Papers by Paulina Ziółkowska
Scientific Reports
SAGIT is an instrument created for the clinical assessment of acromegaly. Our objective was to te... more SAGIT is an instrument created for the clinical assessment of acromegaly. Our objective was to test the usefulness of this tool in assessing disease activity of acromegalic patients in a single centre of Poznan, Poland using a retrospective study. Medical records of patients with acromegaly hospitalised at the Department of Endocrinology, Metabolism and Internal Medicine of Poznan University of Medical Sciences in Poland between January 2015 and December 2020 were analysed. SAGIT scores were assessed according to each patient's clinical and biochemical data. The results show that SAGIT scores were higher in treatment-naïve patients and the lowest in controlled patients. There were positive correlations between SAGIT scores and concentrations of calcium, phosphorus, HbA1C levels, and tumour invasiveness at the time of diagnosis. However, parameters such as age, vitamin D concentration, and time from diagnosis showed an inverse relationship with the SAGIT score. In ROC curve analy...
Therapeutic Advances in Endocrinology and Metabolism
Purpose: The role of nicotinamide phosphoribosyltransferase (NAMPT)/visfatin in a more aggressive... more Purpose: The role of nicotinamide phosphoribosyltransferase (NAMPT)/visfatin in a more aggressive course of many malignancies has been proven. Previous studies have noticed the importance of visfatin in thyroid neoplastic tissue, but the diagnostic and prognostic value of its serum concentration has not been investigated so far. Our study aimed to consider whether extracellular NAMPT (eNAMPT) could be a potential serum marker in recurrent papillary thyroid cancer (PTC). Methods: It was a prospective observational study with consecutive enrolment. We recruited 100 patients with PTC after thyroidectomy with postoperative 131I ablation and 100 healthy controls. Also, 50 randomly selected patients underwent laboratory assessment (including eNAMPT serum concentration by ELISA Assay Kit, TSH, free thyroid hormones, TSH-stimulated thyroglobulin Tg, antibodies – TgAbs, TPOAb) and body composition analysis twice: at admission and 6 months after being on suppressive levothyroxine doses. TSH-s...
Oncology Letters, 2021
Recent studies have revealed the significant role of SMYD3 and EZH2 genes in the development and ... more Recent studies have revealed the significant role of SMYD3 and EZH2 genes in the development and aggressiveness of numerous types of malignant tumor. Therefore, the present study aimed to investigate the expression of SMYD3 and EZH2 in papillary thyroid cancer, and to determine the correlation between the expression of these genes and clinical characteristics. Resected thyroid tissue samples from 62 patients with papillary thyroid cancer were investigated. Thyroid tissue derived from the healthy regions of removed nodular goiters from 30 patients served as the control group. Reverse transcription-quantitative PCR analysis was employed to detect relative mRNA expression levels. Primer sequences and TaqMan ® hydrolysis probe positions for EZH2 and SMYD3 were determined using the Roche Universal ProbeLibrary Assay Design Center version 2.50. EZH2 expression was detected in all thyroid cancer samples and in 83.3% of benign lesions. Notably, EZH2 was revealed to be upregulated in thyroid cancer tissues compared with control tissues (P=0.0002). EZH2 expression was positively correlated with tumor stage (P<0.0001; r= 0.504), and multiple comparison analysis revealed that the highest expression of EZH2 was detected in samples staged pT4 (P= 0.0001). SMYD3 expression was detected in all thyroid cancer samples and in 96.7% of healthy thyroid tissues; notably, the expression levels were similar in both groups. In addition, there was no correlation between SMYD3 expression and the aggressiveness of papillary thyroid cancer. In conclusion, overexpression of the EZH2 gene may be associated with the development of papillary thyroid cancer and EZH2 may be a potential therapeutic target in papillary thyroid cancer.
Endocrine Connections, 2021
Dysregulation of thyroid function has known impact on body metabolism, however, data regarding me... more Dysregulation of thyroid function has known impact on body metabolism, however, data regarding metabolic outcome after restoration of thyroid function is limited. Therefore, the aim of the study was to investigate the effect of restoration of euthyroidism on serum visfatin, and its associations with insulin resistance and body composition. This is an observational study with consecutive enrollment. Forty-nine hyperthyroid (median age of 34 years) and 44 hypothyroid women (median age of 46 years) completed the study. Laboratory parameters and body composition analysis were assessed before and after the therapy. In the hyperthyroid group, visfatin concentrations increased (P < 0.0001), while glucose concentrations decreased (P < 0.0001). Total body mass and fat mass in the trunk and limbs significantly increased during the treatment. In the hypothyroid group, significant weight loss resulted from decrease of fat and muscle masses in trunk and limbs. Visfatin serum concentrations...
