2019 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (EIConRus), 2019
This paper presents the power amplifier using GaN High Electron Mobility Transistor (HEMT) techno... more This paper presents the power amplifier using GaN High Electron Mobility Transistor (HEMT) technology for Monolithic Microwave Integrated Circuit (MMIC). The input and output impedances are 50 Ohm. The supply voltage is equal to 3 V. The power amplifier provides maximum frequency 73 GHz and gain 6.08 dB in linear mode. In the nonlinear mode, power amplifier provides power added efficiency (PAE) equaled to 64.66% while power input is equal to 6.85 dBm. When power amplification is increased then supply voltage is 7V and power input is 12.45 dBm, power amplifier provides power added efficiency (PAE) equaled to 73 %. The amplifier was designed by using Microwave Office (AWR) with model EEHEMT for the transistor.
This paper presents four variants of the power amplifier using the 0.25-µm GaAs High Electron Mob... more This paper presents four variants of the power amplifier using the 0.25-µm GaAs High Electron Mobility Transistor (HEMT)Technology for Monolithic Microwave Integrated Circuits (MMIC). The input power is equal to 5 dBm. The supply voltage is equal to 3 V, and the bias voltage is equal to −0.3 V. The input-output impedances are 50 Ohm. The simple power amplifier provides maximum gain equal to 14 dB. The simple power amplifier with a matching circuit provides maximum gain equal to 14.15 dB. The balanced power amplifier provides maximum gain equal to 11.77 dB. The three-cascade power amplifier provides maximum gain equal to 15.57 dB. Four variants of the amplifier were designed by using Microwave Office (AWR) with model MATRK for the transistor.
Background: Special regulatory role of prostaglandin E2 has been postulated in aspirin-induced as... more Background: Special regulatory role of prostaglandin E2 has been postulated in aspirin-induced asthma. The aim if this study was to investigate the effects of aspirin on systemic production of prostaglandin E2 and cysteinyl leukotrienes in patients with asthma. Methods: We determined urinary concentrations of two main prostaglandin E2 metabolites: 13,14-dihydro-15keto-PGE2 using commercial enzyme immunoassay and 9,15-dioxo-11alpha-hydroxy-2,3,4,5-tetranor-prostane-1,20-dioic acid using gas chromatography/mass spectrometry; and leukotriene E4 using immunoassay. Determinations were performed at baseline and following oral aspirin and celecoxib challenges, in two well-defined asthma phenotypes: aspirin-sensitive and aspirin-tolerant patients. Results: Aspirin precipitated bronchial reactions in all aspirin-sensitive, but in none of the aspirin-tolerant patients. Celecoxib 400 mg was well tolerated by all patients except for one with aspirin-induced asthma. At baseline mean prostaglandin E2 metabolites values did not differ between the groups. Following different aspirin provocation doses, the two main prostaglandin E2 metabolites were decreased in the aspirin-tolerant group, but their mean level remained unchanged in the aspirin-sensitive group. The dose of aspirin had no effect on the magnitude of the response on the prostaglandin E2 metabolites and its duration. In both groups urinary prostaglandin E2 metabolites decreased following celecoxib challenge. No correlation was found between prostaglandin E2 metabolites and leukotriene E4. Conclusion: Aspirin-precipitated asthmatic attacks are not associated with changes in the systemic prostaglandin E2 production. In contrast, prostaglandin E2 systemic production becomes depressed by aspirin in nonsensitive patients. This different response might indicate COX-1 dependent prostaglandin E2 control of inflammatory cells in AIA. Thus, PGE2 is released during the clinical reactions to aspirin through an alternate COX-2 pathway. Clinical implications of this finding are in line with current observations of good tolerance of the selective COX-2 inhibitors in sensitive patients.
