Tert-butylation of phenol using N-(1,4-sulfonic acid) butyl triethylammonium hydrogen sulfate ion... more Tert-butylation of phenol using N-(1,4-sulfonic acid) butyl triethylammonium hydrogen sulfate ionic liquid catalyst in a batch reactor is optimized the process parameters using Response Surface Methodology. A Box-Behnken experimental design is applied to optimize the parameters such as Reaction time, temperature, reactant mole ratio and catalyst (IL) to phenol mole ratio of reaction. The optimized parameters are to minimize stringent experimental conditions and maintain the usage of catalyst. Maximum phenol conversion and selective yield of 2,4-DTBP were found in batch experiments at modest temperature, phenol to alcohol ratio, catalyst (IL) to phenol ratio with optimum time.
The inhibitive effect of compound (1-acetyl-4, 5-dihydro-5-Bromophenyl-3-(thiophen-2yl) pyrazoles... more The inhibitive effect of compound (1-acetyl-4, 5-dihydro-5-Bromophenyl-3-(thiophen-2yl) pyrazoles) on mild steel in 1M H 2SO 4 and 1M HCl was investigated by weight loss, Potentiodynamic polarization and electro chemical impidence studies. The synthesized compound of 1-acetyl-4, 5-dihydro-5-Bromophenyl-3-(thiophen-2yl) pyrazoles was characterized by FTIR, 1 H NMR, 13 C NMR and mass. The purity of the compound confirmed by TLC. The corrosion inhibition rate was increased with increasing the concentration of our synthesized inhibitor (1-acetyl-4, 5dihydro-5-Bromophenyl-3-(thiophen-2yl) pyrazoles). The synergetic effect also studied and observed good correlation between halides and our inhibitor. The adsorption isotherm was also confirmed by Langmuir adsorption isotherm.
The study was conducted for the removal of Methylen e blue dye from aqueous solutions onto citric... more The study was conducted for the removal of Methylen e blue dye from aqueous solutions onto citric acid modified leaves of Ricinus communis (CALRC). The properties of this adsorbent were characterized by Yield, Iodi ne value, surface acidity and basicity, Boehm’s titration, ze ta potential and FTIR measurements. Adsorption expe riments were carried out systematically by batch mode experiment s to investigate the influence of different factors , such as contact time, initial concentration of dye solution a d pH of the solutions. The maximum adsorption of MB dye was observed at 5.26 pH for CALRC (81.29 %). The Langmu ir, Freundlich, Temkin and Dubin-Radushkevich isoth erm models were used to analyze the equilibrium data. T he data were also fitted to kinetic models such as pseudo-first order, pseudo-second order, Intra particle and Elov ich model. The adsorption equilibrium data were wel l fitted by the Langmuir model. Kinetic studies showed that the adsorption followed pseudo-second o...
Accepted on 26 August 2014 ______________________________________________________________________... more Accepted on 26 August 2014 _____________________________________________________________________________ ABSTRACT Series of 4-4(Aryl)-6-(thiophen-2-yl)-pyrimdine-2-amines and its Substituted bromo, methyl, methoxy groups were synthesized by micro wave irradiation and also in conventional method. The synthesized compounds were characterized by FT-IR, One dimentional 1 H NMR and 13 C NMR spectroscopy and elemental analysis. In FT-IR spectrum the absorption frequencies at 3483 cm -1 is due the presence of NH2 of primary amino group. The absorption frequencies at 1571.99 cm -1 , 1367.53 cm -1 is due the presence of C=N andC-N of pyrimidine moiety respectively. In 1 H NMR spectrum the singlet observed at 5.19 ppm for two protons are primary amino group. The singlet observed at down field region at 7.08 ppm is due H-5 of pyrimidine moiety. In 13 C NMR spectrum, the 13 C resonance at 165.68 ppm is assigned to the amino group bearing carbon C-2 of pyrimidine moiety. The 13 C resonance obser...
