Çukurova anestezi ve cerrahi bilimler dergisi, Dec 31, 2021
Mucormycosis is a rare but usually fatal opportunistic infection and especially seen in patients ... more Mucormycosis is a rare but usually fatal opportunistic infection and especially seen in patients with diabetes mellitus and hematologic malignancies. Since the infection is usually caused by inhalation of spores, the paranasal sinuses and lungs are most affected. Risk factors include uncontrolled diabetes mellitus, hematological malignancies, and long-term corticosteroid use. Early diagnosis and treatment is important. Infection usually initiates like bacterial pneumonia and clinic; radiologic findings are nonspecific. The underlying causes should be treated, surgical debridement should be performed, and appropriate antifungal drugs should be given. In this article, a very rare case of mediastinal lymph node mucormycosis with mild clinical course without pulmonary or endobronchial involvement is presented in the light of the literature.
Calismamizin amaci ust gastrointestinal sistem (GIS) endoskopisi yapilmis pediatrik yas grubu (0-... more Calismamizin amaci ust gastrointestinal sistem (GIS) endoskopisi yapilmis pediatrik yas grubu (0-18) hastalarin histopatolojik ozelliklerini, Helicobacter pilori (HP) insidansini, intestinal metaplazi insidansini ve demografik ozelliklerini tartismak ve sunmaktir. GEREC VE YONTEM Konya Egitim ve Arastirma Hastanesi Patoloji bolumunde 2010-2018 yillari arasinda ust GIS endoskopisi yapilmis ve mide biyopsisi alinmis 1612 hasta calismaya dahil edilmistir. Biyopsiler Hemotoksilen&Eozin, modifiye Giemsa ve Periyodik asit schiff -Alcian Blue yontemi ile boyanarak isik mikroskobunda degerlendirildi. HP varligi, eozinofil infiltrasyonu, Mononukleer hucre infiltrasyonu, notrofil infiltrasyonu, atrofi, intestinal metaplazi, HP varligi incelendi ve Sydney Sistemine gore negatif (0), hafif (+1), orta (+2), siddetli (+3) olarak siniflandirildi. Lenfoid agregat/folikul varligi, yok/var olarak skorlandi. BULGULAR Calismaya alinan olgularin 767 (%47,5)’i kiz, 845 (%52,5)’i erkek olup, yas ortalamal...
Objective: The study was designed to determine the relationship between survival time of standard... more Objective: The study was designed to determine the relationship between survival time of standardized uptake value (SUV max and SUV mean) and metabolic tumor volume (MTV) in patients with non-small cell lung cancer (NSCLC), and examine the impact of demographic, clinical, and radiological data of these patients on survival. Materials and Methods: We performed a retrospective analysis of the records of 79 patients with NSCLC who presented to our hospital between May 2010 and March 2013, received a final diagnosis, and underwent 18 F-FDG PET/CT for staging. Clinical, radiological, and 18 F-FDG PET/CT parameters with an impact on prognosis such as the SUV max of the primary tumor as calculated by the volumetric region of interest in the 18 F-FDG PET/CT scans during initial diagnosis, mean SUV of the tumor, and MTV obtained with a threshold of SUV max greater than 2.5 were recorded and statistically analyzed. A statistical analysis was carried out based on the clinical, radiological, and PET/CT findings of the patients who were divided into 2 groups: survivors and nonsurvivors. Results: Seventy patients (88.6%) were men, and 9 (11.4%) were women. The mean age was 63.65 ± 11.51 years in the nonsurvivor group (n = 40) versus 62.74 ± 10.60 years in the survivor group (n = 39) (Table 1). The mean survival time from diagnosis was 7.9 ± 6.52 months in the nonsurvivor group versus 14.09 ± 7.41 months in the survivor group. The mean survival time was 12.9 ± 7.9 months for those aged 60 or younger, whereas it was 9.9 ± 7.2 years for those aged 60 or older. According to the Cox regression analysis, higher MTV [relative risk (RR), 1.006; P = 0.03] and mean SUV max (mSUV) (RR, 1.302; P = 0.03) had a significant impact on shortening of the mean survival time. However, no statistical significance was reached for SUV max measurements (RR, 0.970; P = 0.39). Furthermore, there was a significant relationship between increased tumor size (<2 cm, 2-4 cm, and ≥4 cm) and shortened mean survival time (P = 0.03). Conclusion: The present study showed that MTV and mSUV of FDG PET/CT scans of the tumor, but not SUV max , had a significant impact on survival time of patients with NSCLC. Based on this result, we believe that we might have more accurate information about the survival time of our patients if we also evaluate mSUV and MTV in combination with mSUV, which is frequently used for diagnosis and monitoring of patients with NSCLC during our daily practice.
