Papers by erdem cetinkaya
İzmir tepecik eğitim hastanesi dergisi, 2009
İzmir tepecik eğitim hastanesi dergisi, 2015
PubMed, Aug 1, 2010
Aim of the present report is to describe a case of radionecrosis related to radiotherapy of the l... more Aim of the present report is to describe a case of radionecrosis related to radiotherapy of the larynx and to review the literature. A review was made of the hospital chart, surgery report, imaging studies and pathological findings of a 51-year-old male patient came to our attention. Results indicated that radionecrosis often requires total laryngectomy. It is very rare, but morbidity and mortality rates are high. The interval between conclusion of radiation therapy and development of radionecrosis ranges from 3 to 12 months. In this report, a case of radionecrosis is presented which has been managed using the organ sparing strategy. In conclusion, the larynx may be spared when radionecrosis occurs but more investigations are required in order to define the most appropriate treatment.
İzmir tepecik eğitim hastanesi dergisi, 2015
Rhinology, Oct 24, 2022
Background: Recent studies reported the relationship between genetic variations and TAS2R38, whic... more Background: Recent studies reported the relationship between genetic variations and TAS2R38, which is a bitter taste receptor expressed in the cilia of human sinonasal epithelial cells, among the predisposing factors playing role in immune response to upper respiratory tract bacterial infection. The present study aims to examine the relationship of TAS2R38 genotype with the active microorganism and the effect of genotype on the surgical outcomes among chronic rhinosinusitis patients. Methodology: 34 patients undergoing endoscopic sinus surgery (ESS) for chronic rhinosinusitis with or without polyps (23 CRSwNP, 11 CRSsNP) and 30 patients undergoing septoplasty surgery for isolated nasal septum deviation were included. All the patients were genotyped for TAS2R38. Scoring was made using endoscopic Modified Lund-Kennedy and radiological Lund-Mackay systems preoperatively. Sino-Nasal Outcome Test with 22 items (SNOT-22) was implemented preoperatively and postoperatively. Nasal swab culture samples were taken intraoperatively from CRS patients and the active microorganism were isolated. Results: In the TAS2R38 genotyping of the study group, PAV/PAV was found in 32.4% of patients, PAV/AVI in 47.1%, and AVI/AVI in 20.6%. In the control group, PAV/PAV was found in 26.7%, PAV/AVI in 36.7%, and AVI/AVI in 36.7%. In the study group, there was no statistically significant difference between the CRS and CRS subgroups in terms of TAS2R38 genotype distributions. The changes in patients' preoperative and postoperative SNOT-22 scores were similar between the genotypes. Proliferation was detected in culture in the whole AVI-AVI group, 81.8% of PAV-PAV group, and 56.3% of PAV-AVI group but the difference was not found to be statistically significant. The proliferation level of Staphylococcus epidermidis by TAS2R38 genotype was found to be statistically significantly higher among patients, who had AVI-AVI genotype, in CRSwNP. Conclusions: We did not find a statistically significant relationship between the TAS2R38 genotype and CRS subtype, sinonasal bacterial infection risk increase and surgical success rate in CRS patients. Long-term and large-scale studies are needed, which are to be carried out by individual genotyping and sequencing to provide more information on the effects of these genetic variants.
Kulak burun boğaz uygulamaları, Mar 23, 2016
Baş ve boyun kanseri hastalarında yüksek malnütrisyon riski vardır. Bu hastalarda yoğun beslenme ... more Baş ve boyun kanseri hastalarında yüksek malnütrisyon riski vardır. Bu hastalarda yoğun beslenme desteğini teşvik etmek için giderek artan kanıtlar bulunmaktadır. Beslenme desteğinin amaçları beslenme bozukluğunu engellemek ve tedavi etmek, antitümör tedaviye dayanma gücünü artırmak, antitümör tedavinin yan etkilerini azaltmak ve yaşam standardını artırmaktır. Avrupa Klinik Beslenme ve Metabolizma Derneği kılavuzları kanser hastaları için beslenme hakkında Avrupa'dan ilk kanıta dayalı önerilerdir. Bu derlemede, beslenme bozukluğu değerlendirmeleri, beslenme sorunları, beslenme danışmanlığı ve hasta deneyimleri özetlendi. Anahtar sözcükler: Baş ve boyun kanseri; malnütrisyon; beslenme desteği. ABSTR ACT Head and neck cancer patients live under a high risk of nutrition deficiency. There is an increasing body of evidence to approve intensive nourishment help to these patients. The purposes of nourishment support are to avert and handle dietary deficiency, augment tolerance to cancer therapy, reduce the adverse effects of cancer therapy, and increase quality of life. The European Society for Clinical Nutrition and Metabolism guidelines are the first evidence-based European recommendations for nourishment for cancer patients. In this review, we summarized malnutrition assessments, nutritional problems, and nutritional counselling and patient experiences.
