OBJECTIVE To investigate the effect of programmed nursing combined with cognitive behavioral inte... more OBJECTIVE To investigate the effect of programmed nursing combined with cognitive behavioral intervention on clinical efficacy and neurological function of patients with intracerebral hemorrhage (ICH). METHODS In this retrospective study, 96 patients with ICH admitted to our hospital were enrolled and divided into a programmed group and a joint group, with 48 cases in each group. Patients in the programmed group were treated with programmed nursing while those in the joint group were given cognitive behavior intervention based on programmed nursing, for 28 days. The Fugl-Meyer (FM) Assessment Scale was used to evaluate the motor function of patients, the Barthel index to analyze the activities of daily living (ADL), and the National Institutes of Health Stroke Scale (NIHSS) and Glasgow Outcome Scale (GOS) to assess the neurological function. The quality of life of patients was evaluated by the World Health Organization quality of life Brief Version (WHOQOL-BREF), and the nursing sat...
Inhibition of host protein functions using established drugs produces a promising antiviral effec... more Inhibition of host protein functions using established drugs produces a promising antiviral effect with excellent safety profiles, decreased incidence of resistant variants and favorable balance of costs and risks. Genomic methods have produced a large number of robust host factors, providing candidates for identification of antiviral drug targets. However, there is a lack of global perspectives and systematic prioritization of known virus-targeted host proteins (VTHPs) and drug targets. There is also a need for host-directed repositioned antivirals. Here, we integrated 6140 VTHPs and grouped viral infection modes from a new perspective of enriched pathways of VTHPs. Clarifying the superiority of nonessential membrane and hub VTHPs as potential ideal targets for repositioned antivirals, we proposed 543 candidate VTHPs. We then presented a large-scale drug–virus network (DVN) based on matching these VTHPs and drug targets. We predicted possible indications for 703 approved drugs agai...
PurposeDiscuss the implementation effect of cervical cancer comprehensive treatment patients appl... more PurposeDiscuss the implementation effect of cervical cancer comprehensive treatment patients applying whole-course high-quality care combined with network continuation care.MethodsFrom August 2020 to August 2021, 120 patients who met the inclusion criteria for comprehensive treatment of cervical cancer were divided into the regular group (n = 60) who received conventional care and the joint group (n = 60) who received whole-course high-quality care combined with network continuation care, according to the method of care. The comprehensive treatment cognition level, comprehensive treatment compliance, adverse reaction rate, quality of life questionnaire (QLQ-C30) score, self-rating anxiety/depression scale (SAS/SDS) score, and nursing satisfaction were compared between the two groups.ResultsAfter care, the comprehensive treatment cognition score and comprehensive treatment compliance score were higher in the joint group than in the regular group (P < 0.05). After care, the inciden...
IEEE Transactions on Dependable and Secure Computing, 2022
Data deduplication is a technique to eliminate duplicate data in order to save storage space and ... more Data deduplication is a technique to eliminate duplicate data in order to save storage space and enlarge upload bandwidth, which has been applied by cloud storage systems. However, a cloud storage provider (CSP) may tamper user data or cheat users to pay unused storage for duplicate data that are only stored once. Although previous solutions adopt message-locked encryption along with Proof of Retrievability (PoR) to check the integrity of deduplicated encrypted data, they ignore proving the correctness of duplication check during data upload and require the same file to be derived into same verification tags, which suffers from brute-force attacks and restricts users from flexibly creating their own individual verification tags. In this paper, we propose a verifiable deduplication scheme called VeriDedup to address the above problems. It can guarantee the correctness of duplication check and support flexible tag generation for integrity check over encrypted data deduplication in an integrative way. Concretely, we propose a novel Tag-flexible Deduplication-supported Integrity Check Protocol (TDICP) based on Private Information Retrieval (PIR) by introducing a novel verification tag called note set, which allows multiple users holding the same file to generate their individual verification tags and still supports tag deduplication at the CSP. Furthermore, we make the first attempt to guarantee the correctness of data duplication check by introducing a novel User Determined Duplication Check Protocol (UDDCP) based on Private Set Intersection (PSI), which can resist a CSP from providing a fake duplication check result to users. Security analysis shows the correctness and soundness of our scheme. Simulation studies based on real data show the efficacy and efficiency of our proposed scheme and its significant advantages over prior arts.
2011 Second International Conference on Mechanic Automation and Control Engineering, 2011
The conventional direct torque control system in low speed condition has the larger motor torque ... more The conventional direct torque control system in low speed condition has the larger motor torque ripple, that makes the system's low-speed performance poor. To address this problem, we use neural network supervisory controller to replace the original PID controller based on the traditional direct torque control system, and create a system model by the Sim Power Systems of MATLAB software. This system is simulated on the MATLAB / Simulink simulation platform, and the simulation results are compared with the original system's. Simulation results show that this method can effectively reduce the torque ripple of the direct torque control system in low-speed condition and improve the system's low-speed performance.
Objective To investigate the clinical features of isolated occipital lobe epilepsy (OLE, epilepto... more Objective To investigate the clinical features of isolated occipital lobe epilepsy (OLE, epileptogenic focus is confined to the occipital lobe) and extended OLE (epileptogenic focus also relates to the other lobes outside occipital lobe) to guide the clinical diagnosis and treatment. Methods A retrospective analysis was performed on the clinical data of 32 patients with OLE, admitted to our hospital from June 2011 to June 2013. And the patients were divided into 2 groups: isolated OLE (n=14) and extended OLE (n=18). The basic situation, seizure and diagnosis between patients in the two groups were compared. Results There were no significant differences in most clinical data between isolated and extended OLE patients, such as gender, disease duration, seizure type, premedication, localization diagnosis and surgical outcome (P>0.05). However, as compared with that in isolated OLE patients, non visual aura in extended OLE patients was more common, with significant difference (P 0.05...