European review for medical and pharmacological sciences, 2021
OBJECTIVE Chemicals that disrupt the endocrine homeostasis of the human body, otherwise known as ... more OBJECTIVE Chemicals that disrupt the endocrine homeostasis of the human body, otherwise known as endocrine disruptors (EDCs), are found in the blood, urine, amniotic fluid, or adipose tissue. This paper presents the current knowledge about EDCs and the reproductive system. MATERIALS AND METHODS The article is an overview of the impact of EDCs and their mechanism of action, with particular emphasis on gonads, based on the information available on medical databases (PubMed, Web of Science, EMBASE and Google Scholar, EMBASE and Web of Science) until May 2021. RESULTS EDCs occur in everyday life, e.g., they are components of adhesives, brake fluids, and flame retardants; they are used in the production of polyvinyl chloride (PVC), plastic food boxes, pacifiers, medicines, cosmetics (bisphenol A, phthalates), hydraulic fluids, printing inks (polychlorinated biphenyls - PCBs), receipts (bisphenol A, BSA) and raincoats (phthalates); they are also a component of polyvinyl products (e.g. toy...
Scientific Reports, 2021
Thyroid diseases may cause a variety of functional and structural body changes, including eye and... more Thyroid diseases may cause a variety of functional and structural body changes, including eye and vision abnormalities, which can have a negative impact on a patient’s well-being. However, only a few studies on the impact of other benign thyroid diseases on the visual process are available in the literature. In this study, using the Polish version of the thyroid-specific quality of life (ThyPROpl) questionnaire, we aimed to determine the self-reported influence of benign thyroid diseases (e.g., nodular goiter, toxic nodular goiter, Graves’ disease, thyroid orbitopathy, Hashimoto’s thyroiditis, and surgical hypothyroidism) on patients’ eyes and vision. This was a prospective study. In total, 374 randomly selected euthyroid patients and 255 control subjects responded to the ThyPROpl questionnaire and the results were evaluated. Nearly 69% of the respondents reported that the most frequent condition was “reduced sight.” Men most often reported wet/tearing eyes (66%). The occurrence of ...
Background We aimed to investigate the effect of restoration of euthyroidism on serum visfatin in... more Background We aimed to investigate the effect of restoration of euthyroidism on serum visfatin in severe thyroid dysfunction, and its associations with insulin resistance and body composition. Methods This was an observational study with consecutive enrollment. We included females newly diagnosed with overt hypo- or hyperthyroidism caused by autoimmune thyroid diseases. Laboratory parameters and body composition analysis were assessed before and after the therapy. Results Initially, 105 females were enrolled: 49 hyperthyroid (median age of 34 years) and 44 hypothyroid (median age of 46) completed the study. In the hyperthyroid group, visfatin levels increased (
Polish Archives of Internal Medicine, 2018
Introduction:Goiter recurrence occurs in a substantial number of patients after thyroid resection... more Introduction:Goiter recurrence occurs in a substantial number of patients after thyroid resection. Objectives:We aimed to investigate the prevalence and risk factors of recurrent goiters, influence of goiter recurrence on patient quality of life (QoL) and the efficacy of therapy with radioactive iodine (RAI). Patients and Methods:This was a case-control study. All thyroidectomized patients admitted within the past year to the outpatient department were included in the study and their medical records were analyzed. Recurrence was defined as nodular lesions within the remnant tissue or enlargement of the remaining thyroid tissue which required therapy (reoperation or radioiodine). Clinical and biochemical data were collected. Randomly selected patients were asked to answer ThyPROpl for health-related QoL assessment; 30 healthy subjects were recruited for comparison. Results:481 out of 538 patients were included in the study: 68 patients with a recurrent goiter and 413 without recurrence. Higher TSH at follow-up and lobectomy were the strongest risk factors for goiter recurrence, followed by a longer observation period. Postoperative LT4 therapy was associated with a lower risk of recurrence. Efficacy of RAI was similar to secondary thyroidectomy. Scores in all comparable scales for patients with recurrent goiters were significantly worse than those in the general population. Conclusions: Lobectomies should be avoided as a primary surgical treatment for benign thyroid diseases, and levothyroxine therapy should be individually considered in each patient.Radioiodine therapy seems to be a safe and effective treatment option for recurrent goiters. Recurrent goiters, although successfully treated, have a negative impact on QoL.
Polish Archives of Internal Medicine, 2016
Statistical analysis A statistical analysis was performed with MedCalc version 15.8 (MedCalc Soft... more Statistical analysis A statistical analysis was performed with MedCalc version 15.8 (MedCalc Software bvba, Ostend, Belgium). Normality was analyzed by the Shapiro-Wilk test. Variables with normal distribution were compared using the paired samples t test. When data did not follow normal distribution, comparisons of analyzed
Thyroid Research, 2016
Declarations Ethics approval and consent to participate Not applicable Consent for publication No... more Declarations Ethics approval and consent to participate Not applicable Consent for publication Not applicable Availability of data and materials Not applicable Competing interests The author declares no conflict of interests. Funding Not applicable Peer review This short paper underwent the journal's standard peer review process for supplements.
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Papers by Paulina Ziółkowska