Papers by nasser ebrahimi daryani
Medical Journal of The Islamic Republic of Iran, 2021
Background: Ulcerative colitis (UC) is specified by a chronic mucosal inflammation that has a del... more Background: Ulcerative colitis (UC) is specified by a chronic mucosal inflammation that has a deleterious impact on the quality of life (QoL). Coenzyme Q10 (CoQ10) appears to influence disease activity by its obvious properties. Therefore, the current research intends to assess the impacts of CoQ10 on QoL, disease activity, and blood pressure in UC patients. Methods: This clinical trial performed on men and women with UC in 2017 who were attended the gastrointestinal center of Hazrat Rasool Akram Hospital and private clinic. Eighty-eight UC patients were randomly allocated to receive either CoQ10 (200 mg/day) or placebo for 8 weeks. The anthropometric parameters, blood pressure, inflammatory bowel disease questionnaire-32 (IBDQ-32) score, and the Simple Clinical Colitis Activity Index (SCCAI) score were measured pre and post-intervention. P-value <0.05 was considered to be statistically significant. All statistical analysis was done using SPSS software version 24. Results: Eighty-six UC patients (44 males) with a mean age of 39.29 (10.19) years completed the trial. The results of between-and within-group analysis revealed that the SCCAI score (p<0.001 and p<0.001, respectively), diastolic blood pressure (p=0.025 and p=0.001, respectively), and systolic blood pressure (p=0.001 and p<0.001, respectively) decremented significantly; while, the mean IBDQ-32 (p<0.001 and p=0.001, respectively) increased substantially in the CoQ10 group; whereas there was no significant difference in anthropometric indices in both groups. Conclusion: Findings suggest that CoQ10 can be used as a potential intervention for diminishing the disease severity and blood pressure and may improve QoL and UC patients. IRCT number: IRCT20090822002365N17.
JGH Open, 2022
In this study we indicated that impaired serological responses to SARS‐CoV‐2 infection among pati... more In this study we indicated that impaired serological responses to SARS‐CoV‐2 infection among patients with IBD, could have significant implications for this group of patients and should be considered in vaccination program.
The present treatment goals for inflammatory bowel diseases (IBD) especially ulcerative colitis (... more The present treatment goals for inflammatory bowel diseases (IBD) especially ulcerative colitis (UC) include rapid induction of clinical remission, steroid-free maintenance of clinical remission, mucosal healing and improvement of quality of life in UC patients. Immunomodulators have been reserved for steroid-dependent or steroid-refractory UC patients. Among these agents, azathioprine/6-mercaptopurine should be used for maintenance of remission in quiescent UC. Calcineurin inhibitors can be prescribed as a short-term rescue therapy in steroid-refractory UC patients, but the long term efficacy of these agents remains unclear. According to retrospective studies, methotraxate is not recommended for inducing and maintaining remission in UC. Novel biological therapies targeting different specific immunological pathways continue to be developed and introduced for a variety of clinical scenarios in IBD. Infliximab is currently used for induction and maintenance therapy in patients who hav...
All in-text references underlined in blue are linked to publications on ResearchGate, letting you... more All in-text references underlined in blue are linked to publications on ResearchGate, letting you access and read them immediately.
The booster dose of hepatitis B for childhood? Effect of intermittent clamping of the portal tria... more The booster dose of hepatitis B for childhood? Effect of intermittent clamping of the portal triad on the rat liver HEV and porcine caliciviruses in pig farms
Frontiers in Nutrition, 2021
Background and Aims: Although irritable bowel syndrome is one of the most common gastrointestinal... more Background and Aims: Although irritable bowel syndrome is one of the most common gastrointestinal disorders presented to gastroenterologists, therapeutic strategies are not yet well-established. Accordingly, we conducted a randomized, double-blind, placebo-controlled, clinical trial to evaluate the possible superiority of adding glutamine supplement to low fermentable oligo- di- monosaccharides and polyols (FODMAP) diet in patients with irritable bowel syndrome (IBS).Methods: Eligible adults were randomized to receive a low FODMAP diet either with glutamine (15 g/day) or a placebo for 6 weeks. The primary endpoint was a significant reduction in IBS-symptom severity score (IBS-SSS). Secondary endpoints were changes in IBS symptoms, stool frequency, consistency, and quality of life.Results: The study group enrolled 50 patients, among which 22 participants from each group completed the study protocol. The glutamine group had significant changes in total IBS-severity score, dissatisfact...
