Papers by abdulrahman ibrahim
Tikrit Journal of Engineering Science, 2020
Diagnostics, 2021
Interstitial lung diseases (ILDs) are chronic irreversible pulmonary conditions with significant ... more Interstitial lung diseases (ILDs) are chronic irreversible pulmonary conditions with significant morbidity and mortality. Diagnostic approaches to ILDs are complex and multifactorial. Effective therapeutic interventions are continuously investigated and explored with substantial progress, thanks to advances in basic understanding and translational efforts. Extracellular vesicles (EVs) offer a new paradigm in diagnosis and treatment. This leads to two significant implications: new disease biomarker discovery that enables reliable diagnosis and disease assessment and the development of regenerative medicine therapeutics that target fibroproliferative processes in diseased lung tissue. In this review, we discuss the current understanding of the role of diseased tissue-derived EVs in the development of interstitial lung diseases, the utility of these EVs as diagnostic and prognostic tools, and the existing therapeutic utility of EVs. Furthermore, we review the potential therapeutic appl...
Spag17 DEFICIENCY IMPAIRS NEURAL CELL DIFFERENTIATION IN DEVELOPING BRAIN By Olivia Jeong Min Cho... more Spag17 DEFICIENCY IMPAIRS NEURAL CELL DIFFERENTIATION IN DEVELOPING BRAIN By Olivia Jeong Min Choi, B.S. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University Virginia Commonwealth University, 2019 Advisor: Maria E. Teves, Ph.D. Department of Obstetrics and Gynecology The development of the nervous system is a multi-level, time-sensitive process that relies heavily on cell differentiation. However, the molecular mechanisms that control brain development remain poorly understood. We generated a knockout (KO) mouse for the cilia associated gene Spag17. These animals develop hydrocephalus and enlarged ventricles consistent with the role of Spag17 in the motility of ependymal cilia. However, other phenotypes that cannot be explained by this role were also present. Recently, a mutation in Spag17 has been associated with brain malformations and severe intellectual disability in humans. Therefore, we hypothesiz...
Melkersson-Rosenthal syndrome (MRS) was first described and named after E. Melkersson in 1928 and... more Melkersson-Rosenthal syndrome (MRS) was first described and named after E. Melkersson in 1928 and C. Rosenthal in 1931. MRS is a rare cause of recurrent facial nerve palsy and can manifest as facial paralysis, orofacial edema, and/or tongue fissuring. Presenting with the complete triad, it was scarcely reported in literature. However, the patient reported here had the complete triad. MRS should be considered when facial paralysis is recurrent or when it presents with orofacial edema, and/or tongue fissuring.
Khazar Journal of Humanities and Social Sciences
Quality assurance practices are input, process, and output systems that are put in place by schoo... more Quality assurance practices are input, process, and output systems that are put in place by school administrators in order to ensure academic standards. It is on this premise that this study examined quality assurance practices as determinants of academic staff effectiveness. The study population consists of 6,577 academic staff in South-west Nigerian Polytechnics. Stratified and random sampling techniques were used to select 327 academic staff. An adapted instrument titled “Quality Assurance Practices Questionnaire’’ (QAPQ) and “Academic Staff Effectiveness Questionnaire’’ (ASEQ) were used to collect relevant data. Data collected were analysed using percentage and correlation methods. Findings indicate several quality assurance practices, which include quality assurance in the recruitment of lecturers, staff supervision, capacity building, and library services. Also, the study revealed a significant relationship between quality assurance practices and academic staff effectiveness. ...
Frontiers in Cell and Developmental Biology
Pulmonary fibrosis is a progressive disease for which no curative treatment exists. We have previ... more Pulmonary fibrosis is a progressive disease for which no curative treatment exists. We have previously engineered dermal fibroblasts to produce extracellular vesicles with tissue reparative properties dubbed activated specialized tissue effector extracellular vesicles (ASTEX). Here, we investigate the therapeutic utility of ASTEX in vitro and in a mouse model of bleomycin-induced lung injury. RNA sequencing demonstrates that ASTEX are enriched in micro-RNAs (miRs) cargo compared with EVs from untransduced dermal fibroblast EVs (DF-EVs). Treating primary macrophages with ASTEX reduced interleukin (IL)6 expression and increased IL10 expression compared with DF-EV-exposed macrophages. Furthermore, exposure of human lung fibroblasts or vascular endothelial cells to ASTEX reduced expression of smooth muscle actin, a hallmark of myofibroblast differentiation (respectively). In vivo, intratracheal administration of ASTEX in naïve healthy mice demonstrated a favorable safety profile with no...
