WWW.MDEDGE.COM/CUTIS Eligible for 1 MOC SA Credit From the ABD This Photo Challenge in our print ... more WWW.MDEDGE.COM/CUTIS Eligible for 1 MOC SA Credit From the ABD This Photo Challenge in our print edition is eligible for 1 self-assessment credit for Maintenance of Certification from the American Board of Dermatology (ABD). After completing this activity, diplomates can visit the ABD website (http://www.abderm.org) to self-report the credits under the activity title “Cutis Photo Challenge.” You may report the credit after each activity is completed or after accumulating multiple credits.
Vak›f Gureba E¤itim ve Araflt›rma Hastanesi, Dermatoloji ve Veneroloji Klini¤i, ‹stanbul, Türkiye... more Vak›f Gureba E¤itim ve Araflt›rma Hastanesi, Dermatoloji ve Veneroloji Klini¤i, ‹stanbul, Türkiye 21 Y Ya az z› ›fl flm ma a A Ad dr re es si i/ /A Ad dd dr re es ss s f fo or r C Co or rr re es sp po on nd de en nc ce e: : Dr. Filiz Cebeci, Vak›f Gureba E¤itim ve Araflt›rma Hastanesi, Dermatoloji ve Veneroloji Klini¤i, ‹stanbul, Türkiye E-posta: [email protected] G Ge el li ifl fl T Ta ar ri ih hi i/ /R Re ec ce ei iv ve ed d: : 02.12.2008 K Ka ab bu ul l T Ta ar ri ih hi i/ /A Ac cc ce ep pt te ed d: : 17.12.2008 Özet Amaç: Behçet hastal›¤› (BH), bafll›ca tekrarlayan oral ülserasyon, genital ülserasyon ve üveit ile karakterize, kronik, infla-matuar ve etyolojisi bilinmeyen multisistemik bir hastal›kt›r. Hastal›¤›n patogenezinde faktör V leiden (FVL) gen mutasyonu gibi trombofilik defektler önemli rol oynayabilir. Son zamanlarda BH'nda tromboz ve göz tutulumu ile birlikte FVL gen mutasyonunun birlikteli¤i gösterilmifltir. Bu çal›flman›n amac›, BH'nda FVL gen mutasyonu...
A non-smoking man in his seventh decade presented with a lesion he had had for about 5 years on t... more A non-smoking man in his seventh decade presented with a lesion he had had for about 5 years on the right external surface of the lip 1 mm from the vermilion border. On physical examination, a yellowish-coloured, non-tender, verrucous mass of 0.5 × 0.7 cm was observed. A histopathological examination of the first 3-mm punch biopsy was non-diagnostic. The histopathological evaluation of a second, 5-mm-deep punch biopsy made by a pathology expert in oral lesions revealed a diagnosis of verruciform xanthoma. The key to the diagnosis of verruciform xanthoma is to recognize xanthoma cells. However, these cells may be insufficient in number in small and superficial biopsy material and overlooked by a pathologist especially when lacking knowledge of this uncommon lesion. Verruciform xanthoma of the lower lip at the vermilion border is an extremely rare entity described in 5 cases worldwide to date. We aimed to bring verruciform xanthoma to readers’ attention for a differential diagnosis of...
The aim of this study was to determine the frequency of complementary and alternative medicine (C... more The aim of this study was to determine the frequency of complementary and alternative medicine (CAM) methods used in children and adolescents with chronic skin diseases, which methods parents prefer, and to what extent these methods are useful. This cross-sectional study was conducted between June and November 2014 in patients with chronic skin diseases attending the outpatient pediatric dermatology clinics of three hospitals in Turkey. Data were collected using self-administered questionnaires from the parents of the patients. A total of 307 patients were included in the study, 168 (54.7%) of whom were female and 139 (45.3%) male. The mean age was 12.3 ± 4.3 years. Eighty of the children (26.1%) had used CAM methods in the previous year. Longer disease duration and having a father with at least a university degree were highly associated with CAM use (p < 0.05). The most used method was herbal remedies available at home. Most patients used CAM methods to support the primary treatment given by their dermatologists. Only eight CAM users (2.6%) reported any side effects. Thirty-nine (48.8%) did not mention CAM use to their doctors. The overall satisfaction rate was 4.5 ± 3.1 on a 10-point rating scale. CAM use rates are high in children with chronic skin problems, and parents generally prefer herbal treatments. Satisfaction with the results of CAM use is moderate. Parents generally do not share CAM use information with their doctors unless they are asked.