Elli sekiz yaşındaki kadın hasta, sol ayak bileğinde 20 yıldır var olan yanık skarı üzerinde 2 yı... more Elli sekiz yaşındaki kadın hasta, sol ayak bileğinde 20 yıldır var olan yanık skarı üzerinde 2 yıldır gelişen papülomatöz lezyon ile başvurdu. Hastadan skuamöz hücreli karsinom ve keratoakantom ön tanıları ile önce insizyonel daha sonra eksizyonel biyopsi yapıldı. Hastaya histopatolojik bulgular eşliğinde verruka vulgaris tanısı konuldu. Yanık skarı üzerinde skuamöz hücreli karsinom, bazal hücreli karsinom ve melanom, geliştiği bilinmekle birlikte verruka vulgaris gelişimi nadir görülmektedir.
Primer izole trakeobronşiyal amiloidozis (TBA), oldukça nadir görülen bir hastalıktır. Progressif... more Primer izole trakeobronşiyal amiloidozis (TBA), oldukça nadir görülen bir hastalıktır. Progressif dispne, öksürük ve hemoptizi gibi semptomlarla kendini gösterebilir. Hava yolu obsrtrüksiyonu, atelektazilere ve tekrarlayan bronkopulmoner enfeksiyonlara neden olabilir. Soliter nodüller tümör benzeri yanıltıcı görünümler verebilir. 70 yaşında erkek hasta genel durum bozukluğu öksürük, balgam, nefes darlığı şikayeti ile acil servise başvurdu ve göğüs hastalıkları servisine yatırıldı. 15 yıldır parkinson hastalığı olan hastamızın akciğer filminde belirgin bir patoloji tesbit edilmedi. BT Toraks'da sağ akciğer alt lob posterobazal ve laterobazal segmentte geniş boyutlu konsolidasyon alanı mevcuttu. Yapılan bronkoskopide sol üst lob karinasında polipoid lezyon görüldü. Alınan bronkoskopik biyopsi örneği amiloidoz olarak raporlandı. Başka organ tulumu saptanmayan izole TBA' lı olgumuzu literatür eşliğinde sunmayı amaçladık. Anahtar kelimeler: Amiloidoz, akciğer, kongo kırmızısı.
Laryngeal oncocytic cysts and cystadenomas are uncommon and observed in 0.1–1% of laryngeal biops... more Laryngeal oncocytic cysts and cystadenomas are uncommon and observed in 0.1–1% of laryngeal biopsy specimens. A 66-year-old male was admitted to the hospital with a hoarse voice of 6 months duration. On laryngoscopic examination, a lesion of the left anterior vocal cord was present. It was excised by direct laryngoscopy and histopathologic examination revealed a cystic cavity with papillary projections into the lumen. The epithelial lining comprised bland oncocytic epithelium. These findings are characteristic of laryngeal oncocytic cystadenoma. Endoscopic excision is curative in these lesions. Oncocytic cystadenoma is a rare, cystic neoplasm that occurs in late adulthood. It may be considered in the clinicopathologic differential diagnosis of laryngeal lesions.
Background/aim: Laminin-1 and matrix metalloproteinase (MMP)-9 may play roles in the progression ... more Background/aim: Laminin-1 and matrix metalloproteinase (MMP)-9 may play roles in the progression from benign to malignant endometrium, so we aimed to investigate their levels of expression in these tissues. Materials and methods: This case-control study was conducted at a tertiary care center between January 2014 and December 2016. Paraffin blocks of 50 specimens of benign endometrium with proliferative (n = 20), secretory (n = 11), and atrophic (n = 5) endometrium; simple endometrial hyperplasia without atypia (n = 12); and endometrial polyp (n = 2) histology and 49 specimens of malignant endometrium with endometrioid (n = 40), serous (n = 7), clear cell (n = 1), and undifferentiated (n = 1) types were immunostained with laminin-1 and MMP-9 antibodies and assessed for basement membrane continuity for laminin-1 and the percentage and intensity of MMP-9 expression in epithelial cytoplasm. Results: Laminin-1 continuity in the basement membrane was higher in benign (92%) compared to malignant (16.3%) endometrium (p < 0.0001) without any difference between the subgroups within each group (p > 0.05). All atrophic endometria and endometrial polyps and 23.5% of low grade endometrioid and none of the other endometrial cancers showed uninterrupted basement membrane staining with laminin-1. All cases in malignant endometrium expressed MMP-9 with either low or high immunoreactivity while none of the cases in benign endometrium showed a high staining with MMP-9 (p < 0.01). Proliferative and hyperplastic endometrium together with grade 1 endometrioid cancer expressed MMP-9 better than the atrophic endometrium (p < 0.05). The immunoreactivity with MMP-9 increased gradually from secretory to hyperplastic endometrium and serous carcinoma (p < 0.05). MMP-9 expression in all types of cancers except grade 1 endometrioid and clear cell compared to proliferative endometrium was significantly higher (p < 0.05) and increased from proliferative to grade 2 endometrioid, grade 3 endometrioid, serous and undifferentiated endometrial carcinoma. Conclusion: Gradual increments in MMP-9 expression and basement membrane laminin-1 discontinuity may indicate progression from normal to hyperplastic and to low-and high-grade cancerous endometrium.
