Papers by hadi irawiraman
Digestive Diseases and Sciences, 2022
Approximately 30% of stage II and 50–60% of stage III colorectal cancer (CRC) patients who have u... more Approximately 30% of stage II and 50–60% of stage III colorectal cancer (CRC) patients who have undergone surgery will develop recurrence within 5 years. Thus, more reliable prognostic biomarkers are urgently needed to identify the high-risk subset of patients who will benefit from postoperative adjuvant therapy. We retrospectively analyzed 911 stage II/III CRC patients in multiple cohorts. Using a series of bioinformatic and statistical approaches, an individualized prognostic signature was established in the training cohort and validated in four other independent cohorts. An integrated decision tree was generated to improve risk stratification, and a nomogram was built to quantify risk assessment for individual patients. Epithelial-mesenchymal transition (EMT) was identified as a dominant risk factor for recurrence-free survival (RFS) in stage II/III CRC patients. The EMT-related gene signature could discriminate high-risk subsets in a training cohort and four independent validation cohorts (with 473, 89, 130, 74 and 145 patients, respectively). Survival analyses demonstrated that the EMT-related gene signature served as an independent risk factor for RFS in different subgroups. The decision tree could optimize the risk stratification, and the nomogram could predict the 5-year RFS probability accurately. The proposed EMT-related prognostic signature is a useful biomarker to predict RFS and identify the high-risk subset in stage II/III CRC patients.
Jurnal Respirasi, Jan 30, 2023
Lung and colorectal carcinoma are commonly found in cancer and often cause mortality worldwide. C... more Lung and colorectal carcinoma are commonly found in cancer and often cause mortality worldwide. Colorectal cancer (CRC) is the third most common cause of death. Although multiple primary cancers can exist, these two malignancies rarely happen simultaneously. This case report shows a patient diagnosed with squamous cell carcinoma of the lung and rectal adenocarcinoma with metastases to the liver, ocular, and cerebrum. Case: A 54-year-old woman came with chest pain accompanied by persistent and progressive breathing difficulty, cough, loss of appetite, and weight loss of almost 15 kg. The patient experienced sudden lower and upper extremities weakness two weeks after being hospitalized. The patient also experienced blurred vision and swelling of the eyes. At that time, the patient had an endoscopy procedure, and the biopsy showed colitis with severe dysplasia. Based on clinical and radiologic findings, the patient had lung and colon cancer. Conclusion: Dual primary carcinoma rarely happens, and metastases from different neoplasms are difficult. Warren and Gates' criteria could be used to diagnose dual primary carcinoma, especially if diagnostic studies could not be performed. Signal that the hedgehog gene is still active when the neonate is born is suspected of causing these carcinomas.
DOAJ (DOAJ: Directory of Open Access Journals), Oct 1, 2021
Xanthogranulomatous pyelonephritis (XGP) is a rare form of chronic pyelonephritis, which is chall... more Xanthogranulomatous pyelonephritis (XGP) is a rare form of chronic pyelonephritis, which is challenging to diagnose because its clinical presentation mimics other entities and is commonly associated with a history of urinary tract obstruction. We report a case of XGP in a young adult without nephrolithiasis and urinary tract obstruction. A 23-year-old woman presented with intermittent abdominal pain in the right upper quadrant persisting for the last ten months. The pain was dull, poorly localized, and started spreading to the right back, right shoulder, and right thigh in the last three months. Other complaints included fever, chills, pain during urination, and nausea. The patient had a history of infrequent urination, recurrent urinary tract infections (UTIs), and a low fluid intake. A physical examination revealed that the patient had right upper quadrant abdominal tenderness and right costovertebral angle tenderness. Laboratory findings showed leukocytosis and neutrophilia. The radiological examination revealed a round mass in the superior pole of the right kidney with mixed cystic and solid components, and a well-defined margin. It further enlarged from 4.5 cm to 10.6 cm in diameter in three months. The urologist performed a total right nephrectomy. The histopathological examination showed XGP with renal abscess. Proteus mirabilis was identified from the pus specimen culture. XGP should be considered in the diagnosis of patients having chronic UTI presented with or without the findings of urinary tract obstruction.