Background: Cytolethal distending toxin (Cdt) is one of the bacterial toxins that present in a va... more Background: Cytolethal distending toxin (Cdt) is one of the bacterial toxins that present in a variety of Gram-negative human pathogens, such as E. coli, Salmonella spp., and Campylobacter spp. CDT composed of three subunits encoded by three adjacent genes, including cdtA, cdtB and cdtC. It is approved that cdtB had toxic activity and caused DNA damage of the host cell. Despite its presence in different bacterial species, role of Cdt in acute and chronic infections, such as gastroenteritis and irritable bowel syndrome (IBS), is unclear. To analyze this correlation, we studied the prevalence of cdtB among different enteropathogenic bacteria in patients with gastroenteritis and IBS compared with healthy people. Materials and Methods: In this cross-sectional descriptive study, 230 stool samples were collected from patients with gastroenteritis, IBS, and healthy people. The presence of Cdt-B encoding bacteria, including Escherichia coli, Campylobacter spp., Yersinia entercolitica, Provi...
Medical Journal of the Islamic Republic of Iran, 2020
Background: In a resource-demanding COVID-19 pandemic, guidelines can free up health care resourc... more Background: In a resource-demanding COVID-19 pandemic, guidelines can free up health care resources needed for providing better care to those with COVID-19 and other patients. This study was performed to design a guideline to manage patients with colorectal cancers during the COVID-19pandemic. Methods: To design this guideline, major topics and headings of colon and rectal cancers (CRC) were selected and included. Based on the extent of COVID-19 infection in the community and availability of hospital resources, the guideline has been designed for 2 major COVID-19 phases. Several multidisciplinary discussion sessions were held to review the comments of experts, finalize the data, and write the guideline. Results: This guideline has been prepared in 2 main COVID-19 phases of the community/hospital. Phase A refers to the condition where a large number of COVID-19 patients are admitted to the hospital, but limited surgical ICU beds and facilities are still accessible. In phase B, many p...
Archives of Iranian medicine, 2016
BACKGROUND The burden of inflammatory bowel disease (IBD) hasn't been reported in Iran. We ai... more BACKGROUND The burden of inflammatory bowel disease (IBD) hasn't been reported in Iran. We aimed to estimate the prevalence and incidence of IBD and its trend in Iran at national and subnational level from 1990 to 2012. METHODS We conducted a systematic review of English and Persian databases about the epidemiology of IBD. We also collected outpatient data from 17 provinces of Iran using almost all public and private referral gastroenterology clinics. Prevalence and incidence rate was calculated at national and subnational levels. The Kriging method was used to extrapolate provinces with missing data and GPR model to calculate time trends of rates at subnational level. RESULTS We found 16 case series, two population-based studies, and two review articles. We collected 11,000 IBD cases from outpatient databases. Among them, 9,269 (84.26%) had ulcerative colitis (UC), 1,646 (14.96%) had Crohn's disease (CD), and 85 had intermediate colitis (IC). A total of 5,452 (49.56%) patie...
Background The aim of this study was to develop a therapeutic plan based on hypnotherapy for pati... more Background The aim of this study was to develop a therapeutic plan based on hypnotherapy for patients with irritable bowel syndrome (IBS) and determine the effectiveness of this treatment on the intensity of IBS symptoms and rumination of patients with IBS. Materials and Methods: The research design was a quasi-experimental with a pre-test, a post-test, and 3 months of follow-up. Of the patients who were referred to gastroenterology clinics in Tehran, 32 patients with IBS were randomly divided into two groups; hypnotherapy group and control group. Medical treatment along with hypnotherapy was individually conducted for eight sessions in the intervention group and the control group received only medical treatment. IBS Symptom Severity Scale (IBS-SSS) and rumination were completed in pretest, post-test, and follow-up stages by the patients and data were analyzed with repeated measures analysis of variance. Results: The variable scores of symptoms severity and rumination in experimenta...
The use of anticoagulant and antiplatelet agents has become more prevalent during the past decade... more The use of anticoagulant and antiplatelet agents has become more prevalent during the past decades. These drugs may potentially cause gastrointestinal (GI) bleeding. Thus, there is an increasing need for GI endoscopy in patients who take these medications. In patients who take anticoagulant and antiplatelet agents, the appropriate conditions under which endoscopic procedures should be performed remain unclear. In this manuscript, we reviewed studies regarding this context in an attempt to present a practical guideline for management these patients.
Wernike encephalopathy(WE )caused by thiamine deficiency was a critical but reversible disorder.... more Wernike encephalopathy(WE )caused by thiamine deficiency was a critical but reversible disorder. It can be occurred after acute pancreatitis due to prolonged fasting. WE after acute pancreatitis was rarely suspected and diagnosed at early stages. We reported a 44 year-old woman with severe acute pancreatitis who developed altered mental status and bilateral nystagmus and ophthalmoplegia soon after 14 days of fasting. The brain MRI confirmed the diagnosis. After empiric treatment with thiamine all of the neurological symptoms reversed except only some antegrade and retrograde amnesia . In this case report considering thiamine deficiency in any patients with fasting and neurological symptoms, was addressed since WE was a reversible disorder if it was diagnosed in early stage.