Giriş ve Amaç Servikal premalign ve malign lezyonların erken tanı ve tedavisinde ve Pap (Papanico... more Giriş ve Amaç Servikal premalign ve malign lezyonların erken tanı ve tedavisinde ve Pap (Papanicolaou) smear ve HPV tarama testlerinin önemi bilinmektedir. Bu çalışma ile üçüncü basamak tek merkez servikal tarama testi- biyopsi sonuçlarını karşılaştırmalı analiz ederek sunmayı amaçladık. Gereç ve Yöntemler Çalışmaya 3.basamak tek bir merkezde jinekolojik onkoloji polikliniğine başvuran ve kolposkopik biyopsi yapılan 272 hasta dâhil edildi. Olguların Pap smear sonuçları Betesta sistemine göre klasifiye edildi. HPV-DNA tiplendirmesi PCR yöntemi ile yapıldı. Tüm servikal biyopsi örneklerinden elde edilen H&E, p16 ve ki 67 boyalı preperatlar ışık mikroskobunda değerlendirildi. Sonuçlar istatistiksel olarak karşılaştırmalı analiz edildi. Bulgular ve sonuç HPV tarama testi, Ko-test ve Pap smear yöntemlerinin biyopsi ile uyumlarının karşılaştırılmasında HPV tarama testi anlamlı bulunmuştur (p0,05). Servikal smear testi genel topluma uygulanan bir tarama testi olup kuşkulu olgularda HPV tes...
in the Diagnosis of Helicobacter pylori Infection, and In Vitro Activity of Various Antimicrobial... more in the Diagnosis of Helicobacter pylori Infection, and In Vitro Activity of Various Antimicrobials Against Helicobacter pylori ÖZET Amaç: Çalışmada, dispeptik şikayetlerle başvuran hastalardan alınan mide antrum biyopsi örneklerinde, hızlı üreaz testi (HÜT), kültür ve histoloji yöntemleriyle Helicobacter pylori infeksiyonu varlığının araştırılması; izolatların amoksisilin, klaritromisin, levofloksasin ve metronidazole karşı dirençlerinin antibiyotik gradyan yöntemiyle belirlenmesi amaçlandı. Yöntemler: Antrum ve korpus bölgelerinden alınan 278 biyopsi örneğinin mikrobiyolojik ve histopatolojik incelemeleri yapıldı. Biyopsi örneklerinde H. pylori varlığı; kültür, histoloji ve HÜT testleri ile araştırıldı. İzolatların; amoksisilin, klaritromisin, levofloksasin ve metronidazole karşı antimikrobiyal dirençleri antibiyotik gradyan yöntemiyle tespit edildi. Kültür altın standard yöntem olarak belirlendi ve histoloji ve HÜT için duyarlılık ve özgüllük hesaplandı. Ayrıca histoloji ve HÜT'ün birlikte pozitifliği altın standard kriteri kabul edilerek kültür için duyarlılık ve özgüllük oranları hesaplandı. Bulgular: Çalışmada, H. pylori pozitifliği; 278 hastanın 140'ında kültür, 174'ünde histoloji ve 191'nde HÜT ile belirlendi. Kültür, histoloji ve HÜT yöntemlerinin duyarlılık oranları %76.5 ve %88.3, %87.8 ve özgüllükleri %63, %94.2 ve %57.2 olarak tespit edildi. Kültürden izole edilen 140 H. pylori suşunda antibiyotik gradyan yöntemiyle antibiyotik direnci araştırıldı; amoksisilin, klaritromisin, levofloksasin ve metronidazole karşı direnç oranları sırasıyla 9 (%6.4), 22 (%15.7), 17 (%12.1), 57 (%40.7) olarak tespit edildi. Sonuçlar: Çalışmada; kültür, HÜT ve histoloji yöntemleri arasında en duyarlı testin HÜT olduğu görüldü. Kültür yönteminin özgüllüğünü yüksek olarak tespit etmemize rağmen, duyarlılığı diğer yöntemlere göre oldukça düşüktü. H. pylori kültürünün duyarlılığının düşük olması; bakterinin nazlı, güç üreyen bir mikroorganizma olması, klinik örneğin alınması ve transport koşullarının izolasyon şansını doğrudan etkilemesi gibi faktörlerden kaynaklanabilir. Anahtar Kelimeler: H. pylori, histopatoloji, hızlı üreaz testi, kültür, antimikrobiyal direnç Bu çalışma Creative Commons Atıf-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Bir pulmoner hyalinize granüloma (PHG) olgusunu sunmak. Olgu Sunumu: 48 yafl›nda kad›n hastan›n t... more Bir pulmoner hyalinize granüloma (PHG) olgusunu sunmak. Olgu Sunumu: 48 yafl›nda kad›n hastan›n tesadüfen çekilen direkt akci¤er grafisinde bilateral kitle gölgeleri izlendi. Hastada klinik bulgu yoktu. Aç›k akci¤er biyopsisi ile ç›kar›lan iki nodülün kesit yüzeyleri homojendi. Hyalinize kollajen demetler ve kronik inflamatuar hücre infiltrasyonunun varl›¤› ile olguya histopatolojik olarak pulmoner hyalinize granüloma tan›s› kondu. Sonuç: Nadir görülen bu benign hastal›¤›n multipl pulmoner nodüllerin ay›r›c› tan›s›nda hat›rlanmas›na dikkat çekmek amac›yla olgu sunuldu.