Jurnal Sains dan Kesehatan, Apr 30, 2022
Kanker payudara merupakan kanker yang paling banyak ditemui pada perempuan serta menjadi salah sa... more Kanker payudara merupakan kanker yang paling banyak ditemui pada perempuan serta menjadi salah satu penyebab morbiditas dan mortalitas pada perempuan di seluruh dunia. Di Indonesia pada tahun 2020 terdapat kurang lebih 65.000 kasus baru, dengan perkiraan jumlah kasus dalam 5 tahun terakhir sejumlah 200.000 kasus. Status reseptor hormonal Estrogen Receptor (ER) dan Progesterone Receptor (PR) dipakai sebagai standar dalam menentukan prognosis dan prediksi terhadap respon dari suatu modalitas terapi tertentu pada kanker payudara invasif NST melalui pemeriksaan imunohistokimia. Faktor risiko terkait hormon yang mempengaruhi paparan estrogen dan progesteron diduga berkaitan dengan kanker payudara yang mengekspresikan ER/PR positif. Penelitian ini bertujuan untuk mengetahui hubungan usia dan paritas dengan ekspresi ER/PR pada kanker payudara invasif NST. Penelitian ini merupakan studi analitik cross sectional dengan menggunakan data sekunder yang diperoleh dari 82 sampel kanker payudara invasif NST di RSUD Abdul Wahab Sjahranie Samarinda periode 2019-2020 dengan teknik purposive sampling. Analisis hubungan pada semua variabel menghasilkan nilai p>0,05. Hubungan antara usia dan paritas dengan ekspresi ER/PR menghasilkan nilai p secara berurutan 0,344 dan 0,977. Tidak terdapat hubungan yang bermakna antara usia dan paritas dengan ekspresi ER/PR pada kanker payudara invasif NST di RSUD Abdul Wahab Sjahranie Samarinda.
Jurnal Sains dan Kesehatan, Aug 31, 2021
Malaria merupakan penyakit menular tropis yang disebabkan oleh Plasmodium yang terdapat pada nyam... more Malaria merupakan penyakit menular tropis yang disebabkan oleh Plasmodium yang terdapat pada nyamuk Anopheles betina. Pada infeksi malaria dapat menyebabkan perubahan hematologi. Tujuan: Untuk mengetahui profil hematologi pasien malaria rawat inap di RSUD Panglima Sebaya Kabupaten Paser periode Januari 2015-Maret 2018. Metode: Penelitian ini bersifat deskriptif observasional dengan metode cross-sectional. Data berasal dari rekam medik 120 pasien malaria dengan teknik purposive sampling. Hasil: Angka kejadian malaria tahun 2015 sebanyak 37 pasien (31%), tahun 2016 sebanyak 40 pasien (33%), tahun 2017 sebanyak 30 pasien (25%) dan Januari-Maret 2018 sebanyak 13 pasien (11%). Pasien malaria banyak terjadi pada jenis kelamin laki-laki sebesar 105 pasien (87,5%) dan usia 15-64 tahun sebesar 112 pasien (93,3%). Sebanyak 64 pasien (53,3%) terinfeksi Plasmodium falciparum, 53 pasien (44,2%) terinfeksi Plasmodium vivax, dan 3 pasien (2,5%) terinfeksi mixed infection. Pada profil hematologi menunjukkan 63 pasien (52,5%) memiliki kadar hemoglobin normal, 105 pasien (87,5%) mengalami trombositopenia, dan 81 pasien (67,5%) memiliki jumlah leukosit normal. Kesimpulan: Kejadian malaria paling banyak tahun 2016, dominan pada laki-laki dan usia produktif, terinfeksi P. falciparum, dengan kadar hemoglobin dan jumlah leukosit normal, serta trombositopenia.
