Tissues typically harbor subpopulations of resident immune cells that function as rapid responder... more Tissues typically harbor subpopulations of resident immune cells that function as rapid responders to injury and whose activation leads to induction of an adaptive immune response, playing important roles in repair and protection. Since the lens is an avascular tissue, it was presumed that it was absent of resident immune cells. Our studies now show that resident immune cells are a shared feature of the human, mouse, and chicken lens epithelium. These resident immune cells function as immediate responders to injury and rapidly populate the wound edge following mock cataract surgery to function as leader cells. Many of these resident immune cells also express MHCII providing them with antigen presenting ability to engage an adaptive immune response. We provide evidence that during development immune cells migrate on the ciliary zonules and localize among the equatorial epithelial cells of the lens adjacent to where the ciliary zonules associate with the lens capsule. These findings suggest that the vasculature‐rich ciliary body is a source of lens resident immune cells. We identified a major role for these cells as rapid responders to wounding, quickly populating each wound were they can function as leaders of lens tissue repair. Our findings also show that lens resident immune cells are progenitors of myofibroblasts, which characteristically appear in response to lens cataract surgery injury, and therefore, are likely agents of lens pathologies to impair vision like fibrosis.
Following injury, mesenchymal repair cells are activated to function as leader cells that modulat... more Following injury, mesenchymal repair cells are activated to function as leader cells that modulate wound healing. These cells have the potential to differentiate to myofibroblasts, resulting in fibrosis and scarring. The signals underlying these differing pathways are complex and incompletely understood. The ex vivo mock cataract surgery cultures are an attractive model with which to address this question. With this model we study, concurrently, the mechanisms that control mesenchymal leader cell function in injury repair within their native microenvironment and the signals that induce this same cell population to acquire a myofibroblast phenotype when these cells encounter the environment of the adjacent tissue culture platform. Here we show that on injury, the cytoskeletal protein vimentin is released into the extracellular space, binds to the cell surface of the mesenchymal leader cells located at the wound edge in the native matrix environment, and supports wound closure. In pro...
Bobbie Ann Adair White, EdD, MA , Janice Walker, DHA, MBA-HCM, BSN, RN, and Alejandro C. Arroliga... more Bobbie Ann Adair White, EdD, MA , Janice Walker, DHA, MBA-HCM, BSN, RN, and Alejandro C. Arroliga, MD, MSc Department of Humanities in Medicine, Texas A&M University College of Medicine, Temple, Texas; Center for Interprofessional Studies and Innovation, Institute of Health Professions, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Baylor Scott & White Health, Temple, Texas; Department of Medicine, Texas A&M University College of Medicine, Temple, Texas
A novel method is presented for taking seminar and lecture notes. The method encourages concentra... more A novel method is presented for taking seminar and lecture notes. The method encourages concentration on the talk being given and also helps train students to see how to give good presentations.
Collaborative visit agenda setting between patient and doctor is recommended. We assessed the fea... more Collaborative visit agenda setting between patient and doctor is recommended. We assessed the feasibility, acceptability, and utility of patients attending a large primary care safety-net clinic typing their agendas into the electronic visit note before seeing their clinicians. One hundred and one patients and their 28 clinicians completed post-visit surveys. Patients and clinicians agreed that the agendas improved patient-clinician communication (patients 79%, clinician 74%), and wanted to continue having patients type agendas in the future (73%, 82%). Enabling patients to type visit agendas may enhance care by engaging patients and giving clinicians an efficient way to prioritize patients' concerns.
Page 1. Janice r. walker and todd taylor second edition Page 2. Page 3. The Columbia Guide to Onl... more Page 1. Janice r. walker and todd taylor second edition Page 2. Page 3. The Columbia Guide to Online Style SECOND EDITION Page 4. Page 5. Parti Locating and Citing Source Materials Page 6. Page 7. 1 RESEARCH IN THE ...
Tissues typically harbor subpopulations of resident immune cells that function as rapid responder... more Tissues typically harbor subpopulations of resident immune cells that function as rapid responders to injury and whose activation leads to induction of an adaptive immune response, playing important roles in repair and protection. Since the lens is an avascular tissue, it was presumed that it was absent of resident immune cells. Our studies now show that resident immune cells are a shared feature of the human, mouse, and chicken lens epithelium. These resident immune cells function as immediate responders to injury and rapidly populate the wound edge following mock cataract surgery to function as leader cells. Many of these resident immune cells also express MHCII providing them with antigen presenting ability to engage an adaptive immune response. We provide evidence that during development immune cells migrate on the ciliary zonules and localize among the equatorial epithelial cells of the lens adjacent to where the ciliary zonules associate with the lens capsule. These findings suggest that the vasculature‐rich ciliary body is a source of lens resident immune cells. We identified a major role for these cells as rapid responders to wounding, quickly populating each wound were they can function as leaders of lens tissue repair. Our findings also show that lens resident immune cells are progenitors of myofibroblasts, which characteristically appear in response to lens cataract surgery injury, and therefore, are likely agents of lens pathologies to impair vision like fibrosis.
Following injury, mesenchymal repair cells are activated to function as leader cells that modulat... more Following injury, mesenchymal repair cells are activated to function as leader cells that modulate wound healing. These cells have the potential to differentiate to myofibroblasts, resulting in fibrosis and scarring. The signals underlying these differing pathways are complex and incompletely understood. The ex vivo mock cataract surgery cultures are an attractive model with which to address this question. With this model we study, concurrently, the mechanisms that control mesenchymal leader cell function in injury repair within their native microenvironment and the signals that induce this same cell population to acquire a myofibroblast phenotype when these cells encounter the environment of the adjacent tissue culture platform. Here we show that on injury, the cytoskeletal protein vimentin is released into the extracellular space, binds to the cell surface of the mesenchymal leader cells located at the wound edge in the native matrix environment, and supports wound closure. In pro...
Bobbie Ann Adair White, EdD, MA , Janice Walker, DHA, MBA-HCM, BSN, RN, and Alejandro C. Arroliga... more Bobbie Ann Adair White, EdD, MA , Janice Walker, DHA, MBA-HCM, BSN, RN, and Alejandro C. Arroliga, MD, MSc Department of Humanities in Medicine, Texas A&M University College of Medicine, Temple, Texas; Center for Interprofessional Studies and Innovation, Institute of Health Professions, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Baylor Scott & White Health, Temple, Texas; Department of Medicine, Texas A&M University College of Medicine, Temple, Texas
A novel method is presented for taking seminar and lecture notes. The method encourages concentra... more A novel method is presented for taking seminar and lecture notes. The method encourages concentration on the talk being given and also helps train students to see how to give good presentations.
Collaborative visit agenda setting between patient and doctor is recommended. We assessed the fea... more Collaborative visit agenda setting between patient and doctor is recommended. We assessed the feasibility, acceptability, and utility of patients attending a large primary care safety-net clinic typing their agendas into the electronic visit note before seeing their clinicians. One hundred and one patients and their 28 clinicians completed post-visit surveys. Patients and clinicians agreed that the agendas improved patient-clinician communication (patients 79%, clinician 74%), and wanted to continue having patients type agendas in the future (73%, 82%). Enabling patients to type visit agendas may enhance care by engaging patients and giving clinicians an efficient way to prioritize patients' concerns.
Page 1. Janice r. walker and todd taylor second edition Page 2. Page 3. The Columbia Guide to Onl... more Page 1. Janice r. walker and todd taylor second edition Page 2. Page 3. The Columbia Guide to Online Style SECOND EDITION Page 4. Page 5. Parti Locating and Citing Source Materials Page 6. Page 7. 1 RESEARCH IN THE ...
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