Grundsätzlich sind die Erfolge von Impfungen und Impfprogrammen für die Prävention von Infektions... more Grundsätzlich sind die Erfolge von Impfungen und Impfprogrammen für die Prävention von Infektionskrankheiten und deren Komplikationen weltweit anerkannt. Dennoch fällt aktuell gerade in industrialisierten Staaten ein Vertrauensschwund auf: Impfungen und öffentlich empfohlene Impfprogramme werden immer weniger wahrgenommen. Stichwort "Impfskepsis". Die WHO sieht darin mittlerweile ein komplexes globales Problem. Doch wie ist es lösbar? DEFINITION Unter Impfskepsis ("vaccine hesitancy") versteht die Weltgesundheitsorganisation (WHO) eine verzögerte Akzeptanz von Impfungen bis hin zur vollständigen Ablehnung von Impfprogrammen.
Acute respiratory tract infections (ARI) contribute the highest burden of disease in children to ... more Acute respiratory tract infections (ARI) contribute the highest burden of disease in children to date.Besides the high incidence in outpatients,ARI are important causes of hospital admission and possibly chronic disease. There are numerous diseases as well as numerous pathogens.Individual risk factors such as the age-specific immunity and epidemiological variables determine the high disease burden.Children also play a key role in the epidemiology in the referring total population.There were no precise,pathogen-specific data so far for Germany,but epidemiologic data on several airway viruses were published recently.The population-based incidence of community-acquired pneumonia, RSV-and Influenza-positive hospitalizations was in the same range as reported from neighborhood countries and the US.Also the epidemiology of parainfluenza-,adeno-and enteroviruses seems to be very similar to these countries.Precise data are important for individual care as well as intervention strategies in public health,such as the planning and priority setting of immunization recommendations.A newly created webbased early warning system organized by the network PID-ARI.Net sponsored by the German Ministry for Education and Research (BMBF) is expected to keep the medical community up to date on these pathogens.
* Hochrechnung basierend auf 2 Fällen, daher mit großer Unsicherheit behaftet; ** Spikevax wird i... more * Hochrechnung basierend auf 2 Fällen, daher mit großer Unsicherheit behaftet; ** Spikevax wird in Kanada und den USA ab dem Alter ≥ 18 Jahren eingesetzt
Das Leitsymptom Fieber ist einer der häufigsten Gründe für die Inanspruchnahme des Gesundheitssys... more Das Leitsymptom Fieber ist einer der häufigsten Gründe für die Inanspruchnahme des Gesundheitssystems in der Pädiatrie. In den meisten Fällen handelt es sich um harmlose und selbstlimitierende, meist durch eine Infektion bedingte Erkrankungen.
Prof. Dr. Fred Zepp Universitätsmedizin Mainz, Mainz Sind Sie als Kinderärztin/Kinderarzt mit Ihr... more Prof. Dr. Fred Zepp Universitätsmedizin Mainz, Mainz Sind Sie als Kinderärztin/Kinderarzt mit Ihrer IT-Ausstattung an Ihrem Arbeitsplatz in Praxis oder Klinik zufrieden? Haben Sie das Gefühl, dass digitale Systeme Sie in Ihrem Alltag konzeptionell unterstützen und zu einer Arbeitszeitersparnis führen? – Die Nutzung elektronischer oder digitaler Datenerfassungsund Übertragungssysteme hat sich in den letzten 30 Jahren radikal gewandelt. Erste dezentrale Computersysteme zur Erstellung von Arztbriefen, analogemedizinische Bilddokumentation, die Faksimile-Übertragung und das kollegiale Telefonat wurden abgelöst durch zentral vernetzte Patientendokumentationssysteme, Videokommunikation, komplette elektronische Datenerstellung und -verarbeitung. Medizinische Patienteninformationen werden in großen Datenbanken innerhalb der Versorger archiviert. In Medien und Politik werden seit Langem die digitale Patienten-Chipkarte, die Vernetzung von ambulanter und stationärer Versorgung sowie die digit...
