Papers by marzieh alizadeh
Food and Chemical Toxicology, 2022
Synthetic azo dyes are widely used in a variety of industries, but many of them pose a risk to hu... more Synthetic azo dyes are widely used in a variety of industries, but many of them pose a risk to human health, particularly when consumed in large quantities. As a result, their existence in products should be closely monitored. D&C red 33 and Patent Blue V are mostly used in cosmetics, especially in toothpaste and mouthwashes. A novel carbon paste electrode modified with ZIF-8/g-C3N4/Co nanocomposite and 1-methyl-3-butylimidazolium bromide as an ionic liquid was employed as a highly sensitive reproducible electrochemical sensor for the simultaneous determination of these common dyes. ZIF structure has unique properties such as high surface area, suitable conductivity, and excellent porosity. The electrochemical behavior of the suggested electrode was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS). To characterize the synthesized nanocomposites, scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) were applied to investigate the structure of nanocomposites. Under the optimized conditions, the modified sensor offered a wide linear concentration range 0.08-10 μM (R2 = 0.9906) and 10-900 μM (R2 = 0.9932) with a low limit of detection of 0.034 μM. The value of diffusion coefficient (D), and the electron transfer coefficient (α) was calculated to be 310 × 10-5, and 0.9 respectively. This technique offered a successful performance for the determination of target analyte in the real samples with acceptable results between 96% and 107%.
Journal of Food Measurement and Characterization
Food and Chemical Toxicology
Food and Chemical Toxicology, 2022
This study provides a comprehensive review of the latest developments in the electrochemical impr... more This study provides a comprehensive review of the latest developments in the electrochemical impressions of the important dyestuffs including amaranth and carminic acid. Food colors are organic substances that have important effects on human health and food safety. While these substances do not pose a problem when used in the daily intake (ADI) amounts, they harm human health when consumed excessively. Amaranth and carminic acid are synthetic and natural food colors ingredients, respectively. Analysis of these substances in food, pharmaceutical, cosmetic and textile samples is extremely important because of their genotoxicity, cytostatic and cytotoxic effects. Electroanalytical methods, which have great advantages over traditional analytical methods, shed light on the scientific world. Electrochemical monitoring modules, which are fast, simple, accurate, reliable, and highly selective, are promising for the determination of both substances. Until now, amaranth and carminic acid food determinations have been carried out successfully with electrochemical monitoring techniques in many numbers in the literature. Voltammetric techniques are the most widely used among these electroanalytical methods. In particular, square wave and differential pulse voltammetric techniques, which have extraordinary properties, have been heavily preferred. Limits of detection (LOD) comparable to the standard analytical method have been achieved using these methods, which have very quick analysis durations, high precision and accuracy, do not require long preprocessing, and have great selectivity. In addition, more sensitive and selective analyses of amaranth and carminic acid in natural samples were carried out with numerous indicator electrodes. The merits of powerful electrochemical monitoring studies for the determination of both food colors during the last decade are presented in this study. Moreover, parameters such as analytical applications, detection limits, electrochemical methods, selectivity, working electrodes, and working ranges are summarized in detail.
Journal of Food Measurement and Characterization, 2022
This work primarily focused on the design of electrochemical and modified analytical sensors by t... more This work primarily focused on the design of electrochemical and modified analytical sensors by two highly conductive and powerful modifiers including titanium oxide nanotubes/single wall carbon nanotubes (TiO2-SWCNTs) and 1-hexyl 3-methyl imidazolium hexafluorophosphate (HMH) to detect bisphenol A (BPA) in the well water, municipal water, and soft drinks. In this regard, carbon paste electrode (CPE) was amplified with HMH and TiO2-SWCNTs, and then it was utilized for voltammetric sensing of bisphenol A in aqueous solution. The ability of sensor for determination of bisphenol A was assessed by chronoamperometric, cyclic voltammetric and differential pulse voltammetric (DPV) methods. At optimal condition of pH=5.0, TiO2-SWCNTs/HMH/CPE offered a powerful catalytic effect on oxidation signal of bisphenol A and enhanced its current about 7.77 times. Using DP voltammetric method, the TiO2-SWCNTs/HMH/CPE showed a linear dynamic range of 3.0 nM – 450 µM, and a good limit of detection of 1.0 nM. Moreover, TiO2-SWCNTs/HMH/CPE provided acceptable recovery data for determination of bisphenol A in real samples such as well water, Urban water and soft drink.