Jurnal kebidanan mutiara Mahakam, Mar 13, 2020
Surgical site infection (SSI) is an infection at the part of the body that was exposed by a surge... more Surgical site infection (SSI) is an infection at the part of the body that was exposed by a surgeon during an operation. SSI is one of the most common and most preventable nosocomial infection among other nosocomial infections, but the incidence of surgical site infections especially in abdominal surgery still shows a significant burden. Risk factors of surgical site infections include old age, type of surgical wound, comorbidities, inadequate prophylactic antibiotics, nutritional statuses, and long duration of surgery. This study aimed to explain an overview of the incidence of postoperative abdominal wound infection in Abdul Wahab Sjahranie General Hospital, Samarinda. This research method was a laboratory descriptive study. The research data was taken from surgical wound swabs and medical record data of 40 post-abdominal surgery patients who made the bandage changes for the first time and met the inclusion and exclusion criteria. The results showed 30 patients (75%) had surgical site infections. The highest percentage of infected patients aged over 40 years, i.e. in 15 people (37.5%). Most of the infected patients had clean contaminated wounds, i.e. in 23 patients (57.5%). The majority of infected patients did not have concomitant diseases, i.e. 27 people (67.5%). Gram-positive bacteria, specifically Staphylococcus epidermidis was the most infectious bacteria identified in 10 patients (33.3%). All infected patients, i.e. 30 patients (75%) received prophylactic antibiotics. The highest frequencies of infected patients had normal nutritional status, i.e.17 patients(42.5%), and the incidence of infection was more common in patients with duration <120 minutes, i.e. 20 patients (50%)
Journal of dentomaxillofacial science, Aug 1, 2018
Objective: The aim of this literature review is to highlights the role and mechanisms of propolis... more Objective: The aim of this literature review is to highlights the role and mechanisms of propolis at the molecular level in relief toothache caused by dental pulp inflammation. Methods: This review complied data from our study as well as from other researchers, focusing on molecular mechanism of inflammation, dental pain mechanism caused by inflammation and the role of propolis on inflammatory process. Results: Both in vitro and in vivo or even clinical research revealed that propolis has anti-inflammatory. Propolis could suppresses cyclooxygenase (COX) and lipoxygenase (LOX) enzymes during inflammation. COX-2 is mainly inhibited by flavonoid which suppresses prostaglandin endoperoxide synthase at high concentration depending on the hydrophilicity and structure whereas LOX is mainly inhibited by quercetin component of propolis. The major component of propolis is the caffeic acid (3.4-dihydroxycinnamic acid) phenethyl ester (CAPE). It has anti-inflammatory by inhibits LOX and COX enzymes that are involved in the AA metabolism pathways COX-2 is mainly inhibited by flavonoid which suppresses prostaglandin endoperoxide synthase at high concentration depending on the hydrophilicity and structure whereas LOX is mainly inhibited by quercetin component of propolis. The major component of propolis is the caffeic acid (3.4-dihydroxycinnamic acid) phenethyl ester (CAPE). It has anti-inflammatory by inhibits LOX and COX enzymes that are involved in the AA metabolism pathways. Conclusion: It could be that propolis effective to relief toothache (odontalgia).
Jurnal Kesehatan Andalas
Nasopharyngeal carcinoma is a malignancy that originates from the epithelial tissues lining the n... more Nasopharyngeal carcinoma is a malignancy that originates from the epithelial tissues lining the nasopharynx and is considered one of the most common malignant cancers which cause mortality in Indonesia. Neutrophils and lymphocytes are the first lines to provide body immunity against foreign substances. Neutrophil-to-Lymphocyte Ratio (NLR) is a prognostic factor in various malignancies. Objective: To investigated the correlation between pre-therapy Neutrophil-to-Lymphocyte Ratio (NLR) and survival rate among patients with nasopharyngeal carcinoma at Abdoel Wahab Sjahranie Regional Public Hospital in 2018. Methods: The Neutrophil-to-Lymphocyte Ratio (NLR) data were obtained from outpatient medical records at Abdoel Wahab Sjahranie Regional Public Hospital in 2018. In addition, the data on mortality status were collected based on the information after directly contacting the patients. A purposive sampling technique was used to collect the data. Thirty-three data of patient medical reco...