Fixed drug eruption (FDE) is an adverse effect observed with various drugs such as nonsteroidal a... more Fixed drug eruption (FDE) is an adverse effect observed with various drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) and various antibiotics. Acemetacin, a prodrug of indomethacin, is an NSAID licensed for use in rheumatic disease and other musculoskeletal disorders. We present a case of acemetacin-induced FDE in a 49-year-old woman. To the best of our knowledge, this is the second case report detailing clinical and histopathological findings of a patient with FDE caused by acemetacin.
Vitiligo is an acquired depigmenting skin disease characterized by the loss of functioning epider... more Vitiligo is an acquired depigmenting skin disease characterized by the loss of functioning epidermal melanocytes. Vitiligo can be associated with an autoimmune disorder. An unusual and important aspect of vitiligo is its relationship to melanoma. We present herein a 34-year-old man who developed regional lymph node metastases of malignant melanoma 2 years after the diagnosis of vitiligo.
41 ÖzET Amaç: Hirsutizm reprodüktif yaştaki kadınlarda en yaygın klinik endokrinolojik problemdir... more 41 ÖzET Amaç: Hirsutizm reprodüktif yaştaki kadınlarda en yaygın klinik endokrinolojik problemdir. Sebebi genellikle benign bir bozukluk olmakla beraber; hir-sutizm nadiren androjen sekrete eden tümör veya Cushing sendromu gibi daha ciddi endokrinolojik hastalığın bir işareti olabilir. Bu çalışmanın amacı reprodüktif yaştaki hirsutizmli kadınlarda hirsutiz-min etiyolojik faktörlerini ve klinik özelliklerini or-taya koymaktı. Materyal ve Metod: Bu çalışmaya 2000-2006 tarih-leri arasında hirsutizm polikliniğimizde izlenen, ça-lışmadan dışlanma kriterleri uygulandıktan sonra geriye kalan 271 hasta dahil edildi. Verilere hirsut hasta dosyaları geriye dönük olarak taranarak ula-şıldı. Ulaşılan veriler detaylı klinik değerlendirme, endokrinolojik araştırma ve pelvik ultrasonografi bulgularından oluştu. Bulgular: Hirsutizmin etiyolojisinde %49,8 poli-kistik over sendromu (PKOS) ve %39,5 oranında idiopatik hirsutizm (İH) iki major grup olarak belir-lendi. Bunları sırasıyla %5,9 tanımlanamay...
European review for medical and pharmacological sciences
The pathogenesis of thrombosis in Behçet's Disease (BD) is unknown, however, multiple factors... more The pathogenesis of thrombosis in Behçet's Disease (BD) is unknown, however, multiple factors leading to the disease may include hypercoagulability, hypofibrinolysis and endothelial injury. We sought to evaluate the frequency of erythema nodosum-like lesions (ENLL) due to the presence of vasculitis in ENLL observed in BD in male patients with BD with and without deep vein thrombosis. To our knowledge this is the first study to investigate the association of ENLL between the groups with or without thrombosis in only male patients with BD. The study included 92 patients, 41 of whom had deep vein thrombosis (DVT) and 51 had no thrombosis that met the international diagnosis criteria for BD. Vascular involvement was diagnosed based on clinical signs; radiological findings from Doppler, ultrasonography and/or angiography computed tomographic or magnetic resonance. ENLL were diagnosed by means of biopsy in suspected cases. Since both groups were age-matched, there were no statisticall...
Radiation recall phenomenon is an acute, egzematous reaction that develops throughout a previousl... more Radiation recall phenomenon is an acute, egzematous reaction that develops throughout a previously irradiated area, precipitated by the administration of docetaxel, doxorubicin, gemcitabine and paclitaxel. We report a 52-year-old woman with breast cancer who received locoregional radiotherapy followed by trastuzumab monotherapy. Three day after the first cycle of trastuzumab monotherapy, dermatitis developed in the previously irradiated skin. (Turkderm 2014; 48: Suppl 2: 85-6) Key Words: Trastuzumab, radiation recall dermatitis, breast cancer Radyasyon recall-anımsatma dermatiti daha önceden radyoterapi uygulanan alanda sıklıkla docetaxel, doxorubicin, gemcitabine ve paclitaxel gibi kemoterapotik ilaçların uygulanması ile ortaya çıkan akut, ekzematöz tablodur. Burada meme kanseri sonrasında lokal radyoterapi uygulanan ve ardından trastuzumab monoterapisi başlanan 52 yaşında bayan olgu sunulmaktadır. Trastuzumab tedavisinin ilk siklusundan 3 gün sonra daha önce radyasyon alan deride ...
