1. Haga un algoritmo que calcule el factorial del número 4. 2. Haga un algoritmo que calcule el á... more 1. Haga un algoritmo que calcule el factorial del número 4. 2. Haga un algoritmo que calcule el área de un cuadrado, cuya longitud del lado es 5. 3. Haga un algoritmo que tenga dos variables en el entorno de memoria con los siguientes valores: En la primera variable el valor de "hola". En la segunda variable el valor de "SPPC". 4. Haga un algoritmo que intercambie el contenido de las variables indicadas en el ejercicio anterior, esto es: en el entorno de memoria Inicialmente el contenido de las variables en el entorno de memoria debe ser: (a)Variable1: "hola". (b)Variable2: "SPPC" Luego de ejecutar el algoritmo, el entorno de memoria final debe ser: (a)Variable1: "SPPC" (b)Variable2: "hola" 5. Haga un algoritmo que solicite al usuario el nombre y escriba por pantalla "Buenos días Sr(a)", y el nombre del usuario.
Caloric restriction (CR) without malnutrition delays aging and extends lifespan in diverse specie... more Caloric restriction (CR) without malnutrition delays aging and extends lifespan in diverse species; however, its effect on resistance to illness and mortality in primates is not clearly established. We
Peritoneal Dialysis International Journal of the International Society For Peritoneal Dialysis, May 1, 2008
Uruguay is a South American country (3241003 inhabitants) where renal replacement treatment is un... more Uruguay is a South American country (3241003 inhabitants) where renal replacement treatment is universally available. The aim of this study was to analyze the incidence and outcome of peritonitis, and the causative organisms and their sensitivity, in order to recommend an empiric initial antibiotic treatment. A retrospective descriptive study of all peritonitis during the period 2004 -2005 was performed (144 peritonitis, 44% due to gram-positive bacteria). We conclude that the high prevalence of methicillin-resistant coagulase-negative staphylococci justifies the use of vancomycin in the national empiric initial antibiotic protocols.
The main drawback in shunt hybrid filters is the lead current injection need. This paper describe... more The main drawback in shunt hybrid filters is the lead current injection need. This paper describes a strategy to reduce the lead current in a three phase four wires LC coupled parallel hybrid filter for harmonics cancellation. Simulation and experimental results are given to show the behavior of the system.
Currently, there is some scientific interest on study- ing creativity and how it can be modeled b... more Currently, there is some scientific interest on study- ing creativity and how it can be modeled by com- puter programs. One of the active subareas focuses on the generation of text, with some prior success systems. In this paper, we describe an example of this kind of system that automatically generates texts related to Greek mythology. We have elab- orated
Isolated ulnar luxation of metacarpal V without fractures at the basis or of adjunct bones is a r... more Isolated ulnar luxation of metacarpal V without fractures at the basis or of adjunct bones is a rarely observed entity with available data in the literature based on few case reports. Careful interpretation of radiological findings leads to a correct diagnosis. Missed lesions may result in chronic pain syndrome at the site of injury. The functional role of the ligamentum metacarpale transversum profundum in this type of injury is frequently underestimated. Here, we present a case report and elucidate diagnostic pathways and treatment options based on the available literature.
El perfeccionamiento de herramientas inmunológicas ha promovido un desarrollo en la biología mole... more El perfeccionamiento de herramientas inmunológicas ha promovido un desarrollo en la biología molecular y celular en diferentes campos, no solo en biomedicina humana o animal, sino también en el campo marino. Con la aparición de los anticuerpos monoclonales como herramienta inmunológica se ha hecho posible la detección de larvas marinas, líneas celulares sanguíneas en peces, toxinas, proteínas específicas y seguimiento de las mismas dentro de sistemas celulares y tejidos, etc. Además de poder complementar su uso con anticuerpos policlonales y fagos recombinantes, empleando técnicas como Inmunofluorescencia, Citometría de flujo, Western Blot o Microscopia Confocal, para su consecuente caracterización.
2008 34th Annual Conference of IEEE Industrial Electronics, 2008
This paper presents a DSP based equipment aimed for power electronics and motor control applicati... more This paper presents a DSP based equipment aimed for power electronics and motor control applications that, in opposite with conventional training equipments, provides a great flexibility to design several applications. The equipment is a modular system with a DC power supply, three-phase MOS-bridge, a signal acquisition system, a DSP development kit and several loads, i.e. DC or AC motors and passive loads. This platform allows to deliver higher power than similar educational power electronic kits. The platform has galvanic isolation between the control system and the power plant. It also has several protections that make easy interaction between the student and the platform. We also show two typical applications: a voltage-frequency control for a low-voltage three-phase induction motor and a voltage regulation system for a buck converter. The students are able to program these applications in the laboratory or by an e-learning web platform.
