Papers by hasan büyükaslan
Medical research archives, Dec 31, 2022
Istanbul Medical Journal, 2016
Neuropsychiatric Disease and Treatment, Oct 1, 2019
Background: The pathophysiology of conversion disorder (CD) is still not fully established. Many ... more Background: The pathophysiology of conversion disorder (CD) is still not fully established. Many psychiatric disorders are known to be associated with inflammatory processes. We aimed to compare the routine hemogram values of CD patients with those of the participants in the healthy control group, to assess the inflammation levels of the two groups. Methods: This study was conducted with CD patients (n=158) and healthy controls (n=145). Routine hematological parameters were examined in each participant. Group comparisons were made with Mann-Whitney U-test and Student's t-test. Regression analysis and receiver operating curve (ROC) analysis were also performed for the analysis of independent predictors. Results: The comparisons revealed that while neutrophil-to-lymphocyte ratio (NLR), plateletto-lymphocyte ratio (PLR), platelet, neutrophil, red cell distribution width (RDW), and mean platelet volume (MPV) were significantly higher in CD group (P<0.05), lymphocyte was decreased in that group (P>0.05). Multivariate and ROC analyses showed MPV, RDW, and NLR as independent predictors (P<0.05). ROC curve showed that MPV values of 7.8 or above could predict the CD with 84% sensitivity and 85% specificity (area under curve [AUC] =0.878; 95% confidence interval [CI]: 0.817-0.939), RDW values of 11.0 or above could predict the CD with 82% sensitivity and 73% specificity (AUC=0.871; 95% CI: 0.815-0.926), and NLR values of 1.8 or above could predict the CD with 85% sensitivity and 78% specificity (AUC=0.865; 95% CI: 0.802-0.929). Conclusion: CD is related to the acute inflammatory process. MPV, RDW, and NLR can reflect this inflammation. These parameters could be used in differential diagnosis; increased RDW and MPV levels can be used as a novel marker in CD.
PubMed, 2015
Posterior reversible encephalopathy syndrome (PRES) is a cliniconeuroradiologic disorder affectin... more Posterior reversible encephalopathy syndrome (PRES) is a cliniconeuroradiologic disorder affecting the brain's occipital and parietal lobes characterized by altered mental status, seizures, headache and blurred vision. Eclampsia is one of the main causes of posterior reversible encephalopathy. We aimed to discuss here literature guided clinical and radiologic findings of four women who had experienced status epilepticus at peripartum period and diagnosed as PRES.
The American Journal of Emergency Medicine, 2022
STUDY OBJECTIVE To determine the analgesic efficacy of TENS treatment in patients with renal coli... more STUDY OBJECTIVE To determine the analgesic efficacy of TENS treatment in patients with renal colic in the emergency department (ED). METHODS This double-blind, randomized controlled trial was conducted in a tertiary care ED. Patients with a definitive diagnosis of renal colic were assigned (1:1) as randomized to receive the real TENS with frequency 100 Hz, pulse width 200 microseconds, voltage 2 mA, or placebo with sham TENS. Pain intensity was measured using visual analog scales (VAS) at baseline, after 15 and 30th minutes. RESULTS A total of 100 patients were included in the final analysis: 50 patients treated with real TENS and 50 patients treated with sham TENS. VAS scores in both groups were similar at baseline. The mean reduction in VAS score at 15 min was 33.3 ± 17.6 (95% Confidence interval (CI): 28.3 to 38.3) for the real TENS group and 14.9 ± 11.6 (95% CI 11.6 to 18.2) for the sham TENS group (mean difference: 18.4 (95% CI: 12.5 to 24.4, P < 0.0001). The mean reduction in VAS score at 30 min was 63.7 ± 21.1 (95% CI: 57.7 to 69.7) for the real TENS group and 14.9 ± 16.2 (95% CI: 19.5 to 10.3) for the sham TENS group (mean difference: 48.8, 95% CI: 41.4 to 56.3, P < 0.0001). Four patients (8%) in the real TENS group and 24 patients (48%) in the sham TENS group required the rescue medication after 30th minutes. CONCLUSIONS TENS is effective for acute pain treatment in renal colic patients in the ED. TENS therapy could be a treatment option for renal colic.
