Papers by john jady Hurtado
CrystEngComm, 2022
Complex [Co(DNB)2] was recrystallized in water (H2O), methanol (CH3OH), ethanol:acetone (EtOH: Ac... more Complex [Co(DNB)2] was recrystallized in water (H2O), methanol (CH3OH), ethanol:acetone (EtOH: Act), dimethyl sulfoxide (DMSO), acetone (Act), and acetonitrile (ACN). As result, mono or trinuclear molecules were obtained depending on...
ChemistrySelect, 2017
Reactions of Cu(ClO4)2⋅6H2O with 2,6‐bis(3,5‐dimethylpirazol‐1‐ylmethyl)pyridine (dmpz‐py) (1), 2... more Reactions of Cu(ClO4)2⋅6H2O with 2,6‐bis(3,5‐dimethylpirazol‐1‐ylmethyl)pyridine (dmpz‐py) (1), 2,6‐bis(4‐iodo‐3,5‐dimethylpirazol‐1‐ylmethyl)pyridine (I‐dmpz‐py) (2) and 2,6‐bis(4‐nitro‐3,5‐dimethylpirazol‐1‐ylmethyl)pyridine (NO2‐dmpz‐py) (3) yield the corresponding metal complexes: [Cu(dmpz‐py)(H2O)(ClO4)]ClO4 (4), [Cu(I‐dmpz‐py)(H2O)](ClO4)2 (5) and [Cu(NO2‐dmpz‐py)(H2O)(ClO4)2] (6). The complexes were isolated in high yields as stable solids at room temperature and characterized by melting point, electrical conductivity, and infrared and ultraviolet/visible spectroscopy. In addition, the crystal structures of the new complexes were determined by single‐crystal X‐ray diffraction and showed square‐base pyramidal (4), distorted square‐planar (5) and octahedral (6) geometries. All three complexes were active in the ring opening polymerization of ϵ‐caprolactone under solvent‐free conditions, producing polycaprolactones of narrow polydispersity and high crystallinity. The results obt...
Vector borne and zoonotic diseases (Larchmont, N.Y.), Jan 3, 2018
An organic salt and four metal complexes derived from azole were evaluated against embryonated To... more An organic salt and four metal complexes derived from azole were evaluated against embryonated Toxocara canis eggs (TCE). The new organic salt, (LH)(FeCl), where L = 3,5-bis(3,5-dimethylpyrazole-1-ylmethyl)toluene (5), a potential environmental disinfectant, was isolated as an air-stable yellow solid and characterized by elemental analysis, electrical conductivity, mass spectrometry, and infrared and ultraviolet/visible spectroscopy. In addition, the structure of 5 was determined by single-crystal X-ray diffraction. Compound 2 showed high anti-TCE activity. Interestingly, these compounds showed little effect on hepatocytes, indicating that they are not cytotoxic. These results will assist in the design of anti-TCE compounds.
ACS Omega, 2020
A new monophosphine Cu(I) complex bearing bis(pyrazolyl)methane (L 1) (CuIL 1 PPh 3) was synthesi... more A new monophosphine Cu(I) complex bearing bis(pyrazolyl)methane (L 1) (CuIL 1 PPh 3) was synthesized and used as a catalyst for the three-component click reaction from an alkyl halide, sodium azide, and terminal alkyne to furnish 1,4disubstituted 1,2,3-triazoles in up to 93% yield. The catalyst is highly stable, compatible with oxygen/water, and works with total efficiency under ultrasonic condition. The structure of the complex was studied and confirmed by X-ray crystallography, finding a riveting relationship with its catalytic activity. This sustainable triazoles synthesis is distinguished by its high atom economy, low catalyst loading (up to 0.5 mol %), broad substrate scope, short reaction times, operational simplicity, and an easy gram-scale supply of a functionalized product for subsequent synthetic applications.