OBJECTIVE To evaluate ectopic adrenal cortical tissue (EACT) and identify clinical, pathological ... more OBJECTIVE To evaluate ectopic adrenal cortical tissue (EACT) and identify clinical, pathological and radiological aspects. STUDY DESIGN Retrospective review of pathology reports in a single tertiary institution between 2010 and 2020 was conducted. Patients diagnosed with EACT were included for analysis. Demographic characteristics, accompanying pathologies and clinicopathological and radiological findings of these patients were analyzed. RESULTS There was a total of 17 patients in the cohort. Fifteen were boys and 2 were adults (1 male). The mean diameter of the EACT nodule was 0.25 cm (range 0.2-0.5 cm). All EACTs were incidentally diagnosed. Seven EACTs were diagnosed during an inguinal hernia repair, 6 during orchidopexy, 1 during partial orchiectomy, 2 during orchiectomy and 1 during hysterectomy and bilateral salpingoophorectomy due to uterine prolapse. DISCUSSION EACT is a rare entity that is mostly found incidentally during inguinoscrotal interventions. Radiological discrimination of EACT may not be easy and thus, not detected prior to surgery. Clinical significance of EACT is not very well understood, however it tends to be a benign pathology. Although it is more commonly found in children, adults may present with EACT, as well. CONCLUSION A tiny yellowish nodule detected in the inguinoscrotal region should be suspected for EACT by pediatric urologists, surgeons, and pathologists.
Aim: Our study aims to find the relationship between the degree of GATA-3 expression in breast ca... more Aim: Our study aims to find the relationship between the degree of GATA-3 expression in breast cancer and other prognostic factors such as ER, PR, HER-2, Ki67, and axillary metastasis. Materials and Methods: The cases in which GATA-3 immunohistochemical staining was applied to breast cancer tissues between 2018 and 2020 were detected. Immunohistochemically stained preparations of ER, PRG, GATA-3, Ki-67, and HER-2 of these cases were obtained from the hospital archive and evaluated by two pathologists. Results: As a result, GATA-3 was directly proportional to PR and ER and inversely proportional to Ki 67. GATA-3 expression was associated with a higher Ki-67 mitotic index compared to the percentage of ER and PR expression. Conclusion: According to the results of our study, indicating GATA-3 positivity and negativity as well as the degree of expression in the pathology reports of breast tumors will help the clinician in terms of differentiation and prognosis of the tumor. Finally, brea...
Objective: This study aimed to find out valuable parameters that predict the nature of breast pap... more Objective: This study aimed to find out valuable parameters that predict the nature of breast papillary lesions before excision, and we compared our results with those in the literature. Materials and Methods: We reviewed the medical records and pathology slides of patients diagnosed with papillary neoplasm after undergoing a coreneedle biopsy between 2010 and 2020, who, subsequently, underwent surgical excision in a single tertiary care institution. The core biopsy results and pathology results of excision materials were compared with the radiological, pathological, and demographic findings. Results: A total of 51 patients were included in the study. According to the excision results, the patients were divided into two groups: the atypical group, which included 20 patients (39.3%), and the benign group, which included 31 patients (61.7%). The results of the core biopsy showed that the loss of myoepithelial cell layer was identified in 18 patients in the atypical group, while it was present in all patients in the benign group. Tumor sizes were larger and patient ages were older in the atypical group compared with the benign group. No significant difference was found between atypical and benign groups in terms of breast imaging-reporting and data system (BI-RADS) classification and location (right vs left; central vs peripheral). The upgrade rate was between 0% and 16% in literature, while it was 4% in our study. Conclusion: There is no consensus on whether patients diagnosed with papillary neoplasia as a result of core biopsy will undergo excision. According to our results, patients with following criteria should have their lesions excised: those who are advanced in age, those who are diagnosed with a papillary lesion as a result of core biopsies with loss of myoepithelial cell layer, and those who are diagnosed with large-sized lesions without loss of myoepithelial cell layer. Patients diagnosed with small-sized lesions without loss of myoepithelial cell layer and who are young in age are to be followed up without the need for lesion excision. The lesions should be adequately sampled.