Inhalation Toxicology, 2005
Carbon monoxide is a nonirritant, odorless, colorless gas, and is lighter than air. It is an end ... more Carbon monoxide is a nonirritant, odorless, colorless gas, and is lighter than air. It is an end product of the incomplete combustion of hydrocarbons. Its effects are most prominent in organs sensitive to oxygen deprivation, such as the heart, brain, and kidney. Carbon monoxide poisoning becomes more abundant in winter and at cold places. In Turkey, every year we see several deaths due to poisonous gas leaks from coal or wood stoves. Deaths particularly due to hypoxia-related central nervous system damage and ventricular dysrhythmias are observed. On the other hand, an association between thromboembolic accidents and carbon monoxide poisoning has been shown in literature. Thromboembolic accidents in the mesenteric, central nervous system, and extremities are reported. However, no atrial thrombus has been mentioned. In this study, a case of an atrial thrombus associated with carbon monoxide poisoning following a diagnosis of carbon monoxide poisoning and treatment in the emergency room is reported and the literature is revisited.
Turkish journal of emergency medicine, 2013
Cor triatriatum sinistra (CTS) is a rare congenital cardiac anomaly. The orifice diameter on the ... more Cor triatriatum sinistra (CTS) is a rare congenital cardiac anomaly. The orifice diameter on the membrane dividing left atria and pulmonary artery pressure are important determinants in the clinical course. Patients usually display symptoms mimicing mitral valve stenosis during young adult. We diagnosed CTS as a structural heart disease in a 17-year old young woman with syncopal attack. We presented this case to point out CTS, which is a rare cause of syncope etiology among structural heart diseases.
Journal of Academic Emergency Medicine Case Reports, Apr 4, 2014
Introduction: Complaints of palpitations during pregnancy are common and often follow a benign cl... more Introduction: Complaints of palpitations during pregnancy are common and often follow a benign clinical course. Tachycardia requiring intervention occurs in about 0.2-0.3% of these patients. Case Report: A pregnant 27-year-old with a history of rheumatic mitral valve disease was admitted with complaints of palpitations. Patient developed new onset atrial fibrillation and, with the implemented successful direct current electrical cardioversion, returned to sinus rhythm. Conclusion: Electrical cardioversion, applied with attention to placement with low-joule and foetuses kept as far as possible away from the pad, is considered to be safe in pregnant women with arrhythmia requiring cardioversion.
Clinical and Experimental Hypertension, Jul 11, 2012
Data about circadian blood pressure (BP) in normotensive patients with gestational diabetes melli... more Data about circadian blood pressure (BP) in normotensive patients with gestational diabetes mellitus (GDM) are lacking. Thus, we sought to compare dipper and nondipper circadian variation of BP profile between normotensive women complicated with GDM and normal pregnant women. Forty-two women with GDM and 33 normal uncomplicated pregnant women who met the entry criteria for the study were enrolled in the study. Twenty-four-hour noninvasive ambulatory blood pressure monitoring and echocardiography to measure the left ventricle mass index and diastolic parameters were performed. Nocturnal blood pressure dipping was calculated as follows: (awake BPsleep BP) Â 100/ awake BP. Patients with a nocturnal reduction in average daytime systolic BP and diastolic BP of less than 10% were classified as nondippers. Left ventricle mass index was higher in normotensive pregnant women with GDM group than in normal pregnant subjects (101.98 AE 24 g/m 2 vs. 90.67 AE 15 g/m 2 , P < .018). Significant nocturnal systolic and diastolic nondippings were observed in GDM groups compared with normal subjects. From diastolic variables, the mitral E velocity and isovolumetric relaxation time were compatible with diastolic dysfunction relaxation abnormalities (P ¼ .003 and P ¼ .015, respectively) in nondipper group. From all confounding factors, only E velocity (P ¼ .002) and diagnosis of GDM (P < .001) were predictive of nondipper circadian variation. This study shows that (i) circadian BP is impaired in normotensive pregnant subjects with GDM, (ii) the left ventricle mass index is higher in pregnant subjects with GDM than in normal pregnant subjects who despite a 24-hour BP are within normal limits, and (iii) in nocturnal nondipper group, the tendency to having diastolic relaxation abnormalities is noted.
PubMed, Dec 1, 2009
Objective: To assess the effectiveness of Ankaferd blood stopper (ABS) in the topical control of ... more Objective: To assess the effectiveness of Ankaferd blood stopper (ABS) in the topical control of bleeding due to cutaneous/subcutaneous incisions. Methods: We included in this study, 69 patients with cancer that were admitted for port insertion to the Emergency Department of Gaziantep University Hospital, Gaziantep, Turkey, between May and July 2008. We used the wet compress form of ABS in 37 patients (group I), and regular dry sterile sponges in 32 patients (group II), to stop the bleeding that occurs during the clinically indicated vascular port insertion in patients with cancer. The success rate in terms of bleeding control, time needed to stop the bleeding, recurrence of bleeding, and complications were recorded. Results: A total of 69 patients were included in this study. The average time needed to stop the bleeding was 32.97 +/- 29.9 seconds for group I, and 123.75 +/- 47.5 seconds for group II. Bleeding restarted in 24% in group I, and in 50% in group II. Among the patients in group I, 13.5% developed localized redness, and 8.1% minor swelling, while 8.1% reported local pain at the wound site; in 5.4% of the patients, the sutures at the wound site opened. The same parameters were recorded for group II; 9.4% for localized redness, 0.0% for minor swelling, 6.2% reported local pain, and the sutures at the wound site opened in 3.2% (p=0.592). Conclusion: The Ankaferd blood stopper was proven to stop local bleeding in a shorter time, with a lower recurrence rate in comparison with the sterile sponge.