BMC Chemistry
Relevant virulence traits in Candida spp. are associated with dimorphic change and biofilm format... more Relevant virulence traits in Candida spp. are associated with dimorphic change and biofilm formation, which became an important target to reduce antifungal resistance. In this work, Co(II) complexes containing a benzotriazole derivative ligand showed a promising capacity of reducing these virulence traits. These complexes exhibited higher antifungal activities than the free ligands against all the Candida albicans and non-albicans strains tested, where compounds 2 and 4 showed minimum inhibitory concentration values between 15.62 and 125 μg mL−1. Moreover, four complexes (2–5) of Co(II) and Cu(II) with benzotriazole ligand were synthesized. These compounds were obtained as air-stable solids and characterized by melting point, thermogravimetric analysis, infrared, Raman and ultraviolet/visible spectroscopy. The analysis of the characterization data allowed us to identify that all the complexes had 1:1 (M:L) stoichiometries. Additionally, Density Functional Theory calculations were ca...
Inorganic Chemistry Frontiers, 2017
Ligand-mediated antiferromagnetic coupling induces aromatic-ring behavior.
IEEE Sensors Journal, 2014
Recent advances in the electrochemical application of glassy carbon electrode for determination o... more Recent advances in the electrochemical application of glassy carbon electrode for determination of selected drugs in pharmaceutical formulations are reviewed. Several analytical techniques such as liquid chromatography, high performance liquid chromatography, spectrophotometry, chemiluminescence, and capillary electrophoresis-mass spectrometry have been used for the detection and separation of pharmaceutical active components due to their high sensitivity and great selectivity. However, all these methods are complicated, time-consuming and require expensive equipment. In contrast to these conventional techniques, the electrochemical technique overcomes those drawbacks owing to its low cost, rapid response and application in on-site test. Special attention is paid on this review for electrochemical application of bare and modified glassy carbon electrode for the
Revista de Investigaciones Universidad del Quindío, 2013
En una mezcla de los disolventes tolueno-tetrahidrofurano, se hizo reaccionar YCl3 con Li[N(SiMe3... more En una mezcla de los disolventes tolueno-tetrahidrofurano, se hizo reaccionar YCl3 con Li[N(SiMe3)2] para formar el producto YCl2[N(SiMe3)2](THF)3 (1). Este precursor se hizo reaccionar con los ligandos tridentados: 2,6-bis(3,5-dimetilpirazol-1-ilmetil)piridina y 2,6-bis(indazol-2-ilmetil)piridina obteniéndose los complejos pincer de fórmula general YCl2[N(SiMe3)2]{2,6-bis(azolilmetil)piridina-N,N,N}(2,3). Los complejos de itrio(III) fueron preparados a escala de RMN y caracterizados mediante técnicas espectroscópicas de RMN (1H, 13C, 29Si). A temperatura ambiente, los complejos mostraron una alta actividad catalítica para la polimerización de ε-caprolactona. Los polímeros obtenidos se caracterizaron por espectroscopía IR, RMN y para la determinación de los pesos moleculares se utilizó cromatografía de exclusión por tamaño (SEC)
Sensors, 2018
This work reports the development of a composite of the ionic liquid 1-butyl-3-methylimidazolium ... more This work reports the development of a composite of the ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIM]BP4) and chitosan (CS) described in previous reports through a new method using cyclic voltammetry with 10 cycles at a scan rate of 50.0 mV s−1. This method is different from usual methods such as casting, deposition, and constant potential, and it allows the development of an electroactive surface toward the oxidation of rutin by stripping voltammetry applied to the detection in tropical fruits such as orange, lemon, and agraz (Vaccinium meridionale Swartz), with results similar to those reported in previous studies. In addition, the surface was characterized by electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), and Raman spectroscopy. The limit of detection was 0.07 µmol L−1 and the relative standard deviation (RSD) of 10 measurements using the same modified electrode was 0.86%. Moreover, the stability of the sensor was studied fo...