A new novel series Ethyl-4-(biphenyl-2-yl)-2-oxo-6-arylcyclohex-3-ene carboxylates are constructe... more A new novel series Ethyl-4-(biphenyl-2-yl)-2-oxo-6-arylcyclohex-3-ene carboxylates are constructed by the reaction of ethylacetoacetate with biphenyl chalcones compounds under four step Michal addition reaction and ethanol used as a solvent and the chalcones synthesized by common Claisen-Schmidt condensation method. The reactions were monitored by Thin layer Chromatography (TLC). The characterization of the synthesized compounds by Infra-Red (IR), Proton Nuclear Magnetic Resonance (1H-NMR), Carbon-13 Nuclear Magnetic Resonance (13CNMR), Correlation Spectroscopy (COSY), Heteronuclear Single Quantum Coherence (HSQC) and Mass spectral data’s and elemental analysis. The synthesized compounds treated against Gram-positive and Gram-negative bacterial strains, the electron with-drawing group’s particularly substituted derivatives (F) group shows greater inhibition against Gram-negative bacterial strain Escherichia coli and the electron donating (OCH3) substitution derivative has shown exce...
A new sequence of new pyrazoline derivatives (5a-5h) was synthesized from 2-naphthylstyryl chalco... more A new sequence of new pyrazoline derivatives (5a-5h) was synthesized from 2-naphthylstyryl chalcone to react with hydrazine hydrate in the presence of n-butyric acid using the cyclization method. Synthesized compounds (5a-5h) chemical structure was elucidated by FT-IR, Proton and Carbon NMR Spectral data and CHN analysis. All the compounds (5a-5h) were subjected to in-vitro biological activity using disk diffusion method. The electronwithdrawing fluoro substituted compound 5b was better antibacterial activity against the bacterial strain of Pseudomonas aeruginosa and also the electron-withdrawing compound like bromo substitution 5d was excellent activity against bacterial strain of Escherichia coli and the fluoro substituted compound 5b was shown excellent activity against the gram-positive bacterial strain of Streptococcus pyogenes which was compared with the standard drug (Ciprofloxacin). The fluoro substituted compound 5b shown good antifungal activity against candida albicans. After that synthesized compounds (5a-5h) were subjected to molecular docking studies using bacterial protein and breast cancer protein. From this result, the synthesized compounds (5a-5h) have a high binding affinity score compared with the standard drug ciprofloxacin. Based on the high binding affinity score, compound 5b was subjected to in-vitro anticancer activity by MTT assay method against MDA MB-231 Cell line. From this result, the fluro substituted compound 5b showed good activity at low concentration (6.25 µg/ml). The LC 50 value of this compound 5b is 27.76 ± 0.003 µg/ml. Compounds 5b and 5h are the most important compound and there is only needed to develop new antibacterial agents. The compounds (5a-5h) are also subjected to ADME (druglikness) property using Osiris program, a result that 5c has the best druglikness property and 0.51 drug score with 32.67Å total polar surface area.
A convenient synthesis of 1-thiocarbamoyl-3-phenyl-5-diphenyl-4,5-dihydro-(1H)-pyrazole derivativ... more A convenient synthesis of 1-thiocarbamoyl-3-phenyl-5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives (2a-2g) was carried out by the condensation reaction of (E)-3-(phenyl)-1-(biphenyl-2-yl)-3-arylprop-2-en-1-ones (1a-1g) with thiosemicarbazide, sodium hydroxide as a catalyst in the presence of ethanol as solvent. Further, (E)-3-(phenyl)-1-(biphenyl-2-yl)-3-arylprop-2-en-1-ones were synthesized by the Claisen-Schmidt condensation reaction of substituted aldehydes with 4-acetylbiphenyl in the presence of basic ethanolic solution. The structure of synthesized compounds were confirmed by FT-IR, 1 H NMR, 13 C NMR and 1 H-1 H COSY. The antimicrobial susceptibility tests of synthesized compounds were screened against Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa. The docking studies also carried out by using 1UAG receptor for all the synthesized compounds (2a-2g).
