Skip to main content

Feyza Yurt

Followers

0

Following

1

Public Views

Interests

Uploads

Papers by Feyza Yurt

The role of thiol-disulfide and ischemia-modified albumin levels in the diagnosis of childhood appendicitis

Anatolian Current Medical Journal

Aim: The accurate diagnosis of acute appendicitis can be achieved by a combination of evaluation ... more Aim: The accurate diagnosis of acute appendicitis can be achieved by a combination of evaluation of clinical symptoms, physical examination findings and history taking, but is still challenging for the clinician. Some biochemical markers have been evaluated for the purpose of increasing the diagnostic accuracy rate for appendicitis. In this study, our aim is to evaluate the diagnostic value of thiol-disulfide levels and IMA, in pediatric patients with suspected acute appendicitis. Materials And Methods: The children (1-17 years age) who were admitted to our clinic for suspected acute appendicitis between March 2017 and September 2017 were evaluated. A total of 238 children are enrolled in the study; 119 were operated for suspected acute appendicitis and the 119 children who did not have appendicitis constituted the control group. Serum levels of native thiol (-SH), total thiol (SH + SS), dynamic disulfide (SS), dynamic disulfide (SS)/total thiol (SH + SS) ratio, albumin, ischemic mo...

The strong relationship between disease severity and thiol-disulphide homeostasis in patients with restless legs syndrome

Ortadoğu Tıp Dergisi, 2018

Amac: Bu calisma, primer huzursuz bacak sendromu (RLS) hastalarinda yeni bir oksidatif stres beli... more Amac: Bu calisma, primer huzursuz bacak sendromu (RLS) hastalarinda yeni bir oksidatif stres belirteci olan tiyol-disulfid homeostazisini arastirmak amaciyla yapildi. Gerec ve Yontem: Otuz sekiz hasta ve 43 saglikli birey calismaya alindi. Serum nativ tiyol, total tiyol, disulfit ve disulfid / nativ tiyol oranlari yeni bir otomatik yontem kullanilarak olculmustur. RLS tanisi Uluslararasi Huzursuz Bacak Sendromu Calisma Grubu (IRLSSG) tarafindan onerilen kriterlere gore konuldu ve RLS siddeti IRLSSG Şiddet Olcegi kullanilarak degerlendirildi. Bulgular: Serum nativ tiyol ve total tiyol duzeyleri anlamli derecede dusuk (sirasiyla p<0.001; p=0.007), disulfid ve disulfid / nativ tiyol orani anlamli olarak daha yuksekti (sirasiyla p=0.017; p<0.001). RLS kontrol grubu ile karsilastirildi. IRLSSG Onem Olcegi ve tiyol-disulfid homeostasisi parametreleri arasinda anlamli korelasyonlar bulundu (r=-0.56, nativ tiyol icin p<0.001; total tiyol icin r=-0.51, p<0.001; disulfid icin r=0....

Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression

Clinical Psychopharmacology and Neuroscience, 2020

Objective: Bipolar disorder and unipolar depressive disorder are complex phenotypes. There appear... more Objective: Bipolar disorder and unipolar depressive disorder are complex phenotypes. There appear to be phenotypical, mechanistic, and therapeutic differences between bipolar depression (BD) and unipolar depression (UD). There is a need for understanding the underlying biological variation between these clinical entities. The role of oxidative processes underlying bipolar disorder and depression has been demonstrated. Thiol-disulfide homeostasis (TDH) is a recent oxidative stress marker. In this study, we aimed to inspect patients with bipolar depression and unipolar depression in terms of thiol-disulfide balance and to compare them with healthy controls. Methods: Patients admitted to the outpatient clinic of Ankara Numune Training and Research Hospital and diagnosed either as a depressive episode with bipolar disorder (n = 37) or unipolar depression (n = 24) according to DSM-5 criteria, along with healthy controls (HC) (n = 50), were included in the study. Native thiol, total thiol, and disulfide levels were compared across the groups. Results: In comparison to HC, both BD and UD groups had higher disulfide levels, disulfide/native thiol ratio, and disulfide/total thiol ratio. No significant differences between BD and UD were detected in terms of disulfide level, disulfide/native thiol ratio, and disulfide/total thiol ratio. Conclusion: Increased levels of disulfide, native thiol, and disulfide/total thiol ratios compared to healthy controls in both UD and BD groups may be indicative of the presence of oxidative damage in these two clinical conditions. To clarify the role of oxidative stress in the pathophysiology of depressive disorders and investigate TDH, longitudinal studies in patients with medication-free UD and BD are required.