Increases in the world’s population and population density promote the spread of emerging pathoge... more Increases in the world’s population and population density promote the spread of emerging pathogens. Vaccines are the most cost-effective means of preventing this spread. Traditional methods used to identify and produce new vaccines are not adequate, in most instances, to ensure global protection. New technologies are urgently needed to expedite large scale vaccine development. mRNA-based vaccines promise to meet this need. mRNA-based vaccines exhibit a number of potential advantages relative to conventional vaccines, namely they (1) involve neither infectious elements nor a risk of stable integration into the host cell genome; (2) generate humoral and cell-mediated immunity; (3) are well-tolerated by healthy individuals; and (4) are less expensive and produced more rapidly by processes that are readily standardized and scaled-up, improving responsiveness to large emerging outbreaks. Multiple mRNA vaccine platforms have demonstrated efficacy in preventing infectious diseases and tre...
Perfluoroalkyl substances (PFASs) are a complex group of man-made chemicals with high stability a... more Perfluoroalkyl substances (PFASs) are a complex group of man-made chemicals with high stability and mobility leading to ubiquitous environmental contamination and accumulation in the food chain. In human serum/plasma samples, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are the lead compounds. They are immunotoxic in experimental animals, and epidemiological studies provided evidence of a diminished production of vaccine antibodies in young children. However, information on children of the first year of age is missing but relevant, as they have a relatively high exposure if breastfed, and may have a higher susceptibility as their immune system is developing. In a cross-sectional study with 101 healthy 1-year-old children, internal levels of persistent organic pollutants and a broad panel of biological parameters were investigated at the end of the 1990s. Additional analysis of PFASs resulted in plasma levels (mean ± SD) of PFOA and PFOS of 3.8 ± 1.1 and 6.8 ± 3...
Background paper to the decision to recommend the vaccination with the inactivated herpes zoster ... more Background paper to the decision to recommend the vaccination with the inactivated herpes zoster subunit vaccine Statement of the German Standing Committee on Vaccination (STIKO) at the Robert Koch Institute
Bekanntmachungen-Amtliche Mitteilungen In June 2018 the German Standing Committee on Vaccination ... more Bekanntmachungen-Amtliche Mitteilungen In June 2018 the German Standing Committee on Vaccination (STIKO) endorsed the following recommendation: The STIKO recommends vaccination of boys aged 9-14 years against human papillomavirus (HPV). Immunization should take place before the first sexual contact. Like HPV vaccination for girls, two vaccine doses at least 5 months apart are needed at the age of 9-14 years. If the first HPV vaccine dose is given at the age of 15 years or older, three vaccine doses are needed. Catch-up vaccination should take place up to the age of 17 years. The aim of vaccinating girls and boys is to reduce the disease burden of HPV-associated tumours. This paper presents the scientific background of this recommendation, including the results of literature reviews and the grading of the quality of the available evidence. A German version of this paper is available in the Epidemiologische Bulletin 26/2018 [1].
International Archives of Allergy and Immunology, 1999
Drug Dosage The authors and the publisher have exerted every effort to ensure that drug selection... more Drug Dosage The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center (see 'General Information').
Summary The effects of the swine lymphocyte antigen (SLA) system on different performance traits ... more Summary The effects of the swine lymphocyte antigen (SLA) system on different performance traits were investigated in Swiss pig breeds. Litter size and piglet weight at birth and at weaning were considered and in gilts the average daily weight gain, backfat and muscle thickness as well as percentage valuable cuts were measured. These data were analysed with least squares procedures. Although the effect of SLA on these traits was very small, a few haplotypes seemed to have some influence. Sows of the Large White breed carrying H12 had a significant smaller and those with H24 had a bigger litter size at weaning. Some mating studies were performed to investigate the effects of SLA homozygosity. The obtained results suggest that this has a negative effect on the litter size, especially when H19 in the Large White breed and H7 in Landrace are involved.
