Papers by abdullahi Abbas
www.impactjournals.com/oncotarget / Oncotarget, Vol. 5, No. 17
Fighting the COVID-19 Pandemic, 2021
Myths are widely dispersed but false ideologies or misconceptions. With the thousands of deaths r... more Myths are widely dispersed but false ideologies or misconceptions. With the thousands of deaths recorded daily and the negative toll of the novel coronavirus disease (COVID-19) on public health, national economy, and human interaction, it remains surprising how people are still being swayed by conspiracy theories. Due to the novelty of the disease, the quest for an answer, what works, and what does not work gave room for the propagation of misinformation, especially on social media. Identifying and debunking myths is very important in managing disease outbreak, since myths can negatively influence the response of people to preventive and containment strategies. Major proponents of COVID-19 myths have promoted their falsehood on the guise that it is a biological weapon engineered to control the world population. Others have also falsely claimed the use of antibiotics or other antiviral drugs in the treatment of COVID-19 and that COVID-19 is no worse than the common flu or it is just ...
Asian Journal of Applied Sciences, 2020
ABSTRACT---Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resu... more ABSTRACT---Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion / insulin action or both which could leads to increase level of oxidative stress and decrease in antioxidant defense system and may play role in the development of diabetic complications. The present study examines the effects of antioxidant rich supplements (Alphabetic) on antioxidant status of one hundred (100) diabetic subjects attending Usmanu Danfodiyo University Teaching Hospital (UDUTH) for at least one year and the results were compared with those of fifty (50) diabetes mellitus non-supplemented and fifty (50) apparently healthy non-diabetic subjects. Standard analytical procedures were used for all the parameters measured including the effects of supplementation on Fasting Blood Glucose, oxidative stress marker (MDA), Reduced gluthathione and antioxidant vitamins (C, E and β-carotene) parameters were evaluated. The results revealed that th...
Tropical Journal of Natural Product Research, 2020
oxidative damage to membranes and may also enhance susceptibility to lipid peroxidation. 5,6 Trac... more oxidative damage to membranes and may also enhance susceptibility to lipid peroxidation. 5,6 Trace-element deficiencies or problems with its absorption are frequently associated to chronic diseases. Chronic hyperglycemia may cause significant alterations in the status of some micronutrients, and on the other hand, some of these nutrients can directly modulate glucose homeostasis. 7,8 The early imbalances of some specific metals may play a role in upsetting normal glucose and insulin metabolism. 9 Despite the great strides made in the understanding and management of diabetes, the disease and disease related complications remains unabated. Phytochemicals identified from traditional medicinal plants are presenting an exciting opportunity for the development of new types of therapeutics. 10 Epidemiological studies demonstrated that many phytonutrients from fruits might protect the human body against oxidative stress. It is a known fact that nutrition and health care are interrelated. Thus the consumption of natural antioxidant phytochemicals was noted to have potential health benefits. 11 Abelmoschus esculentus, 'AE" (Okra or lady"s finger) is a flowering plant in the mallow family. It is one of the most important vegetables widely cultivated throughout the tropical and temperate regions of the world for its tender fruits. 12 This plant is popular with its mucilaginous properties and has been acclaimed to have various health benefits which include anti-diabetic properties. 13 Okra is also known for being high in antioxidants activity as it is rich in phenolic compounds with important biological properties like quarcetin and flavonol derivatives, catechin oligomers and hydroxycinnamic derivatives. 14 The fruit of this particular plant is rich in nutrients like protein, niacin, riboflavin, thiamine, folate, vitamins A, B6, C and K, Phosphorus, Zinc, Copper, Potassium, Magnesium, Calcium, and Manganese all of which plays vital role in human diet and health.
This study used a national representative sample of 3380 household from the general household sur... more This study used a national representative sample of 3380 household from the general household survey-panel (GHS-Panel) to examine the causes and coping strategies among the rural households in Nigeria. The post-planting survey visit, which is the first round of its kind in Nigeria was carried out in (August-October, 2010), it was done immediately after planting season to collect information on land preparation, input and labour utilization. The results shown that soaring food prices and drought together constituted the highest causes of household food insecurity with about (42%) according to the household responses. The cumulative food insecurity strategy index (CSI) is an inverse function approach, which means that an increase in the use of coping strategies indicate a decrease in food security. The results reveal that, households within the age category of greater than or equals to 71 years are having the highest CSI (71.1%). While the least food insecure are the household heads w...