Amac: Karin ici basinc (KIB) artisi ile Abdominal Kompartman Sendromu (AKS) arasindaki iliskiyi m... more Amac: Karin ici basinc (KIB) artisi ile Abdominal Kompartman Sendromu (AKS) arasindaki iliskiyi mesane ici basincini olcerek incelemek. Gerec ve Yontem: Bu calismada Selcuk Universitesi Meram Tip Fakultesi Acil Servisi’ne akut batin nedeniyle muracaat eden 61 olgu kullanildi. Olgulardan 25’i ileus, 13’u akut pankreatit, 11’i mezenter iskemi ve 12’si gastrointestinal perforasyon tanisi aldi. Olgularin tamaminda mesaneye yerlestirilen bir sonda araciligiyla karin ici basincinin bir gostergesi olan mesane ici basinci olculdu. Bu olcumle es zamanli olarak arteriyel ve venoz kanda pH, PaCO2, PaO2, SGOT, SGPT, ure ve kreatinin degerlerine bakildi. Ilk basvuru aninda yapilan bu islemler, 24, 48 ve 72. saatlerde tekrar edildi. KIB artisi ile kan degerleri arasindaki iliski incelendi Bulgular: Calismamizda KIB artisinin bobrekler, solunum sistemi ve karaciger uzerinde birtakim degisikliklere yol actigi izlendi. KIB 10 cm H2O’yu gecince bobrek fonksiyonlarinin bozulmaya basladigi, 20 cm H2O b...
Cukurova Anestezi ve Cerrahi Bilimler Dergisi, 2020
Çalışmamızın amacı hastanemizde 10 yıllık sürede myelolipom tanısı alan hastaların klinik ve pato... more Çalışmamızın amacı hastanemizde 10 yıllık sürede myelolipom tanısı alan hastaların klinik ve patolojik özelliklerini ortaya koymaktır. Gereç ve yöntem: Nisan 2009-Nisan 2019 tarihleri arasında Konya Eğitim ve Araştırma Hastanesi'nde myelolipom tanısı alan olgular retrospektif olarak incelendi. Bulgular: 10 yıllık sürede hastanemizde 7 olgu myelolipom tanısı almıştır. Olguların ortanca yaşı 33 ortanca tümör çapı 13 cm'dir. Olguların beşi kadın, ikisi erkektir. Tümörlerin altısı adrenal bezde, biri karaciğerde lokalizedir. Adrenal yerleşimli tümörlerin tamamı sağ tarafta lokalizedir. Olguların beşi sağ üst kadranda ağrı şikâyeti ile başvurmuştur, iki olguda ise tümör insidental olarak saptanmıştır. Adrenal kaynaklı 6 myelolipom değişen sürelerde takip edildikten sonra cerrahi olarak rezeke edilmiştir, karaciğer kaynaklı myelolipom ise klinik olarak takip edilmektedir. Tümörleri cerrahi olarak rezeke edilen olguların cerrahi sonrası takip süreleri 13-123 ay arasında değişmektedir. Olguların hiçbirinde nüks veya metastaz saptanmamıştır. Sonuç: Myelolipomlar yağ doku ve kemik iliği elemanlarından oluşan nadir görülen benign tümörlerdir. En sık adrenal bezde görülür. Adrenal myelolipomlar adrenal korteksin ikinci sık tümörüdür. Sıklıkla kadınlarda, sağ tarafta ve 5-7. dekatlarda izlenir. Ortalama 5 cm çaplı tümörler olup 31 cm çaplı myelolipomlar da bildirilmiştir. Çoğu asemtomatik olup insidental olarak saptanır, büyük tümörler semptomatik olabilir. Myelolipomlar klinik olarak takip edilebilir, büyük ve semptomatik tümörler cerrahi olarak rezeke edilebilir. Prognoz çok iyidir, malign transformasyon bildirilmemiştir.
Thymolipoma is a rare and benign lesion originating from the anterior mediastinum. Thymolipoma is... more Thymolipoma is a rare and benign lesion originating from the anterior mediastinum. Thymolipoma is mostly diagnosed incidentally. However, cough, dyspnea and chest pain can be seen. A 35-year-old male patient presented to our hospital with the complaint of shortness of breath lasting for one month. The physical examination revealed a massive pleural effusion on the right. In computed tomography (CT) imaging of the thorax, a soft tissue density of 7.5x5x5 cm in size, containing calcifications were observed in the anterior mediastinum. A right thoracotomy was performed for the treatment and to make a definite diagnosis. The histopathological examination resulted in the diagnosis of a thymolipoma. We presented our case with its differential diagnosis because of its rarity.