Osteoarthritis is a chronic joint disease which has a serious impact on the health and quality of... more Osteoarthritis is a chronic joint disease which has a serious impact on the health and quality of life of affected humans and animals. As an inhibitor of inducible nitric oxide synthase (iNOS), aminoguanidine (AG) displays anti-inflammatory effects. The purpose of the present study was to investigate the effect of AG on the expression of iNOS and cyclooxygenase-2 (COX-2), and the activity of the NF-κB signaling pathway in rat chondrocytes stimulated by interleukin-1β (IL-1β). The viability of chondrocytes treated with AG (0.3, 1 or 3 mM) alone was determined using a Cell Counting Kit-8 assay. Subsequently, the chondrocytes were treated with either 10 ng/ml IL-1β alone, or co-treated with increasing concentrations of AG (0.3, 1 or 3 mM) and 10 ng/ml IL-1β. The protein levels of COX-2, iNOS, phosphorylated (p)-p65, p65, p-NF-κβ inhibitor α (IκBα), IκBα, p-inhibitor of NF-κβ-β (IKKβ) and IKKβ were evaluated by western blotting. NF-κB translocation was determined by immunofluorescence analysis. Western blotting and reverse transcription-quantitative PCR were used to detect expression levels of relevant proteins/genes. The results suggested that the inhibitory effect of AG on the protein and gene expression levels of iNOS and COX-2 in IL-1β-treated chondrocytes was dose-dependent. In addition, AG decreased the level of phosphorylation of IKKβ, IκBα and NF-κB p65, the degradation of IKKβ, IκBα and p65, and the translocation of NF-κB in IL-1β-stimulated chondrocytes. The most significant inhibitory effect of AG was observed at a concentration of 1 mM. Therefore, the present study suggested that AG may serve as a potential agent to reduce the inflammatory response of chondrocytes stimulated by IL-1β.
Abstract Forming solid solutions between two isostructural compounds is an important strategy of ... more Abstract Forming solid solutions between two isostructural compounds is an important strategy of regulating thermal transport in solids and boosting thermoelectric performance of narrow gap semiconductors. However, its full potential is not reached in a large variety of systems because of the known miscibility gap. A typical example includes PbS-PbTe where a limited solubility is demonstrated for one in another. Here in this study we show that the miscibility gap between PbS and PbTe is well bridged by introducing 30 mol% PbSe. This considerably extends the solubility limit of PbTe from only ∼4 mol% in PbS to at least 16 mol% in PbS0.7Se0.3, thus remarkably reducing the lattice thermal conductivity from a solid solution point of view. More importantly, it is found that carrier mobility of PbS is negligibly affected by this heavy alloying process, which is against conventional knowledge that higher concentration of defects leads to stronger carrier scattering. Our electron localization functions (ELF) mapping calculation results suggest an increased overlap of the adjacent electron clouds and decreased periodic potential fluctuations when the miscibility gap between PbS and PbTe gets bridged by PbSe. Therefore, the strengthened chemical bond covalency of PbS upon PbSe/PbTe alloying is responsible for the well reserved carrier mobilities. The simultaneous optimization of electron and phonon transport enabled by miscibility gap engineering (also applicable to many other technologically important thermoelectric materials) greatly boosts the thermoelectric performance of n-type Ga-doped PbS, leading to an excellent peak ZT of ∼1.1 at ∼723 K together with a record high average ZT value of 0.73 (300-723 K) in the samples of Pb0.99Ga0.01S0.7-xSe0.3Tex (x ≥ 0.12).
The coexistence of fast ionic conduction and high thermoelectric performance in certain mixed ion... more The coexistence of fast ionic conduction and high thermoelectric performance in certain mixed ionic-electronic conductors afford new opportunities and challenges beyond the traditional semiconductors and semimetals. However, their applications are limited due to phase instability under a high current density and large temperature difference. Here, we show that the high thermoelectric performance of superionic conductor Cu 2 Se is stabilized through regulating the behaviors of Cu + ions and electrons in a Schottky heterojunction between the Cu 2 Se host matrix and in situ formed BiCuSeO nanoparticles. The accumulation of Cu + ions via an ionic capacitive effect at the Schottky junction under the direct current modifies space charge distribution in the electric double layer, exerting an electrostatic field, which blocks the long-range migration of Cu + and produces a drastic reduction of Cu + ion This article is protected by copyright. All rights reserved. 3 migration in the composite by nearly two orders of magnitude. Moreover, this heterojunction impedes electrons transferring from BiCuSeO to Cu 2 Se, obstructing the reduction reaction of Cu + into Cu metal at the interface and hence stabilizes the -Cu 2 Se phase under a high DC current density and/or a large temperature gradient. Furthermore, incorporation of BiCuSeO in Cu 2 Se optimizes the carrier concentration and intensifies phonon scattering, contributing to the peak figure of merit ZT value of ~ 2.7 at 973 K and high average ZT value of ~1.5 between 400 K and 973 K for the Cu 2 Se/BiCuSeO composites. This discovery thus provides a new avenue for stabilizing mixed ionic-electronic conduction thermoelectrics, and fresh insights into controlling ion migration in these ionic transport dominated materials including perovskite photovoltaic materials, solid electrolytes, and solid state batteries. One sentence summary: The space charge region in the Schottky junction between the Cu 2 Se host matrix and in situ formed BiCuSeO under a direct current causes drastic suppression of Cu + ion migration in the composites, and obstructs the reduction reaction of Cu + into Cu metal, which, together with the effective regulation of carrier concentration as well as enhanced interfacial phonon scattering, greatly stabilizes the improved thermoelectric performance.
