Papers by elham abdollahi
Biopreservation and Biobanking
Journal of clinical and translational research, Jun 29, 2022
Journal of Clinical and Nursing Research, 2022
Background: Cervical ripening is an important factor in predicting successful labor induction. In... more Background: Cervical ripening is an important factor in predicting successful labor induction. In an unfavorable cervix, ripening should be done before induction. In this study, the effect of misoprostol and that of misoprostol plus estradiol on cervical ripening were compared. Methods: This randomized, double-blinded study included a total of 190 pregnant women who were identified for pregnancy termination due to maternal or fetal cause at 37 weeks with Bishop score of less than 4. The patients were assessed between April 2015 to April 2016 in two university hospitals at northeast Iran (Omol-Banin Hospital and Emam Reza Hospital, Mashhad). The patients who met the inclusion criteria were randomly assigned to two groups: the intervention group (Group A), who received 25 micrograms of vaginal misoprostol plus 50 micrograms of estradiol, and the control group (Group B), who received 25 micrograms of vaginal misoprostol only. Misoprostol was administered at 4-hour intervals until cervi...
European Heart Journal, 2020
Background and purpose Anionic nanoliposomes can regulate lipid metabolism by interacting with pl... more Background and purpose Anionic nanoliposomes can regulate lipid metabolism by interacting with plasma lipoproteins. Here, we aimed to investigate the protective effects of anionic nanoliposomes against hyperlipidemia and atherosclerosis in the rabbit fed a high-fat diet (HFD) recapitulating human hyperlipidemia and atherosclerosis. Methods To prepare anionic nanoliposome formulations [containing hydrogenated soy phosphatidylcholine (HSPC) and 1,2-distearoyl-sn-glycero-3- phosphoglycerol (DSPG)] and [containing 1,2-Dimyristoyl-sn-glycero-3-phosphorylcholine (DMPC) and 1,2-Dimyristoyl-sn-glycero-3-phosphorylcholine (DMPG)], lipid film hydration method followed by extrusion. Physical properties of the prepared liposome formulations, including particle size (diameter, nm), polydispersity index (PDI), and surface charge, were determined using dynamic light scattering (DLS) technique. New Zealand white male rabbits (4–6 months old, weight 2±0.15 kg) were fed on a regimen chow diet contain...
In this research, the interaction of [CuL(DMF)], [NiL(DMF)] and [VOL(DMF)] (where L = ((E)-4-((2-... more In this research, the interaction of [CuL(DMF)], [NiL(DMF)] and [VOL(DMF)] (where L = ((E)-4-((2-amino-5-nitrophenylimino)methyl)benzene-1,3-diol)) complexes derived from tridentate Schiff base ligand with bovine serum albumin (BSA) and DNA was investigated via electronic absorption and fluorescence spectroscopy. The Ultraviolet-Visible (UV-Vis) spectra exhibited an isosbestic point for the complexes through titration with DNA. The experimental results showed the presence of intercalation interaction between the complexes and calf-thymus DNA (CT-DNA). The interaction of BSA protein and complexes was significant. The recorded florescence spectra of complexes interacting with DNA and BSA revealed the static quenching manner. The free binding energies of complexes and their interaction modes with DNA and BSA were determined by the molecular docking. MTT-dye reduction technique was applied to define cytotoxicity of [NiL(DMF)], [CuL(DMF)] and [VOL(DMF)] complexes against breast cancer 4T...
Autoimmunity Reviews, 2020
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
European Heart Journal, 2019
Background PCSK9 inhibitors have emerged as an effective lipid-lowering approach. Although the re... more Background PCSK9 inhibitors have emerged as an effective lipid-lowering approach. Although the results of available studies suggest a positive association of plasma PCSK9 levels with glycemic parameters and risk of DM, the effects of PCSK9 inhibitors on glucose intolerance and insulin resistance as the key features of DM remain unclear. Purpose The present study was directed to determine effect of vaccine-mediated PCSK9 inhibition on glucose intolerance and insulin resistance in experimental diabetic rats. Methods Nanoliposomal vaccine composing from PCSK9-linked nanoliposome particles mixed in Alum adjuvant was subcutaneously injected four times with bi-weekly intervals in Wistar-Albino rats. Two weeks after the last immunization, vaccinated and non-vaccinated rats were subjected to diabetes experiment induced by single intraperitoneal injection of streptozotocin (STZ). One week after STZ injection, glucose tolerance ability of each animal was evaluated by using oral glucose tolera...