The aim of this study was to analyze the impact of single Roux-en-Y reconstruction (RYR) and doub... more The aim of this study was to analyze the impact of single Roux-en-Y reconstruction (RYR) and double Roux-en-Y reconstruction (dRYR) on intraoperative outcome and postoperative morbidity and mortality after pancreaticoduodenectomy (PD) or pylorus-preserving pancreaticoduodenectomy (PPPD). All patients who underwent surgery between 2000 and 2005 for dRYR and RYR after PD or PPPD at the study hospital were evaluated for inclusion. Comparison of categorical patient characteristics was performed using the χ (2) test. Data were reported as median and range. Differences were analyzed with the Mann-Whitney U test. Postoperative complications were graded according to the Clavien-Dindo classification scheme and the recommendations of the International Study Group of Pancreatic Surgery (ISGPS). A total of 319 patients were included in final analysis. The median time of surgery was significantly shorter when performing a single Roux-en-Y loop reconstruction (55 min in PD and 50 min in PPPD) (p < 0.001). Saved time had a significant effect on the cost of surgery (p < 0.001). No impact on postoperative outcome according to the Clavien-Dindo classification, the ISGPS definitions of pancreatic fistulas, and delayed gastric emptying was evident. The relaparotomy rate due to severe postoperative hemorrhage was significantly higher in the dRYR PD cohort (2.2 vs. 11.9 %, p < 0.001). Double Roux-en-Y reconstruction of the alimentary tract is not beneficial in terms of surgical outcome and postoperative morbidity and mortality and should be avoided due to unnecessarily prolonged surgery.
SPE Annual Technical Conference and Exhibition, 2009
... Salt Drilling While Underreaming Behaviors Illuminated by Distributed Downhole MeasurementsBo... more ... Salt Drilling While Underreaming Behaviors Illuminated by Distributed Downhole MeasurementsBobbie Jo Kull and Richard G. Duff, SPE, Chevron ... Key observations about the development of vibrations while opening the reamer, drilling, drilling transitions and back reaming are ...
Copyright 2009, Society of Petroleum Engineers This paper was prepared for presentation at the 20... more Copyright 2009, Society of Petroleum Engineers This paper was prepared for presentation at the 2009 SPE European Formation Damage Conference held in Scheveningen, The Netherlands, 2729 May 2009. This paper was selected for presentation by an SPE ...
Objetivo: Tratar de demostrar que la testosterona libre calculada es el mejor parámetro para el d... more Objetivo: Tratar de demostrar que la testosterona libre calculada es el mejor parámetro para el diagnóstico del síndrome de déficit de testosterona (SDT) y, por tanto, debería poder determinarse ya en la primera visita.
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that has n... more Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that has no effective treatment up to date. Drug discovery tasks have been hampered due to the lack of knowledge in its molecular etiology together with the limited animal models for research. Recently, a motor neuron disease animal model has been developed using β-N-methylamino-L-alanine (L-BMAA), a neurotoxic amino acid related to the appearing of ALS. In the present work, the neuroprotective role of VP2.51, a small heterocyclic GSK-3 inhibitor, is analysed in this novel murine model together with the analysis of autophagy. VP2.51 daily administration for two weeks, starting the first day after L-BMAA treatment, leads to total recovery of neurological symptoms and prevents the activation of autophagic processes in rats. These results show that the L-BMAA murine model can be used to test the efficacy of new drugs. In addition, the results confirm the therapeutic potential of GSK-3 inhibitors, and...
Objetivo: Tratar de demostrar que si el tratamiento androgénico en pacientes con síndrome de défi... more Objetivo: Tratar de demostrar que si el tratamiento androgénico en pacientes con síndrome de déficit de testosterona (SDT) no es suficiente para mejorar la función eréctil, habrá que añadir a la testosterona otros tratamientos para la disfunción eréctil, pues habitualmente coexisten otras patologías concomitantes, igualmente responsables de dicha disfunción.