Investigation of dysfunctional HDL using myeloperoxidase / paraoxonase ratio in lymphoma

Harran Üniversitesi Tıp Fakültesi Dergisi, 2019

Background: The aim of this study is to investigate the myeloperoxidase/paraoxonase ratio which i... more Background: The aim of this study is to investigate the myeloperoxidase/paraoxonase ratio which indicates dysfunction of high-density lipoprotein in various types of lymphoma characterized by abnormal lipid metabolism, oxidative stress, and inflammation. Methods: Thirty lymphoma patients and 30 healthy subjects were enrolled in this study. Serum myeloperoxidase, paraoxonase, arylesterase, lipid hydroperoxide and routine biochemistry tests levels were measured on an automated analyzer. The diagnosis of lymphoma patients was made according to the histological examination of the biopsy material. Results: Compared with healthy control group; the albumin, arylesterase, high-density lipoprotein, thiol, and Hemoglobin levels were significantly lower while myeloperoxidase / paraoxonase, myeloperoxidase/arylesterase, and lipid hydroperoxide levels were significantly higher, in patients with lymphoma. Also, lipid hydroperoxide level was significantly correlated with myeloperoxidase / paraoxon...

The strong relationship between disease severity and thiol-disulphide homeostasis in patients with restless legs syndrome

Ortadoğu Tıp Dergisi, 2018

The strong relationship between disease severity and thiol-disulphide homeostasis in patients wit... more

Does extracorporeal shockwave lithotripsy therapy affect thiol-disulfide homeostasis?

Pakistan journal of medical sciences

Extracorporeal Shockwave Lithotripsy (ESWL) is a non-invasive method that is effective at crushin... more Extracorporeal Shockwave Lithotripsy (ESWL) is a non-invasive method that is effective at crushing stones in the upper urinary tract. Disturbance of the thiol/disulfide homeostasis, in favor of the disulfide, has been shown to be involved in the disease pathogenesis. A total of 36 individuals that underwent ESWL had blood samples collected before ESWL (0hrs), 6hrs, and one week after the ESWL. Sera native and total as wells as disulfide amount was measured using an automated method sodium borohydrate (NaBH) reduction. In addition, Ischemia Modified Albumin (IMA) levels were measured using colorimetric assay method. Native thiol level was reduced at the 6th hour following ESWL compared to baseline. While the ratios of disulfide level, Disulfide/Total Thiol (DTT), Disulfide/Native Thiol (DNT) and IMA level were increased at the 6th hour following ESWL compared to baseline, they were found to be similar with their baseline values at the end of 1st week. Total thiol and native /total th...

The Variation of Disulfides in the Progression of Type 2 Diabetes Mellitus

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, Jan 29, 2018

The purpose of this study was to examine thiol-disulfide balance in patients with type 2 diabetes... more The purpose of this study was to examine thiol-disulfide balance in patients with type 2 diabetes mellitus. This study included 32 subjects with known type 2 diabetes mellitus without complications, 30 patients with type 2 diabetes mellitus with complications, 28 newly diagnosed patients with type 2 diabetes mellitus, and 45 healthy individuals. Thiol-disulfide profile tests were quantified in all groups. Compared to the control group, patients in each of the diabetic groups had significantly lower native and total thiol levels, higher disulfide levels, and higher disulfide/native thiol and disulfide/total thiol ratios (<0.05 for all). Disulfide levels were significantly lower in the newly diagnosed group than in other diabetic groups (<0.05). There were significant associations between glycemic parameters and thiol-disulfide tests (<0.05). A disequilibrium between thiol-disulfide pairs occurs in patients with type 2 diabetes mellitus, and a gradual increase to disulfide le...