During the last decade, cases of the fish parasite Anisakis simplex infection and allergy in huma... more During the last decade, cases of the fish parasite Anisakis simplex infection and allergy in human have increased in countries with high fish consumption. Our aim was to perform an extended seroprevalence study of anti-IgE antibodies against this parasite in Norway, one of the high fish-consuming countries. At the Department of Immunology and Transfusion Medicine and the Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway, two main groups of anonymized serum samples were collected; the first (n = 993) from recently recruited blood donors (designated 'BDO') and the second (n = 414) from patient with total IgE levels ≥1000 kU/l (designated 'IGE+'). The sera were analysed by the ImmunoCAP(®) method for total IgE and IgE antibodies against A. simplex, house dust mite (HDM), shrimp, cod, crab, brine shrimp and shrimp tropomyosin. The A. simplex positive sera were further tested by an enzyme-linked immunosorbent assay (ELISA) method, which uses 2 recombinant (r) major allergens, rAni s 1 and rAni s 7 as target antigens. SDS-PAGE and Western immunoblotting analyses were also performed. Whereas the prevalences by ImmunoCAP(®) were 0.4% and 16.2% in the BDO and IGE+ groups, respectively, analyses with recombinant allergens showed only 0.0% and 0.2%. Cross-reactivity and immunoblotting analyses suggested that most of the ImmunoCAP(®) positive sera were probably false-positive due to cross-sensitization to shrimp and HDM. However, positivity due to other A. simplex antigens should also be considered. Compared with other high fish-consuming countries, we observed a very low seroprevalence of anti-Anisakis IgE antibodies in a Norwegian population.
Background We hypothesized that food allergy causes a state of non-specific jejunal dysmotility. ... more Background We hypothesized that food allergy causes a state of non-specific jejunal dysmotility. This was tested in a mouse model. Methods Balb/c mice were epicutaneously sensitized with ovalbumin and challenged with 10 intragastric ovalbumin administrations every second day. Smooth muscle contractility of isolated circular jejunal sections was studied in organ bath with increasing concentrations of carbamylcholine chloride (carbachol). Smooth muscle layer thickness and mast cell protease-1 (MMCP-1) positive cell density were assayed histologically. Serum MMCP-1 and immunoglobulins were quantified by ELISA, and mRNA expressions of IFN-γ, IL-4, IL-6 and TGFβ-1 from jejunal and ileal tissue segments were analyzed with quantitative real-time PCR. Results Ovalbumin-specific serum IgE correlated with jejunal MMCP-1+ cell density. In the allergic mice, higher concentrations of carbachol were required to reach submaximal muscular stimulation, particularly in preparations derived from mice ...
Aluminum sulfate (alum) has been applied in hundreds of eutrophic lakes and wetlands worldwide fo... more Aluminum sulfate (alum) has been applied in hundreds of eutrophic lakes and wetlands worldwide for >4 decades to inactivate internal P loading and to reduce potentially toxic cyanobacteria blooms. However, the ecological effects of alum additions on benthic invertebrate activities and the feedback effect of invertebrate bioturbation on alum effectiveness in binding P are not well known. We conducted a microcosm experiment to assess how functional traits of bioturbating invertebrates (chironomid larvae and tubificid oligochaetes) interact with sediment characteristics and alum addition to influence P fluxes in sediment cores from 3 eutrophic, flooded muck fields (former natural wetlands converted to celery fields, now being restored to wetlands). In the absence of alum, bioturbation activities by chironomids (tube builders and ventilators) stimulated P release from the sediment to the overlying water, whereas tubificids (gallery creators and producers of fecal pellets at the sediment surface) increased P retention in sediment cores from the 2 highest organic muck fields. The addition of alum induced a sharp reduction of P concentration in the water column of all treated cores, and bioturbation activity had little overall effect on alum’s ability to prevent P release from sediments. Only tubificid activity in the most organic sediment resulted in a small but statistically significant release of P to the water column. Chironomid larvae and tubificid worms are usually the most dominant taxa in nutrient-enriched ecosystems, so understanding their interactions with alum and habitat characteristics can be important for identifying the ecological consequences of restoration practices in eutrophic freshwater ecosystems.