We present four studies (one correlational and three experimental) of American Whites that examin... more We present four studies (one correlational and three experimental) of American Whites that examine relationships between White and minority demographic shifts, intergroup threat, and support for extreme-right groups and actions. We focus in particular on the role of collective existential threat (i.e., a perception that the ingroup will cease to exist), along with three alternative/competing intergroup threats: status threat, symbolic threat, prototypicality threat. Though no zero-order relationship was found between perceived White population decline and far-right variables, we find evidence that (1) perceived White population decline leads to collective existential threat net of other perceived demographic shifts, (2) collective existential threat is related to far-right support net of other threats, and (3) perceived White decline has a robust indirect relationship with measures of farright support via collective existential threat.
AIMS Osteoarthritis (OA) is a common joint disease and the main cause of disability. We sought to... more AIMS Osteoarthritis (OA) is a common joint disease and the main cause of disability. We sought to determine the effective concentration of emodin on chondrocytes and to identify the dosage of emodin that induces a comparable therapeutic effect with the COX-2 inhibitor drug, celecoxib that is currently used to treat OA. MATERIAL AND METHODS In vitro experiments induced inflammation of chondrocytes by IL-1β, and an osteoarthritis model was established in vivo by cutting rat anterior cruciate ligament. Western Blot, Real-time PCR, HE staining, Safranin O-green staining and immunohistochemistry were performed to detect MMP-3, MMP-13, ADAMTS-4, iNOS and COL2A1 on the chondrocytes or the tibial plateau. The cytokine activity and content in serum of six groups of rats were measured by kit. RESULTS It was found that the surface layer of the cartilage was thicker and smoother after the administration of emodin. Tissue expression of MMP-3, MMP-13, ADAMTS-4 and iNOS were significantly (p < 0.05) decreased in chondrocytes and cartilage treated with different doses of emodin, and the content of COL2A1 was reversed. Emodin also significantly decreased the blood levels of COX-2 and PGE2. The effective emodin in vitro was 5 μmol/L, whereas emodin at 80 mg/kg was equivalent to celecoxib in vivo. CONCLUSION Emodin reduces the expression of cartilage matrix degradation biomarkers, thereby reducing the degradation of cartilage matrix and protecting the knee joint cartilage. Emodin at 5 μmol/L shows the best concentration to treat chondrocytes, and the protective effect of emodin at 80 mg/kg is comparable to that of celecoxib.
Baicalein has been shown to have chondroprotective potential in vitro. However, its effect on dis... more Baicalein has been shown to have chondroprotective potential in vitro. However, its effect on disease modification in osteoarthritis (OA) is largely unknown. The present study is aimed at determining whether baicalein could slow the progression of OA and inhibit OA-related inflammation in a rat model of destabilization of the medial meniscus (DMM) and the underlying mechanisms. The rats subjected to DMM surgery were treated with baicalein (0.8, 1.6, and 3.2 μg/L, 50 μL, once a week) by intra-articular injection for 6 weeks. Dexamethasone (0.4 mg/mL, 50 μL, once a week) was used as a positive control. Histologic grading of cartilage degeneration was performed using the Osteoarthritis Research Society International (OARSI) recommended grading system (on a scale of 0-6). The expression levels of molecules associated with cartilage homeostasis and inflammatory cytokines were analyzed; moreover, the NLRP3 inflammasome activation and cartilage oxidative stress-associated molecules were de...
Ketamine has become a popular recreational drug due to its neuronal anesthesia effect and low pri... more Ketamine has become a popular recreational drug due to its neuronal anesthesia effect and low price. The process of learning and memory is part of the distinctive high-level neural activities in animals. We investigated the effects of subanesthetic and anesthetic doses of ketamine on the learning and memory-related signal transduction mechanisms. We used the Morris water maze test to execute rats’ learning and memory ability and detected changes of Arc mRNA and Arc, cAMP-response element-binding protein (CREB), phospho-CREB (p-CREB), extracellular signal-regulated kinase (ERK), and phospho-ERK (p-ERK) protein expression in the hippocampus 10 min and 24 h after administration. Ten min after ketamine injection, the Arc gene and the protein expression levels increased in all groups; p-ERK only increased in the chronic subanesthetic dose group. After 24 h, the Arc gene and the protein expression levels of the subanesthetic dose group increased, but those of the chronic subanesthetic dos...
Objective: This study was conducted to investigate the potential effects of prolonged photoperiod... more Objective: This study was conducted to investigate the potential effects of prolonged photoperiod on the serum lipids, carcass traits, and meat quality of Jinjiang cattle during winter.Methods: Thirty-four Jinjiang bulls aged between 14 and 16 months were randomly assigned to two groups that were alternatively subjected to either natural daylight +4 h supplemental light (long photoperiod, LP) or natural daylight (natural photoperiod, NP) for 96 days. The potential effects on the levels of serum lipids, carcass traits, meat quality, and genes regulating lipid metabolism in the intramuscular fat (IMF) of the cattle were evaluated.Results: Jinjiang cattle kept under LP showed significant increase in both dry matter intake and backfat thickness. the serum glucose and the plasma leptin levels were significantly reduced, while that of melatonin and insulin were observed to be increased. The crude fat contents of biceps femoris muscle and longissimus dorsi muscle were higher in LP than in ...