Serum Lipase / Amylase Activity Ratio for Screening Insulin Resistance

Tıpta Yenilikçi Yaklaşımlar Dergisi, 2021

Early diagnosis of insulin resistance (IR) is important to prevent the development of type 2 diab... more Early diagnosis of insulin resistance (IR) is important to prevent the development of type 2 diabetes mellitus (DM). Type 2 DM is mainly considered as an endocrine disorder however some recent studies show that exocrine functions of the pancreas are insufficient in type 2 DM. Our aim in this study to evaluate the relation of insulin resistance with pancreatic exocrine functions. Fasting glucose, insulin, amylase, lipase, HbA1c, and demographic information of subjects were taken from the laboratory information system. Children and the diabetic subjects were excluded. Included subjects were separated according to the insulin sensitivity status determined by homeostatic model assessment. There were 335 individuals in the insulin sensitive (IS) group, 275 in the moderate IR group, and 164 in the severe IR group. The average age is 45 (34-54). Serum lipase and amylase levels were used as an indicator of pancreatic exocrine functions. Serum amylase, lipase and serum lipase/amylase activity ratio were compared between groups. Serum amylase levels were 67.8, 63 and 65.3 U/L; serum lipase levels were 31, 31 and 25.5 U / L, serum lipase/amylase ratios were 47%, 50% and 38% in the IS, moderate IR and severe IR groups, respectively. There is a significant difference in serum amylase levels between insulin-sensitive (IS) and moderate IR groups (p=0.02) and in serum lipase levels between IS and severe IR, and between moderate IR and severe IR (p<0.001, p<0.001 respectively). When we use serum lipase/amylase activity ratio to compare groups with each other, there is a significant difference between IS and moderate IR, IS and severe IR, and moderate IR and severe IR (p= 0.015, p<0.001, p< 0.001 respectively). Our results show that the exocrine functions of the pancreas are affected in insulin resistance and serum lipase/amylase activity ratio can be used as a new parameter to define and screen insulin sensitivity status of the body.

P278 The EEG alpha response is affected by changes in sex hormone levels in two phases of menstrual cycle

Clinical Neurophysiology, 2017

performed in the menstrual and luteal phases. Reproductive hormone levels (estradiol, progesteron... more performed in the menstrual and luteal phases. Reproductive hormone levels (estradiol, progesterone, FSH and LH) were measured with electrochemiluminescence immunoassay. The delta power values were analyzed by artifact-free 45 epochs lasting 2 s. We investigated the relationship between the hormone levels and delta power values in the two phases of menstrual cycle. Results: The mean of estrodiol, progesterone, FSH and LH levels in the menstrual cycle were 26.01 pg/ml; 0.15 ng/ml; 6.33 mIU/ml and 5.28 mIU/ml, while the mean of estrodiol, progesterone, FSH and LH levels in the follicular phase were 130.7 pg/ml; 8.51 ng/ml; 3.48 mIU/ml and 7.19 mIU/ml, respectively. The mean of the delta power values in occipital region was 20.42 in menstrual phase while it was 27.21 in luteal phase. Therewithal, the mean of the delta power values in frontal region was 24.96 in menstrual phase while it was 25.42 in luteal phase. The highest difference was seen in occipital region whereas the lowest difference was in frontal region. Conclusion: We obtained that increased blood levels of estradiol and progesterone in luteal phase enhance the delta power values in occipital region.

P277 The effects of sex hormone fluctuations in menstrual cycle on the EEG delta response

Clinical Neurophysiology, 2017

The current study examined the relationship of circulatory BDNF with vascular function in Parkins... more The current study examined the relationship of circulatory BDNF with vascular function in Parkinson's disease (PD). Method: ELISA was used to determine plasma BDNFin PD patients and healthy control (CT). Additionally, forearm resting blood flow (RBf), vascular resistance (RVr), venous capacitance (RVc), and venous outflow (RVo) as well as post occlusion blood flow (OcBf), vascular resistance (OcVr), venous capacitance (OcVc), and venous outflow (OcVo) were obtained using strain-gauge plethysmography. Results: Simple linear regression showed that being PD patient can predict (p < 0.05) 12.9% of BDNF, 16.8% of RVc, 15.0% of OcVc, and 13.6% of OcVo. Subsequent stepwise regression included BDNF, RVc, OcVc, and OcVo, showed that being PD patient predicted (p < 0.05) 58.0% of BDNF, 47.7% of OcVo, and 15.1% of OcVc. Another simple linear regression demonstrated that BDNF predicted (p < 0.05) 18.5% of OcBf, 22.0% of OcVr, and 24.1% of OcVc in PD. In a subsequent stepwise linear regression, BDNF explained 26% ofOcVr (p = 0.008) and 42% of OcVc (p = 0.002) in PD. Discussion: The study showed that BDNF is reduced and related to altered vascular function in PD. Conclusion: The results suggest that BDNF might contribute to preserving and maybe improving vascular function in PD. Significance: The study warrants for identify strategies to increase BDNF, thus improve vascular function.