Chemosphere, 2022
Numerous people suffer from accidental or deliberate exposure to different pesticides when poison... more Numerous people suffer from accidental or deliberate exposure to different pesticides when poisoning with aluminum phosphate (AlP) is increasing in the eastern countries. Aluminum phosphate is a conventional insecticide that quickly reacts with water or the moistures in the atmosphere and produces fatal phosphine gas, which absorbs quickly by the body. Oral consumption or inhalation of AlP leads to excessive reaction of the body such as fatigue, vomiting, fever, palpitation, Vasodilatory shock, increasing blood pressure, cardiac dysfunction, pulmonary congestion, shortness of breath, and death. The garlic smell from the patient's mouth or exhale is one of the methods to recognize the positioning. Due to the lack of individual antidotes, several supportive treatments are required. The present study focused on the available and new therapies that help reduce the effect of AlP poisoning and the mortality rate. The therapies are divided into the antioxidant-related agent and the other agents. The impacts of each agent on the experimental cases are reported.
Chemosphere, 2021
Drug efficiency can be considerably boosted while adverse effects can be reduced by precisely mon... more Drug efficiency can be considerably boosted while adverse effects can be reduced by precisely monitoring the concentration of anti-cancer drugs. Thus, one of the most important parameters for human health is the monitoring and detection of anticancer drugs during chemotherapy treatment. Herein, a glassy carbon electrode (GCE) was modified by Pt- and Pd-incorporated ZnO nanoparticles-decorated single-wall carbon nanotubes (Pt-Pd-ZnO/SWCNTs) nanocomposites, and ds-DNA (Calf Thymus) that was a biological recognition element, and it was aimed to be utilized as an ultrasensitive and effective electroanalytical biosensor for idarubicin (IDR) monitoring. Various physicochemical characterization techniques including transmission electron microscopy (TEM), field-emission scanning electron microscopy (FE-SEM) with energy-dispersive X-ray spectroscopy (EDS) were used to investigate the morphology and structure of the Pt-Pd-ZnO/SWCNTs nanocomposite, which was produced via straightforward chemical precipitation combined with the one-pot method. The layer-by-layer modification technique was implemented to fabricate the ds-DNA/Pt-Pd-ZnO/SWCNTs/GCE to be further utilized as a voltammetric sensor for sensitive monitoring of idarubicin in biological fluids and pharmaceutical substances. The electroanalytical method implemented to detect idarubicin was based to detect the ds-DNA's guanine base signal on the surface of the modified electrode in the absence and presence of the anticancer drug. The results explicated that the developed biosensor performed well in determining idarubicin in concentrations ranging from 1.0 nM to 65 μM, with a detection limit of 0.8 nM. The idarubicin detection ability of the modified electrode in real samples was evaluated, and the recovery data was acquired in the range of 98.0% and 104.75%. In the final step, the preferential intercalative binding mode of idarubicin drug with ds-DNA was approved by molecular docking study. This study paves the way for engineering highly sensitive DNA biosensors to be employed in the monitoring of anticancer drugs by combining the benefits of nanocomposites and valuable information of a molecular docking study.
