Medzinárodné smernice bežne integrujú komplementárne a integratívne prístupy do manažmentu muskul... more Medzinárodné smernice bežne integrujú komplementárne a integratívne prístupy do manažmentu muskuloskeletálnej bolesti, čo zlepšuje celkovú kvalitu života a súčasne znižuje závislosť na konvenčnej farmakologickej liečbe a súvisiace riziko vedľajších účinkov.
Mezinárodní směrnice běžně zapojují doplňkové a integrativní přístupy do léčby muskuloskeletální ... more Mezinárodní směrnice běžně zapojují doplňkové a integrativní přístupy do léčby muskuloskeletální bolesti, což zlepšuje celkovou kvalitu života a současně snižuje závislost na konvenční farmakologické léčbě a s tím související riziko nežádoucích účinků.
Le linee guida internazionali includono generalmente approcci complementari e integrativi nella g... more Le linee guida internazionali includono generalmente approcci complementari e integrativi nella gestione del dolore muscoloscheletrico. Ciò consente di migliorare il benessere globale, riducendo al contempo il ricorso alle terapie farmacologiche tradizionali e il rischio di effetti indesiderati ad esse associato.
Международные рекомендации обычно включают комплементарные и интегративные подходы к лечению мыше... more Международные рекомендации обычно включают комплементарные и интегративные подходы к лечению мышечно-скелетной боли. Это улучшает общее самочувствие при одновременном снижении зависимости от традиционных фармакологических методов лечения и связанного с ними риска побочных эффектов.
Photodermatology, Photoimmunology and Photomedicine, May 21, 2022
Physical properties and biological effects of mineral trioxide aggregate mixed with methylcellulo... more Physical properties and biological effects of mineral trioxide aggregate mixed with methylcellulose and calcium chloride Objectives: Methylcellulose (MC) is a chemical compound derived from cellulose. MTA mixed with MC reduces setting time and increases plasticity. CaCl 2 as a setting time accelerator on the physical and biological properties of MTA. Material and Methods: Test materials were divided into 3 groups; Group 1(control): distilled water; Group 2: 1% MC/CaCl 2 ; Group 3: 2% MC/ CaCl 2 gene expression of bone sialoprotein (BSP) was detected by RT-PCR and realtime PCR. The expression of alkaline phosphatase (ALP) and mineralization behavior were evaluated using an ALP staining and an alizarin red staining. Results: Compressive strength, pH, and cell viability of MTA mixed with MC/ CaCl 2 2 in MTA with MC/CaCl 2 compared to the control (p<.05). This study revealed higher expression of ALP and mineralization in cells exposed to MTA mixed with water and MTA mixed with MC/CaCl 2 compared to the control (p<.05). physical and biological effect of MTA. It suggests that these cements may
International guidelines are commonly integrating complementary and integrative approaches into t... more International guidelines are commonly integrating complementary and integrative approaches into the management of musculoskeletal pain. This improves overall well-being while concomitantly reducing the reliance on conventional pharmacological treatments and the associated risk of side effects.
Physical properties and biological effects of mineral trioxide aggregate mixed with methylcellulo... more Physical properties and biological effects of mineral trioxide aggregate mixed with methylcellulose and calcium chloride Objectives: Methylcellulose (MC) is a chemical compound derived from cellulose. MTA mixed with MC reduces setting time and increases plasticity. CaCl 2 as a setting time accelerator on the physical and biological properties of MTA. Material and Methods: Test materials were divided into 3 groups; Group 1(control): distilled water; Group 2: 1% MC/CaCl 2 ; Group 3: 2% MC/ CaCl 2 gene expression of bone sialoprotein (BSP) was detected by RT-PCR and realtime PCR. The expression of alkaline phosphatase (ALP) and mineralization behavior were evaluated using an ALP staining and an alizarin red staining. Results: Compressive strength, pH, and cell viability of MTA mixed with MC/ CaCl 2 2 in MTA with MC/CaCl 2 compared to the control (p<.05). This study revealed higher expression of ALP and mineralization in cells exposed to MTA mixed with water and MTA mixed with MC/CaCl 2 compared to the control (p<.05). physical and biological effect of MTA. It suggests that these cements may
Far‐infrared radiation (FIR) has been investigated for reduction of pain and improvement of derma... more Far‐infrared radiation (FIR) has been investigated for reduction of pain and improvement of dermal blood flow. The FIRTECH patch is a medical device designed to re‐emit FIR radiated by the body. This phase 1 study was conducted to evaluate the local effects of the FIRTECH patch on local skin perfusion, microcirculation and oxygenation. This prospective, randomized, open‐label, parallel designed study admitted 20 healthy participants to a medical research facility for treatment for 31 h on three anatomical locations. During treatment, imaging assessments consisting of laser speckle contrast imaging, near‐infrared spectroscopy, side‐stream dark‐field microscopy, multispectral imaging and thermography were conducted regularly on patch‐treated skin and contralateral non‐treated skin. The primary endpoint was baseline perfusion increase during treatment on the upper back. Secondary endpoints included change in baseline perfusion, oxygen consumption and temperature of treated versus untre...
