Journal of Evolution of Medical and Dental Sciences, 2016
BACKGROUND ENT problems are common in Paediatric population. The main objective of this study is ... more BACKGROUND ENT problems are common in Paediatric population. The main objective of this study is to determine the prevalence of common ENT problems in a paediatric age group in a semiurban based medical college hospital (Chengalpattu Medical College and Hospital, Chengalpattu, Tamilnadu). MATERIALS AND METHODS Retrospective study of Op case records of ENT Department for six months' period. Case records up to 12 years of age were analysed for age, sex and clinical diagnosis made by qualified ENT specialists. The period of study was from July 2015 to December 2015.
C. elegans C46H11.4 gene encodes a Let-23 fertility effector/regulator protein of the EGF-recepto... more C. elegans C46H11.4 gene encodes a Let-23 fertility effector/regulator protein of the EGF-receptor class of the tyrosine kinase family. Alternative splicing is a major mechanism of generating protein diversity in higher eukaryotes. C. elegans genome sequencing consortium has reported three alternatively spliced transcripts of C46H11.4 gene which encodes for three hypothetical proteins namely, C46H11.4a, C46H11.4b and C46H11.4c. Using a combination of various bioinformatics tools like gene or exon finding programmes, blast searches, alignment tools etc followed by experimental validation, we report the presence of three more alternatively spliced transcripts which encode for novel hypothetical proteins C46H11.4d, C46H11.4e and C46H11.4f. These isoforms arise as a result of alternative splicing in the pre-mRNA encoded by gene C46H11.4. These novel un-reported spliced variants not only point towards the extent of alternative splicing in C. elegans genes but also hint towards the complex nature of alternative splicing.
Journal of Evolution of Medical and Dental Sciences, 2016
BACKGROUND ENT problems are common in Paediatric population. The main objective of this study is ... more BACKGROUND ENT problems are common in Paediatric population. The main objective of this study is to determine the prevalence of common ENT problems in a paediatric age group in a semiurban based medical college hospital (Chengalpattu Medical College and Hospital, Chengalpattu, Tamilnadu). MATERIALS AND METHODS Retrospective study of Op case records of ENT Department for six months' period. Case records up to 12 years of age were analysed for age, sex and clinical diagnosis made by qualified ENT specialists. The period of study was from July 2015 to December 2015.
C. elegans C46H11.4 gene encodes a Let-23 fertility effector/regulator protein of the EGF-recepto... more C. elegans C46H11.4 gene encodes a Let-23 fertility effector/regulator protein of the EGF-receptor class of the tyrosine kinase family. Alternative splicing is a major mechanism of generating protein diversity in higher eukaryotes. C. elegans genome sequencing consortium has reported three alternatively spliced transcripts of C46H11.4 gene which encodes for three hypothetical proteins namely, C46H11.4a, C46H11.4b and C46H11.4c. Using a combination of various bioinformatics tools like gene or exon finding programmes, blast searches, alignment tools etc followed by experimental validation, we report the presence of three more alternatively spliced transcripts which encode for novel hypothetical proteins C46H11.4d, C46H11.4e and C46H11.4f. These isoforms arise as a result of alternative splicing in the pre-mRNA encoded by gene C46H11.4. These novel un-reported spliced variants not only point towards the extent of alternative splicing in C. elegans genes but also hint towards the complex nature of alternative splicing.
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