International Journal of Electrochemical Science, 2021
Phenol and its derivatives are one of the main important pollutants of water sources. Highly sens... more Phenol and its derivatives are one of the main important pollutants of water sources. Highly sensitive electrochemical sensor modified with titanium oxide nanotubes/single-wall carbon nanotubes nanocomposite and room temperature ionic liquid (1-hexyl 3-methyl imidazolium hexafluorophosphate) (TiO2/NT/SWCNTs/IL/CPE) was fabricated for the determination of phenol in well water, seawater and urban water samples. The TiO2/NT/SWCNTs nanocomposite synthesized with thermal process and characterized with FESEM and TEM methods. Ration of mediators and pH value of solution were optimized as important factors on sensor ability for phenol determination and results confirmed best condition were obtained at pH= 6.0, 15% (v:v; 1-hexyl 3-methyl imidazolium hexafluorophosphate/paraffin oil) and 6% (w:w; TiO2/NT/SWCNTs/graphite powder). In continuous, the recorded differential pulse voltammograms (DPV) confirmed that the electro-oxidation current of phenol improved about 2.9 times by TiO2/NT/SWCNTs/IL/CPE compare to CPE and the phenol oxidation potential decrease about 105 mV. Then, the interference species on the determination of phenol evaluated and reported results showed high selectivity of TiO2/NT/SWCNTs/IL/CPE for sensing phenol in water samples. DP voltammograms show wide linear dynamic ranges between 0.1-300 µM and a good limit of detection of about 0.05 µM for sensing phenol. Finally, TiO2/NT/SWCNTs/IL/CPE is used to determine phenol in different water samples with acceptable recovery data.
Nanoscale Research Letters, 2021
Brucellosis is considered as the most common bacterial zoonosis in the world. Although the labora... more Brucellosis is considered as the most common bacterial zoonosis in the world. Although the laboratory findings are the most reliable diagnosis today, the current laboratory methods have many limitations. This research aimed to design and evaluate the performance of a novel technique based on the localized surface plasmon resonance (LSPR) to eliminate or reduce existing shortcomings. For this purpose, smooth lipopolysaccharides were extracted from Brucella melitensis and Brucella abortus and fixed on the surface of the gold nanoparticles through covalent interactions. After some optimizing processes, dynamic light scattering was used to characterize the probe. The detection of captured anti-Brucella antibody was performed by measuring the redshift on LSPR peak followed by the determination of cutoff value, which indicated a significant difference between controls and true positive patients (P value < 0.01). Furthermore, 40 sera from true negative samples and positive patients were...
Chemosphere, 2021
In the present study, gold nanoparticles were locally well-decorated on the surface of TiO2 using... more In the present study, gold nanoparticles were locally well-decorated on the surface of TiO2 using the tungstophosphoric acid (HPW), as UV-switchable reducing intermediate linkers. The prepared Au NPs/HPW/TiO2 nanostructure was characterized using FTIR, XRD, EDS, SEM and TEM, which confirmed the successful attachment of quasi-spherical Au NPs in the range of 20-30 nm on the surface of HPW modified TiO2. Also, the FTIR results show that the Au NPs were binded to TiO2 through the terminal the oxygen atoms HPW. The photocatalytic performance of prepared nanostructures was assessed in degradation of nitrobenzene. The nitrobenzene photodegradation kinetic study revealed that it well followed the Langmuir-Hinshelwood kinetic model with the apparent rate constant of 0.001 min-1 using anatase TiO2, 0.0004 min-1 using HPW, 0.0014 using HPW/TiO2, while it was obtained 0.0065 min-1 using Au NPs@HPW/TiO2 nanostructure. It shows that the photocatalytic rate of the prepared nanocomposites increased by 6.5- and 4.6-fold compared to photoactivity of anatase TiO2 and HPW/TiO2 respectively. Also, the photocatalytic mechanism of process was proposed. Moreover, the reusability study confirmed that its photocatalytic activity still remained high after three cycles.
Chemosphere, 2022
In this work, we report a novel enzymatic biosensor based on glutathione peroxidase (GSH-Px), gra... more In this work, we report a novel enzymatic biosensor based on glutathione peroxidase (GSH-Px), graphene oxide (GO) and nafion for the electrochemical sensing of glutathione (GSH) in body fluids. GSH-Px was immobilized covalently via 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) onto modified glassy carbon electrode (GCE) decorated with GO and nafion and successfully used for sensing of GSH in the presence of H2O2 as catalyst with Michaelis-Menten constant about 0.131 mmol/L. The active surface are of GCE improve from 0.183 cm2 to 0.225 cm2 after modification with GO. The introduced biosensor (GSH-Px/GO/nafion/GCE) was used for monitoring of GSH over the range 0.003-370.0 μM, with a detection limit of 1.5 nM using differential pulse voltammetric (DPV) method. The GSH-Px/GO/nafion/GCE was successfully applied to the determination of GSH in real samples.