Recent efforts have been focused on the development of centrally active COMT inhibitors, which ca... more Recent efforts have been focused on the development of centrally active COMT inhibitors, which can be valuable assets for neurological disorders such as Parkinson's disease, due to the severe hepatotoxicity risk associated with tolcapone. New nitrocatechol COMT inhibitors based on naturally-occurring caffeic acid and caffeic acid phenethyl ester were developed. All nitrocatechol derivatives displayed potent inhibition of peripheral and cerebral COMT within the nanomolar range. Drug-like derivatives 13, 15 and 16 were predicted to cross the blood-brain barrier in vitro and were significantly less toxic than tolcapone and entacapone when incubated at 50 µM with rat primary hepatocytes. Moreover, their unique acidity and electrochemical properties decreased the chances of formation of reactive quinone-imines and, as such, the potential for hepatotoxicity. The binding mode of 16 confirmed that the major interactions with COMT were established via the nitrocatechol ring, allowing der...
Depuis la découverte de la toxicité de ľoxygène (O2) (»poison vital«) par Lavoisier en 1785 et le... more Depuis la découverte de la toxicité de ľoxygène (O2) (»poison vital«) par Lavoisier en 1785 et les travaux de Lorrain-Smith, la controverse persiste. Historiquement, les premières descriptions de cette toxicité concernent le poumon. Avec ľavancée des connaissances et des techniques, les mécanismes physiologiques et physiopathologiques de cette toxicité ont commencé à être décryptés. Ľutilisation de ľO2 en clinique humaine reste
A novel reducing system comprised of phenylsilane and catalytic amounts of MO (CO)~ in refluxing ... more A novel reducing system comprised of phenylsilane and catalytic amounts of MO (CO)~ in refluxing THF efficiently effects conjugate reduction of Michael acceptors, including a, &unsaturated ketones, carboxylic acids, carboxylic esters, amides, and nitriles. The ...
1. Haga un algoritmo que calcule el factorial del número 4. 2. Haga un algoritmo que calcule el á... more 1. Haga un algoritmo que calcule el factorial del número 4. 2. Haga un algoritmo que calcule el área de un cuadrado, cuya longitud del lado es 5. 3. Haga un algoritmo que tenga dos variables en el entorno de memoria con los siguientes valores: En la primera variable el valor de "hola". En la segunda variable el valor de "SPPC". 4. Haga un algoritmo que intercambie el contenido de las variables indicadas en el ejercicio anterior, esto es: en el entorno de memoria Inicialmente el contenido de las variables en el entorno de memoria debe ser: (a)Variable1: "hola". (b)Variable2: "SPPC" Luego de ejecutar el algoritmo, el entorno de memoria final debe ser: (a)Variable1: "SPPC" (b)Variable2: "hola" 5. Haga un algoritmo que solicite al usuario el nombre y escriba por pantalla "Buenos días Sr(a)", y el nombre del usuario.
Caloric restriction (CR) without malnutrition delays aging and extends lifespan in diverse specie... more Caloric restriction (CR) without malnutrition delays aging and extends lifespan in diverse species; however, its effect on resistance to illness and mortality in primates is not clearly established. We
Peritoneal Dialysis International Journal of the International Society For Peritoneal Dialysis, May 1, 2008
Uruguay is a South American country (3241003 inhabitants) where renal replacement treatment is un... more Uruguay is a South American country (3241003 inhabitants) where renal replacement treatment is universally available. The aim of this study was to analyze the incidence and outcome of peritonitis, and the causative organisms and their sensitivity, in order to recommend an empiric initial antibiotic treatment. A retrospective descriptive study of all peritonitis during the period 2004 -2005 was performed (144 peritonitis, 44% due to gram-positive bacteria). We conclude that the high prevalence of methicillin-resistant coagulase-negative staphylococci justifies the use of vancomycin in the national empiric initial antibiotic protocols.
The main drawback in shunt hybrid filters is the lead current injection need. This paper describe... more The main drawback in shunt hybrid filters is the lead current injection need. This paper describes a strategy to reduce the lead current in a three phase four wires LC coupled parallel hybrid filter for harmonics cancellation. Simulation and experimental results are given to show the behavior of the system.
Currently, there is some scientific interest on study- ing creativity and how it can be modeled b... more Currently, there is some scientific interest on study- ing creativity and how it can be modeled by com- puter programs. One of the active subareas focuses on the generation of text, with some prior success systems. In this paper, we describe an example of this kind of system that automatically generates texts related to Greek mythology. We have elab- orated
Isolated ulnar luxation of metacarpal V without fractures at the basis or of adjunct bones is a r... more Isolated ulnar luxation of metacarpal V without fractures at the basis or of adjunct bones is a rarely observed entity with available data in the literature based on few case reports. Careful interpretation of radiological findings leads to a correct diagnosis. Missed lesions may result in chronic pain syndrome at the site of injury. The functional role of the ligamentum metacarpale transversum profundum in this type of injury is frequently underestimated. Here, we present a case report and elucidate diagnostic pathways and treatment options based on the available literature.