Crystal Growth & Design, 2019
Molecules, 2018
In this work, six complexes (2–7) of Cr(III) and Co(II) transition metals with triazole ligands w... more In this work, six complexes (2–7) of Cr(III) and Co(II) transition metals with triazole ligands were synthesized and characterized. In addition, a new ligand, 3,5-bis(1,2,4-triazol-1-ylmethyl)toluene (1), was synthesized and full characterized. The complexes were obtained as air-stable solids and characterized by melting point, electrical conductivity, thermogravimetric analysis, and Raman, infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that complexes 3–7 had 1:1 (M:L) stoichiometries and octahedral geometries, while 2 had a 1:2 (M:L) ratio, which was supported by DFT calculations. The complexes and their respective ligands were evaluated against bacterial and fungal strains with clinical relevance. All the complexes showed higher antibacterial and antifungal activities than the free ligands. The complexes were more active against fungi than against bacteria. The activities of the chromium complexes against Candida tropicalis are of great intere...
Molecules (Basel, Switzerland), Jan 10, 2017
The reaction of isophthaloyl dichloride with 1-1,2,4-triazole afforded the new ligand 1,3-phenyle... more The reaction of isophthaloyl dichloride with 1-1,2,4-triazole afforded the new ligand 1,3-phenylenebis(1,2,4-triazole-1-yl)methanone (). A series of Co(II), Cu(II), Zn(II) and Ni(II) complexes were synthesized using and then characterized by melting point analysis, elemental analysis, theoretical calculations, thermogravimetric analysis, X-ray powder diffraction, nuclear magnetic resonance, infrared and Raman spectroscopy. Experimental and computational studies predict the formation of coordination polymers (CPs). The cobalt and copper CPs and zinc(II) complex were found to be good initiators for the ring-opening polymerization of ε-caprolactone (CL) under solvent-free conditions. ¹H-NMR analysis showed that the obtained polymers of CL were mainly linear and had terminal hydroxymethylene groups. Differential scanning calorimetry showed that the obtained polycaprolactones had high crystallinity, and TGA showed that they had decomposition temperatures above 400 °C. These results provi...
International Journal of Electrochemical Science, 2016
Reaction of o-phenylenediamine and 8-formyl-7-hydroxycoumarin yield a new coumarin salen ligand, ... more Reaction of o-phenylenediamine and 8-formyl-7-hydroxycoumarin yield a new coumarin salen ligand, (CSB) which was isolated as orange air-stable solid and characterized by melting point, thermogravimetric analysis (TGA), mass spectra, infrared and NMR (1 H, 13 C) spectroscopy. New CSB was dispersed in nafion and nafion-CSB composite was deposited on a glassy carbon electrode. The modified electrode nafion-CSB/GCE allowed the formation in-situ of mercury film for detection of Pb (II) and Cd(II) by anodic stripping voltammetry (ASV) in buffer phosphate solution pH 3.0 and 4.0. Optimal conditions were studied (mercury concentration: C Hg 40.0 mg L-1 ; CSB concentración; C CSB ; 20.0 µmol L-1 ; pH 3.0 and pH 4.0; E ACC :-1.1 V and t ACC : 80).The detection limit (3σ/b) for Pb (II) Cd (II) were of 0.15 µg L-1 for Pb(II) and Cd(II) at pH 3.0. Moreover, 0.071 and 0.080 µg L-1 for Pb(II) and Cd(II), respectively at pH 4.0, The method was validated using ICP multi-element standard solution IX (Merck) containing As, Be, Cd, Cr(VI), Hg, Ni, Pb, Se and Tl 100 mg L-1. Finally, river, tap and mineral waters were analyzed.
Acta crystallographica. Section E, Crystallographic communications, 2016
The mol-ecular structure of the title compound, C20H16N6, contains two benzotriazole units bonded... more The mol-ecular structure of the title compound, C20H16N6, contains two benzotriazole units bonded to a benzene nucleus in a meta configuration, forming dihedral angles of 88.74 (11) and 85.83 (10)° with the central aromatic ring and 57.08 (9)° with each other. The three-dimensional structure is controlled mainly by weak C-H⋯N and C-H⋯π inter-actions. The mol-ecules are connected in inversion-related pairs, forming the slabs of infinite chains that run along the [-110] and [110] directions.