In this paper, the removal of 2,4,6-trichlorophenol (2,4,6-TCP) by synthesized Ni/Fe nanoparticle... more In this paper, the removal of 2,4,6-trichlorophenol (2,4,6-TCP) by synthesized Ni/Fe nanoparticles were investigated. At the same time, the factors, such as the dosage of Ni/Fe, Ni content in Ni/Fe nanoparticles, sulfate ion, HA, coexisting substances in water which affected the removal of 2,4,6-TCP by synthesized Ni/Fe nanoparticles were also investigated. Under the experimental conditions, the removal efficiency of 2,4,6-TCP by Ni/Fe nanoparticles in water was about 72% for 2 h. The dosage of Ni/Fe, Ni content in Ni/Fe nanoparticles, and Fe3+ all promoted the dechlorination reaction of 2,4,6-TCP by Ni/Fe nanoparticles. Sulfate, oxalic acid and citric acid played an inhibitory role on the removal of 2,4,6-TCP by Ni/Fe nanoparticles in water. Fe2+ had no obvious affect to the removal of 2,4,6-TCP by Ni/Fe nanoparticles in water. In addition, low initial HA concentration was favorable for the removal of 2,4,6-TCP by Ni/Fe nanoparticles, while high concentrations of HA played an inhib...
A series of novel 1,2,4-triazole derivatives containing oxime ether and phenoxy pyridine moiety w... more A series of novel 1,2,4-triazole derivatives containing oxime ether and phenoxy pyridine moiety were designed and synthesized. The new compounds were identified by nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HRMS). Compound (Z)-1-(6-(4-nitrophenoxy)pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one O-methyl oxime (5a18) was further confirmed by X-ray single crystal diffraction. Their antifungal activities were evaluated against eight phytopathogens. The in vitro bioassays indicated that most of the title compounds displayed moderate to high fungicidal activities. Compound (Z)-1-(6-(4-bromo-2-chlorophenoxy)pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one O-methyl oxime (5a4) exhibited a broad-spectrum antifungal activities with the EC50 values of 1.59, 0.46, 0.27 and 11.39 mg/L against S. sclerotiorum, P. infestans, R. solani and B. cinerea, respectively. Compound (Z)-1-(6-(2-chlorophenoxy)pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one O...
The etiology of osteoarthritis (OA) is multifactorial, with no effective disease-modifying-drugs.... more The etiology of osteoarthritis (OA) is multifactorial, with no effective disease-modifying-drugs. L-theanine has been reported to inhibit inflammatory responses in some diseases and this study aimed to investigate the effect of L-theanine on Interleukin-1(IL-1)β-stimulated chondrocytes, and in an injury-induced OA rat model. Primary chondrocytes were stimulated by IL-1β (10 ng/mL) for 24 h and then co-cultured with L-theanine for 24 h. The effects of L-theanine on IL-1β-stimulated expression of pro-inflammatory cytokines and hydrolytic enzyme were analyzed using Western blotting, quantitative polymerase chain reaction (q-PCR) and enzyme-linked immunosorbent assay (ELISA) kits. An immunofluorescence assay was used to detect nuclear factor kappa B (NF-κB) phosphorylation. OA was induced by anterior cruciate ligament transection (ACLT) surgery in rats and celecoxib was used as a positive control. OA severity was measured using the Osteoarthritis Research Society International (OARSI) g...
Dysregulated intratumoral immune reactions are shaped by complex networks of cytokines, which coo... more Dysregulated intratumoral immune reactions are shaped by complex networks of cytokines, which coordinate with tumor cells to determine tumor progression and aggressiveness. In lung adenocarcinoma (LUAD), the role of intratumoral cytokine gene expression for stratifying prognosis has not been systematically investigated. Using high-dimensional datasets of cancer specimens from clinical patients in The Cancer Genome Atlas (TCGA), we explored the transcript abundance and prognostic impact of 27 clinically evaluable cytokines in 500 LUAD tumor samples according to clinicopathological features and two common driver mutations (EGFR and KRAS). We found that reduced expression of IL12B presented as the single prognostic factor for both poor overall survival (OS) and recurrence free survival (RFS) with high hazard ratios. Moreover, we identified that elevated expression of IL6, CXCL8 and CSF3 were additional independent predictors of poor RFS in LUAD patients. Their prognostic significance w...
This paper presents evidence from five studies (total White N = 7,209) that White American's raci... more This paper presents evidence from five studies (total White N = 7,209) that White American's racial identity centrality is related to self-reported levels of far-right extremism. Furthermore, evidence from two of the studies shows that social dominance orientation (SDO) is another robust predictor of far-right extremism. Results also show that SDO can moderate the relationship between White identity and extremism such that the association is stronger for Whites with a higher level of SDO. Therefore, evidence suggests that the role of Whites' racial identity centrality is particularly relevant, and SDO is an important variable that may moderate the association between Whites' racial identity centrality and their far-right extremism in the contemporary political era.
The four impact exemption curves in ASME are convenient to estimate the minimum design metal temp... more The four impact exemption curves in ASME are convenient to estimate the minimum design metal temperature (MDMT) of ferritic steel. However they can't distinguish low temperature fracture toughness of ferritic steel well. Materials with similar fracture toughness, divided into different impact exemption curves will have different MDMT and conservative degree. And the MDMT of ferritic steel are estimated by the steel grade. There are differences in toughness for steel with same steel grade from different factories and different heats and batches of the same factory. In this paper, the seven MDMT curves, identified with labels I, II, III, IV, V, VI and VII are proposed based on assumed yield strength and seven reference temperatures, (T 0MC = 20°C, 0°C, −20°C, −40°C, −60°C, −80°C and −100°C) which can cover the temperature range for commonly used pressure vessels made from ferritic steel. The MDMT for a ferritic steel can be determined once the reference temperature and yield strength are measured. SA508-3 and Q345R, as a representative of ferritic steel are used to illustrate the applicability of the MDMT curves.