B-ENT, Nov 17, 2021
Background: Surveys on quality of life (QOL) of male-to-female (MTF) transsexuals have found low ... more Background: Surveys on quality of life (QOL) of male-to-female (MTF) transsexuals have found low QOL scores before and increased satisfaction scores after sex-reassignment surgery (SRS). To our knowledge, many of them lack standardized questionnaires and comparisons with normative data to evaluate different vaginoplasty techniques. Aim: To analyze patient satisfaction and QOL after SRS. Methods: Forty-seven patients participated in this study. All patients had surgery with our self-developed combined technique on average 19 months before the survey. They completed a self-developed indicationspecific questionnaire concerning demographic and socioeconomic issues and postoperative satisfaction. Furthermore, a standardized self-assessment questionnaire on satisfaction and QOL (Fragen zur Lebenszufriedenheit Module [FLZ M ]; Questions on Life Satisfaction Modules) was used. The FLZ M consists of three modules (general life satisfaction, satisfaction with health, and satisfaction with body image) with scores of weighted satisfaction for each item. Results of the general and health modules were compared with normative data. Outcomes: Demographics, QOL, general life satisfaction, satisfaction with health, and satisfaction with body image. Results: The self-developed indication-specific questionnaire showed that 91% experienced an improvement of QOL. All patients stated they would undergo SRS again and did not regret it at all. Patients stated their femininity significantly increased. For the FLZ M , the sum score for general life satisfaction (P < .001) was significantly lower than the normative data, whereas the sum score of the satisfaction with health module (P ¼ .038) did not reach statistical significance. The two modules also showed positive trends for different items. Values of the body image module showed a significant increase in satisfaction with breasts (P < .001) and genitals (P ¼ .002). Clinical Implications: The findings of this survey emphasize the importance of SRS in the interdisciplinary gender-reassignment process. The detailed description of our combined technique could help to improve the surgical outcome and patient satisfaction of this complex and non-standardized surgery. Strengths and Limitations: This is the first description of a new surgical technique (combined technique) for MTF SRS. QOL was assessed by a large number of patients by standardized questionnaires and could be compared with normative data. Because this is a retrospective study, we can draw only careful conclusions for pre-and postoperative changes. Conclusion: Our self-developed combined surgical technique seemed to have a positive influence on QOL after SRS. Satisfaction with breasts, genitals, and femininity increased significantly and show the importance of surgical treatment as a key therapeutic option for MTF transsexuals.
Osmangazi tıp dergisi, Sep 24, 2020
Kulak burun boğaz ve baş boyun cerrahisi dergisi, 2020
Şubat 2020 tarihinde taksonomik bir sınıflandırma olan "Şiddetli akut solunum yolu sendromu koron... more Şubat 2020 tarihinde taksonomik bir sınıflandırma olan "Şiddetli akut solunum yolu sendromu koronavirüs 2" (SARS-CoV-2), 2019-nCoV ve Wuhan yeni koronavirüs suşunu ifade eden bir terim oldu. Aynı gün saatler içinde Dünya Sağlık Örgütü bu terimi COVID-19 olarak resmîleştirdi. SARS-CoV-2 genomu 29.903 bp tek sarmallı RNA (ss-RNA) olan bir korona virüstür. 1 Yeni koronavirüs hastalığı (COVID-19) belirtileri tipik olarak kuru öksürük, ateş ve nefes darlığı belirtilerini içerir. Ancak, hastalığın yoğun görülmeye başladığı Güney Kore, Çin, İtalya, İspanya, Fransa, İngiltere, Amerika Birleşik Devletleri ve diğer ülkelerden gelen ani koku kaybının ilk belirti olarak bildirildiği raporların artması yeni koronavirüs enfeksiyonunun erken bir göstergesi olduğuna dair kuvvetli kanıtlar olarak değerlendirilmiştir. 22 Mart 2020'de Amerikan Kulak Burun Boğaz Akademisi, anosmiyi hastalığın semptomlarına eklemiş ve klinisyenler için Anosmi Raporlama Aracı geliştirmiştir. 2 ANOSMi MEKANizMASI Literatürde önceki yıllardaki çalışmalar, birçok viral etkenin üst solunum yolu viral enfeksiyonlarını ta
DergiPark (Istanbul University), Sep 1, 2019
Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, 2020