The aim of this study was to evaluate the diagnostic performance of two-dimensional shear wave el... more The aim of this study was to evaluate the diagnostic performance of two-dimensional shear wave elastography in the differentiation of malignant and benign breast lesions. Material and Methods: A total of 83 breast lesions in 76 patients were prospectively investigated with B-mode ultrasonography and two-dimensional shear wave elastography techniques. B-mode ultrasonography findings were classified based on BI-RADS lexicon 5th edition. The mean elasticity and the standard deviation of speed mode (m/s) and elasticity mode (kPa) were calculated for all breast lesions. Diagnostic performances of each quantitative parameters were compared. Results: Of 83 breast lesions, 45 (54.2%) were benign and 38 (45.7%) were malignant. Among the all shear wave elastography parameters, the standard deviation (E SD) of the shear wave speed (m/s) had the highest AUROC (0.953) value. When a cutoff value of 0.85 m/s was used for E SD of speed mode, sensitivity, specificity, accuracy, PPV, and NPV were detected as 94.7%, 88.8%, 91.5%, 87.8%, and 95.2%, respectively. Conclusions: Two-dimensional shear wave elastography has excellent diagnostic performance in the differentiation of benign and malignant breast lesions. The standard deviation (E SD) of speed modehad the best diagnostic performance when compared other quantitative parameters.
Background/aim: To evaluate the diagnostic performance of strain elastography (SE) combined with ... more Background/aim: To evaluate the diagnostic performance of strain elastography (SE) combined with B-mode ultrasound in distinguishing between idiopathic granulomatous mastitis (IGM) and malignant breast lesions. Materials and methods: Seventy-seven malignant breast lesions and 36 IGM were assessed using B-mode ultrasound and SE. Ultrasonographic findings for all the breast lesions were classified based on the 2013 American College of Radiology Breast Imaging Reporting and Data System (BI-RADS-US), and the SE findings were evaluated based on the strain ratio and a five-point scale. The diagnostic performances of B-mode ultrasonography, SE, and the combination of both methods were compared. Results: Significant differences in strain ratio and elastography scores were found between IGM and malignant breast lesions. When the lesions were assessed with B-mode ultrasound alone, in order to distinguish between IGM and malignant breast lesions, sensitivity, specificity, positive predictive v...
Çukurova anestezi ve cerrahi bilimler dergisi, Dec 31, 2021
Mucormycosis is a rare but usually fatal opportunistic infection and especially seen in patients ... more Mucormycosis is a rare but usually fatal opportunistic infection and especially seen in patients with diabetes mellitus and hematologic malignancies. Since the infection is usually caused by inhalation of spores, the paranasal sinuses and lungs are most affected. Risk factors include uncontrolled diabetes mellitus, hematological malignancies, and long-term corticosteroid use. Early diagnosis and treatment is important. Infection usually initiates like bacterial pneumonia and clinic; radiologic findings are nonspecific. The underlying causes should be treated, surgical debridement should be performed, and appropriate antifungal drugs should be given. In this article, a very rare case of mediastinal lymph node mucormycosis with mild clinical course without pulmonary or endobronchial involvement is presented in the light of the literature.
Calismamizin amaci ust gastrointestinal sistem (GIS) endoskopisi yapilmis pediatrik yas grubu (0-... more Calismamizin amaci ust gastrointestinal sistem (GIS) endoskopisi yapilmis pediatrik yas grubu (0-18) hastalarin histopatolojik ozelliklerini, Helicobacter pilori (HP) insidansini, intestinal metaplazi insidansini ve demografik ozelliklerini tartismak ve sunmaktir. GEREC VE YONTEM Konya Egitim ve Arastirma Hastanesi Patoloji bolumunde 2010-2018 yillari arasinda ust GIS endoskopisi yapilmis ve mide biyopsisi alinmis 1612 hasta calismaya dahil edilmistir. Biyopsiler Hemotoksilen&Eozin, modifiye Giemsa ve Periyodik asit schiff -Alcian Blue yontemi ile boyanarak isik mikroskobunda degerlendirildi. HP varligi, eozinofil infiltrasyonu, Mononukleer hucre infiltrasyonu, notrofil infiltrasyonu, atrofi, intestinal metaplazi, HP varligi incelendi ve Sydney Sistemine gore negatif (0), hafif (+1), orta (+2), siddetli (+3) olarak siniflandirildi. Lenfoid agregat/folikul varligi, yok/var olarak skorlandi. BULGULAR Calismaya alinan olgularin 767 (%47,5)’i kiz, 845 (%52,5)’i erkek olup, yas ortalamal...