المجلة العراقية لتكنولوجيا المعلومات
Advances in Pharmacology and Pharmacy
Aim: Milicia excelsa stem bark is used as sedative and for treating mental illnesses among the Ha... more Aim: Milicia excelsa stem bark is used as sedative and for treating mental illnesses among the Hausa tribe of Northern Nigeria, but there is no scientific rationale for its use. Hence, this study investigated the oral acute toxicity and sedative potential of ethanol stem bark extract, n-hexane, ethylacetate, n-butanol and aqueous fractions of the stem bark extract in mice. The phytoconstituents in the extract and fractions were quantified. Methodology: The acute toxicity of the extract and fractions were investigated using OECD guidelines 425 of 2008. The sedative effects of the extract and fractions were investigated using pentobarbital-, and ketamine-induced sleep tests. Results and discussion: The results obtained showed that the acute toxicity of the extract and fractions were > 5000 mg/kg, suggesting that the extract and fractions may be safe. The extract, n-hexane, ethylacetate and aqueous fractions significantly (p<0.05) reduced sleep latencies, indicative of sedative effects, effective for sleep induction, while the extract and all the fractions significantly (p<0.05) prolonged the sleep durations, suggesting sedative effects, effective for sleep maintenance. Conclusion: This study therefore, concluded that the extract and fractions may be safe. The study further concluded that the sedative effect of the extract and fractions may be due to the abundance of flavonoids in the extract and fractions. Thus, providing scientific rationale for its ethnomedicinal use. However, further study may be warranted to isolate and characterize the sleep promoting bioactive principles as well as carry out GABA binding assay of the isolated compound(s) in ESB and its various fractions.
Materials Today: Proceedings
Abstract Compliant mechanisms are flexible devices that can produce useful work through elastic d... more Abstract Compliant mechanisms are flexible devices that can produce useful work through elastic deformations. Compliance is a relatively novel approach, that contrasts with the conventional rigid body approach common in most mechanisms. The advantages of compliant mechanisms over conventional rigid body mechanisms include reduced parts, lower costs due to reduced assembly, reduced inventory storage, ease of manufacturing, improved performance, reduced weight, elimination of lubrication, and the ability to create miniature mechanisms. The present work investigates the finite element analysis of compliant mechanism for plier type device using linear solver in Pre/Post tool available in Siemens NX 12. A computer aided design (CAD) model of the mechanism is recreated through approximate geometry tracing and the model are recorded for optimization. The model parameters are then imported into Pre/Post tool for simulation using the Linear Solver. The model is simulated to understand behaviors of displacement, stress and strains. To achieve this a Finite Element Analysis is conducted on the model and the results of the FEA study are presented in the study under fixed load conditions for Acrylonitrile Butadiene Styrene (ABS), Polylactic Acid (PLA) and Thermoplastic polyurethane (TPU) polymers. From the results of the study, it can be concluded that compliant mechanism can be reliably achieved for the application required using ABS as the desired useful work is achieved within the range of elastic deformation for the material.
BMC Urology
Background: Urinary bladder agenesis is a very rare congenital anomaly with very few cases report... more Background: Urinary bladder agenesis is a very rare congenital anomaly with very few cases reported in the literature. Case presentation: We report a one-month-old baby presenting with ambiguous genitalia and recurrent urinary tract infections. Her clinical course was complicated by renal impairment. Magnetic resonant imaging (MRI) revealed a diagnosis of bladder agenesis with bilateral ectopic insertion of the ureters into the vagina, associated with several other anomalies. The patient underwent bilateral high anterior ureterostomies in an hospital abroad at 5.5 months of age. She then developed ureteral necrosis that had to be corrected with left pyeloplasty and by placing a left nephrostomy tube for drainage. Eventually, the patient's renal function declined, and she developed chronic kidney disease (CKD).The case with its imaging findings and pathogenesis as well as a review of the literature are presented. Conclusions: Urinary bladder agenesis is a rare congenital condition that can be associated with multiple anomalies. Early diagnosis and therapeutic intervention can prevent progression to chronic kidney disease.
