-HCL could be a suitable substrate for biomedical applications. Eudragit L-100 nanofibrous mats containing Moxifloxacin hydrochloride (MOX-HCL) showed immediate DDSs for localized drug release in the wound infection at slightly acidic or alkaline conditions where faster drug release rate is required for wound healing.
/5). All the patients did not assume any antidyslipidemic treatment. Mean sphygmomanometric blood... more /5). All the patients did not assume any antidyslipidemic treatment. Mean sphygmomanometric blood pressure was: 150ϩ/-19/90ϩ/-10 mmHg; mean PP was: 60ϩ/-15 mm Hg and heart rate: 72ϩ/-12 beats/ min. Total-cholesterol, HDL-cholesterol, Triglicerides and LDL-cholesterol were: 225ϩ/-37 mg/dl, 56ϩ/-15 mg/dl, 143ϩ/-61 mg/dl and 140ϩ/-34 mg/dl, respectively. A significant correlation was observed between PP and LDL-cholesterol (linear regression analysis; rϭ 0.21, pϽ.02), whereas the correlation between PP and Total-cholesterol, and between PP and HDL-cholesterol did not reach a statistical significance (rϭ 0.17, pϭ.07; rϭ-0.13, pϭ.18, respectively). In conclusion, in the population studied of resistant hypertensive patients, the correlation found between pulse pressure and LDL-cholesterol suggests that, in presence of persistently elevated blood pressure, plasma lipids may influence the vascular stiffness, expressed by pulse pressure values. Possibly, the vascular alterations linked to dyslipidemia may account for resistence versus pharmacological therapy.
Prostate cancer (PCa) is the second most common malignancy amongst men worldwide. Under PCa maint... more Prostate cancer (PCa) is the second most common malignancy amongst men worldwide. Under PCa maintenance therapy drugs acting as antagonists/partial agonists of hormone receptors against the prostate tissue are used in clinical practices. Prominent drugs being Cyproterone acetate, Flutamide, Bicalutamide, they not only cause acute and long-term toxicity, but also develops drug resistance among patients. Our focus has been on phytochemicals which do not exhibit any cytotoxicity and have significant androgen receptor (AR) inhibition activity. As Protein- Ligand interactions play a key role in structure based drug design, so by using molecular docking, we screened 803 phytochemicals and investigated their binding affinity against AR. The three dimensional (3D) structure of AR was retrieved from Protein Data Bank, and docked with 3D Pubchem structures of 803 phytochemicals using Argus Lab. Molecular docking and drug likeness studies were made using ADMET properties while Lipinski's r...
Background: Overall, the incidence of colorectal cancer appears to be stable or diminishing. Howe... more Background: Overall, the incidence of colorectal cancer appears to be stable or diminishing. However, based on our regional cancer institute's datas, we have observed the increasing incidence of colorectal cancer in patients ≤40 age. The aim of this study was to verify the rising trend, clinico-pathological features and survival in colorectal cancer in patients ≤40,in comparison to patients >40 age. Materials and methods: A retrospective study was conducted to review all patients≤ 40 age and more than 40 year of age separatly with a diagnosis of colorectal cancer from January 2004 to December 2012. Results: Young patients were 24.17% of total 1096 colorectal cases. In young patients 60.37% were male and 39.63% were female. 9% young had family history & only 8% had history of alcohol intake. Onset of symptoms to reaching diagnosis period is longer in younger patients.(Range 3 months to 1 year in young, while 1 months to 6 months in older). Higher pathological T stage was seen in the younger age group when compared with patients above 40 years. Also the younger age group showed more advanced N stage when compared with patients above 40 years. With final TNM staging, in younger age group 66% were in stage IV and 30% were in stage III. Eighty percent of all young cancer deaths were within 22 months (from 8months to 22 months). Conclusion: Above results show the aggressive nature and late diagnosis of carcinoma colorectal in young. These data highlight a need for thorough evaluation of young with colorectal symptoms and in high risk population, also life style modification agenda by Govt .or non Govt. organization.