Objective: The study was designed to determine the relationship between survival time of standard... more Objective: The study was designed to determine the relationship between survival time of standardized uptake value (SUV max and SUV mean) and metabolic tumor volume (MTV) in patients with non-small cell lung cancer (NSCLC), and examine the impact of demographic, clinical, and radiological data of these patients on survival. Materials and Methods: We performed a retrospective analysis of the records of 79 patients with NSCLC who presented to our hospital between May 2010 and March 2013, received a final diagnosis, and underwent 18 F-FDG PET/CT for staging. Clinical, radiological, and 18 F-FDG PET/CT parameters with an impact on prognosis such as the SUV max of the primary tumor as calculated by the volumetric region of interest in the 18 F-FDG PET/CT scans during initial diagnosis, mean SUV of the tumor, and MTV obtained with a threshold of SUV max greater than 2.5 were recorded and statistically analyzed. A statistical analysis was carried out based on the clinical, radiological, and PET/CT findings of the patients who were divided into 2 groups: survivors and nonsurvivors. Results: Seventy patients (88.6%) were men, and 9 (11.4%) were women. The mean age was 63.65 ± 11.51 years in the nonsurvivor group (n = 40) versus 62.74 ± 10.60 years in the survivor group (n = 39) (Table 1). The mean survival time from diagnosis was 7.9 ± 6.52 months in the nonsurvivor group versus 14.09 ± 7.41 months in the survivor group. The mean survival time was 12.9 ± 7.9 months for those aged 60 or younger, whereas it was 9.9 ± 7.2 years for those aged 60 or older. According to the Cox regression analysis, higher MTV [relative risk (RR), 1.006; P = 0.03] and mean SUV max (mSUV) (RR, 1.302; P = 0.03) had a significant impact on shortening of the mean survival time. However, no statistical significance was reached for SUV max measurements (RR, 0.970; P = 0.39). Furthermore, there was a significant relationship between increased tumor size (<2 cm, 2-4 cm, and ≥4 cm) and shortened mean survival time (P = 0.03). Conclusion: The present study showed that MTV and mSUV of FDG PET/CT scans of the tumor, but not SUV max , had a significant impact on survival time of patients with NSCLC. Based on this result, we believe that we might have more accurate information about the survival time of our patients if we also evaluate mSUV and MTV in combination with mSUV, which is frequently used for diagnosis and monitoring of patients with NSCLC during our daily practice.
Elli sekiz yaşındaki kadın hasta, sol ayak bileğinde 20 yıldır var olan yanık skarı üzerinde 2 yı... more Elli sekiz yaşındaki kadın hasta, sol ayak bileğinde 20 yıldır var olan yanık skarı üzerinde 2 yıldır gelişen papülomatöz lezyon ile başvurdu. Hastadan skuamöz hücreli karsinom ve keratoakantom ön tanıları ile önce insizyonel daha sonra eksizyonel biyopsi yapıldı. Hastaya histopatolojik bulgular eşliğinde verruka vulgaris tanısı konuldu. Yanık skarı üzerinde skuamöz hücreli karsinom, bazal hücreli karsinom ve melanom, geliştiği bilinmekle birlikte verruka vulgaris gelişimi nadir görülmektedir.
Primer izole trakeobronşiyal amiloidozis (TBA), oldukça nadir görülen bir hastalıktır. Progressif... more Primer izole trakeobronşiyal amiloidozis (TBA), oldukça nadir görülen bir hastalıktır. Progressif dispne, öksürük ve hemoptizi gibi semptomlarla kendini gösterebilir. Hava yolu obsrtrüksiyonu, atelektazilere ve tekrarlayan bronkopulmoner enfeksiyonlara neden olabilir. Soliter nodüller tümör benzeri yanıltıcı görünümler verebilir. 70 yaşında erkek hasta genel durum bozukluğu öksürük, balgam, nefes darlığı şikayeti ile acil servise başvurdu ve göğüs hastalıkları servisine yatırıldı. 15 yıldır parkinson hastalığı olan hastamızın akciğer filminde belirgin bir patoloji tesbit edilmedi. BT Toraks'da sağ akciğer alt lob posterobazal ve laterobazal segmentte geniş boyutlu konsolidasyon alanı mevcuttu. Yapılan bronkoskopide sol üst lob karinasında polipoid lezyon görüldü. Alınan bronkoskopik biyopsi örneği amiloidoz olarak raporlandı. Başka organ tulumu saptanmayan izole TBA' lı olgumuzu literatür eşliğinde sunmayı amaçladık. Anahtar kelimeler: Amiloidoz, akciğer, kongo kırmızısı.
Laryngeal oncocytic cysts and cystadenomas are uncommon and observed in 0.1–1% of laryngeal biops... more Laryngeal oncocytic cysts and cystadenomas are uncommon and observed in 0.1–1% of laryngeal biopsy specimens. A 66-year-old male was admitted to the hospital with a hoarse voice of 6 months duration. On laryngoscopic examination, a lesion of the left anterior vocal cord was present. It was excised by direct laryngoscopy and histopathologic examination revealed a cystic cavity with papillary projections into the lumen. The epithelial lining comprised bland oncocytic epithelium. These findings are characteristic of laryngeal oncocytic cystadenoma. Endoscopic excision is curative in these lesions. Oncocytic cystadenoma is a rare, cystic neoplasm that occurs in late adulthood. It may be considered in the clinicopathologic differential diagnosis of laryngeal lesions.