El perfeccionamiento de herramientas inmunológicas ha promovido un desarrollo en la biología mole... more El perfeccionamiento de herramientas inmunológicas ha promovido un desarrollo en la biología molecular y celular en diferentes campos, no solo en biomedicina humana o animal, sino también en el campo marino. Con la aparición de los anticuerpos monoclonales como herramienta inmunológica se ha hecho posible la detección de larvas marinas, líneas celulares sanguíneas en peces, toxinas, proteínas específicas y seguimiento de las mismas dentro de sistemas celulares y tejidos, etc. Además de poder complementar su uso con anticuerpos policlonales y fagos recombinantes, empleando técnicas como Inmunofluorescencia, Citometría de flujo, Western Blot o Microscopia Confocal, para su consecuente caracterización.
2008 34th Annual Conference of IEEE Industrial Electronics, 2008
This paper presents a DSP based equipment aimed for power electronics and motor control applicati... more This paper presents a DSP based equipment aimed for power electronics and motor control applications that, in opposite with conventional training equipments, provides a great flexibility to design several applications. The equipment is a modular system with a DC power supply, three-phase MOS-bridge, a signal acquisition system, a DSP development kit and several loads, i.e. DC or AC motors and passive loads. This platform allows to deliver higher power than similar educational power electronic kits. The platform has galvanic isolation between the control system and the power plant. It also has several protections that make easy interaction between the student and the platform. We also show two typical applications: a voltage-frequency control for a low-voltage three-phase induction motor and a voltage regulation system for a buck converter. The students are able to program these applications in the laboratory or by an e-learning web platform.
The aim of this study was to analyze the impact of single Roux-en-Y reconstruction (RYR) and doub... more The aim of this study was to analyze the impact of single Roux-en-Y reconstruction (RYR) and double Roux-en-Y reconstruction (dRYR) on intraoperative outcome and postoperative morbidity and mortality after pancreaticoduodenectomy (PD) or pylorus-preserving pancreaticoduodenectomy (PPPD). All patients who underwent surgery between 2000 and 2005 for dRYR and RYR after PD or PPPD at the study hospital were evaluated for inclusion. Comparison of categorical patient characteristics was performed using the χ (2) test. Data were reported as median and range. Differences were analyzed with the Mann-Whitney U test. Postoperative complications were graded according to the Clavien-Dindo classification scheme and the recommendations of the International Study Group of Pancreatic Surgery (ISGPS). A total of 319 patients were included in final analysis. The median time of surgery was significantly shorter when performing a single Roux-en-Y loop reconstruction (55 min in PD and 50 min in PPPD) (p < 0.001). Saved time had a significant effect on the cost of surgery (p < 0.001). No impact on postoperative outcome according to the Clavien-Dindo classification, the ISGPS definitions of pancreatic fistulas, and delayed gastric emptying was evident. The relaparotomy rate due to severe postoperative hemorrhage was significantly higher in the dRYR PD cohort (2.2 vs. 11.9 %, p < 0.001). Double Roux-en-Y reconstruction of the alimentary tract is not beneficial in terms of surgical outcome and postoperative morbidity and mortality and should be avoided due to unnecessarily prolonged surgery.
SPE Annual Technical Conference and Exhibition, 2009
... Salt Drilling While Underreaming Behaviors Illuminated by Distributed Downhole MeasurementsBo... more ... Salt Drilling While Underreaming Behaviors Illuminated by Distributed Downhole MeasurementsBobbie Jo Kull and Richard G. Duff, SPE, Chevron ... Key observations about the development of vibrations while opening the reamer, drilling, drilling transitions and back reaming are ...
Copyright 2009, Society of Petroleum Engineers This paper was prepared for presentation at the 20... more Copyright 2009, Society of Petroleum Engineers This paper was prepared for presentation at the 2009 SPE European Formation Damage Conference held in Scheveningen, The Netherlands, 2729 May 2009. This paper was selected for presentation by an SPE ...