Sialolithiazis tükrük bezlerinin parankimi ve duktus yapıları içinde kalsifik materyalin birikmes... more Sialolithiazis tükrük bezlerinin parankimi ve duktus yapıları içinde kalsifik materyalin birikmesi nedeniyle oluşan bir hastalıktır. Hastalığın semptomatik insidansı, yıllık milyonda 27 vakadır. Semptomatik olması halinde sıklıkla tükrük bezinde şişlik ve ağrı ile seyreder. Semptomatik seyreden sialolithiazis olgularında taşın %80 oranında submandibuler glandda yerleşimli olduğu görülmüştür. Günümüzde semptomatik olguların tedavisi için minimal invaziv cerrahi girişimler ön plandadır. Minimal invaziv cerrahi yaklaşımlar ile fasial, lingual ve hypoglossal sinir hasarlarının en aza indirildikleri belirtilmiştir. Ayrıca yaygın inanışın aksine; yapılan birçok çalışmada taş çıkarıldıktan sonra bezin işlevinin geriye döndüğü gösterilmiştir. Sunumumuzda sağ submandibuler sialolithiazis olgusunun cerrahi uygulanmadan nasıl tedavi edildiği literatür eşliğinde sunulmuştur.
Journal of Turkish Sleep Medicine, 2016
Hipoksinin bir göstergesi olan laktat, uyku ile ilişkili solunum bozukluklarında yüksek risk taşı... more Hipoksinin bir göstergesi olan laktat, uyku ile ilişkili solunum bozukluklarında yüksek risk taşıyan grupları belirlemede ve pozitif hava yolu basıncı (PAP) tedavisinin etkinliğini izlemede faydalı olabilir. Bu çalışmada obstrüktif uyku apnesi (OUA) ve uyku ile ilişkili hipoventilasyon ve hipoksemi sendromları hastalarında PAP tedavisinin ardından kandaki arteriyel laktat seviyesi değişimini ve tedavinin etkinliği açısından bu değişimi izlemenin uygulanabilirliğini araştırmayı amaçladık. Gereç ve Yöntem: Polisomnografi ile tanı konulan 64 OUA hastasına PAP titrasyonu uygulandı. Solunum fonksiyon testi, tüm gece PAP titrasyonu, arteriyel kan gazı ve titrasyon öncesi ve sonrasında arteriyel laktat analizi ölçümleri yapıldı. Gecelik laktat değişimi hesaplandı. Bulgular: Çalışmada yer alan 64 hastadan 49'u OUA grubunda, 15'i ise Obezite Hipoventilasyon sendromu artı OUA grubundaydı. PAP tedavisinden önce ve sonra hastaların laktat seviyelerinde istatistiksel açıdan anlamlı bir fark bulunamadı [1,97 (±0,7)-1,98 (±0,6)] (p>0,05). OUA hasta grubunda laktat değişimi ile tedavi öncesi hızlı göz hareketi olmayan %1-2 (r=-0,328, p=0,021), T %90 (r=-0,356, p=0,012) ve toplam apne hipopne indeksi (AHİ) (r=-0,424, p=0,002) arasında ters bir ilişkinin söz konusu olduğu belirlendi. Laktat değişiminin tedavi öncesinde ölçülen oksijen satürasyonu (r=0,396, p=0,005) ve minimum oksijen satürasyonu (r=0,361, p=0,011) ile pozitif korelasyon sergilediği tespit edildi. Sonuç: Çalışmamız, OUA için hastalık şiddeti göstergeleri olan AHİ, ortalama ve minimum oksijen satürasyonu ve T %90 ile laktat değişimi arasında bir ilişki olduğunu göstermiştir. Bu sonuçlar PAP tedavisinin muhtemel laktat artışını önleyebileceğini düşündürmektedir. Anahtar Kelimeler: Apne, hipoksi, obstrüktif uyku apne, polisomnografi, pozitif basınçlı hava yolu tedavisi Objective: Lactate, as an indicator of hypoxia, may be useful in sleeprelated breathing disorders to identify higher risk groups and monitor the effectiveness of positive airway pressure (PAP) treatment. We aimed to investigate the change in arterial lactate level in blood after PAP treatment in patients with obstructive sleep apnea (OSA) and sleeprelated hypoventilation and hypoxemic syndromes and its applicability for monitoring this change regarding the effectiveness of the treatment. Materials and Methods: PAP titration was applied to 64 OSA patients diagnosed with polysomnography. Measurements included pulmonary function testing, overnight PAP titration, arterial blood gases, and analysis of arterial lactate before and after titration. Overnight lactate level change was calculated. Results: Of the 64 patients in the study, 49 were in the OSA group and 15 were in the Obesity Hypoventilation syndrome plus OSA group. No statistically significant difference was detected among the patients in terms of lactate levels before and after PAP treatment [1.97 (±0.7)-1.98 (±0.6)] (p>0.05). In the OSA patient group, we detected an inverse relationship between Lactate and pre-treatment non-rapid eye movement 1-2% (r=-0.328, p=0.021), T 90% (r=-0.356, p=0.012), and total apnea hypopnea index (AHI) (r=-0.424, p=0.002). Lactate is found to be positively correlated with pre-treatment measured oxygen saturation (r=0.396, p=0.005), and with minimum oxygen saturation (r=0.361, p=0.011). Conclusion: Our study showed that there is a relationship between AHI, average and minimum oxygen saturation and T 90% and lactate difference, which are severity indicators for OSA. These results suggest that PAP treatment may prevent possible lactate increase.