Background Lower back pain (LBP) and osteoarthritis (OA) are common musculoskeletal disorders and... more Background Lower back pain (LBP) and osteoarthritis (OA) are common musculoskeletal disorders and account for around 17.0% of years lived with disability worldwide; however, there is a lack of real-world data on these conditions. Paracetamol brands are frequently prescribed in France for musculoskeletal pain and include Doliprane, Dafalgan, and Ixprim (tramadol-paracetamol). Objective The objective of this retrospective study was to understand the journey of patients with LBP or OA when treated with paracetamol. Methods Three studies were undertaken. Two studies analyzed electronic medical records from general practitioners (GPs) and rheumatologists of patients with OA or LBP, who had received at least one paracetamol prescription between 2013 and 2018 in France. Data were extracted, anonymized, and stratified by gender, age, and provider specialty. The third study, an infodemiology study, analyzed associations between terms used on public medical forums and Twitter in France and th...
Internationale Leitlinien enthalten im Allgemeinen komplementäre und integrative Verfahren zur Be... more Internationale Leitlinien enthalten im Allgemeinen komplementäre und integrative Verfahren zur Behandlung von Muskel- und Knochenschmerzen. Dies erhöht das Wohlbefinden insgesamt und reduziert den Bedarf an konventioneller medikamentöser Behandlung und die damit verbundenen Nebenwirkungsrisiken.
International guidelines are commonly integrating complementary and integrative approaches into t... more International guidelines are commonly integrating complementary and integrative approaches into the management of musculoskeletal pain. This improves overall well-being while concomitantly reducing the reliance on conventional pharmacological treatments and the associated risk of side effects.
Background: When using inpatient claims data to identify hospitalizations in supplemental Medicar... more Background: When using inpatient claims data to identify hospitalizations in supplemental Medicare beneficiaries, e.g., in the MarketScan database, there is a concern that the coverage of hospitalizations in such inpatient claims may be incomplete. However, whether hospitalizations are covered by inpatient claims or not, they incur professional charges that are recorded in the professional claims data in the MarketScan Medicare database. In the context of identifying hospitalizations that might be related to heart failure (HF) in dronedarone users, we compared different approaches to identify such hospitalizations. Objective: To assess the impact of using professional claims in addition to inpatient claims on identifying hospitalizations that might be related to HF. Methods: A total of 20,834 dronedarone users who were supplemental Medicare beneficiaries between July 2009 (launch date in US) and December 2012 were identified in the MarketScan database. The hospitalizations that migh...
PURPOSE Dronedarone may increase digoxin plasma levels through inhibition of P-glycoprotein. Usin... more PURPOSE Dronedarone may increase digoxin plasma levels through inhibition of P-glycoprotein. Using real-world data, we evaluated the risk of digitalis intoxication in concomitant users of dronedarone and digoxin compared digoxin-alone users. METHODS We used the Clinformatics DataMart, a US claims database, to identify adult patients with atrial fibrillation (AF) or atrial flutter (AFL) who concomitantly used dronedarone and digoxin and those who used digoxin alone between July 2009 and March 2016. Digitalis intoxication during follow-up until March 2016 was ascertained using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) and International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM). Adjusted hazard ratios (HR) for digitalis intoxication in concomitant users versus users of digoxin alone were estimated, controlling for age, sex, cohort entry year, number of medical encounters for AF or AFL, history of conge...
Traditionally, musculoskeletal pain management has focused on the use of conventional treatments ... more Traditionally, musculoskeletal pain management has focused on the use of conventional treatments to relieve pain. However, multi-modal integrative medicine including alternative/complementary treatments is becoming more widely used and integrated into treatment guidelines around the world. The uptake of this approach varies according to country, with generally a higher uptake in developed countries and in females aged more than 40 years. Integral to the concept described here, is that the body has an innate ability to selfheal, which can be optimized by the use of integrative medical strategies. Stress triggers for acute or recurring musculoskeletal pain are diverse and can range from physical to psychological. The mechanism by which the body responds to triggers and initiates the self-healing processes is complex, but five body networks or processes are thought to be integral: the nervous system, microcirculation/vasodilation, immune modulation, muscular relaxation/ contraction and psychological balance. Multi-modal integrative medicine approaches include nutritional/dietary modification, postural/muscular training exercises, and cognitive behavioral mind/body techniques. This article will review the self-healing concept and provide plausible scientific evidence where available.