Proceedings of Anticancer Research
Pathologic inflammatory conditions are frequently correlated with dynamic alterations through mac... more Pathologic inflammatory conditions are frequently correlated with dynamic alterations through macrophage activation, with classically activated M1 cells associated with promoting and sustaining inflammation and M2 cells implicated in resolving or smoldering chronic inflammation. Inflammation is a common feature of various chronic diseases, and it has direct involvement in the emergence and progression of these conditions. Macrophages participate in an autoregulatory loop characterizing inflammatory process, as they produce a wide range of biologically active mediators that exert either deleterious or beneficial effects during inflammation. Therefore, balancing the ratio of M1/M2 macrophages can help to ameliorate the inflammatory landscape of pathological conditions. This review will explore the role of macrophage polarization in distant pathological inflammatory conditions, such as cancer, autoimmunity, renal inflammation, stroke, and atherosclerosis, while sharing macrophage-drive...
Polyhedron, 2019
Experimental and theoretical studies of Palladium(II) and Platinum(II) complexes derived from di-... more Experimental and theoretical studies of Palladium(II) and Platinum(II) complexes derived from di-(2-pyridyl)methyl-N,N'-dibenzyldithiocarbamate,
Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1990
The relationship of serum high density lipoprotein cholesterol (HDL-C) levels and of the HDL2-C a... more The relationship of serum high density lipoprotein cholesterol (HDL-C) levels and of the HDL2-C and HDL3-C subfractions to several factors associated with coronary risk was examined in a cross-sectional study, which included 655 men and 731 women ages 20 to 64 years. Participants with coronary heart disease (CHD) had lower levels of HDL-C, HDL2-C, and HDL3-C; however, only HDL-C in women was significant. Maleness, body mass index, triglyceride levels, tobacco use, and carbohydrate intake (in men) were significantly inversely related to total HDL-C, while alcohol intake was significantly positively related to HDL-C. The associations were stronger for HDL2-C than for HDL3-C, except that alcohol intake in men was more strongly related to HDL3-C. The findings of this study suggest that several factors that influence CHD risk do so in part through modifying HDL2-C levels.
Background and Aims: The ABO blood group system is recognized as major and clinically significant... more Background and Aims: The ABO blood group system is recognized as major and clinically significant blood group. This group is not only important in terms of blood transfusion and organ transplantation, but also has been utilized in genetic, fertility and infertility researches. The objective of the present study was to evaluate a possible relationship between ABO blood group system and ASA with male infertility. Materials and Methods: This is a retrospective, case-control study. Our study was carried out on samples referred to Research and Clinical Center for Infertility, Yazd, Iran. ABO blood group, titer of ASA and sperm analysis data of 150 infertile males (case group) and 150 fertile males (control group) was evaluated based on medical records of the patients. Data were then analyzed with SPSS 16 software using t-test and chi-square tests. Results: Our results indicated that there is a significant relationship between male infertility and O blood group (p= 0.02) whereas no signif...
Life Sciences, 2022
Ao Professor Francisco Ferraz de Toledo, pelo apoio, compr � ensão e dedicação, durante a orienta... more Ao Professor Francisco Ferraz de Toledo, pelo apoio, compr � ensão e dedicação, durante a orientação em todas as fa ses do curso. Aos Professores J u l i o Ma r c os F i l h o e S i l v i o Mo u r e C í ce ro, p � las sugestões e críticas oportunas. Ao Professor Roberto Simionato Moraes, pelas análises esta tísticas em computador e colaboração na interpretação des tas análises. Ao Ministério da Agricultura, e particularmente a sua Dele gacia no Piaui, pela possibilidade de afastamento, faci-1 idades e auxílio concedidos para a realização do Curso de Pós-Graduação.
Journal of Diabetes Research
Background and Aim. The impact of Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitio... more Background and Aim. The impact of Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition on glycemic indices in diabetes mellitus remains far from clear. We explored the effects of PCSK9 inhibition on glycemic indices in the diabetes rat model. Methods. To prepare the anti-PCSK9 vaccine, a peptide construct called Immunogenic Fused PCSK9-Tetanus (IFPT) was linked to the surface of nanoliposome carriers. Healthy rats received four subcutaneous injections of the vaccine at biweekly intervals. Two weeks after the last vaccination, anti-PCSK9 antibody titers, PCSK9 targeting, and inhibition of PCSK9–low-density lipoprotein receptor (LDLR) interaction were evaluated. After verification of antibody generation, the immunized rats were intraperitoneally treated with a single dose (45 mg/kg) of streptozotocin (STZ) to induce diabetes mellitus. The levels of fasting blood glucose (FBG) were measured, and the oral glucose tolerance test (OGTT) as well as the insulin tolerance test (I...
