Papers by michael thompson
Accreditation and Quality Assurance, 2008
ABSTRACT The ‘characteristic function’ $$ \sigma = \sqrt {\alpha^{2} + \left( {\beta c} \right)^{... more ABSTRACT The ‘characteristic function’ $$ \sigma = \sqrt {\alpha^{2} + \left( {\beta c} \right)^{2} } ,$$ with two empirically determined parameters α and β, is proposed as a general purpose function to describe the variation of precision (in terms of standard deviation σ), or uncertainty, with analyte concentration c (here denoting any compositional quantity), for specific analytical methods applied to a defined type of test material. In this study it is applied to examples of analytical data collected under ‘instrumental’ conditions for estimating precision. The function fitted the data well, with no systematic lack of fit. The study therefore extends the range of applications of this function.
American Journal of Physiology-Cell Physiology, 2006
Nicotinic acid adenine dinucleotide phosphate (NAADP) has recently been shown to act as a second ... more Nicotinic acid adenine dinucleotide phosphate (NAADP) has recently been shown to act as a second messenger controlling intracellular Ca2+responses in mammalian cells. Many questions remain regarding this signaling pathway, including the role of the ryanodine receptor (RyR) in NAADP-induced Ca2+transients. Furthermore, the exact metabolic pathway responsible for the synthesis of NAADP in vivo has not been determined. Here, we demonstrate that the NAADP mediated Ca2+release system is present in human myometrial cells. We also demonstrate that human myometrial cells use the NAADP second messenger system to generate intracellular Ca2+transients in response to histamine. It has been proposed in the past that the NAADP system in mammalian cells is dependent on the presence of functional RyRs. Here, we observed that the histamine-induced Ca2+transients are dependent on both the NAADP and inositol 1,4,5-trisphosphate signaling pathways but are independent of RyRs. The enzyme CD38 has been s...
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Papers by michael thompson