Medzinárodné smernice bežne integrujú komplementárne a integratívne prístupy do manažmentu muskul... more Medzinárodné smernice bežne integrujú komplementárne a integratívne prístupy do manažmentu muskuloskeletálnej bolesti, čo zlepšuje celkovú kvalitu života a súčasne znižuje závislosť na konvenčnej farmakologickej liečbe a súvisiace riziko vedľajších účinkov.
Mezinárodní směrnice běžně zapojují doplňkové a integrativní přístupy do léčby muskuloskeletální ... more Mezinárodní směrnice běžně zapojují doplňkové a integrativní přístupy do léčby muskuloskeletální bolesti, což zlepšuje celkovou kvalitu života a současně snižuje závislost na konvenční farmakologické léčbě a s tím související riziko nežádoucích účinků.
Le linee guida internazionali includono generalmente approcci complementari e integrativi nella g... more Le linee guida internazionali includono generalmente approcci complementari e integrativi nella gestione del dolore muscoloscheletrico. Ciò consente di migliorare il benessere globale, riducendo al contempo il ricorso alle terapie farmacologiche tradizionali e il rischio di effetti indesiderati ad esse associato.
Международные рекомендации обычно включают комплементарные и интегративные подходы к лечению мыше... more Международные рекомендации обычно включают комплементарные и интегративные подходы к лечению мышечно-скелетной боли. Это улучшает общее самочувствие при одновременном снижении зависимости от традиционных фармакологических методов лечения и связанного с ними риска побочных эффектов.
Photodermatology, Photoimmunology and Photomedicine, May 21, 2022
Physical properties and biological effects of mineral trioxide aggregate mixed with methylcellulo... more Physical properties and biological effects of mineral trioxide aggregate mixed with methylcellulose and calcium chloride Objectives: Methylcellulose (MC) is a chemical compound derived from cellulose. MTA mixed with MC reduces setting time and increases plasticity. CaCl 2 as a setting time accelerator on the physical and biological properties of MTA. Material and Methods: Test materials were divided into 3 groups; Group 1(control): distilled water; Group 2: 1% MC/CaCl 2 ; Group 3: 2% MC/ CaCl 2 gene expression of bone sialoprotein (BSP) was detected by RT-PCR and realtime PCR. The expression of alkaline phosphatase (ALP) and mineralization behavior were evaluated using an ALP staining and an alizarin red staining. Results: Compressive strength, pH, and cell viability of MTA mixed with MC/ CaCl 2 2 in MTA with MC/CaCl 2 compared to the control (p<.05). This study revealed higher expression of ALP and mineralization in cells exposed to MTA mixed with water and MTA mixed with MC/CaCl 2 compared to the control (p<.05). physical and biological effect of MTA. It suggests that these cements may
International guidelines are commonly integrating complementary and integrative approaches into t... more International guidelines are commonly integrating complementary and integrative approaches into the management of musculoskeletal pain. This improves overall well-being while concomitantly reducing the reliance on conventional pharmacological treatments and the associated risk of side effects.
Physical properties and biological effects of mineral trioxide aggregate mixed with methylcellulo... more Physical properties and biological effects of mineral trioxide aggregate mixed with methylcellulose and calcium chloride Objectives: Methylcellulose (MC) is a chemical compound derived from cellulose. MTA mixed with MC reduces setting time and increases plasticity. CaCl 2 as a setting time accelerator on the physical and biological properties of MTA. Material and Methods: Test materials were divided into 3 groups; Group 1(control): distilled water; Group 2: 1% MC/CaCl 2 ; Group 3: 2% MC/ CaCl 2 gene expression of bone sialoprotein (BSP) was detected by RT-PCR and realtime PCR. The expression of alkaline phosphatase (ALP) and mineralization behavior were evaluated using an ALP staining and an alizarin red staining. Results: Compressive strength, pH, and cell viability of MTA mixed with MC/ CaCl 2 2 in MTA with MC/CaCl 2 compared to the control (p<.05). This study revealed higher expression of ALP and mineralization in cells exposed to MTA mixed with water and MTA mixed with MC/CaCl 2 compared to the control (p<.05). physical and biological effect of MTA. It suggests that these cements may
Far‐infrared radiation (FIR) has been investigated for reduction of pain and improvement of derma... more Far‐infrared radiation (FIR) has been investigated for reduction of pain and improvement of dermal blood flow. The FIRTECH patch is a medical device designed to re‐emit FIR radiated by the body. This phase 1 study was conducted to evaluate the local effects of the FIRTECH patch on local skin perfusion, microcirculation and oxygenation. This prospective, randomized, open‐label, parallel designed study admitted 20 healthy participants to a medical research facility for treatment for 31 h on three anatomical locations. During treatment, imaging assessments consisting of laser speckle contrast imaging, near‐infrared spectroscopy, side‐stream dark‐field microscopy, multispectral imaging and thermography were conducted regularly on patch‐treated skin and contralateral non‐treated skin. The primary endpoint was baseline perfusion increase during treatment on the upper back. Secondary endpoints included change in baseline perfusion, oxygen consumption and temperature of treated versus untre...