2019 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (EIConRus), 2019
This paper presents the power amplifier using GaN High Electron Mobility Transistor (HEMT) techno... more This paper presents the power amplifier using GaN High Electron Mobility Transistor (HEMT) technology for Monolithic Microwave Integrated Circuit (MMIC). The input and output impedances are 50 Ohm. The supply voltage is equal to 3 V. The power amplifier provides maximum frequency 73 GHz and gain 6.08 dB in linear mode. In the nonlinear mode, power amplifier provides power added efficiency (PAE) equaled to 64.66% while power input is equal to 6.85 dBm. When power amplification is increased then supply voltage is 7V and power input is 12.45 dBm, power amplifier provides power added efficiency (PAE) equaled to 73 %. The amplifier was designed by using Microwave Office (AWR) with model EEHEMT for the transistor.
This paper presents four variants of the power amplifier using the 0.25-µm GaAs High Electron Mob... more This paper presents four variants of the power amplifier using the 0.25-µm GaAs High Electron Mobility Transistor (HEMT)Technology for Monolithic Microwave Integrated Circuits (MMIC). The input power is equal to 5 dBm. The supply voltage is equal to 3 V, and the bias voltage is equal to −0.3 V. The input-output impedances are 50 Ohm. The simple power amplifier provides maximum gain equal to 14 dB. The simple power amplifier with a matching circuit provides maximum gain equal to 14.15 dB. The balanced power amplifier provides maximum gain equal to 11.77 dB. The three-cascade power amplifier provides maximum gain equal to 15.57 dB. Four variants of the amplifier were designed by using Microwave Office (AWR) with model MATRK for the transistor.
Background: Special regulatory role of prostaglandin E2 has been postulated in aspirin-induced as... more Background: Special regulatory role of prostaglandin E2 has been postulated in aspirin-induced asthma. The aim if this study was to investigate the effects of aspirin on systemic production of prostaglandin E2 and cysteinyl leukotrienes in patients with asthma. Methods: We determined urinary concentrations of two main prostaglandin E2 metabolites: 13,14-dihydro-15keto-PGE2 using commercial enzyme immunoassay and 9,15-dioxo-11alpha-hydroxy-2,3,4,5-tetranor-prostane-1,20-dioic acid using gas chromatography/mass spectrometry; and leukotriene E4 using immunoassay. Determinations were performed at baseline and following oral aspirin and celecoxib challenges, in two well-defined asthma phenotypes: aspirin-sensitive and aspirin-tolerant patients. Results: Aspirin precipitated bronchial reactions in all aspirin-sensitive, but in none of the aspirin-tolerant patients. Celecoxib 400 mg was well tolerated by all patients except for one with aspirin-induced asthma. At baseline mean prostaglandin E2 metabolites values did not differ between the groups. Following different aspirin provocation doses, the two main prostaglandin E2 metabolites were decreased in the aspirin-tolerant group, but their mean level remained unchanged in the aspirin-sensitive group. The dose of aspirin had no effect on the magnitude of the response on the prostaglandin E2 metabolites and its duration. In both groups urinary prostaglandin E2 metabolites decreased following celecoxib challenge. No correlation was found between prostaglandin E2 metabolites and leukotriene E4. Conclusion: Aspirin-precipitated asthmatic attacks are not associated with changes in the systemic prostaglandin E2 production. In contrast, prostaglandin E2 systemic production becomes depressed by aspirin in nonsensitive patients. This different response might indicate COX-1 dependent prostaglandin E2 control of inflammatory cells in AIA. Thus, PGE2 is released during the clinical reactions to aspirin through an alternate COX-2 pathway. Clinical implications of this finding are in line with current observations of good tolerance of the selective COX-2 inhibitors in sensitive patients.