Jurnal Respirasi
Introduction: Lung and colorectal carcinoma are commonly found in cancer and often cause mortalit... more Introduction: Lung and colorectal carcinoma are commonly found in cancer and often cause mortality worldwide. Colorectal cancer (CRC) is the third most common cause of death. Although multiple primary cancers can exist, these two malignancies rarely happen simultaneously. This case report shows a patient diagnosed with squamous cell carcinoma of the lung and rectal adenocarcinoma with metastases to the liver, ocular, and cerebrum. Case: A 54-year-old woman came with chest pain accompanied by persistent and progressive breathing difficulty, cough, loss of appetite, and weight loss of almost 15 kg. The patient experienced sudden lower and upper extremities weakness two weeks after being hospitalized. The patient also experienced blurred vision and swelling of the eyes. At that time, the patient had an endoscopy procedure, and the biopsy showed colitis with severe dysplasia. Based on clinical and radiologic findings, the patient had lung and colon cancer. Conclusion: Dual primary carci...
Jurnal Sains dan Kesehatan
Kanker payudara merupakan kanker yang paling banyak ditemui pada perempuan serta menjadi salah sa... more Kanker payudara merupakan kanker yang paling banyak ditemui pada perempuan serta menjadi salah satu penyebab morbiditas dan mortalitas pada perempuan di seluruh dunia. Di Indonesia pada tahun 2020 terdapat kurang lebih 65.000 kasus baru, dengan perkiraan jumlah kasus dalam 5 tahun terakhir sejumlah 200.000 kasus. Status reseptor hormonal Estrogen Receptor (ER) dan Progesterone Receptor (PR) dipakai sebagai standar dalam menentukan prognosis dan prediksi terhadap respon dari suatu modalitas terapi tertentu pada kanker payudara invasif NST melalui pemeriksaan imunohistokimia. Faktor risiko terkait hormon yang mempengaruhi paparan estrogen dan progesteron diduga berkaitan dengan kanker payudara yang mengekspresikan ER/PR positif. Penelitian ini bertujuan untuk mengetahui hubungan usia dan paritas dengan ekspresi ER/PR pada kanker payudara invasif NST. Penelitian ini merupakan studi analitik cross sectional dengan menggunakan data sekunder yang diperoleh dari 82 sampel kanker payudara i...
Xanthogranulomatous pyelonephritis (XGP) is a rare form of chronic pyelonephritis, which is chall... more Xanthogranulomatous pyelonephritis (XGP) is a rare form of chronic pyelonephritis, which is challenging to diagnose because its clinical presentation mimics other entities and is commonly associated with a history of urinary tract obstruction. We report a case of XGP in a young adult without nephrolithiasis and urinary tract obstruction. A 23-year-old woman presented with intermittent abdominal pain in the right upper quadrant persisting for the last ten months. The pain was dull, poorly localized, and started spreading to the right back, right shoulder, and right thigh in the last three months. Other complaints included fever, chills, pain during urination, and nausea. The patient had a history of infrequent urination, recurrent urinary tract infections (UTIs), and a low fluid intake. A physical examination revealed that the patient had right upper quadrant abdominal tenderness and right costovertebral angle tenderness. Laboratory findings showed leukocytosis and neutrophilia. The ...
Jurnal Sains dan Kesehatan, 2021
ABSTRAKHipertensi adalah peningkatan tekanan darah yang disebabkan peningkatan curah jantung dan ... more ABSTRAKHipertensi adalah peningkatan tekanan darah yang disebabkan peningkatan curah jantung dan resistensi perifer pembuluh darah. Hipertensi dapat diobati dengan obat-obatan dan konsumsi buah serta sayur terutama buah yang mengandung kalium seperti pisang ambon. Penelitian ini bertujuan untuk mengetahui pengaruh konsumsi pisang ambon dalam membantu terapi penurunan tekanan darah pada penderita hipertensi di wilayah kerja Puskesmas Bontang Selatan. Metode yang digunakan adalah quasy experimental dengan desain non-equivalent control group. Sampel pada penelitian ini sebanyak 15 penderita hipertensi yang memenuhi kriteria inklusi. Analisis data menggunakan uji Paired T-Test, Wilcoxon Signed Ranks Test, Mann-Whitney dan Kruskal-Wallis. Hasil analisis univariat menunjukkan rata-rata tekanan darah kelompok kontrol sebelum perlakuan 152/92 mmHg dan setelah perlakuan 149,33/92 mmHg dibandingkan rata-rata tekanan darah kelompok perlakuan sebelum perlakuan 152/88,67 mmHg dan setelah perlaku...