Introduction: Preterm delivery is the most important cause of neonatal mortality and morbidity. I... more Introduction: Preterm delivery is the most important cause of neonatal mortality and morbidity. Infections and chronic inflammation are one of the main causes of preterm delivery. C-reactive protein (CRP) is a marker of inflammation that is secreted by hepatic cells in response to inflammatory stimuli. We examined the association between c-reactive protein as a marker of inflammation in pregnant women and risk of preterm delivery Methods: This prospective case-control study was conducted between 2011 and 2012 on 200 pregnant women who referred to gynecologists office in Shiraz, Iran. Subjects were divided into three groups: 63 pregnant women who delivered before week 30 of pregnancy, 30 pregnant women who delivered between weeks 30-37 and 107 controls who delivered at term. Serum CRP was evaluated by Immunoturbidimetry Assay method with photometric analyzer in all groups. Data were analyzed by SPSS software version 16 and ANOVA test. P value Results: CRP concentration among women wi...
Clinical, Biological and Molecular Aspects of COVID-19
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SA... more Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly pathogenic with relatively high mortality and morbidity. In addition to pneumonia, acute respiratory distress syndrome, and microembolic disorder, a high proportion of patients with SARS-CoV-2 develop lymphopenia and cytokine storm disorder. This review explores the underlying mechanisms behind the pathogenesis of SARS-CoV-2, especially the immune mechanisms, which could be potentially used as therapeutic targets for the management of COVID-19.
Current Pharmaceutical Design
Exosomes are small extracellular vesicles that pass genetic material between various cells to mod... more Exosomes are small extracellular vesicles that pass genetic material between various cells to modulate or alter their biological function. The role of exosomes is to communicate with the target cell for cell-to-cell communication. Their inherent characteristics of exosomes, such as adhesion molecules, allow targeting specifically to the receiving cell. Exosomes are involved in cell to cell communication in the immune system including antigen presentation, natural killer cells (NK cells) and T cell activation/polarisation, immune suppression and various anti-inflammatory processes. In this review, we have described various functions of exosomes secreted by the immune cells in initiating, activating and modulating immune responses; and highlight the distinct roles of exosomal surface proteins and exosomal cargo. Potential applications of exosomes such as distribution vehicles for immunotherapy are also discussed.
Iranian Biomedical Journal
Background: Vitamin D insufficiency and deficiency can be associated with adverse effects on fetu... more Background: Vitamin D insufficiency and deficiency can be associated with adverse effects on fetus and pregnancy outcomes. This study aimed at evaluating the effect of 1,25VitD3 on specific transcription factor and markers of Tregs and Th17 cells in PBMCs of women with URPL as a case group and PBMCs of healthy women as a control group. Methods: Samples from 20 non-pregnant patients with a history of URPL were compared to 20 normal non-pregnant women. PBMCs were divided into three wells for each subject in the presence of 1,25VitD3 (50 nM, for 16 hours), PHA (10 µM; positive control), and without any treatment (negative control). By Real-time PCR (Taqman assay), specific transcription factors of Tregs and Th17 cells, FOXP3, ROR-γt, GITR, and CTLA-4 mRNA expressions in two groups were measured. Results: FOXP3/ROR-γt mRNA expression in PBMCs decreased significantly in women experiencing URPL compared to the control group (p = 0.0001). Although 1,25VitD3 (50 nM) increased FOXP3 gene expression (p = 0.0001), it did not significantly affect ROR-γt gene expression. Besides, 1,25VitD3 treatment significantly increased FOXP3/ROR-γt mRNA expression from baseline in PBMCs of the fetal loss group compared to that of the control group (p = 0.01). The 1,25VitD3 also increased GITR gene expression (p = 0.017) in PBMCs of URPL women compared to the controls. Conclusion: Vitamin D deficiency may be a contributor to recurrent pregnancy loss and suggests that the supplementation of women with Vitamin D pre-pregnancy may be protective against URPL via affecting Tregs signature genes, FOXP3 and GITR.
Journal of Molecular Structure
Current Molecular Pharmacology
Background: Vitamin D insufficiency and deficiency can be associated with adverse effects on preg... more Background: Vitamin D insufficiency and deficiency can be associated with adverse effects on pregnancy outcomes, which may include recurrent pregnancy loss though the mechanisms are yet unknown. The aim of this study was to evaluate the effect of 1,25VitD3 on regulatory T cells (Tregs) and T helper17 (Th17) cell populations in vitro in unexplained recurrent pregnancy loss (URPL) patients and healthy women. Methods: Samples from 20 non-pregnant women with a history of URPL were compared to 20 normal non-pregnant women. Peripheral blood mononuclear cells (PBMC) were divided in to 3 wells for each subject: in the presence of 1,25 vitD3 (50 nM, for 16 hours), PHA (positive control) (10µM) and without any treatment (as a baseline or negative control). The percentage of regulatory T cells and Th17 cells was measured by flow cytometry at baseline and then after cell culture experiments. Results: Our study indicated that the percentage of Tregs in the patients with URPL was significantly lo...
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Papers by elham abdollahi