WWW.MDEDGE.COM/CUTIS Eligible for 1 MOC SA Credit From the ABD This Photo Challenge in our print ... more WWW.MDEDGE.COM/CUTIS Eligible for 1 MOC SA Credit From the ABD This Photo Challenge in our print edition is eligible for 1 self-assessment credit for Maintenance of Certification from the American Board of Dermatology (ABD). After completing this activity, diplomates can visit the ABD website (http://www.abderm.org) to self-report the credits under the activity title “Cutis Photo Challenge.” You may report the credit after each activity is completed or after accumulating multiple credits.
Vak›f Gureba E¤itim ve Araflt›rma Hastanesi, Dermatoloji ve Veneroloji Klini¤i, ‹stanbul, Türkiye... more Vak›f Gureba E¤itim ve Araflt›rma Hastanesi, Dermatoloji ve Veneroloji Klini¤i, ‹stanbul, Türkiye 21 Y Ya az z› ›fl flm ma a A Ad dr re es si i/ /A Ad dd dr re es ss s f fo or r C Co or rr re es sp po on nd de en nc ce e: : Dr. Filiz Cebeci, Vak›f Gureba E¤itim ve Araflt›rma Hastanesi, Dermatoloji ve Veneroloji Klini¤i, ‹stanbul, Türkiye E-posta: [email protected] G Ge el li ifl fl T Ta ar ri ih hi i/ /R Re ec ce ei iv ve ed d: : 02.12.2008 K Ka ab bu ul l T Ta ar ri ih hi i/ /A Ac cc ce ep pt te ed d: : 17.12.2008 Özet Amaç: Behçet hastal›¤› (BH), bafll›ca tekrarlayan oral ülserasyon, genital ülserasyon ve üveit ile karakterize, kronik, infla-matuar ve etyolojisi bilinmeyen multisistemik bir hastal›kt›r. Hastal›¤›n patogenezinde faktör V leiden (FVL) gen mutasyonu gibi trombofilik defektler önemli rol oynayabilir. Son zamanlarda BH'nda tromboz ve göz tutulumu ile birlikte FVL gen mutasyonunun birlikteli¤i gösterilmifltir. Bu çal›flman›n amac›, BH'nda FVL gen mutasyonu...
A non-smoking man in his seventh decade presented with a lesion he had had for about 5 years on t... more A non-smoking man in his seventh decade presented with a lesion he had had for about 5 years on the right external surface of the lip 1 mm from the vermilion border. On physical examination, a yellowish-coloured, non-tender, verrucous mass of 0.5 × 0.7 cm was observed. A histopathological examination of the first 3-mm punch biopsy was non-diagnostic. The histopathological evaluation of a second, 5-mm-deep punch biopsy made by a pathology expert in oral lesions revealed a diagnosis of verruciform xanthoma. The key to the diagnosis of verruciform xanthoma is to recognize xanthoma cells. However, these cells may be insufficient in number in small and superficial biopsy material and overlooked by a pathologist especially when lacking knowledge of this uncommon lesion. Verruciform xanthoma of the lower lip at the vermilion border is an extremely rare entity described in 5 cases worldwide to date. We aimed to bring verruciform xanthoma to readers’ attention for a differential diagnosis of...
The aim of this study was to determine the frequency of complementary and alternative medicine (C... more The aim of this study was to determine the frequency of complementary and alternative medicine (CAM) methods used in children and adolescents with chronic skin diseases, which methods parents prefer, and to what extent these methods are useful. This cross-sectional study was conducted between June and November 2014 in patients with chronic skin diseases attending the outpatient pediatric dermatology clinics of three hospitals in Turkey. Data were collected using self-administered questionnaires from the parents of the patients. A total of 307 patients were included in the study, 168 (54.7%) of whom were female and 139 (45.3%) male. The mean age was 12.3 ± 4.3 years. Eighty of the children (26.1%) had used CAM methods in the previous year. Longer disease duration and having a father with at least a university degree were highly associated with CAM use (p < 0.05). The most used method was herbal remedies available at home. Most patients used CAM methods to support the primary treatment given by their dermatologists. Only eight CAM users (2.6%) reported any side effects. Thirty-nine (48.8%) did not mention CAM use to their doctors. The overall satisfaction rate was 4.5 ± 3.1 on a 10-point rating scale. CAM use rates are high in children with chronic skin problems, and parents generally prefer herbal treatments. Satisfaction with the results of CAM use is moderate. Parents generally do not share CAM use information with their doctors unless they are asked.