OBJECTIVE To investigate the effect of programmed nursing combined with cognitive behavioral inte... more OBJECTIVE To investigate the effect of programmed nursing combined with cognitive behavioral intervention on clinical efficacy and neurological function of patients with intracerebral hemorrhage (ICH). METHODS In this retrospective study, 96 patients with ICH admitted to our hospital were enrolled and divided into a programmed group and a joint group, with 48 cases in each group. Patients in the programmed group were treated with programmed nursing while those in the joint group were given cognitive behavior intervention based on programmed nursing, for 28 days. The Fugl-Meyer (FM) Assessment Scale was used to evaluate the motor function of patients, the Barthel index to analyze the activities of daily living (ADL), and the National Institutes of Health Stroke Scale (NIHSS) and Glasgow Outcome Scale (GOS) to assess the neurological function. The quality of life of patients was evaluated by the World Health Organization quality of life Brief Version (WHOQOL-BREF), and the nursing sat...
Inhibition of host protein functions using established drugs produces a promising antiviral effec... more Inhibition of host protein functions using established drugs produces a promising antiviral effect with excellent safety profiles, decreased incidence of resistant variants and favorable balance of costs and risks. Genomic methods have produced a large number of robust host factors, providing candidates for identification of antiviral drug targets. However, there is a lack of global perspectives and systematic prioritization of known virus-targeted host proteins (VTHPs) and drug targets. There is also a need for host-directed repositioned antivirals. Here, we integrated 6140 VTHPs and grouped viral infection modes from a new perspective of enriched pathways of VTHPs. Clarifying the superiority of nonessential membrane and hub VTHPs as potential ideal targets for repositioned antivirals, we proposed 543 candidate VTHPs. We then presented a large-scale drug–virus network (DVN) based on matching these VTHPs and drug targets. We predicted possible indications for 703 approved drugs agai...
PurposeDiscuss the implementation effect of cervical cancer comprehensive treatment patients appl... more PurposeDiscuss the implementation effect of cervical cancer comprehensive treatment patients applying whole-course high-quality care combined with network continuation care.MethodsFrom August 2020 to August 2021, 120 patients who met the inclusion criteria for comprehensive treatment of cervical cancer were divided into the regular group (n = 60) who received conventional care and the joint group (n = 60) who received whole-course high-quality care combined with network continuation care, according to the method of care. The comprehensive treatment cognition level, comprehensive treatment compliance, adverse reaction rate, quality of life questionnaire (QLQ-C30) score, self-rating anxiety/depression scale (SAS/SDS) score, and nursing satisfaction were compared between the two groups.ResultsAfter care, the comprehensive treatment cognition score and comprehensive treatment compliance score were higher in the joint group than in the regular group (P < 0.05). After care, the inciden...
IEEE Transactions on Dependable and Secure Computing, 2022
Data deduplication is a technique to eliminate duplicate data in order to save storage space and ... more Data deduplication is a technique to eliminate duplicate data in order to save storage space and enlarge upload bandwidth, which has been applied by cloud storage systems. However, a cloud storage provider (CSP) may tamper user data or cheat users to pay unused storage for duplicate data that are only stored once. Although previous solutions adopt message-locked encryption along with Proof of Retrievability (PoR) to check the integrity of deduplicated encrypted data, they ignore proving the correctness of duplication check during data upload and require the same file to be derived into same verification tags, which suffers from brute-force attacks and restricts users from flexibly creating their own individual verification tags. In this paper, we propose a verifiable deduplication scheme called VeriDedup to address the above problems. It can guarantee the correctness of duplication check and support flexible tag generation for integrity check over encrypted data deduplication in an integrative way. Concretely, we propose a novel Tag-flexible Deduplication-supported Integrity Check Protocol (TDICP) based on Private Information Retrieval (PIR) by introducing a novel verification tag called note set, which allows multiple users holding the same file to generate their individual verification tags and still supports tag deduplication at the CSP. Furthermore, we make the first attempt to guarantee the correctness of data duplication check by introducing a novel User Determined Duplication Check Protocol (UDDCP) based on Private Set Intersection (PSI), which can resist a CSP from providing a fake duplication check result to users. Security analysis shows the correctness and soundness of our scheme. Simulation studies based on real data show the efficacy and efficiency of our proposed scheme and its significant advantages over prior arts.
2011 Second International Conference on Mechanic Automation and Control Engineering, 2011
The conventional direct torque control system in low speed condition has the larger motor torque ... more The conventional direct torque control system in low speed condition has the larger motor torque ripple, that makes the system's low-speed performance poor. To address this problem, we use neural network supervisory controller to replace the original PID controller based on the traditional direct torque control system, and create a system model by the Sim Power Systems of MATLAB software. This system is simulated on the MATLAB / Simulink simulation platform, and the simulation results are compared with the original system's. Simulation results show that this method can effectively reduce the torque ripple of the direct torque control system in low-speed condition and improve the system's low-speed performance.
Objective To investigate the clinical features of isolated occipital lobe epilepsy (OLE, epilepto... more Objective To investigate the clinical features of isolated occipital lobe epilepsy (OLE, epileptogenic focus is confined to the occipital lobe) and extended OLE (epileptogenic focus also relates to the other lobes outside occipital lobe) to guide the clinical diagnosis and treatment. Methods A retrospective analysis was performed on the clinical data of 32 patients with OLE, admitted to our hospital from June 2011 to June 2013. And the patients were divided into 2 groups: isolated OLE (n=14) and extended OLE (n=18). The basic situation, seizure and diagnosis between patients in the two groups were compared. Results There were no significant differences in most clinical data between isolated and extended OLE patients, such as gender, disease duration, seizure type, premedication, localization diagnosis and surgical outcome (P>0.05). However, as compared with that in isolated OLE patients, non visual aura in extended OLE patients was more common, with significant difference (P 0.05...