The current novel series of 1-[5-(furan-2-yl)-4,5-dihydro-3-(4-morpholinophenyl)pyrazol-1-yl]etha... more The current novel series of 1-[5-(furan-2-yl)-4,5-dihydro-3-(4-morpholinophenyl)pyrazol-1-yl]ethanone are synthesized from the 3-(furan-2-yl)-1-(4-morpholinophenyl)prop-2-ene-1-one by cyclization reaction. The 3-(furan-2-yl)-1-(4-morpholinophenyl)prop-2-ene-1-one chalcones are derived from the reaction of 4-morpholino acetophenone with substituted furfuraldehyde by common Claisen-Schmidt condensation reaction. The structures of the synthesized compounds skeleton are elucidated by IR, 1 H NMR and 13 C NMR. The antimicrobial susceptibility tests of synthesized compounds are screened against Staphylococcus aureus and Escherichia coli. From the three synthesized compounds the electron-withdrawing substitution (Br) shows good effect against the Gram-positive bacteria and the electron donating substitution (CH3) shows excellent inhibition zone against the Gram-negative bacteria at the concentration level (10 µg/mL). The molecular docking is an effective and component tool for in silico screening of bioactive compounds and Auto Dock 4.2.1 is used to find the binding interaction of synthesized compounds towards 3 selected bacterial proteins (2X5O, 3TYE, 3UDI).
The corrosive inhibitive effect of compound on mild steel in molar solution of H 2 SO 4 and HCl w... more The corrosive inhibitive effect of compound on mild steel in molar solution of H 2 SO 4 and HCl was investigated by weight loss, potentiodynamic polarization and electro chemical impedance studies. 1-Acetyl-4, 5-dihydro-5-phenyl-3-(thiophen-2yl) pyrazoles was synthesized, characterized and structure elucidated by FTIR, 1 H NMR, 13 C NMR. The corrosion inhibition rate was increased by increasing the concentration of inhibitor (1-acetyl-4, 5-dihydro-5-phenyl-3-(thiophen-2yl) pyrazoles) and decreases with increase in temperature. The interaction between inhibitor and surface of steel obey Langmuir isotherm.
A simple and novel synthesis of series carboxylates derivatives were synthesized by reacting diff... more A simple and novel synthesis of series carboxylates derivatives were synthesized by reacting different substituted thiophene-2yl-1-arylprop-3-ene-1-one (chalcones) with ethylacetoacetate in the presence of acid medium. The synthesis was carried out by conventional methods. The synthesized compounds have been monitored by TLC and characterized by elemental analysis, IR, 1 H NMR, 13 C NMR spectroscopy. The synthesised compounds were checked by their drug ability. The drug ability of the compounds was confirmed by Lipinski's Rule (Rule 5).
A new series of bis acetylated hybrid pyrazoles were synthesized and characterized by their melti... more A new series of bis acetylated hybrid pyrazoles were synthesized and characterized by their melting point, elemental analysis, MS, FT-IR, one-dimensional 1 H, and 13 C NMR spectroscopic data. All the synthesized compounds were tested for their in vitro antifungal activities against Candida sp. namely Candida albicans, Candida glabrata, Candida parapsilosis, Candida dubliniensis and Candida tropicalis. A close inspection of the in vitro anticandidal activity profile in differently electron donating (CH3 and OCH3) and electron withdrawing (-F,-Cl, and Br) functional group substituted phenyl rings of novel hybrid pyrazoles exerted strong anticandidal activity against all the tested Candida species.