Associations Between Zinc, Copper and Cognitive Performance in Young Turkish Adults

The International Annals of Medicine, 2018

Background: Trace elements such as zinc (Zn) and copper (Cu) are essential micronutrients have vi... more Background: Trace elements such as zinc (Zn) and copper (Cu) are essential micronutrients have vital roles in immune system functioning, cell propagation and growth, and cognition. Based on the importance of these elements, numerous studies have been conducted to investigate the relationship between the elements and cognition in humans. However, most of these studies were conducted in elderly, children or adults with neurodegenerative diseases such as Alzheimer, Parkinson. This study aimed to reveal the association between plasma levels of Zn, Cu and Zn/Cu ratio and cognitive functions in healthy young Turkish adults. Methods: We measured plasma levels of Zn and Cu in 37 healthy adults (23 women, 14 men, mean age 26,74) whose normal mental state had been assessed via the Montreal Cognitive Assessment-Turkish Version (MoCA-TUR) test representing the major cognitive functions. Results: Results show a significant inverse correlation between plasma levels of copper and MoCA-TUR test score in men (p<0.05). Also, a significant inverse correlation of the plasma levels of zinc with MoCA-TUR tests scores is shown (p<0.05). Zn/Cu ratio was related to cognitive functions only in women (p<0.05). Conclusions: The results of our study suggest that the Zn/Cu ratio, as well as Zn or Cu levels, are associated with cognitive function in adults. However, these associations are different between women and men. We concluded that this difference raised from different nutritional needs and mineral levels of sexes.

The role of thiol-disulfide and ischemia-modified albumin levels in the diagnosis of childhood appendicitis

Anatolian Current Medical Journal

Aim: The accurate diagnosis of acute appendicitis can be achieved by a combination of evaluation ... more Aim: The accurate diagnosis of acute appendicitis can be achieved by a combination of evaluation of clinical symptoms, physical examination findings and history taking, but is still challenging for the clinician. Some biochemical markers have been evaluated for the purpose of increasing the diagnostic accuracy rate for appendicitis. In this study, our aim is to evaluate the diagnostic value of thiol-disulfide levels and IMA, in pediatric patients with suspected acute appendicitis. Materials And Methods: The children (1-17 years age) who were admitted to our clinic for suspected acute appendicitis between March 2017 and September 2017 were evaluated. A total of 238 children are enrolled in the study; 119 were operated for suspected acute appendicitis and the 119 children who did not have appendicitis constituted the control group. Serum levels of native thiol (-SH), total thiol (SH + SS), dynamic disulfide (SS), dynamic disulfide (SS)/total thiol (SH + SS) ratio, albumin, ischemic mo...

The strong relationship between disease severity and thiol-disulphide homeostasis in patients with restless legs syndrome

Ortadoğu Tıp Dergisi, 2018

Amac: Bu calisma, primer huzursuz bacak sendromu (RLS) hastalarinda yeni bir oksidatif stres beli... more Amac: Bu calisma, primer huzursuz bacak sendromu (RLS) hastalarinda yeni bir oksidatif stres belirteci olan tiyol-disulfid homeostazisini arastirmak amaciyla yapildi. Gerec ve Yontem: Otuz sekiz hasta ve 43 saglikli birey calismaya alindi. Serum nativ tiyol, total tiyol, disulfit ve disulfid / nativ tiyol oranlari yeni bir otomatik yontem kullanilarak olculmustur. RLS tanisi Uluslararasi Huzursuz Bacak Sendromu Calisma Grubu (IRLSSG) tarafindan onerilen kriterlere gore konuldu ve RLS siddeti IRLSSG Şiddet Olcegi kullanilarak degerlendirildi. Bulgular: Serum nativ tiyol ve total tiyol duzeyleri anlamli derecede dusuk (sirasiyla p<0.001; p=0.007), disulfid ve disulfid / nativ tiyol orani anlamli olarak daha yuksekti (sirasiyla p=0.017; p<0.001). RLS kontrol grubu ile karsilastirildi. IRLSSG Onem Olcegi ve tiyol-disulfid homeostasisi parametreleri arasinda anlamli korelasyonlar bulundu (r=-0.56, nativ tiyol icin p<0.001; total tiyol icin r=-0.51, p<0.001; disulfid icin r=0....