Fixed drug eruption (FDE) is an adverse effect observed with various drugs such as nonsteroidal a... more Fixed drug eruption (FDE) is an adverse effect observed with various drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) and various antibiotics. Acemetacin, a prodrug of indomethacin, is an NSAID licensed for use in rheumatic disease and other musculoskeletal disorders. We present a case of acemetacin-induced FDE in a 49-year-old woman. To the best of our knowledge, this is the second case report detailing clinical and histopathological findings of a patient with FDE caused by acemetacin.
Vitiligo is an acquired depigmenting skin disease characterized by the loss of functioning epider... more Vitiligo is an acquired depigmenting skin disease characterized by the loss of functioning epidermal melanocytes. Vitiligo can be associated with an autoimmune disorder. An unusual and important aspect of vitiligo is its relationship to melanoma. We present herein a 34-year-old man who developed regional lymph node metastases of malignant melanoma 2 years after the diagnosis of vitiligo.
41 ÖzET Amaç: Hirsutizm reprodüktif yaştaki kadınlarda en yaygın klinik endokrinolojik problemdir... more 41 ÖzET Amaç: Hirsutizm reprodüktif yaştaki kadınlarda en yaygın klinik endokrinolojik problemdir. Sebebi genellikle benign bir bozukluk olmakla beraber; hir-sutizm nadiren androjen sekrete eden tümör veya Cushing sendromu gibi daha ciddi endokrinolojik hastalığın bir işareti olabilir. Bu çalışmanın amacı reprodüktif yaştaki hirsutizmli kadınlarda hirsutiz-min etiyolojik faktörlerini ve klinik özelliklerini or-taya koymaktı. Materyal ve Metod: Bu çalışmaya 2000-2006 tarih-leri arasında hirsutizm polikliniğimizde izlenen, ça-lışmadan dışlanma kriterleri uygulandıktan sonra geriye kalan 271 hasta dahil edildi. Verilere hirsut hasta dosyaları geriye dönük olarak taranarak ula-şıldı. Ulaşılan veriler detaylı klinik değerlendirme, endokrinolojik araştırma ve pelvik ultrasonografi bulgularından oluştu. Bulgular: Hirsutizmin etiyolojisinde %49,8 poli-kistik over sendromu (PKOS) ve %39,5 oranında idiopatik hirsutizm (İH) iki major grup olarak belir-lendi. Bunları sırasıyla %5,9 tanımlanamay...
European review for medical and pharmacological sciences
The pathogenesis of thrombosis in Behçet's Disease (BD) is unknown, however, multiple factors... more The pathogenesis of thrombosis in Behçet's Disease (BD) is unknown, however, multiple factors leading to the disease may include hypercoagulability, hypofibrinolysis and endothelial injury. We sought to evaluate the frequency of erythema nodosum-like lesions (ENLL) due to the presence of vasculitis in ENLL observed in BD in male patients with BD with and without deep vein thrombosis. To our knowledge this is the first study to investigate the association of ENLL between the groups with or without thrombosis in only male patients with BD. The study included 92 patients, 41 of whom had deep vein thrombosis (DVT) and 51 had no thrombosis that met the international diagnosis criteria for BD. Vascular involvement was diagnosed based on clinical signs; radiological findings from Doppler, ultrasonography and/or angiography computed tomographic or magnetic resonance. ENLL were diagnosed by means of biopsy in suspected cases. Since both groups were age-matched, there were no statisticall...
Radiation recall phenomenon is an acute, egzematous reaction that develops throughout a previousl... more Radiation recall phenomenon is an acute, egzematous reaction that develops throughout a previously irradiated area, precipitated by the administration of docetaxel, doxorubicin, gemcitabine and paclitaxel. We report a 52-year-old woman with breast cancer who received locoregional radiotherapy followed by trastuzumab monotherapy. Three day after the first cycle of trastuzumab monotherapy, dermatitis developed in the previously irradiated skin. (Turkderm 2014; 48: Suppl 2: 85-6) Key Words: Trastuzumab, radiation recall dermatitis, breast cancer Radyasyon recall-anımsatma dermatiti daha önceden radyoterapi uygulanan alanda sıklıkla docetaxel, doxorubicin, gemcitabine ve paclitaxel gibi kemoterapotik ilaçların uygulanması ile ortaya çıkan akut, ekzematöz tablodur. Burada meme kanseri sonrasında lokal radyoterapi uygulanan ve ardından trastuzumab monoterapisi başlanan 52 yaşında bayan olgu sunulmaktadır. Trastuzumab tedavisinin ilk siklusundan 3 gün sonra daha önce radyasyon alan deride ...
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