Jurnal Sains dan Kesehatan, 2021
Malaria merupakan penyakit menular tropis yang disebabkan oleh Plasmodium yang terdapat pada nyam... more Malaria merupakan penyakit menular tropis yang disebabkan oleh Plasmodium yang terdapat pada nyamuk Anopheles betina. Pada infeksi malaria dapat menyebabkan perubahan hematologi. Tujuan: Untuk mengetahui profil hematologi pasien malaria rawat inap di RSUD Panglima Sebaya Kabupaten Paser periode Januari 2015-Maret 2018. Metode: Penelitian ini bersifat deskriptif observasional dengan metode cross-sectional. Data berasal dari rekam medik 120 pasien malaria dengan teknik purposive sampling. Hasil: Angka kejadian malaria tahun 2015 sebanyak 37 pasien (31%), tahun 2016 sebanyak 40 pasien (33%), tahun 2017 sebanyak 30 pasien (25%) dan Januari-Maret 2018 sebanyak 13 pasien (11%). Pasien malaria banyak terjadi pada jenis kelamin laki-laki sebesar 105 pasien (87,5%) dan usia 15-64 tahun sebesar 112 pasien (93,3%). Sebanyak 64 pasien (53,3%) terinfeksi Plasmodium falciparum, 53 pasien (44,2%) terinfeksi Plasmodium vivax, dan 3 pasien (2,5%) terinfeksi mixed infection. Pada profil hematologi me...
Jurnal Kesehatan Andalas, Jan 13, 2020
Kanker payudara merupakan penyebab kematian nomor satu akibat kanker dan tingginya angka kematian... more Kanker payudara merupakan penyebab kematian nomor satu akibat kanker dan tingginya angka kematian akibat kanker payudara disebabkan karena banyak penderita kanker payudara yang terdiagnosis saat stadium lanjut. Hal ini disebabkan oleh keterlambatan penderita kanker payudara melakukan pemeriksaan di pelayanan kesehatan. Banyak faktor risiko yang berperan dalam mempengaruhi rentang waktu pemeriksaan penderita kanker payudara di pelayanan kesehatan. Tujuan: Mengidentifikasi hubungan faktor-faktor yang terkait dengan rentang waktu pemeriksaan kanker payudara di pelayanan kesehatan Samarinda. Metode: Desain penelitian ini adalah analitik cross-sectional terhadap 46 penderita kanker payudara di RSUD Abdul Wahab Sjahranie Samarinda. Analisis data menggunakan uji Chi-square dan uji Fisher. Hasil: Terdapat hubungan antara usia dengan rentang waktu pemeriksaan (p=0,022) dan Pemeriksaan Payudara Sendiri (SADARI) dengan rentang waktu pemeriksaan (p=0,000). Faktor risiko lain yang tidak berhubungan adalah keluhan awal, riwayat keluarga kanker payudara, faktor ekonomi, dan pengobatan alternatif. Simpulan: Terdapat hubungan antara usia dan SADARI dengan rentang waktu pemeriksaan penderita kanker payudara di pelayanan kesehatan Samarinda dan tidak terdapat hubungan antara faktor risiko yang lain dengan rentang waktu pemeriksaan penderita kanker payudara di pelayanan kesehatan Samarinda.
Journal of Dentomaxillofacial Science, 2018
Objective: The aim of this literature review is to highlights the role and mechanisms of propolis... more Objective: The aim of this literature review is to highlights the role and mechanisms of propolis at the molecular level in relief toothache caused by dental pulp inflammation. Methods: This review complied data from our study as well as from other researchers, focusing on molecular mechanism of inflammation, dental pain mechanism caused by inflammation and the role of propolis on inflammatory process. Results: Both in vitro and in vivo or even clinical research revealed that propolis has anti-inflammatory. Propolis could suppresses cyclooxygenase (COX) and lipoxygenase (LOX) enzymes during inflammation. COX-2 is mainly inhibited by flavonoid which suppresses prostaglandin endoperoxide synthase at high concentration depending on the hydrophilicity and structure whereas LOX is mainly inhibited by quercetin component of propolis. The major component of propolis is the caffeic acid (3.4-dihydroxycinnamic acid) phenethyl ester (CAPE). It has anti-inflammatory by inhibits LOX and COX enzymes that are involved in the AA metabolism pathways COX-2 is mainly inhibited by flavonoid which suppresses prostaglandin endoperoxide synthase at high concentration depending on the hydrophilicity and structure whereas LOX is mainly inhibited by quercetin component of propolis. The major component of propolis is the caffeic acid (3.4-dihydroxycinnamic acid) phenethyl ester (CAPE). It has anti-inflammatory by inhibits LOX and COX enzymes that are involved in the AA metabolism pathways. Conclusion: It could be that propolis effective to relief toothache (odontalgia).