British Journal of Medicine and Medical Research, 2016
A simple assessment of olfactory acuity is essential and can play a vital role in patient care an... more A simple assessment of olfactory acuity is essential and can play a vital role in patient care and quality-of-life parameters. Any process that interferes with the physiologic environment of the nasal mucosa can be associated with restricted olfaction. Studies have examined how the human sense of smell likely integrates information from complex arrays of odorant chemicals that, individually, would seem to produce conflicting odorous sensations. “Scratch and sniff” format screening tests are readily available and have been standardized for age, gender, and ethnicity. It is important to identify a scent that can be used as in an initial olfactory test If a patient cannot identify this scent, they should take further diagnostic testing. In this review, we give some essential information on office-based olfaction assessment and attempt to cover important aspects of the evaluation, especially from a clinical perspective.
The Journal of Tepecik Education and Research Hospital, 2009
The Journal of Laryngology & Otology, 2011
Objective:To investigate the long-term clinical results of radiofrequency tissue volume reduction... more Objective:To investigate the long-term clinical results of radiofrequency tissue volume reduction for symptomatic inferior turbinate hypertrophy.Study design:Patients who were unresponsive to medical treatment (n = 197) received turbinate reduction using radiofrequency energy. Subjective symptoms were assessed using a 10 cm visual analogue scale, and all patients underwent acoustic rhinometry before the procedure and six, 24, 48 and 60 months afterwards.Results:Of the 197 treated patients, 148 completed the protocol. No significant peri-operative complications were observed. Thirty-two patients required follow-up treatment. Significant improvements were seen in nasal obstruction and discharge scores and in acoustic rhinometry values, at six, 24, 48 and 60 months post-operatively, compared with pre-operative values (p < 0.001 and p < 0.05, respectively).Conclusion:Radiofrequency tissue volume reduction is an effective procedure for inferior turbinate hypertrophy. The clinical b...
Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, 2020
İdiyopatik inflamatuar medial meatal fibrozis (İİMMF) işitme azlığı, sık otore ile başvuran, dış ... more İdiyopatik inflamatuar medial meatal fibrozis (İİMMF) işitme azlığı, sık otore ile başvuran, dış kulak yolunda stenoz görülen hastalarda aklımıza gelmesi gereken nadir bir hastalıktır. 65 yaşındaki kadın hasta 15 yıldır sol kulakta işitme azlığı ve tekrarlayan akıntı şikayetiyle başvurdu. Otoskopik bakıda sol dış kulak yolu cildi mediale doğru kalınlaşmış, lümen çapı azalmış, timpan zar kalınlığı artmıştı. Temporal kemik Bilgisayarlı Tomografisinde (BT) sol dış kulak yolu medialinde kalınlaşmış cilt ve timpan zar izleniyordu. Medikal tedavi ile klinik bulgu ve hasta yakınmasında düzelme olmaması üzere cerrahi önerildi. Onlay timpanoplasti uygulandı. Postoperatif takiplerde dış kulak yolu cildinin normal epitelize olduğu ve timpan zarın normal kalınlıkta olduğu görüldü. Bu makalede İİMMF olgusu klinik bulgular, tanı ve cerrahi tedavi süreci ile birlikte güncel literatür eşliğinde sunulmuştur.
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Papers by erdem cetinkaya