Osteoarthritis is a chronic joint disease which has a serious impact on the health and quality of... more Osteoarthritis is a chronic joint disease which has a serious impact on the health and quality of life of affected humans and animals. As an inhibitor of inducible nitric oxide synthase (iNOS), aminoguanidine (AG) displays anti-inflammatory effects. The purpose of the present study was to investigate the effect of AG on the expression of iNOS and cyclooxygenase-2 (COX-2), and the activity of the NF-κB signaling pathway in rat chondrocytes stimulated by interleukin-1β (IL-1β). The viability of chondrocytes treated with AG (0.3, 1 or 3 mM) alone was determined using a Cell Counting Kit-8 assay. Subsequently, the chondrocytes were treated with either 10 ng/ml IL-1β alone, or co-treated with increasing concentrations of AG (0.3, 1 or 3 mM) and 10 ng/ml IL-1β. The protein levels of COX-2, iNOS, phosphorylated (p)-p65, p65, p-NF-κβ inhibitor α (IκBα), IκBα, p-inhibitor of NF-κβ-β (IKKβ) and IKKβ were evaluated by western blotting. NF-κB translocation was determined by immunofluorescence analysis. Western blotting and reverse transcription-quantitative PCR were used to detect expression levels of relevant proteins/genes. The results suggested that the inhibitory effect of AG on the protein and gene expression levels of iNOS and COX-2 in IL-1β-treated chondrocytes was dose-dependent. In addition, AG decreased the level of phosphorylation of IKKβ, IκBα and NF-κB p65, the degradation of IKKβ, IκBα and p65, and the translocation of NF-κB in IL-1β-stimulated chondrocytes. The most significant inhibitory effect of AG was observed at a concentration of 1 mM. Therefore, the present study suggested that AG may serve as a potential agent to reduce the inflammatory response of chondrocytes stimulated by IL-1β.
Abstract Forming solid solutions between two isostructural compounds is an important strategy of ... more Abstract Forming solid solutions between two isostructural compounds is an important strategy of regulating thermal transport in solids and boosting thermoelectric performance of narrow gap semiconductors. However, its full potential is not reached in a large variety of systems because of the known miscibility gap. A typical example includes PbS-PbTe where a limited solubility is demonstrated for one in another. Here in this study we show that the miscibility gap between PbS and PbTe is well bridged by introducing 30 mol% PbSe. This considerably extends the solubility limit of PbTe from only ∼4 mol% in PbS to at least 16 mol% in PbS0.7Se0.3, thus remarkably reducing the lattice thermal conductivity from a solid solution point of view. More importantly, it is found that carrier mobility of PbS is negligibly affected by this heavy alloying process, which is against conventional knowledge that higher concentration of defects leads to stronger carrier scattering. Our electron localization functions (ELF) mapping calculation results suggest an increased overlap of the adjacent electron clouds and decreased periodic potential fluctuations when the miscibility gap between PbS and PbTe gets bridged by PbSe. Therefore, the strengthened chemical bond covalency of PbS upon PbSe/PbTe alloying is responsible for the well reserved carrier mobilities. The simultaneous optimization of electron and phonon transport enabled by miscibility gap engineering (also applicable to many other technologically important thermoelectric materials) greatly boosts the thermoelectric performance of n-type Ga-doped PbS, leading to an excellent peak ZT of ∼1.1 at ∼723 K together with a record high average ZT value of 0.73 (300-723 K) in the samples of Pb0.99Ga0.01S0.7-xSe0.3Tex (x ≥ 0.12).
The coexistence of fast ionic conduction and high thermoelectric performance in certain mixed ion... more The coexistence of fast ionic conduction and high thermoelectric performance in certain mixed ionic-electronic conductors afford new opportunities and challenges beyond the traditional semiconductors and semimetals. However, their applications are limited due to phase instability under a high current density and large temperature difference. Here, we show that the high thermoelectric performance of superionic conductor Cu 2 Se is stabilized through regulating the behaviors of Cu + ions and electrons in a Schottky heterojunction between the Cu 2 Se host matrix and in situ formed BiCuSeO nanoparticles. The accumulation of Cu + ions via an ionic capacitive effect at the Schottky junction under the direct current modifies space charge distribution in the electric double layer, exerting an electrostatic field, which blocks the long-range migration of Cu + and produces a drastic reduction of Cu + ion This article is protected by copyright. All rights reserved. 3 migration in the composite by nearly two orders of magnitude. Moreover, this heterojunction impedes electrons transferring from BiCuSeO to Cu 2 Se, obstructing the reduction reaction of Cu + into Cu metal at the interface and hence stabilizes the -Cu 2 Se phase under a high DC current density and/or a large temperature gradient. Furthermore, incorporation of BiCuSeO in Cu 2 Se optimizes the carrier concentration and intensifies phonon scattering, contributing to the peak figure of merit ZT value of ~ 2.7 at 973 K and high average ZT value of ~1.5 between 400 K and 973 K for the Cu 2 Se/BiCuSeO composites. This discovery thus provides a new avenue for stabilizing mixed ionic-electronic conduction thermoelectrics, and fresh insights into controlling ion migration in these ionic transport dominated materials including perovskite photovoltaic materials, solid electrolytes, and solid state batteries. One sentence summary: The space charge region in the Schottky junction between the Cu 2 Se host matrix and in situ formed BiCuSeO under a direct current causes drastic suppression of Cu + ion migration in the composites, and obstructs the reduction reaction of Cu + into Cu metal, which, together with the effective regulation of carrier concentration as well as enhanced interfacial phonon scattering, greatly stabilizes the improved thermoelectric performance.