Jurnal Kebidanan Mutiara Mahakam, 2020
Infeksi luka operasi (ILO) adalah infeksi pada bagian tubuh yang terpapar oleh ahli bedah saat pr... more Infeksi luka operasi (ILO) adalah infeksi pada bagian tubuh yang terpapar oleh ahli bedah saat prosedur invasive. ILO merupakan salah satu infeksi nosokomial yang paling umum dan paling dapat dicegah diantara infeksi nosokomial lainnya, namun kejadian infeksi luka operasi terutama pada bedah abdomen masih menunjukkan beban yang signifikan. Faktor resiko infeksi luka operasi meliputi usia tua, jenis luka operasi, penyakit penyerta seperti diabetes mellitus, pemberian antibiotik profilaksis yang tidak adekuat, status gizi pasien seperti obesitas dan malnutrisi serta durasi operasi yang panjang. Penelitian ini bertujuan untuk mengetahui gambaran kejadian infeksi luka operasi pasca bedah abdomen di RSUD Abdul Wahab Sjahranie Samarinda. Metode penelitian ini adalah penelitian deskriptif laboratorik. Data penelitian diambil dari swab luka operasi dan data rekam medik pada 40 pasien pasca bedah abdomen yang melakukan pergantian perban pertama kali serta memenuhi kriteria inklusi dan eksklu...
Jurnal Sains dan Kesehatan, 2021
Abstrak Penyakit Ginjal Kronik (PGK) adalah suatu keadaan klinis ditandai dengan penurunan fungsi... more Abstrak Penyakit Ginjal Kronik (PGK) adalah suatu keadaan klinis ditandai dengan penurunan fungsi ginjal yang terjadi secara progresif lambat dan bersifat irreversible. Ginjal pasien PGK stadium 5 tidak berfungsi bak sehingga membutuhkan terapi pengganti ginjal (TPG) untuk bertahan hidup. Modalitas terapi pengganti ginjal adalah hemodialisis (HD), Continuous Ambulatory Peritoneal Dialysis (CAPD) dan transplantasi ginjal. Penelitian ini bertujuan untuk membandingkan kualitas hidup antara pasien PGK dengan CAPD dan PGK dengan HD di Unit Dialisis RSUD Abdul Wahab Sjahranie Samarinda agar mengetahui terapi mana yang lebih menguntungkan terhadap kualitas hidup pasien PGK. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional dengan responden yang memenuhi kriteria inklusi. Pengumpulan data menggunakan kuesioner KDQOL SF 36. Uji normalitas data menggunakan uji Shapiro-Wilk dan Independent t-test digunakan untuk uji hipotesis. Pasien dengan kualitas h...
Jurnal Sains dan Kesehatan, 2021
Breast cancer is the most type of cancer that affects women in worldwide. The high mortality rate... more Breast cancer is the most type of cancer that affects women in worldwide. The high mortality rate due to breast cancer is caused by the large number of cancer patients who have just arrived at an advanced stage. Breast self-examination (BSE) is an effort to detect breast cancer as early as possible so that it can reduce morbidity and mortality, in which predisposing factors including the level of knowledge can affect a person's willingness to perform breast cancer screening. This study aimed to determine the level of knowledge about breast cancer and BSE behaviour in students of Medical, Faculty of Medicine, Mulawarman University Samarinda. This research was a descriptive study with a cross-sectional approach. Data sources were primary. Primary data was obtained by using a questionnaire instrument that was filled out via google form. Secondary data was obtained from the data archive of the number of female students kept by the Academic and Student Affairs subdivision. The resear...
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Papers by hadi irawiraman