Journal of the Chilean Chemical Society, 2013
The reaction of 3,5-bis(bromomethyl)toluene with benzotriazole yields the bidentate ligand 3,5-bi... more The reaction of 3,5-bis(bromomethyl)toluene with benzotriazole yields the bidentate ligand 3,5-bis(benzotriazol-1-ylmethyl)toluene (1). This ligand reacts with [PdCl 2 (cod)] (cod = 1,5-cyclooctadiene) to give the complex [PdCl 2 {3,5-bis(benzotriazol-1-ylmethyl)tolyl}] (2). These compounds were characterized by elemental analyses, mass spectra, and FTIR and NMR (1 H, 13 C) spectroscopies. The palladium(II) complex 2 shows high activity as catalyst for oxidative amination, involving allyl butyl ether and phthalimide as substrates and PhICl 2 as a stoichiometric oxidant.
Journal of the Brazilian Chemical Society, 2011
A reação de 2-bromo-1,3-bis(bromometil)benzeno com 3,5-dimetilpirazol e 1H-indazol produz os liga... more A reação de 2-bromo-1,3-bis(bromometil)benzeno com 3,5-dimetilpirazol e 1H-indazol produz os ligantes tridentados 2-bromo-1,3-bis(3,5-dimetilpirazol-1-ilmetil)benzeno (1) e 2-bromo-1,3bis(indazol-2-ilmetil)benzeno (2). Estes compostos reagem com [Ni(cod) 2 ] em tetraidrofurano (thf) para formar os complexos de adição oxidativa [NiBr{1,3-bis(azolilmetil)fenil-N,C,N}], azol = 3,5-dimetilpirazol (3) e indazol (4), os quais foram isolados em bons rendimentos como sólidos amarelos estáveis e caracterizados por meio de análise elementar, espectroscopia de absorção no infravermelho com transformada de Fourier (FTIR), espectrometria de massa e ressonância magnética nuclear (NMR). Adicionalmente, as estruturas moleculares de 2 e 4 foram determinadas por difratometria de raios X de monocristal. O complexo 4 foi testado como catalisador na reação de polimerização de etileno. The reaction of 2-bromo-1,3-bis(bromomethyl)benzene with 3,5-dimethylpyrazole and 1H-indazole yields the tridentate ligands 2-bromo-1,3-bis(3,5-dimethylpirazol-1-ylmethyl)benzene (1) and 2-bromo-1,3-bis(indazol-2-ylmethyl)benzene (2). These compounds react with [Ni(cod) 2 ] in tetrahydrofuran (thf) to form the oxidative addition complexes [NiBr{1,3-bis(azolylmethyl)phenyl-N,C,N}], azol = 3,5-dimethylpyrazol (3), indazol (4), which were isolated in good yields as stable yellow solids and characterized by elemental analysis, Fourier-transform infrared spectroscopy (FTIR), mass spectroscopy and nuclear magnetic resonance (NMR). In addition, the molecular structures of 2 and 4 were determined by single-crystal X-ray diffraction analysis. Complex 4 was tested as a catalyst in ethylene polymerization reaction.
Molecules (Basel, Switzerland), Jan 8, 2018
Growing antimicrobial resistance is considered a potential threat for human health security by he... more Growing antimicrobial resistance is considered a potential threat for human health security by health organizations, such as the WHO, CDC and FDA, pointing to MRSA as an example. New antibacterial drugs and complex derivatives are needed to combat the development of bacterial resistance. Six new copper and cobalt complexes of azole derivatives were synthesized and isolated as air-stable solids and characterized by melting point analyses, elemental analyses, thermogravimetric analyses (TGA), and infrared and ultraviolet/visible spectroscopy. The analyses and spectral data showed that the complexes had 1:1 (M:L) stoichiometries and tetrahedral geometries, the latter being supported by DFT calculations. The antibacterial activities of the metal complexes by themselves and combined with silver nanoparticles (AgNPs; 2 μg mL-1) were assessed in vitro by broth microdilution assays against eight bacterial strains of clinical relevance. The results showed that the complexes alone exhibited m...
