2013 8th International Conference on System of Systems Engineering, 2013
Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the human cancer viruses associated with... more Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the human cancer viruses associated with Kaposi's sarcoma, a dominant AIDS-related tumor of endothelial cells, and several B-cell malignancies. Although much advancements have been made in understanding the mechanism of KSHV, signaling pathways activated during early infection and their functions in virus entry are still unclear. From a system of systems point of view, a pathway can be viewed as a biosystem consisting of group of interacting molecules such as genes and proteins to carry out a specific biological function. We developed a method to determine clusters of functionally related pathway at different time conditions as well as identifying the significant subnetworks. This article is the first known to present a system based analysis to infer a biologically relevant functional network specific to KSHV. Such network may reveal discriminative subnetwork markers for the treatment of Kaposi's sarcoma.
2013 8th International Conference on System of Systems Engineering, 2013
Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the human cancer viruses associated with... more Kaposi's sarcoma-associated herpesvirus (KSHV) is one of the human cancer viruses associated with Kaposi's sarcoma, a dominant AIDS-related tumor of endothelial cells, and several B-cell malignancies. Although much advancements have been made in understanding the mechanism of KSHV, signaling pathways activated during early infection and their functions in virus entry are still unclear. From a system of systems point of view, a pathway can be viewed as a biosystem consisting of group of interacting molecules such as genes and proteins to carry out a specific biological function. We developed a method to determine clusters of functionally related pathway at different time conditions as well as identifying the significant subnetworks. This article is the first known to present a system based analysis to infer a biologically relevant functional network specific to KSHV. Such network may reveal discriminative subnetwork markers for the treatment of Kaposi's sarcoma.
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Papers by amy daali