Grundsätzlich sind die Erfolge von Impfungen und Impfprogrammen für die Prävention von Infektions... more Grundsätzlich sind die Erfolge von Impfungen und Impfprogrammen für die Prävention von Infektionskrankheiten und deren Komplikationen weltweit anerkannt. Dennoch fällt aktuell gerade in industrialisierten Staaten ein Vertrauensschwund auf: Impfungen und öffentlich empfohlene Impfprogramme werden immer weniger wahrgenommen. Stichwort "Impfskepsis". Die WHO sieht darin mittlerweile ein komplexes globales Problem. Doch wie ist es lösbar? DEFINITION Unter Impfskepsis ("vaccine hesitancy") versteht die Weltgesundheitsorganisation (WHO) eine verzögerte Akzeptanz von Impfungen bis hin zur vollständigen Ablehnung von Impfprogrammen.
Acute respiratory tract infections (ARI) contribute the highest burden of disease in children to ... more Acute respiratory tract infections (ARI) contribute the highest burden of disease in children to date.Besides the high incidence in outpatients,ARI are important causes of hospital admission and possibly chronic disease. There are numerous diseases as well as numerous pathogens.Individual risk factors such as the age-specific immunity and epidemiological variables determine the high disease burden.Children also play a key role in the epidemiology in the referring total population.There were no precise,pathogen-specific data so far for Germany,but epidemiologic data on several airway viruses were published recently.The population-based incidence of community-acquired pneumonia, RSV-and Influenza-positive hospitalizations was in the same range as reported from neighborhood countries and the US.Also the epidemiology of parainfluenza-,adeno-and enteroviruses seems to be very similar to these countries.Precise data are important for individual care as well as intervention strategies in public health,such as the planning and priority setting of immunization recommendations.A newly created webbased early warning system organized by the network PID-ARI.Net sponsored by the German Ministry for Education and Research (BMBF) is expected to keep the medical community up to date on these pathogens.
* Hochrechnung basierend auf 2 Fällen, daher mit großer Unsicherheit behaftet; ** Spikevax wird i... more * Hochrechnung basierend auf 2 Fällen, daher mit großer Unsicherheit behaftet; ** Spikevax wird in Kanada und den USA ab dem Alter ≥ 18 Jahren eingesetzt
Das Leitsymptom Fieber ist einer der häufigsten Gründe für die Inanspruchnahme des Gesundheitssys... more Das Leitsymptom Fieber ist einer der häufigsten Gründe für die Inanspruchnahme des Gesundheitssystems in der Pädiatrie. In den meisten Fällen handelt es sich um harmlose und selbstlimitierende, meist durch eine Infektion bedingte Erkrankungen.
Prof. Dr. Fred Zepp Universitätsmedizin Mainz, Mainz Sind Sie als Kinderärztin/Kinderarzt mit Ihr... more Prof. Dr. Fred Zepp Universitätsmedizin Mainz, Mainz Sind Sie als Kinderärztin/Kinderarzt mit Ihrer IT-Ausstattung an Ihrem Arbeitsplatz in Praxis oder Klinik zufrieden? Haben Sie das Gefühl, dass digitale Systeme Sie in Ihrem Alltag konzeptionell unterstützen und zu einer Arbeitszeitersparnis führen? – Die Nutzung elektronischer oder digitaler Datenerfassungsund Übertragungssysteme hat sich in den letzten 30 Jahren radikal gewandelt. Erste dezentrale Computersysteme zur Erstellung von Arztbriefen, analogemedizinische Bilddokumentation, die Faksimile-Übertragung und das kollegiale Telefonat wurden abgelöst durch zentral vernetzte Patientendokumentationssysteme, Videokommunikation, komplette elektronische Datenerstellung und -verarbeitung. Medizinische Patienteninformationen werden in großen Datenbanken innerhalb der Versorger archiviert. In Medien und Politik werden seit Langem die digitale Patienten-Chipkarte, die Vernetzung von ambulanter und stationärer Versorgung sowie die digit...