The manuscript reported the effects of antioxidant rich supplement (Alphabetic) on antioxidant en... more The manuscript reported the effects of antioxidant rich supplement (Alphabetic) on antioxidant enzymes (Catalase, Superoxidedismutase and Glutathione peroxidase) and minerals (Selenium, Copper, Zinc, Manganase and Chromium) status of one hundred (100) diabetic subjects attending Usmanu Danfodiyo University Teaching Hospital (UDUTH) for at least one year and the results were compared with those of fifty (50) diabetes mellitus non-supplemented and fifty (50) apparently healthy non-diabetic subjects.
European Journal of Medicinal Chemistry, 2021
Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases involved in cell cycle and transc... more Cyclin-dependent kinases (CDKs) are a family of Ser/Thr kinases involved in cell cycle and transcriptional regulation. CDK9 regulates transcriptional elongation and this unique property has made it a potential target for several diseases. Due to the conserved ATP binding site, designing selective CDK9 inhibitors has been challenging. Here we report our continued efforts in the optimization of 2,4,5-tri-substituted pyrimidine compounds as potent and selective CDK9 inhibitors. The most selective compound 30m was > 100-fold selective for CDK9 over CDK1 and CDK2. These compounds showed broad anti-proliferative activities in various solid tumour cell lines and patient-derived chronic lymphocytic leukaemia (CLL) cells. Decreased phosphorylation of the carboxyl terminal domain (CTD) of RNAPII at Ser-2 and down-regulation of anti-apoptotic protein Mcl-1 were confirmed in both the ovarian cancer model A2780 and patient-derived CLL cells. Scheme 1 Reagents and conditions: (a) i.
Journal of Pharmacy and Pharmacology Research, 2020
Background: Phyllanthus niruri is an annual plant that is widely used in Asia and Africa traditio... more Background: Phyllanthus niruri is an annual plant that is widely used in Asia and Africa traditionally for the treatment of various ailments such as Jaundice, Asthma, Hepatitis, Flu, Dropsy, Diabetes, Malaria, Hemorrhages, Diarrhea, and Anaemia. Objective: This study evaluates the haemotological and biochemical parameters of P. niruri i n 2 , 4dinitrophenylhydrazine-induced haemolytic anaemia in Wister rats for possible antianemic potential. Methods: This study evaluates the Antianaemic effect of the plant extract based on haemotological and biochemical parameters and body weight in 2,4-dinitrophenylhydrazine-induced haemolytic anaemia in Wister rats.
Journal of Cellular Neuroscience and Oxidative Stress, 2020
Generation of reactive oxygen species (ROS) during traumatic brain injury (TBI) has been identifi... more Generation of reactive oxygen species (ROS) during traumatic brain injury (TBI) has been identified as an important factor that is responsible for disease progression and cell death, particularly in secondary injury process. Ascorbic acid (AA) is an exogenous antioxidant that can be used to quench ROS in neurodegeneration. Its antioxidant properties have been reported in some neurodegenerative conditions in rats. In the present study, we examined the neurotherapeutic effects of AA in TBI induced rats. Three groups of seven rats each were used for this study. Group I was induced with TBI and treated with AA (67.5 mg/kg orally), group II was traumatized but not treated (TNT) while group III was neither traumatized nor treated (NTNT). Treatment started 30 min after TBI and lasted for 21 days. Morris water maze (MWM), Elevated plus maze, and Open field test were carried out. Antioxidant enzymes [(Superoxide dismutase (SOD), Catalase (CAT) Glutathion peroxidase (GPx)] and their gene expr...
Polymers, 2020
Supercapacitors are energy storage devices with high power density, rapid charge/discharge rate, ... more Supercapacitors are energy storage devices with high power density, rapid charge/discharge rate, and excellent cycle stability. Carbon-based supercapacitors are increasingly attracting attention because of their large surface area and high porosity. Carbon-based materials research has been recently centered on biomass-based materials due to the rising need to maintain a sustainable environment. Cellulose and lignin constitute the major components of lignocellulose biomass. Since they are renewable, sustainable, and readily accessible, lignin and cellulose-based supercapacitors are economically viable and environmentally friendly. This review aims to systematically analyze published research findings on electrospun lignin, cellulose, and lignin/cellulose nanofibers for use as supercapacitor electrode materials. A rigorous scientific approach was employed to screen the eligibility of relevant articles to be included in this study. The research questions and the inclusion criteria were...