Journal of the Brazilian Chemical Society, 2016
Four new zinc complex derivatives of azoles and ligands were synthesized and isolated as white ai... more Four new zinc complex derivatives of azoles and ligands were synthesized and isolated as white air-stable solids and characterized by elemental analyses, thermogravimetric analysis (TGA), infrared spectroscopy, nuclear magnetic resonance (NMR) and mass spectra. The elemental analysis, theoretical calculations and NMR show that the complexes likely have a 1:1 (M:L) stoichiometry and tetrahedral geometry. To evaluate the biological activity of the complexes and to discuss the role of metal ions and structural properties, the ligands and their metal complexes have been studied. Their antimicrobial activity was determined in vitro by agar-well diffusion and broth microdilution against nine bacterial strains and seven fungal strains with clinical relevance. In vitro assays showed that the complexes exhibited moderate antibacterial and/or antifungal activities. The antimicrobial activity was found to be more active for the metal complexes than the ligands. The metal complexes that contained copper and cobalt, respectively, displayed notable antibacterial and antifungal effects against all the tested bacterial strains. The minimum inhibitory concentration 50 (MIC 50) values were in the range 2454-0.7 μg mL-1. Metal complexes were more effective at inhibiting bacteria than fungi. The results could provide a high-potential solution for antimicrobial growth resistance, for both bacteria and fungi.
International Journal of Electrochemical Science, 2017
New macrocyclic ester (L) was yielded through reaction of catechol with isophthaloylchloride and ... more New macrocyclic ester (L) was yielded through reaction of catechol with isophthaloylchloride and isolated as white solid, air stable at room temperature. L was characterized by melting point, mass spectra, FTIR and NMR (1 H, 13 C) spectroscopy. The molecular structure was determined by singlecrystal X-ray diffraction. The macrocyclic compound was evaluated to determine ultra-trace concentrations of Pb (II) by anodic stripping voltammetry in the presence of Cd(II). The method is based on the formation of a complex between lead and the macrocyclic ester, immobilized on a vitreous carbon electrode, allowing the oxidation of lead by voltammetric scan, using square wave modulation method. Anodic peak current was observed at-0.20 V for Pb(II). Under the best experimental conditions (pH 4.0; L concentration 10.0 mmol L-1 ; accumulative potential (Eacc)-0.8 V and accumulative time (tacc) of 60 s) anodic peak current was proportional to the Pb (II) concentration up to 80.0 μg L-1 , with a detection limit (3σ) of 0.33 μg L-1. The proposed method was validated by determining Pb(II) in model solution with ultra-pure water with satisfactory results.
Polymers, 2018
Five of six new Zn(II) and Cu(II) complexes were active in the ring-opening polymerization (ROP) ... more Five of six new Zn(II) and Cu(II) complexes were active in the ring-opening polymerization (ROP) of ε-caprolactone (CL) under solvent-free conditions, producing polycaprolactones (PCLs) of high crystallinity with molecular weights between 22,900 and 38,700 g mol−1 and decomposition temperatures above 260 °C. 1H NMR analysis demonstrated that the PCLs obtained were mainly linear, having hydroxymethylene groups at the chain ends. The results obtained indicated a significant improvement in terms of the ratio of monomer:initiator compared to related Cu(II) and Zn(II) complexes. In addition, the structures of the complexes 1 and 4 were determined by single-crystal X-ray diffraction. The synthesis and full characterization of all complexes are described in this paper.
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Papers by john jady Hurtado