Background: Earlier studies have reported that anxiety and depressive symptoms have a significant... more Background: Earlier studies have reported that anxiety and depressive symptoms have a significant and negative impact on quality of life. Empirical studies on this research question, however, are lacking in Indonesia. This study aimed to examine the associations of depression and anxiety with quality of life of males with infertility. Subject and Methods: This was a cross-sectional study conducted at a private hospital in Semarang, Central Java. A sample of 213 men with infertility was selected for this study. The dependent variable was quality of life. The independent variables were depression and anxiety. Infertility data were obtained from the medical record. Quality of life was measured by fertility quality of life (FertiQol). Depression and anxiety were measured by hospital anxiety and depression scale (HADS). Strength of correlation was measured by Spearman correlation coefficient. Results: Depression and anxiety were correlated with all domains in the quality of life of males...
The end-organ resistance to androgens has been designated as Androgen Insensitivity Syndrome (AIS... more The end-organ resistance to androgens has been designated as Androgen Insensitivity Syndrome (AIS), an X-linked disorder caused by mutations in the Androgen Receptor (AR) gene. It is generally accepted that defects in the AR gene prevent the normal development of both internal and external genital structures in 46,XY individuals, causing a variety of phenotypes ranging from male infertility to completely normal female external genitalia. Precise diagnosis requires clinical, hormonal and molecular investigation and is of great importance for appropriate gender assignment and management in general. The complexity of phenotypic presentation of AIS with genotype-phenotype variability of identical mutations complicates both the diagnostic procedure and genetic counseling of the affected families. More than 400 different AR gene mutations have thus far been reported but the receptor structure-function relationship and its phenotypic outcome is not yet fully understood. This review focuses on the clinical features and molecular pathophysiology of AIS and explores the relationship of the molecular defects in the AR gene to their clinical expression.
Aims: Mutations in Steroidogenic Acute Regulatory protein (SIAR) cause congenital lipoid adrenal ... more Aims: Mutations in Steroidogenic Acute Regulatory protein (SIAR) cause congenital lipoid adrenal hyperplasia (lipoirl CAH), characterized by absent steroidogenesis, potentially lethal salt loss, 46,XY sex reversal and massively enlarged adrenals engorged with cholesterol esters. Nonclassic lipoid
Background: Earlier studies have reported that anxiety and depressive symptoms have a significant... more Background: Earlier studies have reported that anxiety and depressive symptoms have a significant and negative impact on quality of life. Empirical studies on this research question, however, are lacking in Indonesia. This study aimed to examine the associations of depression and anxiety with quality of life of males with infertility. Subject and Methods: This was a cross-sectional study conducted at a private hospital in Semarang, Central Java. A sample of 213 men with infertility was selected for this study. The dependent variable was quality of life. The independent variables were depression and anxiety. Infertility data were obtained from the medical record. Quality of life was measured by fertility quality of life (FertiQol). Depression and anxiety were measured by hospital anxiety and depression scale (HADS). Strength of correlation was measured by Spearman correlation coefficient. Results: Depression and anxiety were correlated with all domains in the quality of life of males...
The end-organ resistance to androgens has been designated as Androgen Insensitivity Syndrome (AIS... more The end-organ resistance to androgens has been designated as Androgen Insensitivity Syndrome (AIS), an X-linked disorder caused by mutations in the Androgen Receptor (AR) gene. It is generally accepted that defects in the AR gene prevent the normal development of both internal and external genital structures in 46,XY individuals, causing a variety of phenotypes ranging from male infertility to completely normal female external genitalia. Precise diagnosis requires clinical, hormonal and molecular investigation and is of great importance for appropriate gender assignment and management in general. The complexity of phenotypic presentation of AIS with genotype-phenotype variability of identical mutations complicates both the diagnostic procedure and genetic counseling of the affected families. More than 400 different AR gene mutations have thus far been reported but the receptor structure-function relationship and its phenotypic outcome is not yet fully understood. This review focuses on the clinical features and molecular pathophysiology of AIS and explores the relationship of the molecular defects in the AR gene to their clinical expression.
Aims: Mutations in Steroidogenic Acute Regulatory protein (SIAR) cause congenital lipoid adrenal ... more Aims: Mutations in Steroidogenic Acute Regulatory protein (SIAR) cause congenital lipoid adrenal hyperplasia (lipoirl CAH), characterized by absent steroidogenesis, potentially lethal salt loss, 46,XY sex reversal and massively enlarged adrenals engorged with cholesterol esters. Nonclassic lipoid
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