Biochimie, 2019
Mesenchymal stromal cells (MSCs) and secretome are promising therapies for pulmonary arterial hyp... more Mesenchymal stromal cells (MSCs) and secretome are promising therapies for pulmonary arterial hypertension (PAH). This meta-analysis aimed to provide a precise estimate and compare the therapeutic efficacy of MSC and secretome in PAH. We searched six databases (CINAHL, Cochrane, Ovid Medline, PubMed, Science Direct and Scopus) until December 2018 using search terms related to MSCs, secretome and PAH. Twenty-three studies were included for the meta-analysis. The effect size of pulmonary hemodynamics and right ventricular hypertrophy markers was estimated using random effects model. MSCs and secretome significantly improved pulmonary hemodynamics and right ventricular hypertrophy compared to control. Comparison between MSCs and secretome indicate no significant difference in reducing right ventricular systolic pressure (RVSP) and medial wall thickening (MWT). However, treatment of PAH with secretome significantly improved mean pulmonary arterial pressure (mPAP) (p = 0.018) and right ventricular/left ventricular + septum (RV/LV+S) (p = 0.017) better than MSCs. Meta-regression shows that cell type (p = 0.034) is a predictor of MSCs to reduce RVSP in PAH. Similarly, the effect of secretome on MWT was significantly (p = 0.011) better at 4 weeks compared to 2 weeks of intervention. The overall risk of bias ranges from low to moderate; however, some of the essential elements required in reports of animal trials were not reported. There was evidence of publication bias for RV/LV+S and MWT, but not RVSP. This meta-analysis provides evidence of the therapeutic benefits of MSCs and secretome in PAH and the effect of secretome was similar or superior to MSCs.
International Journal of Livestock Research, 2016
A study was undertaken to investigate and compare the major ethnic groups (Hausa, Igbo and Yoruba... more A study was undertaken to investigate and compare the major ethnic groups (Hausa, Igbo and Yoruba) of Nigeria and their corresponding Sex classes (male and female) for perceived preference of salt in meat. Forty individuals from each ethnic group constituting twenty males and twenty female’s subjects were administered open ended questionnaires to generate data.120 subjects conveniently drawn from student population of Usmanu Danfodiyo University, Sokoto. The data obtained from the subjects were analyzed using descriptive statistics. There was no significant difference (P > 0.05) in perceived preference for salt in meat across all subjects, all ethnic groups attributed more salt intake to itself and all sex classes attributed it to females.
Oncotarget, Jan 30, 2014
Cdk9 is a key elongation factor for RNA transcription and functions by phosphorylating the C-term... more Cdk9 is a key elongation factor for RNA transcription and functions by phosphorylating the C-terminal domain of RNA polymerase II. Here we present direct evidence that cdk9 is important for cancer cell survival and describe the characterization of the potent cdk9 inhibitor CDKI-73 in primary human leukemia cells. CDKI-73 induced caspase-dependent apoptosis that was preceded by dephosphorylation of cdk9 and serine 2 of RNA polymerase II. CDKI-73 was more potent than the pan-cdk inhibitor flavopiridol and showed >200-fold selectivity against primary leukemia cells when compared with normal CD34+ cells. Furthermore, CDKI-73 was equipotent in poor prognostic sub-groups of leukemia patients and showed cytotoxic synergy with the nucleoside analog fludarabine. The Mechanism of synergy was associated with CDKI-73-mediated transcriptional inhibition of MCL1 and XIAP that was maintained when used in combination with fludarabine. Our data present a strong rationale for the development of cd...
Oncotarget, Jan 15, 2014
Dysregulation of cellular transcription and translation is a fundamental hallmark of cancer. As C... more Dysregulation of cellular transcription and translation is a fundamental hallmark of cancer. As CDK9 and Mnks play pivotal roles in the regulation of RNA transcription and protein synthesis, respectively, they are important targets for drug development. We herein report the cellular mechanism of a novel CDK9 inhibitor CDKI-73 in an ovarian cancer cell line (A2780). We also used shRNA-mediated CDK9 knockdown to investigate the importance of CDK9 in the maintenance of A2780 cells. This study revealed that CDKI-73 rapidly inhibited cellular CDK9 kinase activity and down-regulated the RNAPII phosphorylation. This subsequently caused a decrease in the eIF4E phosphorylation by blocking Mnk1 kinase activity. Consistently, CDK9 shRNA was also found to down-regulate the Mnk1 expression. Both CDKI-73 and CDK9 shRNA decreased anti-apoptotic proteins Mcl-1 and Bcl-2 and induced apoptosis. The study confirmed that CDK9 is required for cell survival and that ovarian cancer may be susceptible to C...