The aim of the present study was to isolate the skin lightening actives, particularly dendrite el... more The aim of the present study was to isolate the skin lightening actives, particularly dendrite elongation inhibitory compounds from Indian medicinal plants. With this interest, researchers has focused on plant extracts, which are having no side effects and also biodegradable. Artocarpus altilis is traditionally used in various culinary preparations and also other diseases. Methods: The leaves were extracted with methanol by soxhlet apparatus, the dilute extract was concentrated under vacuum through rotary evaporation to get concentrated extract. The crude extract was fractionated with various solvents to get different fractions. The active fraction was chromatographed over silica gel column to separate the active compound. The isolated compound has been characterized by physical and chemical spectral data like, UV, IR, NMR and mass. The dendrite elongation study was conducted by using melanocyte cells, B16F10. Results: The crude methanolic extract, fractions and isolated compound were showed good dendrite elongation activity when compared with control. The active compound has been characterized as dihydrochalcone derivative, AC-5-1 which was earlier reported in the literature. Conclusion: The compound is the first report from the plant and dendrite elongation studies were not done earlier. The crude extract, fractions or active can be used in skin care formulations for lightening the skin.
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2011
One-pot' ultrasound irradiation promoted synthesis and spectral characterization of an array of n... more One-pot' ultrasound irradiation promoted synthesis and spectral characterization of an array of novel 1,1-(5,5-(1,4-phenylene) bis(3-aryl-1H-pyrazole-5,1(4H,5H)-diyl))diethanones, a bis acetylated pyrazoles derivatives
View related articles Citing articles: 1 View citing articles RESEARCH LETTER Activated fly ash-c... more View related articles Citing articles: 1 View citing articles RESEARCH LETTER Activated fly ash-catalyzed synthesis of naphthyl-substituted cyclohexenone carboxylates, indazolonols, and nitro hydrazones in ''dry media''
Abstract An efficient method for the synthesis of imidazole derivatives by a three-component cond... more Abstract An efficient method for the synthesis of imidazole derivatives by a three-component condensation of benzil or 9,10-phenanthrenequinone, aldehydes and ammonium acetate using supported ionic liquid-like phase (SILLP) catalyst under ultrasonic irradiation or classical heating conditions is reported. The present methodology offers several advantages, such as excellent yields, simple procedures, short reaction times, simple work-up and mild conditions. The catalyst is easily separated from the products by filtration and also exhibits remarkable reusable activity. These highly substituted imidazoles were also evaluated for their anti-microbial activity.
A series of imidazo (4, 5-b) pyridinylethoxypiperidones was designed, synthesized and characteriz... more A series of imidazo (4, 5-b) pyridinylethoxypiperidones was designed, synthesized and characterized for evaluation of potential antibacterial activity against Bacillus subtilis, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and antifungal activity against Candida albicans-6, Candida albicans, Aspergillus niger, Candida albicans-51 and Aspergillus flavus. Structure–activity relationship led to the conclusion that compound 39 exerted strong in vitro antibacterial ...
Novel highly functionalized bis cyclohexenone ethyl carboxylates 7-12 were designed, synthesized ... more Novel highly functionalized bis cyclohexenone ethyl carboxylates 7-12 were designed, synthesized and their structures were elucidated by their elemental analysis, MS, FT-IR, one-dimensional 1H, and 13C NMR spectroscopic data. All the synthesized compounds 7-12 were tested for their in vitro antifungal activities against Candida sp. namely Candida albicans, Candida tropicalis, Candida glabrata, Candida parapsilosis, Candida dubliniensis and Candida krusei. A close inspection of the in vitro anticandidal activity profile in differently electron withdrawing (-F, -Cl, and -Br) functional group and electron donating (CH3 and OCH3) substituted phenyl rings of novel highly functionalized bis cyclohexenone ethyl carboxylates 7-12 exerted strong anticandidal activity against all the tested Candida species. All the synthesized compounds 7-12 exhibited MIC value in the range of 6.25-200 μg/mL against all the tested Candida (C.) species. Compound 8 against C. albicans, 9,11 against C. glabrata, 8,10 against C. parapsilosis, 7,9 against C. dubliniensis, 8,10 against C. krusei exhibited excellent anticandidal activity at a MIC value of 6.25 μg/mL. Likewise compound 7, 9-11 against C. albicans, 8, 9, 11 against C. tropicalis, 8 against C. glabrata, 9 against C. parapsilosis, 10 against C. dubliniensis, 9 against C. krusei revealed superior activity at a MIC value of 12.5 μg/mL.
