Papers by mahmoud shaheen
International Surgery Journal, 2018
Background: The surgical intervention for acute appendicitis presenting with appendicular mass is... more Background: The surgical intervention for acute appendicitis presenting with appendicular mass is not well established. The aim of this study was to evaluate the benefits of early laparoscopy and laparoscopic appendectomy (LA) in the treatment of appendicular mass.Methods: During a 1-year period, 48 patients underwent LA for suspected appendicitis (n = 39), generalized peritonitis (n = 1), and an appendicular mass (n = 8).Results: All appendectomies were attempted and done laparoscopically except in one case (appendicular abscess), converted to an open approach. None of appendicular mass patients developed complications. There were no deaths. There was no significant difference between appendicular mass forming patients and non-mass-forming patients who underwent LA for an early appendicular mass as regard to the operative time (median [interquartile range]: 50 [36–60] vs 45 [25–50] min, p = 0.085) and postoperative hospital stay (median [interquartile range]: 2 [1–2] vs [1–2] days,...
Colorectal cancer (CRC) ranks first in males and third in females among all cancers in Saudi Arab... more Colorectal cancer (CRC) ranks first in males and third in females among all cancers in Saudi Arabia. Its frequency of diagnosis has increased significantly over the past ten years. Genetic and environmental factors may have played important roles in the increase in CRC incidence in Saudi Arabia. Using a retrospective study, we studied all patients diagnosed with CRC by endoscopy at King Abdul Aziz University Hospital in Jeddah, Saudi Arabia. For each patient, we collected demographic data, endoscopic findings, hemoglobin results, CEA levels at diagnosis, radiological findings and methods of treatment offered. We included 177 patients in the final analysis. The sample comprised mostly males 103 (58.2%), and 72 (40.0%) were Saudis. The mean age was 56.6±SD 13.3 years old. Male patients were older than female patients (P=.046). Approximately one-third of all patients were younger than 50 years old (50 patients). Most of the patients 164 (92.7%) had a single lesion on the left side rect...
Background: Laparoscopic colectomy is safe and effective, and in some cases, superior to open sur... more Background: Laparoscopic colectomy is safe and effective, and in some cases, superior to open surgery, for a range of benign illnesses. The short-term advantages include less gastrointestinal discomfort, decreased wound infection and surgical morbidity, quicker bowel function restoration, and a shorter duration of hospital stay.Aim of the work & Methodology: evaluate our practice in laparoscopic colectomy by studied 20 patients with benign colorectal disorders admitted to our university hospital between Dec. 2015 and Dec. 2020. Inclusion criteria: 1. Age ranging from 15 to 70 years. 2. Patients with benign colorectal diseases, e.g., diverticular diseases, inflammatory bowel diseases, colonic polyps, rectal prolapse, etc. Exclusion criteria; malignant colorectal tumors and relative contraindication for laparoscopy. We were using classical laparoscopic techniques. Patients were discharged from the hospital when they could tolerate a regular diet. They were followed up at least six mon...
Journal of Clinical Oncology, 2012
e20508 Background: Ewing’s sarcoma is a primary malignant tumour of the bone. Ifosfamide and doxo... more e20508 Background: Ewing’s sarcoma is a primary malignant tumour of the bone. Ifosfamide and doxorubicin hydrochloride are two active drugs. Administration of the maximum feasible doses may help achieve the best result. In this study we proposed to use the combination of vincristine, actinomycin D, doxorubicin hydrochloride, ifosfamide (VAAI) for total of 12 cycles. Methods: All eligible patients will receive initially four cycles of VAAI. Doses include: vincristine maximum 2 mg IV doxorubicin hydrochloride 25 mg/m2 IVpush for 3 days ifosfamide 3 Gm/m2 as an intravenous infusion over 2 hours for 3 days. Each cycle will be repeated every 21 days. Patient will then undergo response evaluation, and subjected to surgical resection when posible. If surgery is incomplete, not possible or refused, radical radiation therapy to a dose of 55 Gy was given. Post operatively patient will recice two cycle of adriamycin base chemotherapy and than will continue with actinomycin d to complete 12 cyc...
Journal of Clinical Oncology, 2014
ABSTRACT Background: Improved local control and survival has been observed with increasing rate o... more ABSTRACT Background: Improved local control and survival has been observed with increasing rate of tumor necrosis >90% with preoperative chemo-radiation for STS. However the rate of necrosis (90%+) following pre-operative chemo radiation remains low (<50%) and likely even less for locally advanced (>8 cm) tumors. The purpose of this study was to increase the rate of tumor necrosis following preoperative chemo-radiation in the management of soft tissue sarcomas (STS) using induction SFGRT. Methods: Fourteen patients with locally advanced extremity STS ranging in size from 8 cm to 26 cm (median 11.5 cm) were treated with high dose megavoltage radiation using an SFGRT technique. Single dose of induction SFGRT 18 Gy was delivered using 6 MV photons followed by external beam radiation 50 Gy combined with iphosfamide 2 gm/m2/day x 3 and mesna 2 gm/day x 3 in divided doses every three weeks followed by surgery 4-6 weeks after completing neoadjuvant therapy. Results: 12 patients completed the planned treatment. 1 patient had treatment interrupted due to Grade 3 skin reaction and 1 patient underwent an amputation of the foot mid treatment. Follow up ranges from 3 months to 43 months (median 14 mo). 13/14 patients underwent limb salvage surgery with 12 having negative margins. 2 patients have had delayed wound healing. 9/14 (65%) patients had > 90 % tumor necrosis with 2 patients having a pathological complete response. 2 additional patients have had greater than 80% necrosis. There have been no local recurrences and 12 patients are alive with no evidence of disease. Conclusions: The combined use of induction SFGRT and external beam radiation/chemotherapy is an effective way to enhance the necrosis and response to neoadjuvant chemo-radiation and potentially improve local control/ limb salvage and survival in locally advanced extremity STS.
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Papers by mahmoud shaheen