Journal of Molecular Liquids, 2021
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Journal of Food Measurement and Characterization, 2021
In this research, functionalized carbon nanotubes were employed to modify a glassy carbon electro... more In this research, functionalized carbon nanotubes were employed to modify a glassy carbon electrode (F-MWCNT/GCE). Several techniques including Fourier Transform Infrared Spectroscopy, scanning electron microscopy, and transmission electron microscopy were utilized for characterization of F-MWCNT. The electrochemical activity of the developed electrode was assessed by differential pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectroscopy. The electrochemical results demonstrated that oxidation of tryptophan (TRP) caused a higher anodic peak current than unmodified GCE. The F-MWCNT/GCE offered a detection limit of 3.63 nM and dynamic ranges of 0.01–0.7 µM for analysis of TRP by the differential pulse voltammetry method. Moreover, tryptophan detection was achieved successfully using F-MWCNT/GCE in milk samples. It can be stated that this method paves the way for a selective, sensitive and straightforward method to determine tryptophan in the real food sample.
Journal of Food Measurement and Characterization, 2021
In the present study, the electrochemical behavior of Folic acid (FA) on the glassy carbon electr... more In the present study, the electrochemical behavior of Folic acid (FA) on the glassy carbon electrode modified with 2D-MoS2 nanosheets has been investigated utilizing differential pulse voltammetry (DPV), cyclic voltammetry (CV), and chronoamperometric techniques at pH 6.0 Britton-Robinson buffer. The experimental conditions, including the pH, scan rate, were optimized. Under the optimized experimental conditions, to determine the selectivity and sensitivity of FA, the DPV procedure was conducted in the linear dynamic range from 0.06 to 1.16 to 1.16–24.3 µM with a detection limit of 32.0 nM. The 2D-MoS2 nanoparticle was synthesized and characterized by EDX and SEM methods. The proposed modified electrode offered an outstanding electrocatalytic activity towards the oxidation of FA. The FA detection successfully validated the analytical reliability of 2D-MoS2/GCE in the food samples with acceptable recoveries at the range of 97.1 and 103.1%. Based on the results, it can be speculated that 2D-MoS2/GCE can be used as an alternative analytical instrument to determine FA in real samples.
Environmental Research, 2021
In the present study, a novel 1-butyl-3-methylimidazolium bromide (BmImBr) impregnated chitosan b... more In the present study, a novel 1-butyl-3-methylimidazolium bromide (BmImBr) impregnated chitosan beads were prepared and characterized using different methods, including XRD, FT-IR, EDX, SEM and BET. The FTIR analysis revealed that the BmImBr was successfully conjugated with the chitosan in the beads structure. The prepared beads were used as an efficient sorbent for the fast removal of methylene blue, as cationic dye model, from aqueous solution, whereas just 25 min was required to reach 86% removal efficiency. The increasing of BmImBr amount improved the adsorption performance of prepared beads. Also, it was found that the dye can be higher adsorbed on the beads surface by increasing the sorbent dosage and pH of solution, while the optimum dosage and pH were obtained 3 mg/L and 11, respectively. The kinetic study showed that the MB adsorption onto the CS-BmImBr beads follows the pseudo-fist order model and the intrinsic penetration controls the adsorption process.The properties of prepared chitosan- BmImBr IL conjugation confirmed that it can be exploited as an efficient adsorbent in the wastewater treatment.
Journal of Food Measurement and Characterization, 2021
Determination of food toxic compounds is one of the significant strategies for investigating food... more Determination of food toxic compounds is one of the significant strategies for investigating food quality. The presence research introduces an electrochemical approach for toxic ractopamine sensing using a gold electrode amplified with gold nanoparticles (Au-Nps/AuME). The oxidation signal of ractopamine was investigated at the surface of Au-Nps/AuME, and results showed a 2.36-fold amplification in current and reducing 100 mV in oxidation potential compare to the pristine gold electrode. The redox reaction of ractopamine shows a pH dependence behavior with two electrons and two protons. Furthermore, the scan rate and chronoamperometric investigation showed a diffusion coefficient of 1.0 × 10−6 cm2/s to the oxidation reaction of ractopamine at the surface of Au-Nps/AuME. Analytical investigation showed a linear dynamic range of 0.1–380 µM for sensing of ractopamine using square wave voltammetric technique. Also, Au-Nps/AuME could be used to measure ractopamine in food samples such as pork samples with a recovery range of 98.3–103.9% and a detection limit of 50 nM.