Thiol/Disulfide Homeostasis in Bipolar and Unipolar Depression

Clinical Psychopharmacology and Neuroscience, 2020

Objective: Bipolar disorder and unipolar depressive disorder are complex phenotypes. There appear... more Objective: Bipolar disorder and unipolar depressive disorder are complex phenotypes. There appear to be phenotypical, mechanistic, and therapeutic differences between bipolar depression (BD) and unipolar depression (UD). There is a need for understanding the underlying biological variation between these clinical entities. The role of oxidative processes underlying bipolar disorder and depression has been demonstrated. Thiol-disulfide homeostasis (TDH) is a recent oxidative stress marker. In this study, we aimed to inspect patients with bipolar depression and unipolar depression in terms of thiol-disulfide balance and to compare them with healthy controls. Methods: Patients admitted to the outpatient clinic of Ankara Numune Training and Research Hospital and diagnosed either as a depressive episode with bipolar disorder (n = 37) or unipolar depression (n = 24) according to DSM-5 criteria, along with healthy controls (HC) (n = 50), were included in the study. Native thiol, total thiol, and disulfide levels were compared across the groups. Results: In comparison to HC, both BD and UD groups had higher disulfide levels, disulfide/native thiol ratio, and disulfide/total thiol ratio. No significant differences between BD and UD were detected in terms of disulfide level, disulfide/native thiol ratio, and disulfide/total thiol ratio. Conclusion: Increased levels of disulfide, native thiol, and disulfide/total thiol ratios compared to healthy controls in both UD and BD groups may be indicative of the presence of oxidative damage in these two clinical conditions. To clarify the role of oxidative stress in the pathophysiology of depressive disorders and investigate TDH, longitudinal studies in patients with medication-free UD and BD are required.

Investigation of dysfunctional HDL using myeloperoxidase / paraoxonase ratio in lymphoma

Harran Üniversitesi Tıp Fakültesi Dergisi, 2019

Background: The aim of this study is to investigate the myeloperoxidase/paraoxonase ratio which i... more Background: The aim of this study is to investigate the myeloperoxidase/paraoxonase ratio which indicates dysfunction of high-density lipoprotein in various types of lymphoma characterized by abnormal lipid metabolism, oxidative stress, and inflammation. Methods: Thirty lymphoma patients and 30 healthy subjects were enrolled in this study. Serum myeloperoxidase, paraoxonase, arylesterase, lipid hydroperoxide and routine biochemistry tests levels were measured on an automated analyzer. The diagnosis of lymphoma patients was made according to the histological examination of the biopsy material. Results: Compared with healthy control group; the albumin, arylesterase, high-density lipoprotein, thiol, and Hemoglobin levels were significantly lower while myeloperoxidase / paraoxonase, myeloperoxidase/arylesterase, and lipid hydroperoxide levels were significantly higher, in patients with lymphoma. Also, lipid hydroperoxide level was significantly correlated with myeloperoxidase / paraoxon...

The strong relationship between disease severity and thiol-disulphide homeostasis in patients with restless legs syndrome

Ortadoğu Tıp Dergisi, 2018

The strong relationship between disease severity and thiol-disulphide homeostasis in patients wit... more

Does extracorporeal shockwave lithotripsy therapy affect thiol-disulfide homeostasis?