During the last decade, cases of the fish parasite Anisakis simplex infection and allergy in huma... more During the last decade, cases of the fish parasite Anisakis simplex infection and allergy in human have increased in countries with high fish consumption. Our aim was to perform an extended seroprevalence study of anti-IgE antibodies against this parasite in Norway, one of the high fish-consuming countries. At the Department of Immunology and Transfusion Medicine and the Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway, two main groups of anonymized serum samples were collected; the first (n = 993) from recently recruited blood donors (designated 'BDO') and the second (n = 414) from patient with total IgE levels ≥1000 kU/l (designated 'IGE+'). The sera were analysed by the ImmunoCAP(®) method for total IgE and IgE antibodies against A. simplex, house dust mite (HDM), shrimp, cod, crab, brine shrimp and shrimp tropomyosin. The A. simplex positive sera were further tested by an enzyme-linked immunosorbent assay (ELISA) method, which uses 2 recombinant (r) major allergens, rAni s 1 and rAni s 7 as target antigens. SDS-PAGE and Western immunoblotting analyses were also performed. Whereas the prevalences by ImmunoCAP(®) were 0.4% and 16.2% in the BDO and IGE+ groups, respectively, analyses with recombinant allergens showed only 0.0% and 0.2%. Cross-reactivity and immunoblotting analyses suggested that most of the ImmunoCAP(®) positive sera were probably false-positive due to cross-sensitization to shrimp and HDM. However, positivity due to other A. simplex antigens should also be considered. Compared with other high fish-consuming countries, we observed a very low seroprevalence of anti-Anisakis IgE antibodies in a Norwegian population.
Background We hypothesized that food allergy causes a state of non-specific jejunal dysmotility. ... more Background We hypothesized that food allergy causes a state of non-specific jejunal dysmotility. This was tested in a mouse model. Methods Balb/c mice were epicutaneously sensitized with ovalbumin and challenged with 10 intragastric ovalbumin administrations every second day. Smooth muscle contractility of isolated circular jejunal sections was studied in organ bath with increasing concentrations of carbamylcholine chloride (carbachol). Smooth muscle layer thickness and mast cell protease-1 (MMCP-1) positive cell density were assayed histologically. Serum MMCP-1 and immunoglobulins were quantified by ELISA, and mRNA expressions of IFN-γ, IL-4, IL-6 and TGFβ-1 from jejunal and ileal tissue segments were analyzed with quantitative real-time PCR. Results Ovalbumin-specific serum IgE correlated with jejunal MMCP-1+ cell density. In the allergic mice, higher concentrations of carbachol were required to reach submaximal muscular stimulation, particularly in preparations derived from mice ...
Aluminum sulfate (alum) has been applied in hundreds of eutrophic lakes and wetlands worldwide fo... more Aluminum sulfate (alum) has been applied in hundreds of eutrophic lakes and wetlands worldwide for >4 decades to inactivate internal P loading and to reduce potentially toxic cyanobacteria blooms. However, the ecological effects of alum additions on benthic invertebrate activities and the feedback effect of invertebrate bioturbation on alum effectiveness in binding P are not well known. We conducted a microcosm experiment to assess how functional traits of bioturbating invertebrates (chironomid larvae and tubificid oligochaetes) interact with sediment characteristics and alum addition to influence P fluxes in sediment cores from 3 eutrophic, flooded muck fields (former natural wetlands converted to celery fields, now being restored to wetlands). In the absence of alum, bioturbation activities by chironomids (tube builders and ventilators) stimulated P release from the sediment to the overlying water, whereas tubificids (gallery creators and producers of fecal pellets at the sediment surface) increased P retention in sediment cores from the 2 highest organic muck fields. The addition of alum induced a sharp reduction of P concentration in the water column of all treated cores, and bioturbation activity had little overall effect on alum’s ability to prevent P release from sediments. Only tubificid activity in the most organic sediment resulted in a small but statistically significant release of P to the water column. Chironomid larvae and tubificid worms are usually the most dominant taxa in nutrient-enriched ecosystems, so understanding their interactions with alum and habitat characteristics can be important for identifying the ecological consequences of restoration practices in eutrophic freshwater ecosystems.
Uploads
Papers by htun lin