Objetivo: Tratar de demostrar que la testosterona libre calculada es el mejor parámetro para el d... more Objetivo: Tratar de demostrar que la testosterona libre calculada es el mejor parámetro para el diagnóstico del síndrome de déficit de testosterona (SDT) y, por tanto, debería poder determinarse ya en la primera visita.
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that has n... more Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that has no effective treatment up to date. Drug discovery tasks have been hampered due to the lack of knowledge in its molecular etiology together with the limited animal models for research. Recently, a motor neuron disease animal model has been developed using β-N-methylamino-L-alanine (L-BMAA), a neurotoxic amino acid related to the appearing of ALS. In the present work, the neuroprotective role of VP2.51, a small heterocyclic GSK-3 inhibitor, is analysed in this novel murine model together with the analysis of autophagy. VP2.51 daily administration for two weeks, starting the first day after L-BMAA treatment, leads to total recovery of neurological symptoms and prevents the activation of autophagic processes in rats. These results show that the L-BMAA murine model can be used to test the efficacy of new drugs. In addition, the results confirm the therapeutic potential of GSK-3 inhibitors, and...
Objetivo: Tratar de demostrar que si el tratamiento androgénico en pacientes con síndrome de défi... more Objetivo: Tratar de demostrar que si el tratamiento androgénico en pacientes con síndrome de déficit de testosterona (SDT) no es suficiente para mejorar la función eréctil, habrá que añadir a la testosterona otros tratamientos para la disfunción eréctil, pues habitualmente coexisten otras patologías concomitantes, igualmente responsables de dicha disfunción.
Recent efforts have been focused on the development of centrally active COMT inhibitors, which ca... more Recent efforts have been focused on the development of centrally active COMT inhibitors, which can be valuable assets for neurological disorders such as Parkinson's disease, due to the severe hepatotoxicity risk associated with tolcapone. New nitrocatechol COMT inhibitors based on naturally-occurring caffeic acid and caffeic acid phenethyl ester were developed. All nitrocatechol derivatives displayed potent inhibition of peripheral and cerebral COMT within the nanomolar range. Drug-like derivatives 13, 15 and 16 were predicted to cross the blood-brain barrier in vitro and were significantly less toxic than tolcapone and entacapone when incubated at 50 µM with rat primary hepatocytes. Moreover, their unique acidity and electrochemical properties decreased the chances of formation of reactive quinone-imines and, as such, the potential for hepatotoxicity. The binding mode of 16 confirmed that the major interactions with COMT were established via the nitrocatechol ring, allowing der...
Depuis la découverte de la toxicité de ľoxygène (O2) (»poison vital«) par Lavoisier en 1785 et le... more Depuis la découverte de la toxicité de ľoxygène (O2) (»poison vital«) par Lavoisier en 1785 et les travaux de Lorrain-Smith, la controverse persiste. Historiquement, les premières descriptions de cette toxicité concernent le poumon. Avec ľavancée des connaissances et des techniques, les mécanismes physiologiques et physiopathologiques de cette toxicité ont commencé à être décryptés. Ľutilisation de ľO2 en clinique humaine reste
A novel reducing system comprised of phenylsilane and catalytic amounts of MO (CO)~ in refluxing ... more A novel reducing system comprised of phenylsilane and catalytic amounts of MO (CO)~ in refluxing THF efficiently effects conjugate reduction of Michael acceptors, including a, &unsaturated ketones, carboxylic acids, carboxylic esters, amides, and nitriles. The ...
Copyright 2009, Society of Petroleum Engineers This paper was prepared for presentation at the 20... more Copyright 2009, Society of Petroleum Engineers This paper was prepared for presentation at the 2009 SPE EUROPEC/EAGE Annual Conference and Exhibition held in Amsterdam, The Netherlands, 811 June 2009. This paper was selected for presentation by an SPE ...
A series of phenothiazine carboxylic acid derivatives, having 6-amino-pyrimidine-2,4(1H,3H)-dione... more A series of phenothiazine carboxylic acid derivatives, having 6-amino-pyrimidine-2,4(1H,3H)-dione moiety via a appropriate linker, were synthesized and evaluated for their affinity toward human histamine H(1) receptor and Caco-2 cell permeability. Selected compounds were further evaluated for their oral anti-histaminic activity in mice and bioavailability in rats. Finally, promising compounds were examined for their anti-inflammatory potential in mice OVA-induced biphasic cutaneous reaction model. Among the compounds tested, phenothiazineacetic acid compound 27 showed both histamine H(1)-receptor antagonistic activity and anti-inflammatory activity in vivo model.
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