We described a case of lymphoid follicular hyperplasia that arose from the ileum of a 52-year-old... more We described a case of lymphoid follicular hyperplasia that arose from the ileum of a 52-year-old woman. Her colonoscopy revealed a large mass in the cecum associated with multiple polypoid lesions in the ileum. Histologic examination demonstrated severe lymphocytic infiltration and lymphoid follicles with regular germinal centers, without evidence of malignancy. A right hemicolectomy was performed, which confirmed the diagnosis of lymphoid follicular hyperplasia.
Middle East Journal of Digestive Diseases, 2021
Colonic malakoplakia is a rare chronic granulomatous disease that can involve many organs such as... more Colonic malakoplakia is a rare chronic granulomatous disease that can involve many organs such as the lung, brain, pancreas, bone, adrenal glands, and genitourinary tract. The most common site of involvement outside the genitourinary tract is the gastrointestinal tract. We report a case of colonic malakoplakia who presented with unintentional weight loss, abdominal pain, and chronic diarrhea. There was a history of lupus nephritis and Sjogren disease, receiving various immunosuppressive drugs. Physical examination other than pallor was unremarkable in this patient, but colonoscopy revealed multiple polyps in the rectum with a cobblestone appearance in the cecum. The histopathological assessment showed infiltration of numerous lymphoplasma cells and neutrophils in the lamina propria, and rare Michaelis-Gutmann bodies were seen in foamy epithelioid histiocytes. These findings are suggestive of malakoplakia. We treated the patient with tetracycline, and after 3 months of follow-up, cli...
Shiraz E-Medical Journal, 2021
Background: Constipation is a common disorder, and its management imposes a significant health bu... more Background: Constipation is a common disorder, and its management imposes a significant health burden. Integration of complementary and alternative medicine into the current health system may result in beneficial outcomes. Objective: This study aimed to evaluate the efficacy and safety of a Persian medicine preparation (Jalinous capsule) on functional constipation. Jalinous capsule is a combination of rose (Rosa damascena), mastic (Pistacia lentiscus), Aloe vera (Aloe barbadensis), and turpeth (Ipomoea turpethum). Methods: From January to December 2019, 126 patients aged 18 - 50 with functional constipation according to Rome IV criteria referred to Imam Khomeini hospital's gastrointestinal disease clinic were blindly randomized into "Jalinous" capsule group and placebo group for four weeks. Both groups received psyllium indeed. The patients were followed up at weeks two and four of the treatment and four weeks after the termination of the intervention. Results: Althoug...
American Journal of Gastroenterology, 2020
Archives of Iranian Medicine, 2020
The coronavirus associated disease 2019 (COVID-19) caused by the SARS-CoV-2 virus has rapidly spr... more The coronavirus associated disease 2019 (COVID-19) caused by the SARS-CoV-2 virus has rapidly spread all around the world and became pandemic in March 2020. Data on liver transplantation and chronic liver disease during the pandemic has remained scarce, and there is little information on whether immunosuppressed patients are at higher risk of developing severe COVID-19 infection. This review provides information for health care providers who care for patients with liver transplantation and chronic liver diseases.
Clinical Gastroenterology, 2019
and bile acid-related metabolites were related to curative effect. The enrichment of Alloprevotel... more and bile acid-related metabolites were related to curative effect. The enrichment of Alloprevotella after FMT may be able to treat ulcerative colitis by regulating bile acid metabolism, improving mucosal permeability and regulating immunity. Future work should focus on the multi center verification and the relationship of immunity and gut microbiome.
Clinical Nutrition ESPEN, 2020
Background: This study was designed to determine the effects of two dosages of vitamin D suppleme... more Background: This study was designed to determine the effects of two dosages of vitamin D supplementation on inflammatory biomarkers in patients with ulcerative colitis (UC). Methods: Fifty mild to moderate active UC patients were randomly assigned to consume either 2000 or 1000 IU/day vitamin D for 12 weeks. Inflammatory biomarkers, disease activity, quality of life, anthropometric indices, dietary intakes, and physical activity were measured at the beginning and the end of the study. Results: Serum level of hs-CRP decreased in both groups at the end of study, but the changes were not significantly different within and between groups. Serum level of TNF-a in the high dose group was reduced at the end of the study non-significantly (P-value ¼ 0.289). In the low dose group, a significant increase in serum TNF-a concentration was observed (p 0.001). The changes in serum TNF-a were significantly different between two groups (p ¼ 0.005); however, after adjusting for the effect of confounders, the significance effect was disappeared (p ¼ 0.162). Activity of NF-kB increased in both groups while this increase was significant in the low dose group compared to the baseline (p 0.001), and to high dose group (p ¼ 0.006). After adjustment for confounders, the difference between groups remained statistically significant (p ¼ 0.002). Conclusion: Our results indicate that 12 weeks supplementation with 2000 IU/day vitamin D prevents from systematic inflammation, while decreasing disease activity in patients with mild to moderate active UC. Further studies are needed to find the optimum dosage and duration of supplementation. This Trial was registered at IRCT.ir with number of IRCT 20100524004010N22.
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Papers by nasser ebrahimi daryani