We present four studies (one correlational and three experimental) of American Whites that examin... more We present four studies (one correlational and three experimental) of American Whites that examine relationships between White and minority demographic shifts, intergroup threat, and support for extreme-right groups and actions. We focus in particular on the role of collective existential threat (i.e., a perception that the ingroup will cease to exist), along with three alternative/competing intergroup threats: status threat, symbolic threat, prototypicality threat. Though no zero-order relationship was found between perceived White population decline and far-right variables, we find evidence that (1) perceived White population decline leads to collective existential threat net of other perceived demographic shifts, (2) collective existential threat is related to far-right support net of other threats, and (3) perceived White decline has a robust indirect relationship with measures of farright support via collective existential threat.
AIMS Osteoarthritis (OA) is a common joint disease and the main cause of disability. We sought to... more AIMS Osteoarthritis (OA) is a common joint disease and the main cause of disability. We sought to determine the effective concentration of emodin on chondrocytes and to identify the dosage of emodin that induces a comparable therapeutic effect with the COX-2 inhibitor drug, celecoxib that is currently used to treat OA. MATERIAL AND METHODS In vitro experiments induced inflammation of chondrocytes by IL-1β, and an osteoarthritis model was established in vivo by cutting rat anterior cruciate ligament. Western Blot, Real-time PCR, HE staining, Safranin O-green staining and immunohistochemistry were performed to detect MMP-3, MMP-13, ADAMTS-4, iNOS and COL2A1 on the chondrocytes or the tibial plateau. The cytokine activity and content in serum of six groups of rats were measured by kit. RESULTS It was found that the surface layer of the cartilage was thicker and smoother after the administration of emodin. Tissue expression of MMP-3, MMP-13, ADAMTS-4 and iNOS were significantly (p < 0.05) decreased in chondrocytes and cartilage treated with different doses of emodin, and the content of COL2A1 was reversed. Emodin also significantly decreased the blood levels of COX-2 and PGE2. The effective emodin in vitro was 5 μmol/L, whereas emodin at 80 mg/kg was equivalent to celecoxib in vivo. CONCLUSION Emodin reduces the expression of cartilage matrix degradation biomarkers, thereby reducing the degradation of cartilage matrix and protecting the knee joint cartilage. Emodin at 5 μmol/L shows the best concentration to treat chondrocytes, and the protective effect of emodin at 80 mg/kg is comparable to that of celecoxib.
Baicalein has been shown to have chondroprotective potential in vitro. However, its effect on dis... more Baicalein has been shown to have chondroprotective potential in vitro. However, its effect on disease modification in osteoarthritis (OA) is largely unknown. The present study is aimed at determining whether baicalein could slow the progression of OA and inhibit OA-related inflammation in a rat model of destabilization of the medial meniscus (DMM) and the underlying mechanisms. The rats subjected to DMM surgery were treated with baicalein (0.8, 1.6, and 3.2 μg/L, 50 μL, once a week) by intra-articular injection for 6 weeks. Dexamethasone (0.4 mg/mL, 50 μL, once a week) was used as a positive control. Histologic grading of cartilage degeneration was performed using the Osteoarthritis Research Society International (OARSI) recommended grading system (on a scale of 0-6). The expression levels of molecules associated with cartilage homeostasis and inflammatory cytokines were analyzed; moreover, the NLRP3 inflammasome activation and cartilage oxidative stress-associated molecules were de...
Ketamine has become a popular recreational drug due to its neuronal anesthesia effect and low pri... more Ketamine has become a popular recreational drug due to its neuronal anesthesia effect and low price. The process of learning and memory is part of the distinctive high-level neural activities in animals. We investigated the effects of subanesthetic and anesthetic doses of ketamine on the learning and memory-related signal transduction mechanisms. We used the Morris water maze test to execute rats’ learning and memory ability and detected changes of Arc mRNA and Arc, cAMP-response element-binding protein (CREB), phospho-CREB (p-CREB), extracellular signal-regulated kinase (ERK), and phospho-ERK (p-ERK) protein expression in the hippocampus 10 min and 24 h after administration. Ten min after ketamine injection, the Arc gene and the protein expression levels increased in all groups; p-ERK only increased in the chronic subanesthetic dose group. After 24 h, the Arc gene and the protein expression levels of the subanesthetic dose group increased, but those of the chronic subanesthetic dos...
Objective: This study was conducted to investigate the potential effects of prolonged photoperiod... more Objective: This study was conducted to investigate the potential effects of prolonged photoperiod on the serum lipids, carcass traits, and meat quality of Jinjiang cattle during winter.Methods: Thirty-four Jinjiang bulls aged between 14 and 16 months were randomly assigned to two groups that were alternatively subjected to either natural daylight +4 h supplemental light (long photoperiod, LP) or natural daylight (natural photoperiod, NP) for 96 days. The potential effects on the levels of serum lipids, carcass traits, meat quality, and genes regulating lipid metabolism in the intramuscular fat (IMF) of the cattle were evaluated.Results: Jinjiang cattle kept under LP showed significant increase in both dry matter intake and backfat thickness. the serum glucose and the plasma leptin levels were significantly reduced, while that of melatonin and insulin were observed to be increased. The crude fat contents of biceps femoris muscle and longissimus dorsi muscle were higher in LP than in ...