Epithelial-mesenchymal transition (EMT) is a plastic transition in tumor progression during which... more Epithelial-mesenchymal transition (EMT) is a plastic transition in tumor progression during which cancer cells undergo dramatic changes acquiring highly invasive properties. Transforming growth factor-β (TGF-β) is an inducer of EMT in epithelial cells and is obligatory for acquiring invasive phenotype in carcinoma. TGF-β plays a vital role in metastasis and tumorigenesis in prostate cancer, and mutations in the components of Wnt signaling pathways are associated with various kinds of cancers including prostate cancer. The purpose of this study was to identify alterations in Wnt signaling pathway components involved during prostate cancer progression and to determine the effect of quercetin on TGF-βinduced EMT in prostate cancer (PC-3) cell line. The expression of epithelial and mesenchymal markers and the components of Wnt signaling pathway were evaluated by real-time polymerase chain reaction. It was observed that quercetin prevented TGF-β-induced expression of vimentin and Ncadherin and increased the expression of E-cadherin in PC-3 cells, thus preventing TGF-β-induced EMT. Furthermore, the relative expression of Twist, Snail, and Slug showed that quercetin significantly decreased TGF-β-induced expression of Twist, Snail, and Slug. In the present study, the expression of epithelial markers were found to be upregulated in naive state and downregulated in induced state whereas the mesenchymal markers were found to be downregulated in naive state and upregulated in induced state. Thus, our study concludes that quercetin may prevent prostate cancer metastasis by regulating the components of Wnt pathway.
The last twenty years of economic reforms have demonstrated that growth is a necessary but not su... more The last twenty years of economic reforms have demonstrated that growth is a necessary but not sufficient condition for sustained poverty reduction. Sustainable poverty reduction needs access. Access comes from the 3Es (Education, Employability and Employment). This paper attempts to explore how privatization in vocational education can impact the quality and scale of vocational skills development in India. The paper formulates tangible ideas that will enable formulation of scalable mechanisms in overcoming the challenges that the vocational training organizations currently face. It also discusses issues of access, quality, efficiency and value of vocational education across various sectors, education qualifications and age groups.
Globally Prostate Cancer is the second most commonly diagnosed and sixth leading cause of Cancer... more Globally Prostate Cancer is the second most commonly diagnosed and sixth leading cause of Cancer mortalities in men worldwide but currently there is no cure for metastatic castration-resistant prostate cancer (CRPC). Chemoresistance and metastasis are the main causes of treatment resistance and mortality in Prostate Cancer patients. Although several advances have been made to control yet there is an urgent need to investigate the mechanisms and pathways for chemoresistance and prostate cancer (PCa) metastasis. Cancer stem cells (CSCs), a sub-population of cancer cells characterised by self-renewal and tumor initiation, have gained intense attention as they not only play a crucial role in cancer relapse but also contribute substantially to chemoresistance. Contributing to the role of CSCs are the miRNAs which are known key regulators of the posttranscriptional regulation of genes involved in a wide array of biological processes including tumorigenesis. The altered expressions of miR...
Patient-reported outcomes (PROs) might detect more toxic effects of radiotherapy than do clinicia... more Patient-reported outcomes (PROs) might detect more toxic effects of radiotherapy than do clinician-reported outcomes. We did a quality of life (QoL) substudy to assess PROs up to 24 months after conventionally fractionated or hypofractionated radiotherapy in the Conventional or Hypofractionated High Dose Intensity Modulated Radiotherapy in Prostate Cancer (CHHiP) trial. The CHHiP trial is a randomised, non-inferiority phase 3 trial done in 71 centres, of which 57 UK hospitals took part in the QoL substudy. Men with localised prostate cancer who were undergoing radiotherapy were eligible for trial entry if they had histologically confirmed T1b-T3aN0M0 prostate cancer, an estimated risk of seminal vesicle involvement less than 30%, prostate-specific antigen concentration less than 30 ng/mL, and a WHO performance status of 0 or 1. Participants were randomly assigned (1:1:1) to receive a standard fractionation schedule of 74 Gy in 37 fractions or one of two hypofractionated schedules: 6...
Pelvic bone metastasis from transitional cell carcinoma of the urinary bladder. ... There are no ... more Pelvic bone metastasis from transitional cell carcinoma of the urinary bladder. ... There are no files associated with this item. ... Items in IMSEAR Digital Repository are protected by copyright, with all rights reserved, unless otherwise indicated. ... Index Medicus for South-...
The Journal of Obstetrics and Gynecology of India, 2014
Satyanarayan is a second year Resident in the Department of Radiation Oncology. He always self st... more Satyanarayan is a second year Resident in the Department of Radiation Oncology. He always self starter, disciplined, confident and goal oriented. He have a keen interest in the area of publication as author as well reviewer and this has been resulted in several publications in indexed journals and conferences (National and International)
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