Background Lower back pain (LBP) and osteoarthritis (OA) are common musculoskeletal disorders and... more Background Lower back pain (LBP) and osteoarthritis (OA) are common musculoskeletal disorders and account for around 17.0% of years lived with disability worldwide; however, there is a lack of real-world data on these conditions. Paracetamol brands are frequently prescribed in France for musculoskeletal pain and include Doliprane, Dafalgan, and Ixprim (tramadol-paracetamol). Objective The objective of this retrospective study was to understand the journey of patients with LBP or OA when treated with paracetamol. Methods Three studies were undertaken. Two studies analyzed electronic medical records from general practitioners (GPs) and rheumatologists of patients with OA or LBP, who had received at least one paracetamol prescription between 2013 and 2018 in France. Data were extracted, anonymized, and stratified by gender, age, and provider specialty. The third study, an infodemiology study, analyzed associations between terms used on public medical forums and Twitter in France and th...
Internationale Leitlinien enthalten im Allgemeinen komplementäre und integrative Verfahren zur Be... more Internationale Leitlinien enthalten im Allgemeinen komplementäre und integrative Verfahren zur Behandlung von Muskel- und Knochenschmerzen. Dies erhöht das Wohlbefinden insgesamt und reduziert den Bedarf an konventioneller medikamentöser Behandlung und die damit verbundenen Nebenwirkungsrisiken.
International guidelines are commonly integrating complementary and integrative approaches into t... more International guidelines are commonly integrating complementary and integrative approaches into the management of musculoskeletal pain. This improves overall well-being while concomitantly reducing the reliance on conventional pharmacological treatments and the associated risk of side effects.
Background: When using inpatient claims data to identify hospitalizations in supplemental Medicar... more Background: When using inpatient claims data to identify hospitalizations in supplemental Medicare beneficiaries, e.g., in the MarketScan database, there is a concern that the coverage of hospitalizations in such inpatient claims may be incomplete. However, whether hospitalizations are covered by inpatient claims or not, they incur professional charges that are recorded in the professional claims data in the MarketScan Medicare database. In the context of identifying hospitalizations that might be related to heart failure (HF) in dronedarone users, we compared different approaches to identify such hospitalizations. Objective: To assess the impact of using professional claims in addition to inpatient claims on identifying hospitalizations that might be related to HF. Methods: A total of 20,834 dronedarone users who were supplemental Medicare beneficiaries between July 2009 (launch date in US) and December 2012 were identified in the MarketScan database. The hospitalizations that migh...
PURPOSE Dronedarone may increase digoxin plasma levels through inhibition of P-glycoprotein. Usin... more PURPOSE Dronedarone may increase digoxin plasma levels through inhibition of P-glycoprotein. Using real-world data, we evaluated the risk of digitalis intoxication in concomitant users of dronedarone and digoxin compared digoxin-alone users. METHODS We used the Clinformatics DataMart, a US claims database, to identify adult patients with atrial fibrillation (AF) or atrial flutter (AFL) who concomitantly used dronedarone and digoxin and those who used digoxin alone between July 2009 and March 2016. Digitalis intoxication during follow-up until March 2016 was ascertained using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) and International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM). Adjusted hazard ratios (HR) for digitalis intoxication in concomitant users versus users of digoxin alone were estimated, controlling for age, sex, cohort entry year, number of medical encounters for AF or AFL, history of conge...
Traditionally, musculoskeletal pain management has focused on the use of conventional treatments ... more Traditionally, musculoskeletal pain management has focused on the use of conventional treatments to relieve pain. However, multi-modal integrative medicine including alternative/complementary treatments is becoming more widely used and integrated into treatment guidelines around the world. The uptake of this approach varies according to country, with generally a higher uptake in developed countries and in females aged more than 40 years. Integral to the concept described here, is that the body has an innate ability to selfheal, which can be optimized by the use of integrative medical strategies. Stress triggers for acute or recurring musculoskeletal pain are diverse and can range from physical to psychological. The mechanism by which the body responds to triggers and initiates the self-healing processes is complex, but five body networks or processes are thought to be integral: the nervous system, microcirculation/vasodilation, immune modulation, muscular relaxation/ contraction and psychological balance. Multi-modal integrative medicine approaches include nutritional/dietary modification, postural/muscular training exercises, and cognitive behavioral mind/body techniques. This article will review the self-healing concept and provide plausible scientific evidence where available.
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