Tert-butylation of phenol using N-(1,4-sulfonic acid) butyl triethylammonium hydrogen sulfate ion... more Tert-butylation of phenol using N-(1,4-sulfonic acid) butyl triethylammonium hydrogen sulfate ionic liquid catalyst in a batch reactor is optimized the process parameters using Response Surface Methodology. A Box-Behnken experimental design is applied to optimize the parameters such as Reaction time, temperature, reactant mole ratio and catalyst (IL) to phenol mole ratio of reaction. The optimized parameters are to minimize stringent experimental conditions and maintain the usage of catalyst. Maximum phenol conversion and selective yield of 2,4-DTBP were found in batch experiments at modest temperature, phenol to alcohol ratio, catalyst (IL) to phenol ratio with optimum time.
The inhibitive effect of compound (1-acetyl-4, 5-dihydro-5-Bromophenyl-3-(thiophen-2yl) pyrazoles... more The inhibitive effect of compound (1-acetyl-4, 5-dihydro-5-Bromophenyl-3-(thiophen-2yl) pyrazoles) on mild steel in 1M H 2SO 4 and 1M HCl was investigated by weight loss, Potentiodynamic polarization and electro chemical impidence studies. The synthesized compound of 1-acetyl-4, 5-dihydro-5-Bromophenyl-3-(thiophen-2yl) pyrazoles was characterized by FTIR, 1 H NMR, 13 C NMR and mass. The purity of the compound confirmed by TLC. The corrosion inhibition rate was increased with increasing the concentration of our synthesized inhibitor (1-acetyl-4, 5dihydro-5-Bromophenyl-3-(thiophen-2yl) pyrazoles). The synergetic effect also studied and observed good correlation between halides and our inhibitor. The adsorption isotherm was also confirmed by Langmuir adsorption isotherm.
The study was conducted for the removal of Methylen e blue dye from aqueous solutions onto citric... more The study was conducted for the removal of Methylen e blue dye from aqueous solutions onto citric acid modified leaves of Ricinus communis (CALRC). The properties of this adsorbent were characterized by Yield, Iodi ne value, surface acidity and basicity, Boehm’s titration, ze ta potential and FTIR measurements. Adsorption expe riments were carried out systematically by batch mode experiment s to investigate the influence of different factors , such as contact time, initial concentration of dye solution a d pH of the solutions. The maximum adsorption of MB dye was observed at 5.26 pH for CALRC (81.29 %). The Langmu ir, Freundlich, Temkin and Dubin-Radushkevich isoth erm models were used to analyze the equilibrium data. T he data were also fitted to kinetic models such as pseudo-first order, pseudo-second order, Intra particle and Elov ich model. The adsorption equilibrium data were wel l fitted by the Langmuir model. Kinetic studies showed that the adsorption followed pseudo-second o...
Accepted on 26 August 2014 ______________________________________________________________________... more Accepted on 26 August 2014 _____________________________________________________________________________ ABSTRACT Series of 4-4(Aryl)-6-(thiophen-2-yl)-pyrimdine-2-amines and its Substituted bromo, methyl, methoxy groups were synthesized by micro wave irradiation and also in conventional method. The synthesized compounds were characterized by FT-IR, One dimentional 1 H NMR and 13 C NMR spectroscopy and elemental analysis. In FT-IR spectrum the absorption frequencies at 3483 cm -1 is due the presence of NH2 of primary amino group. The absorption frequencies at 1571.99 cm -1 , 1367.53 cm -1 is due the presence of C=N andC-N of pyrimidine moiety respectively. In 1 H NMR spectrum the singlet observed at 5.19 ppm for two protons are primary amino group. The singlet observed at down field region at 7.08 ppm is due H-5 of pyrimidine moiety. In 13 C NMR spectrum, the 13 C resonance at 165.68 ppm is assigned to the amino group bearing carbon C-2 of pyrimidine moiety. The 13 C resonance obser...
