Papers by mohammed noorul ameen
SPIE Proceedings, 2001
This paper describes the benefit for potentially rectifying the multiple nonlinear Phonocardiogra... more This paper describes the benefit for potentially rectifying the multiple nonlinear Phonocardiography measurements so that we can apply the linear independent component analysis (ICA) to separate blindly the sources of heart valve murmuring in order to find a noninvasive way to ...
Wavelet Applications VII, 2000
ABSTRACT We wish to generalize the covariance matrix approach (PCA) by the statistical Independen... more ABSTRACT We wish to generalize the covariance matrix approach (PCA) by the statistical Independent Component Analyses (ICA), which have been implemented by Bell-Sejnowski efficiently using ANN methodology. The gain of the statistics is the los of the geometry. In this research, we preserve the texture geometry with a so-called local ICA, in order to extract separately independent features from each class of natural textures. To avoid the curse of the dimensionality due to the local ICA, we furthermore use the divide-and-conquer strategy. A single ICA basis vector is chosen from each texture class, based on the maximum associative recalls from the class training set. Subsequently, another ICA basis is chosen, if necessary, to minimize the false alarm rate, namely the spread of confusion matrix. For the visible remote sensing application, we have designed such an optimum classifier of all natural scene textures with a minimum spread of the confusion matrix.
Science translational medicine, Jan 26, 2014
Patients with recessive dystrophic epidermolysis bullosa (RDEB) lack functional type VII collagen... more Patients with recessive dystrophic epidermolysis bullosa (RDEB) lack functional type VII collagen owing to mutations in the gene COL7A1 and suffer severe blistering and chronic wounds that ultimately lead to infection and development of lethal squamous cell carcinoma. The discovery of induced pluripotent stem cells (iPSCs) and the ability to edit the genome bring the possibility to provide definitive genetic therapy through corrected autologous tissues. We generated patient-derived COL7A1-corrected epithelial keratinocyte sheets for autologous grafting. We demonstrate the utility of sequential reprogramming and adenovirus-associated viral genome editing to generate corrected iPSC banks. iPSC-derived keratinocytes were produced with minimal heterogeneity, and these cells secreted wild-type type VII collagen, resulting in stratified epidermis in vitro in organotypic cultures and in vivo in mice. Sequencing of corrected cell lines before tissue formation revealed heterogeneity of cance...
Geological Society, London, Special Publications, 1999
British Journal of Dermatology, 2000
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Papers by mohammed noorul ameen