Pakistan journal of medical sciences

Extracorporeal Shockwave Lithotripsy (ESWL) is a non-invasive method that is effective at crushin... more Extracorporeal Shockwave Lithotripsy (ESWL) is a non-invasive method that is effective at crushing stones in the upper urinary tract. Disturbance of the thiol/disulfide homeostasis, in favor of the disulfide, has been shown to be involved in the disease pathogenesis. A total of 36 individuals that underwent ESWL had blood samples collected before ESWL (0hrs), 6hrs, and one week after the ESWL. Sera native and total as wells as disulfide amount was measured using an automated method sodium borohydrate (NaBH) reduction. In addition, Ischemia Modified Albumin (IMA) levels were measured using colorimetric assay method. Native thiol level was reduced at the 6th hour following ESWL compared to baseline. While the ratios of disulfide level, Disulfide/Total Thiol (DTT), Disulfide/Native Thiol (DNT) and IMA level were increased at the 6th hour following ESWL compared to baseline, they were found to be similar with their baseline values at the end of 1st week. Total thiol and native /total th...

The Variation of Disulfides in the Progression of Type 2 Diabetes Mellitus

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, Jan 29, 2018

The purpose of this study was to examine thiol-disulfide balance in patients with type 2 diabetes... more The purpose of this study was to examine thiol-disulfide balance in patients with type 2 diabetes mellitus. This study included 32 subjects with known type 2 diabetes mellitus without complications, 30 patients with type 2 diabetes mellitus with complications, 28 newly diagnosed patients with type 2 diabetes mellitus, and 45 healthy individuals. Thiol-disulfide profile tests were quantified in all groups. Compared to the control group, patients in each of the diabetic groups had significantly lower native and total thiol levels, higher disulfide levels, and higher disulfide/native thiol and disulfide/total thiol ratios (<0.05 for all). Disulfide levels were significantly lower in the newly diagnosed group than in other diabetic groups (<0.05). There were significant associations between glycemic parameters and thiol-disulfide tests (<0.05). A disequilibrium between thiol-disulfide pairs occurs in patients with type 2 diabetes mellitus, and a gradual increase to disulfide le...

Serum Lipase / Amylase Activity Ratio for Screening Insulin Resistance

Tıpta Yenilikçi Yaklaşımlar Dergisi, 2021

Early diagnosis of insulin resistance (IR) is important to prevent the development of type 2 diab... more Early diagnosis of insulin resistance (IR) is important to prevent the development of type 2 diabetes mellitus (DM). Type 2 DM is mainly considered as an endocrine disorder however some recent studies show that exocrine functions of the pancreas are insufficient in type 2 DM. Our aim in this study to evaluate the relation of insulin resistance with pancreatic exocrine functions. Fasting glucose, insulin, amylase, lipase, HbA1c, and demographic information of subjects were taken from the laboratory information system. Children and the diabetic subjects were excluded. Included subjects were separated according to the insulin sensitivity status determined by homeostatic model assessment. There were 335 individuals in the insulin sensitive (IS) group, 275 in the moderate IR group, and 164 in the severe IR group. The average age is 45 (34-54). Serum lipase and amylase levels were used as an indicator of pancreatic exocrine functions. Serum amylase, lipase and serum lipase/amylase activity ratio were compared between groups. Serum amylase levels were 67.8, 63 and 65.3 U/L; serum lipase levels were 31, 31 and 25.5 U / L, serum lipase/amylase ratios were 47%, 50% and 38% in the IS, moderate IR and severe IR groups, respectively. There is a significant difference in serum amylase levels between insulin-sensitive (IS) and moderate IR groups (p=0.02) and in serum lipase levels between IS and severe IR, and between moderate IR and severe IR (p<0.001, p<0.001 respectively). When we use serum lipase/amylase activity ratio to compare groups with each other, there is a significant difference between IS and moderate IR, IS and severe IR, and moderate IR and severe IR (p= 0.015, p<0.001, p< 0.001 respectively). Our results show that the exocrine functions of the pancreas are affected in insulin resistance and serum lipase/amylase activity ratio can be used as a new parameter to define and screen insulin sensitivity status of the body.