A new novel series Ethyl-4-(biphenyl-2-yl)-2-oxo-6-arylcyclohex-3-ene carboxylates are constructe... more A new novel series Ethyl-4-(biphenyl-2-yl)-2-oxo-6-arylcyclohex-3-ene carboxylates are constructed by the reaction of ethylacetoacetate with biphenyl chalcones compounds under four step Michal addition reaction and ethanol used as a solvent and the chalcones synthesized by common Claisen-Schmidt condensation method. The reactions were monitored by Thin layer Chromatography (TLC). The characterization of the synthesized compounds by Infra-Red (IR), Proton Nuclear Magnetic Resonance (1H-NMR), Carbon-13 Nuclear Magnetic Resonance (13CNMR), Correlation Spectroscopy (COSY), Heteronuclear Single Quantum Coherence (HSQC) and Mass spectral data’s and elemental analysis. The synthesized compounds treated against Gram-positive and Gram-negative bacterial strains, the electron with-drawing group’s particularly substituted derivatives (F) group shows greater inhibition against Gram-negative bacterial strain Escherichia coli and the electron donating (OCH3) substitution derivative has shown exce...
A new sequence of new pyrazoline derivatives (5a-5h) was synthesized from 2-naphthylstyryl chalco... more A new sequence of new pyrazoline derivatives (5a-5h) was synthesized from 2-naphthylstyryl chalcone to react with hydrazine hydrate in the presence of n-butyric acid using the cyclization method. Synthesized compounds (5a-5h) chemical structure was elucidated by FT-IR, Proton and Carbon NMR Spectral data and CHN analysis. All the compounds (5a-5h) were subjected to in-vitro biological activity using disk diffusion method. The electronwithdrawing fluoro substituted compound 5b was better antibacterial activity against the bacterial strain of Pseudomonas aeruginosa and also the electron-withdrawing compound like bromo substitution 5d was excellent activity against bacterial strain of Escherichia coli and the fluoro substituted compound 5b was shown excellent activity against the gram-positive bacterial strain of Streptococcus pyogenes which was compared with the standard drug (Ciprofloxacin). The fluoro substituted compound 5b shown good antifungal activity against candida albicans. After that synthesized compounds (5a-5h) were subjected to molecular docking studies using bacterial protein and breast cancer protein. From this result, the synthesized compounds (5a-5h) have a high binding affinity score compared with the standard drug ciprofloxacin. Based on the high binding affinity score, compound 5b was subjected to in-vitro anticancer activity by MTT assay method against MDA MB-231 Cell line. From this result, the fluro substituted compound 5b showed good activity at low concentration (6.25 µg/ml). The LC 50 value of this compound 5b is 27.76 ± 0.003 µg/ml. Compounds 5b and 5h are the most important compound and there is only needed to develop new antibacterial agents. The compounds (5a-5h) are also subjected to ADME (druglikness) property using Osiris program, a result that 5c has the best druglikness property and 0.51 drug score with 32.67Å total polar surface area.
A convenient synthesis of 1-thiocarbamoyl-3-phenyl-5-diphenyl-4,5-dihydro-(1H)-pyrazole derivativ... more A convenient synthesis of 1-thiocarbamoyl-3-phenyl-5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives (2a-2g) was carried out by the condensation reaction of (E)-3-(phenyl)-1-(biphenyl-2-yl)-3-arylprop-2-en-1-ones (1a-1g) with thiosemicarbazide, sodium hydroxide as a catalyst in the presence of ethanol as solvent. Further, (E)-3-(phenyl)-1-(biphenyl-2-yl)-3-arylprop-2-en-1-ones were synthesized by the Claisen-Schmidt condensation reaction of substituted aldehydes with 4-acetylbiphenyl in the presence of basic ethanolic solution. The structure of synthesized compounds were confirmed by FT-IR, 1 H NMR, 13 C NMR and 1 H-1 H COSY. The antimicrobial susceptibility tests of synthesized compounds were screened against Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa. The docking studies also carried out by using 1UAG receptor for all the synthesized compounds (2a-2g).