International journal of rheumatic diseases, 2011
Raynaud's phenomenon (RP) commonly co-exists with systemic lupus erythematosus (SLE). The ob... more Raynaud's phenomenon (RP) commonly co-exists with systemic lupus erythematosus (SLE). The obvious pathophysiological mechanism in RP is vasoconstriction. Although the roles of certain vasoconstrictor substances, like endothelin-1, have been identified in RP, underlying mechanisms remain unclear.
European Heart Journal, 2012
The American Journal of Emergency Medicine
Harran Üniversitesi Tıp Fakültesi Dergisi
Amaç: Suriye’de 2011 tarihinde başlayan iç savaş, çok sayıda insanın ölümüne ve yaralanmasına ned... more Amaç: Suriye’de 2011 tarihinde başlayan iç savaş, çok sayıda insanın ölümüne ve yaralanmasına neden olmuştur. Kafa yaralanmaları savaşta ve savaş dışı zamanlarda cerrahi acillerin en önemlilerindendir. Materyal ve method: 2014-2015 yılları arasında Suriye savaşında kurşun ve şarapnel gibi ateşli silah yaralanmalarına bağlı kafa travması nedeniyle başvuran toplam 75 hasta (58 erkek 17 kadin) retrospektif olarak değerlendirildi. İncelemeye nörolojik ve radyolojik incelemeleri yapılmış hastalar dahil edildi. Bulgular: Penetran ateşli silahla yaralı kafa travması nedeniyle hastanemize başvuran 75 hastadan 20’si (%26.67) ölmüştür. Beyin parankimal kanaması olanların ölüm oranı olmayanlara göre anlamlı düzeylerde bulunmuştur (p<0.001). Beyin ödemi olan hastaların ölüm oranı olmayanlara göre anlamlı düzeylerde bulunmuştur (p=0.003). Ayrıca ventriküler kanama ve subaraknoid kanaması olan hastalarda da ölüm oranı olmayanlara göre anlamlıya yakın düzeylerde yüksek bulunmuştur (ventriküler ...
Anadolu psikiyatri dergisi, 2018
European journal of trauma and emergency surgery : official publication of the European Trauma Society, Jan 11, 2018
Gunshot injuries result in serious traumatic tissue damage due to high velocity of the bullet, de... more Gunshot injuries result in serious traumatic tissue damage due to high velocity of the bullet, deep penetration, and ballistic effect. Trauma is known to be related with oxidative stress. Serum thiol levels and disulphide/thiol homeostasis are novel oxidative stress biomarkers. In this study, we aimed to investigate serum thiol levels and disulphide/thiol homeostasis in injury patterns of patients admitted to the emergency department with a gunshot injury. A total of 128 participants were included in the study. The participants were divided into two groups: the patient group (Group 1; n = 73) and healthy controls (Group 2; n = 55). Native thiol, total thiol, disulphide levels, disulphide/native thiol, disulphide/total thiol, and neutrophil-to-lymphocyte ratio (NLR) were measured. The Revised Trauma Scale (RTS) and Glasgow Coma Scale (GCS) scores were calculated. Native thiol, total thiol, and disulphide levels were significantly lower in Group 1 (p < 0.001). Disulphide/native thi...
Medical Science and Discovery, 2016
Posterior reversible encephalopathy syndrome (PRES) is a cliniconeuroradiologic disorder affectin... more Posterior reversible encephalopathy syndrome (PRES) is a cliniconeuroradiologic disorder affecting the brain's occipital and parietal lobes characterized by altered mental status, seizures, headache and blurred vision. Eclampsia is one of the main causes of posterior reversible encephalopathy. We aimed to discuss here literature guided clinical and radiologic findings of four women who had experienced status epilepticus at peripartum period and diagnosed as PRES.
Xinan Nongye Daxue Xuebao, 2006
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Papers by hasan büyükaslan