In this paper, the removal of 2,4,6-trichlorophenol (2,4,6-TCP) by synthesized Ni/Fe nanoparticle... more In this paper, the removal of 2,4,6-trichlorophenol (2,4,6-TCP) by synthesized Ni/Fe nanoparticles were investigated. At the same time, the factors, such as the dosage of Ni/Fe, Ni content in Ni/Fe nanoparticles, sulfate ion, HA, coexisting substances in water which affected the removal of 2,4,6-TCP by synthesized Ni/Fe nanoparticles were also investigated. Under the experimental conditions, the removal efficiency of 2,4,6-TCP by Ni/Fe nanoparticles in water was about 72% for 2 h. The dosage of Ni/Fe, Ni content in Ni/Fe nanoparticles, and Fe3+ all promoted the dechlorination reaction of 2,4,6-TCP by Ni/Fe nanoparticles. Sulfate, oxalic acid and citric acid played an inhibitory role on the removal of 2,4,6-TCP by Ni/Fe nanoparticles in water. Fe2+ had no obvious affect to the removal of 2,4,6-TCP by Ni/Fe nanoparticles in water. In addition, low initial HA concentration was favorable for the removal of 2,4,6-TCP by Ni/Fe nanoparticles, while high concentrations of HA played an inhib...
A series of novel 1,2,4-triazole derivatives containing oxime ether and phenoxy pyridine moiety w... more A series of novel 1,2,4-triazole derivatives containing oxime ether and phenoxy pyridine moiety were designed and synthesized. The new compounds were identified by nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HRMS). Compound (Z)-1-(6-(4-nitrophenoxy)pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one O-methyl oxime (5a18) was further confirmed by X-ray single crystal diffraction. Their antifungal activities were evaluated against eight phytopathogens. The in vitro bioassays indicated that most of the title compounds displayed moderate to high fungicidal activities. Compound (Z)-1-(6-(4-bromo-2-chlorophenoxy)pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one O-methyl oxime (5a4) exhibited a broad-spectrum antifungal activities with the EC50 values of 1.59, 0.46, 0.27 and 11.39 mg/L against S. sclerotiorum, P. infestans, R. solani and B. cinerea, respectively. Compound (Z)-1-(6-(2-chlorophenoxy)pyridin-3-yl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one O...
The etiology of osteoarthritis (OA) is multifactorial, with no effective disease-modifying-drugs.... more The etiology of osteoarthritis (OA) is multifactorial, with no effective disease-modifying-drugs. L-theanine has been reported to inhibit inflammatory responses in some diseases and this study aimed to investigate the effect of L-theanine on Interleukin-1(IL-1)β-stimulated chondrocytes, and in an injury-induced OA rat model. Primary chondrocytes were stimulated by IL-1β (10 ng/mL) for 24 h and then co-cultured with L-theanine for 24 h. The effects of L-theanine on IL-1β-stimulated expression of pro-inflammatory cytokines and hydrolytic enzyme were analyzed using Western blotting, quantitative polymerase chain reaction (q-PCR) and enzyme-linked immunosorbent assay (ELISA) kits. An immunofluorescence assay was used to detect nuclear factor kappa B (NF-κB) phosphorylation. OA was induced by anterior cruciate ligament transection (ACLT) surgery in rats and celecoxib was used as a positive control. OA severity was measured using the Osteoarthritis Research Society International (OARSI) g...
Dysregulated intratumoral immune reactions are shaped by complex networks of cytokines, which coo... more Dysregulated intratumoral immune reactions are shaped by complex networks of cytokines, which coordinate with tumor cells to determine tumor progression and aggressiveness. In lung adenocarcinoma (LUAD), the role of intratumoral cytokine gene expression for stratifying prognosis has not been systematically investigated. Using high-dimensional datasets of cancer specimens from clinical patients in The Cancer Genome Atlas (TCGA), we explored the transcript abundance and prognostic impact of 27 clinically evaluable cytokines in 500 LUAD tumor samples according to clinicopathological features and two common driver mutations (EGFR and KRAS). We found that reduced expression of IL12B presented as the single prognostic factor for both poor overall survival (OS) and recurrence free survival (RFS) with high hazard ratios. Moreover, we identified that elevated expression of IL6, CXCL8 and CSF3 were additional independent predictors of poor RFS in LUAD patients. Their prognostic significance w...
This paper presents evidence from five studies (total White N = 7,209) that White American's raci... more This paper presents evidence from five studies (total White N = 7,209) that White American's racial identity centrality is related to self-reported levels of far-right extremism. Furthermore, evidence from two of the studies shows that social dominance orientation (SDO) is another robust predictor of far-right extremism. Results also show that SDO can moderate the relationship between White identity and extremism such that the association is stronger for Whites with a higher level of SDO. Therefore, evidence suggests that the role of Whites' racial identity centrality is particularly relevant, and SDO is an important variable that may moderate the association between Whites' racial identity centrality and their far-right extremism in the contemporary political era.
The four impact exemption curves in ASME are convenient to estimate the minimum design metal temp... more The four impact exemption curves in ASME are convenient to estimate the minimum design metal temperature (MDMT) of ferritic steel. However they can't distinguish low temperature fracture toughness of ferritic steel well. Materials with similar fracture toughness, divided into different impact exemption curves will have different MDMT and conservative degree. And the MDMT of ferritic steel are estimated by the steel grade. There are differences in toughness for steel with same steel grade from different factories and different heats and batches of the same factory. In this paper, the seven MDMT curves, identified with labels I, II, III, IV, V, VI and VII are proposed based on assumed yield strength and seven reference temperatures, (T 0MC = 20°C, 0°C, −20°C, −40°C, −60°C, −80°C and −100°C) which can cover the temperature range for commonly used pressure vessels made from ferritic steel. The MDMT for a ferritic steel can be determined once the reference temperature and yield strength are measured. SA508-3 and Q345R, as a representative of ferritic steel are used to illustrate the applicability of the MDMT curves.
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