Daunorubicin is a famous anthracycline anticancer chemotherapy drug with many side effects that i... more Daunorubicin is a famous anthracycline anticancer chemotherapy drug with many side effects that is very important to measure in biological samples. A daunorubicin electrochemical biosensor was fabr...
Current Analytical Chemistry, 2022
: N,Nʹ-dialkylimidazolium-ion liquids is one of the important ionic liquids with a wide range of ... more : N,Nʹ-dialkylimidazolium-ion liquids is one of the important ionic liquids with a wide range of application as conductive electrolyte and in electrochemistry. The modified electrodes create a new view in fabrication of electroanalytical sensors. Many modifiers have beeen suggested for modification of electroanalytical sensor since many years ago. Over these years, ionic liquids and especially room temperature ionic liquids have attracted more attention due to their wide range of electrochemical windows and high electrical conductivity. N,Nʹ-dialkylimidazolium-ion liquids are one of the main important ionic liquids suggested for modification of bare electrodes and especially carbon paste electrodes. Although many review articles have reported onthe use of ionic liquids in electrochemical sensors, no review article has been specifically introduced so far on the review of the advantages of N,Nʹ-dialkylimidazolium ionic liquid. Therefore, in this review paper we focused on the introduction of recent advantages of N,Nʹ-dialkyl imidazolium ionic liquid in electrochemistry.
Parasitology Research, 2020
Albendazole is known as the drug of choice for medical treatment of cystic echinococcosis (CE). A... more Albendazole is known as the drug of choice for medical treatment of cystic echinococcosis (CE). Albendazole sulfoxide (ABZ-SO), as the main active metabolite of albendazole, has low efficacy in the disease due to low water solubility and poor absorptivity. PLGA nanoparticles (NPs) enhance the dissolution of poorly soluble drugs, and chitosan (CS) coating enhances oral drug delivery of NPs. In this study, the efficacy of ABZ-SO-loaded CS-PGLA NPs in the treatment of CE was evaluated in laboratory mice. ABZ-SO-loaded CS-PGLA NPs were prepared by nanoprecipitation and characterized by dynamic light scattering method and scanning electron microscopy. Thirty mice were intraperitoneally infected by 1000 protoscoleces of Echinococcus granulosus. Ten months later, the mice were allocated into 3 groups: groups 1 and 2 were treated with ABZ-SO and ABZ-SO-loaded CS-PGLA NPs, respectively, and the mice in group 3 remained untreated as the control group. The drugs were administered by gavage for 45 days at a daily dose of 10 mg/kg. Finally, all mice were opened and the cysts were collected, counted, weighed, and measured separately. The therapeutic effect of ABZ-SO in the number, weight, and volume of the cysts were not statistically significant compared with those in ABZ-SO-loaded CS-PGLA NPs and the control group. However, the therapeutic effect of ABZ-SO-loaded CS-PGLA NPs in the weight and volume of cysts were statistically significant when compared with that in the control group (p ˂ 0.05). In conclusions, this study revealed that ABZ-SO-loaded CS-PGLA NPs could enhance the therapeutic efficacy of ABZ-SO in the treatment of CE in laboratory mice.
Current Biochemical Engineering, 2020
Background: Electrochemical sensors are widely used for the determination of drugs and food compo... more Background: Electrochemical sensors are widely used for the determination of drugs and food compounds. In recent years, the amplification of electrochemical signals with nanomaterials, especially Carbon Nanotubes (CNTs) has created a major revolution in electrochemistry. Objective: The present mini-review paper focused on studying the role of CNTs as conductive mediators for the fabrication of highly sensitive electrochemical sensors. CNTs, with high conductivity and good ability for modification with other materials, are interesting candidates for improving the sensitivity of electrochemical sensors. CNTs or their derivatives are suggested for different applications in electrochemistry and especially analytical biosensors. This review is aimed to discuss the conductivity feature of CNTs in electrochemical sensors.
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Papers by marzieh alizadeh