Increases in the world’s population and population density promote the spread of emerging pathoge... more Increases in the world’s population and population density promote the spread of emerging pathogens. Vaccines are the most cost-effective means of preventing this spread. Traditional methods used to identify and produce new vaccines are not adequate, in most instances, to ensure global protection. New technologies are urgently needed to expedite large scale vaccine development. mRNA-based vaccines promise to meet this need. mRNA-based vaccines exhibit a number of potential advantages relative to conventional vaccines, namely they (1) involve neither infectious elements nor a risk of stable integration into the host cell genome; (2) generate humoral and cell-mediated immunity; (3) are well-tolerated by healthy individuals; and (4) are less expensive and produced more rapidly by processes that are readily standardized and scaled-up, improving responsiveness to large emerging outbreaks. Multiple mRNA vaccine platforms have demonstrated efficacy in preventing infectious diseases and tre...
Perfluoroalkyl substances (PFASs) are a complex group of man-made chemicals with high stability a... more Perfluoroalkyl substances (PFASs) are a complex group of man-made chemicals with high stability and mobility leading to ubiquitous environmental contamination and accumulation in the food chain. In human serum/plasma samples, perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) are the lead compounds. They are immunotoxic in experimental animals, and epidemiological studies provided evidence of a diminished production of vaccine antibodies in young children. However, information on children of the first year of age is missing but relevant, as they have a relatively high exposure if breastfed, and may have a higher susceptibility as their immune system is developing. In a cross-sectional study with 101 healthy 1-year-old children, internal levels of persistent organic pollutants and a broad panel of biological parameters were investigated at the end of the 1990s. Additional analysis of PFASs resulted in plasma levels (mean ± SD) of PFOA and PFOS of 3.8 ± 1.1 and 6.8 ± 3...
Background paper to the decision to recommend the vaccination with the inactivated herpes zoster ... more Background paper to the decision to recommend the vaccination with the inactivated herpes zoster subunit vaccine Statement of the German Standing Committee on Vaccination (STIKO) at the Robert Koch Institute
Bekanntmachungen-Amtliche Mitteilungen In June 2018 the German Standing Committee on Vaccination ... more Bekanntmachungen-Amtliche Mitteilungen In June 2018 the German Standing Committee on Vaccination (STIKO) endorsed the following recommendation: The STIKO recommends vaccination of boys aged 9-14 years against human papillomavirus (HPV). Immunization should take place before the first sexual contact. Like HPV vaccination for girls, two vaccine doses at least 5 months apart are needed at the age of 9-14 years. If the first HPV vaccine dose is given at the age of 15 years or older, three vaccine doses are needed. Catch-up vaccination should take place up to the age of 17 years. The aim of vaccinating girls and boys is to reduce the disease burden of HPV-associated tumours. This paper presents the scientific background of this recommendation, including the results of literature reviews and the grading of the quality of the available evidence. A German version of this paper is available in the Epidemiologische Bulletin 26/2018 [1].
International Archives of Allergy and Immunology, 1999
Drug Dosage The authors and the publisher have exerted every effort to ensure that drug selection... more Drug Dosage The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center (see 'General Information').
Summary The effects of the swine lymphocyte antigen (SLA) system on different performance traits ... more Summary The effects of the swine lymphocyte antigen (SLA) system on different performance traits were investigated in Swiss pig breeds. Litter size and piglet weight at birth and at weaning were considered and in gilts the average daily weight gain, backfat and muscle thickness as well as percentage valuable cuts were measured. These data were analysed with least squares procedures. Although the effect of SLA on these traits was very small, a few haplotypes seemed to have some influence. Sows of the Large White breed carrying H12 had a significant smaller and those with H24 had a bigger litter size at weaning. Some mating studies were performed to investigate the effects of SLA homozygosity. The obtained results suggest that this has a negative effect on the litter size, especially when H19 in the Large White breed and H7 in Landrace are involved.
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Papers by Fred Zepp