P278 The EEG alpha response is affected by changes in sex hormone levels in two phases of menstrual cycle

Clinical Neurophysiology, 2017

performed in the menstrual and luteal phases. Reproductive hormone levels (estradiol, progesteron... more performed in the menstrual and luteal phases. Reproductive hormone levels (estradiol, progesterone, FSH and LH) were measured with electrochemiluminescence immunoassay. The delta power values were analyzed by artifact-free 45 epochs lasting 2 s. We investigated the relationship between the hormone levels and delta power values in the two phases of menstrual cycle. Results: The mean of estrodiol, progesterone, FSH and LH levels in the menstrual cycle were 26.01 pg/ml; 0.15 ng/ml; 6.33 mIU/ml and 5.28 mIU/ml, while the mean of estrodiol, progesterone, FSH and LH levels in the follicular phase were 130.7 pg/ml; 8.51 ng/ml; 3.48 mIU/ml and 7.19 mIU/ml, respectively. The mean of the delta power values in occipital region was 20.42 in menstrual phase while it was 27.21 in luteal phase. Therewithal, the mean of the delta power values in frontal region was 24.96 in menstrual phase while it was 25.42 in luteal phase. The highest difference was seen in occipital region whereas the lowest difference was in frontal region. Conclusion: We obtained that increased blood levels of estradiol and progesterone in luteal phase enhance the delta power values in occipital region.

P277 The effects of sex hormone fluctuations in menstrual cycle on the EEG delta response

Clinical Neurophysiology, 2017

The current study examined the relationship of circulatory BDNF with vascular function in Parkins... more The current study examined the relationship of circulatory BDNF with vascular function in Parkinson's disease (PD). Method: ELISA was used to determine plasma BDNFin PD patients and healthy control (CT). Additionally, forearm resting blood flow (RBf), vascular resistance (RVr), venous capacitance (RVc), and venous outflow (RVo) as well as post occlusion blood flow (OcBf), vascular resistance (OcVr), venous capacitance (OcVc), and venous outflow (OcVo) were obtained using strain-gauge plethysmography. Results: Simple linear regression showed that being PD patient can predict (p < 0.05) 12.9% of BDNF, 16.8% of RVc, 15.0% of OcVc, and 13.6% of OcVo. Subsequent stepwise regression included BDNF, RVc, OcVc, and OcVo, showed that being PD patient predicted (p < 0.05) 58.0% of BDNF, 47.7% of OcVo, and 15.1% of OcVc. Another simple linear regression demonstrated that BDNF predicted (p < 0.05) 18.5% of OcBf, 22.0% of OcVr, and 24.1% of OcVc in PD. In a subsequent stepwise linear regression, BDNF explained 26% ofOcVr (p = 0.008) and 42% of OcVc (p = 0.002) in PD. Discussion: The study showed that BDNF is reduced and related to altered vascular function in PD. Conclusion: The results suggest that BDNF might contribute to preserving and maybe improving vascular function in PD. Significance: The study warrants for identify strategies to increase BDNF, thus improve vascular function.

Associations Between Zinc, Copper and Cognitive Performance in Young Turkish Adults

The International Annals of Medicine, 2018

Background: Trace elements such as zinc (Zn) and copper (Cu) are essential micronutrients have vi... more Background: Trace elements such as zinc (Zn) and copper (Cu) are essential micronutrients have vital roles in immune system functioning, cell propagation and growth, and cognition. Based on the importance of these elements, numerous studies have been conducted to investigate the relationship between the elements and cognition in humans. However, most of these studies were conducted in elderly, children or adults with neurodegenerative diseases such as Alzheimer, Parkinson. This study aimed to reveal the association between plasma levels of Zn, Cu and Zn/Cu ratio and cognitive functions in healthy young Turkish adults. Methods: We measured plasma levels of Zn and Cu in 37 healthy adults (23 women, 14 men, mean age 26,74) whose normal mental state had been assessed via the Montreal Cognitive Assessment-Turkish Version (MoCA-TUR) test representing the major cognitive functions. Results: Results show a significant inverse correlation between plasma levels of copper and MoCA-TUR test score in men (p<0.05). Also, a significant inverse correlation of the plasma levels of zinc with MoCA-TUR tests scores is shown (p<0.05). Zn/Cu ratio was related to cognitive functions only in women (p<0.05). Conclusions: The results of our study suggest that the Zn/Cu ratio, as well as Zn or Cu levels, are associated with cognitive function in adults. However, these associations are different between women and men. We concluded that this difference raised from different nutritional needs and mineral levels of sexes.