The current novel series of 1-[5-(furan-2-yl)-4,5-dihydro-3-(4-morpholinophenyl)pyrazol-1-yl]etha... more The current novel series of 1-[5-(furan-2-yl)-4,5-dihydro-3-(4-morpholinophenyl)pyrazol-1-yl]ethanone are synthesized from the 3-(furan-2-yl)-1-(4-morpholinophenyl)prop-2-ene-1-one by cyclization reaction. The 3-(furan-2-yl)-1-(4-morpholinophenyl)prop-2-ene-1-one chalcones are derived from the reaction of 4-morpholino acetophenone with substituted furfuraldehyde by common Claisen-Schmidt condensation reaction. The structures of the synthesized compounds skeleton are elucidated by IR, 1 H NMR and 13 C NMR. The antimicrobial susceptibility tests of synthesized compounds are screened against Staphylococcus aureus and Escherichia coli. From the three synthesized compounds the electron-withdrawing substitution (Br) shows good effect against the Gram-positive bacteria and the electron donating substitution (CH3) shows excellent inhibition zone against the Gram-negative bacteria at the concentration level (10 µg/mL). The molecular docking is an effective and component tool for in silico screening of bioactive compounds and Auto Dock 4.2.1 is used to find the binding interaction of synthesized compounds towards 3 selected bacterial proteins (2X5O, 3TYE, 3UDI).
The corrosive inhibitive effect of compound on mild steel in molar solution of H 2 SO 4 and HCl w... more The corrosive inhibitive effect of compound on mild steel in molar solution of H 2 SO 4 and HCl was investigated by weight loss, potentiodynamic polarization and electro chemical impedance studies. 1-Acetyl-4, 5-dihydro-5-phenyl-3-(thiophen-2yl) pyrazoles was synthesized, characterized and structure elucidated by FTIR, 1 H NMR, 13 C NMR. The corrosion inhibition rate was increased by increasing the concentration of inhibitor (1-acetyl-4, 5-dihydro-5-phenyl-3-(thiophen-2yl) pyrazoles) and decreases with increase in temperature. The interaction between inhibitor and surface of steel obey Langmuir isotherm.
A simple and novel synthesis of series carboxylates derivatives were synthesized by reacting diff... more A simple and novel synthesis of series carboxylates derivatives were synthesized by reacting different substituted thiophene-2yl-1-arylprop-3-ene-1-one (chalcones) with ethylacetoacetate in the presence of acid medium. The synthesis was carried out by conventional methods. The synthesized compounds have been monitored by TLC and characterized by elemental analysis, IR, 1 H NMR, 13 C NMR spectroscopy. The synthesised compounds were checked by their drug ability. The drug ability of the compounds was confirmed by Lipinski's Rule (Rule 5).
A new series of bis acetylated hybrid pyrazoles were synthesized and characterized by their melti... more A new series of bis acetylated hybrid pyrazoles were synthesized and characterized by their melting point, elemental analysis, MS, FT-IR, one-dimensional 1 H, and 13 C NMR spectroscopic data. All the synthesized compounds were tested for their in vitro antifungal activities against Candida sp. namely Candida albicans, Candida glabrata, Candida parapsilosis, Candida dubliniensis and Candida tropicalis. A close inspection of the in vitro anticandidal activity profile in differently electron donating (CH3 and OCH3) and electron withdrawing (-F,-Cl, and Br) functional group substituted phenyl rings of novel hybrid pyrazoles exerted strong anticandidal activity against all the tested Candida species.