ACS Catalysis
A chemoselective hydroboration protocol with terminal alkene substrates is reported using an elec... more A chemoselective hydroboration protocol with terminal alkene substrates is reported using an electron-rich, low-valent cobalt pincer compound. The process is catalytic and leads to exclusive formation of anti-Markovnikov products, tolerating amino groups, esters, epoxides, ketones, and other functionalities. The protocol was successfully extended toward the hydroboration of nitriles, generating the corresponding amines in moderate to good yields. Labeling studies with deuterated pinacolborane gave insights into the mechanism, establishing the intermediacy of a cobalt hydride, as well as an insertion, β-hydride elimination, and alkene isomerization pathway. These insights provide a rationale for the observed regioselectivity and allow us to propose a catalytic mechanism.
Proceedings of the 3rd International Conference on Civil, Offshore and Environmental Engineering (ICCOEE 2016, Malaysia, 15-17 Aug 2016), 2016
Automation Control and Intelligent Systems, Jan 19, 2015
The present work include preparation of phosphors materials from rare earth (Eu) ion doping Silic... more The present work include preparation of phosphors materials from rare earth (Eu) ion doping Silicon Oxide (SiO 2), and study the characteristics of phosphors for ultraviolet to visible conversion. The phosphor materials have been synthesized by two steps, the first was preparing the powder by solid state method usingSiO 2 , and Eu 2 O 3 with doping concentration of 5% and different calcination temperature (1000, 1200 and 1400 o C), the second step is the preparing of the colloid by dispersing the produced powder in a polyvinyl alcohol solution (4%). Powder preparation achieved by mixing the powder according to weight percentage, milling then calcinning the mixture at the above temperatures. The produced powder was characterized by X-Ray diffraction .The X-Ray resultsshow a mismatch with the standard peaks. The difference may be due to the variation in purity of the materials and the phases before calcination. Colloid preparation achieved by dissolving the PVA in water (4%) then dispersing the powder into the solution by using the hot plate magnetic stirrer and ultrasonic bath. The produced powder was characterized by using Fourier transform infrared (FTIR) and Photoluminescence spectra (PL). The results of photoluminescence spectra show that samples doped with Europium ions emit red color with wave length 612nm.The intensity of emission was increased with increasing calcination temperature.
Dalton Trans., 2016
The synthesis and characterization of a series of cobalt complexes featuring a pincer bis(carbene... more The synthesis and characterization of a series of cobalt complexes featuring a pincer bis(carbene) ligand of the meta-phenylene-bridged bis-N-heterocyclic carbene (ArCCC, Ar = 2,6-diispropylphenyl or mesityl) are reported.
International journal of …, 2003
... network solar cell model Mohammad AbdulHadi1,n,y, AbdulRahman Al-Ibrahim1 and Gurvinder S Vir... more ... network solar cell model Mohammad AbdulHadi1,n,y, AbdulRahman Al-Ibrahim1 and Gurvinder S Virk2 ... Al-Amoudi (1999) showed that a radial basis function network (RBFN) applied to simulation data generated by a mathematical model of ...
… Journal of Energy …, 1999
In Saudi Arabia, the heating, ventilating and air conditioning (HVAC) system typically accounts f... more In Saudi Arabia, the heating, ventilating and air conditioning (HVAC) system typically accounts for 65% of the total electrical energy consumption in buildings. This is due to a very high ambient temperature which persists for a long period of time in a summer season. Moreover, gas turbines efficiency decrease also with the high ambient temperatures. In the HVAC industry cool storage, or commonly known as Thermal Energy Storage (TES) is the most preferred demand side management (DSM) technology for shifting cooling electrical demand from peak daytime periods to off-peak night-time. The most popular and well-suited TES concept for Saudi Arabia is either chilled water or ice storage system, depending upon the applications and the required storage capacity. This paper shows how TES offers a means of reducing the electrical demand in large commercial buildings. Additionally, it is seen that efficiencies of the air cooled chillers are increased if they run overnight. Similarly efficiencies of gas turbine is also increased when a TES based pre-cooled air is used as an inlet to the turbine. This paper also discusses favouring conditions and other aspects of cool storage applications in Saudi Arabia. TES economics are considered and a cost analysis is presented to illustrate the potential savings that can be achieved by the use of TES in Saudi Arabia.
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Papers by abdulrahman ibrahim