Journal of Mid-life Health, 2011
Background: Limitations in spinal mobility can interfere with the attainment of important functio... more Background: Limitations in spinal mobility can interfere with the attainment of important functional skills and activities of daily living and restrictions in spinal mobility are usually the earliest and reliable indicator of diseases. Objective: The aim of this study was to determine the differences of lumbar spinal mobility among healthy adults with advancing age. Materials and Methods: The modified Schober's method was used to measure anterior flexion. The guideline of the American Academy of Orthopaedic Surgeons was adapted to measure lateral flexion and extension. Results: The results of this study indicate that spinal mobility decreases with advancing age. The most significant (P < 0.05) differences occurred between the two youngest and the two oldest age categories. Conclusion: Using these data, we developed normative values of spinal mobility for each sex and age group. This study helps the clinicians to understand and correlate the restrictions of lumbar spinal mobility due to age and differentiate the limitations due to disease.
Journal of Medicinal Chemistry, 2011
Journal of Medicinal Chemistry, 2014
ON01910.Na is a highly effective anticancer agent that induces mitotic arrest and apoptosis. Clin... more ON01910.Na is a highly effective anticancer agent that induces mitotic arrest and apoptosis. Clinical studies with ON01910 in cancer patients have shown efficacy along with an impressive safety profile. While ON01910 is highly active against cancer cells, it has a low oral availability and requires continuous intravenous infusion or multiple gram doses to ensure sufficient drug exposure for biological activity in patients. We have identified two novel series of styrylsulfonyl-methylpyridines. Lead compounds 8, 9a, 18 and 19a are highly potent mitotic inhibitors and selectively cytotoxic to cancer cells. Impressively, these compounds possess excellent pharmaceutical properties and two lead drug candidates 9a and 18 demonstrated antitumor activities in animal models.
Journal of Medicinal Chemistry, 2013
Cancer cells often have a high demand for antiapoptotic proteins in order to resist programmed ce... more Cancer cells often have a high demand for antiapoptotic proteins in order to resist programmed cell death. CDK9 inhibition selectively targets survival proteins and reinstates apoptosis in cancer cells. We designed a series of 4-thiazol-2anilinopyrimidine derivatives with functional groups attached to the C5-position of the pyrimidine or to the C4-thiazol moiety and investigated their effects on CDK9 potency and selectivity. One of the most selective compounds, 12u inhibits CDK9 with IC 50 = 7 nM and shows over 80-fold selectivity for CDK9 versus CDK2. X-ray crystal structures of 12u bound to CDK9 and CDK2 provide insights into the binding modes. This work, together with crystal structures of selected inhibitors in complex with both enzymes described in a companion paper, 34 provides a rationale for the observed SAR. 12u demonstrates potent anticancer activity against primary chronic lymphocytic leukemia cells with a therapeutic window 31-and 107-fold over those of normal Band T-cells.
Diabetes, 2006
Transcription factor 7-like 2 (TCF7L2) is part of the Wnt signaling pathway. Genetic variants wit... more Transcription factor 7-like 2 (TCF7L2) is part of the Wnt signaling pathway. Genetic variants within TCF7L2 on chromosome 10q were recently reported to be associated with type 2 diabetes in Icelandic, Danish, and American (U.S.) samples. We previously observed a modest logarithm of odds score of 0.61 on chromosome 10q, ∼1 Mb from TCF7L2, in the Finland-United States Investigation of NIDDM Genetics study. We tested the five associated TCF7L2 single nucleotide polymorphism (SNP) variants in a Finnish sample of 1,151 type 2 diabetic patients and 953 control subjects. We confirmed the association with the same risk allele (P value <0.05) for all five SNPs. Our strongest results were for rs12255372 (odds ratio [OR] 1.36 [95% CI 1.15–1.61], P = 0.00026) and rs7903146 (1.33 [1.14–1.56], P = 0.00042). Based on the CEU HapMap data, we selected and tested 12 additional SNPs to tag SNPs in linkage disequilibrium with rs12255372. None of these SNPs showed stronger evidence of association tha...
Bioorganic & Medicinal Chemistry Letters, 2007
Synthesis and preliminary in vitro biological evaluation of a selective high-affinity CRTH2 antag... more Synthesis and preliminary in vitro biological evaluation of a selective high-affinity CRTH2 antagonist is described. The stability of an N-benzyl group facilitated synthesis of the corresponding radioligand by tritiation of a brominated precursor. The compound [ 3 H]TRQ11238 represents the first selective CRTH2 antagonist radioligand and exhibited a specific radioactivity of 52 Ci/mmol and a pK d of 9.0.
Uploads
Papers by abdullahi Abbas