The aim of the present study was to isolate the skin lightening actives, particularly dendrite el... more The aim of the present study was to isolate the skin lightening actives, particularly dendrite elongation inhibitory compounds from Indian medicinal plants. With this interest, researchers has focused on plant extracts, which are having no side effects and also biodegradable. Artocarpus altilis is traditionally used in various culinary preparations and also other diseases. Methods: The leaves were extracted with methanol by soxhlet apparatus, the dilute extract was concentrated under vacuum through rotary evaporation to get concentrated extract. The crude extract was fractionated with various solvents to get different fractions. The active fraction was chromatographed over silica gel column to separate the active compound. The isolated compound has been characterized by physical and chemical spectral data like, UV, IR, NMR and mass. The dendrite elongation study was conducted by using melanocyte cells, B16F10. Results: The crude methanolic extract, fractions and isolated compound were showed good dendrite elongation activity when compared with control. The active compound has been characterized as dihydrochalcone derivative, AC-5-1 which was earlier reported in the literature. Conclusion: The compound is the first report from the plant and dendrite elongation studies were not done earlier. The crude extract, fractions or active can be used in skin care formulations for lightening the skin.
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2011
One-pot' ultrasound irradiation promoted synthesis and spectral characterization of an array of n... more One-pot' ultrasound irradiation promoted synthesis and spectral characterization of an array of novel 1,1-(5,5-(1,4-phenylene) bis(3-aryl-1H-pyrazole-5,1(4H,5H)-diyl))diethanones, a bis acetylated pyrazoles derivatives
View related articles Citing articles: 1 View citing articles RESEARCH LETTER Activated fly ash-c... more View related articles Citing articles: 1 View citing articles RESEARCH LETTER Activated fly ash-catalyzed synthesis of naphthyl-substituted cyclohexenone carboxylates, indazolonols, and nitro hydrazones in ''dry media''
Abstract An efficient method for the synthesis of imidazole derivatives by a three-component cond... more Abstract An efficient method for the synthesis of imidazole derivatives by a three-component condensation of benzil or 9,10-phenanthrenequinone, aldehydes and ammonium acetate using supported ionic liquid-like phase (SILLP) catalyst under ultrasonic irradiation or classical heating conditions is reported. The present methodology offers several advantages, such as excellent yields, simple procedures, short reaction times, simple work-up and mild conditions. The catalyst is easily separated from the products by filtration and also exhibits remarkable reusable activity. These highly substituted imidazoles were also evaluated for their anti-microbial activity.
A series of imidazo (4, 5-b) pyridinylethoxypiperidones was designed, synthesized and characteriz... more A series of imidazo (4, 5-b) pyridinylethoxypiperidones was designed, synthesized and characterized for evaluation of potential antibacterial activity against Bacillus subtilis, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and antifungal activity against Candida albicans-6, Candida albicans, Aspergillus niger, Candida albicans-51 and Aspergillus flavus. Structure–activity relationship led to the conclusion that compound 39 exerted strong in vitro antibacterial ...
Novel highly functionalized bis cyclohexenone ethyl carboxylates 7-12 were designed, synthesized ... more Novel highly functionalized bis cyclohexenone ethyl carboxylates 7-12 were designed, synthesized and their structures were elucidated by their elemental analysis, MS, FT-IR, one-dimensional 1H, and 13C NMR spectroscopic data. All the synthesized compounds 7-12 were tested for their in vitro antifungal activities against Candida sp. namely Candida albicans, Candida tropicalis, Candida glabrata, Candida parapsilosis, Candida dubliniensis and Candida krusei. A close inspection of the in vitro anticandidal activity profile in differently electron withdrawing (-F, -Cl, and -Br) functional group and electron donating (CH3 and OCH3) substituted phenyl rings of novel highly functionalized bis cyclohexenone ethyl carboxylates 7-12 exerted strong anticandidal activity against all the tested Candida species. All the synthesized compounds 7-12 exhibited MIC value in the range of 6.25-200 μg/mL against all the tested Candida (C.) species. Compound 8 against C. albicans, 9,11 against C. glabrata, 8,10 against C. parapsilosis, 7,9 against C. dubliniensis, 8,10 against C. krusei exhibited excellent anticandidal activity at a MIC value of 6.25 μg/mL. Likewise compound 7, 9-11 against C. albicans, 8, 9, 11 against C. tropicalis, 8 against C. glabrata, 9 against C. parapsilosis, 10 against C. dubliniensis, 9 against C. krusei revealed superior activity at a MIC value of 12.5 μg/mL.
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