Background/aim: Laminin-1 and matrix metalloproteinase (MMP)-9 may play roles in the progression ... more Background/aim: Laminin-1 and matrix metalloproteinase (MMP)-9 may play roles in the progression from benign to malignant endometrium, so we aimed to investigate their levels of expression in these tissues. Materials and methods: This case-control study was conducted at a tertiary care center between January 2014 and December 2016. Paraffin blocks of 50 specimens of benign endometrium with proliferative (n = 20), secretory (n = 11), and atrophic (n = 5) endometrium; simple endometrial hyperplasia without atypia (n = 12); and endometrial polyp (n = 2) histology and 49 specimens of malignant endometrium with endometrioid (n = 40), serous (n = 7), clear cell (n = 1), and undifferentiated (n = 1) types were immunostained with laminin-1 and MMP-9 antibodies and assessed for basement membrane continuity for laminin-1 and the percentage and intensity of MMP-9 expression in epithelial cytoplasm. Results: Laminin-1 continuity in the basement membrane was higher in benign (92%) compared to malignant (16.3%) endometrium (p < 0.0001) without any difference between the subgroups within each group (p > 0.05). All atrophic endometria and endometrial polyps and 23.5% of low grade endometrioid and none of the other endometrial cancers showed uninterrupted basement membrane staining with laminin-1. All cases in malignant endometrium expressed MMP-9 with either low or high immunoreactivity while none of the cases in benign endometrium showed a high staining with MMP-9 (p < 0.01). Proliferative and hyperplastic endometrium together with grade 1 endometrioid cancer expressed MMP-9 better than the atrophic endometrium (p < 0.05). The immunoreactivity with MMP-9 increased gradually from secretory to hyperplastic endometrium and serous carcinoma (p < 0.05). MMP-9 expression in all types of cancers except grade 1 endometrioid and clear cell compared to proliferative endometrium was significantly higher (p < 0.05) and increased from proliferative to grade 2 endometrioid, grade 3 endometrioid, serous and undifferentiated endometrial carcinoma. Conclusion: Gradual increments in MMP-9 expression and basement membrane laminin-1 discontinuity may indicate progression from normal to hyperplastic and to low-and high-grade cancerous endometrium.
Giriş ve Amaç Servikal premalign ve malign lezyonların erken tanı ve tedavisinde ve Pap (Papanico... more Giriş ve Amaç Servikal premalign ve malign lezyonların erken tanı ve tedavisinde ve Pap (Papanicolaou) smear ve HPV tarama testlerinin önemi bilinmektedir. Bu çalışma ile üçüncü basamak tek merkez servikal tarama testi- biyopsi sonuçlarını karşılaştırmalı analiz ederek sunmayı amaçladık. Gereç ve Yöntemler Çalışmaya 3.basamak tek bir merkezde jinekolojik onkoloji polikliniğine başvuran ve kolposkopik biyopsi yapılan 272 hasta dâhil edildi. Olguların Pap smear sonuçları Betesta sistemine göre klasifiye edildi. HPV-DNA tiplendirmesi PCR yöntemi ile yapıldı. Tüm servikal biyopsi örneklerinden elde edilen H&E, p16 ve ki 67 boyalı preperatlar ışık mikroskobunda değerlendirildi. Sonuçlar istatistiksel olarak karşılaştırmalı analiz edildi. Bulgular ve sonuç HPV tarama testi, Ko-test ve Pap smear yöntemlerinin biyopsi ile uyumlarının karşılaştırılmasında HPV tarama testi anlamlı bulunmuştur (p0,05). Servikal smear testi genel topluma uygulanan bir tarama testi olup kuşkulu olgularda HPV tes...
in the Diagnosis of Helicobacter pylori Infection, and In Vitro Activity of Various Antimicrobial... more in the Diagnosis of Helicobacter pylori Infection, and In Vitro Activity of Various Antimicrobials Against Helicobacter pylori ÖZET Amaç: Çalışmada, dispeptik şikayetlerle başvuran hastalardan alınan mide antrum biyopsi örneklerinde, hızlı üreaz testi (HÜT), kültür ve histoloji yöntemleriyle Helicobacter pylori infeksiyonu varlığının araştırılması; izolatların amoksisilin, klaritromisin, levofloksasin ve metronidazole karşı dirençlerinin antibiyotik gradyan yöntemiyle belirlenmesi amaçlandı. Yöntemler: Antrum ve korpus bölgelerinden alınan 278 biyopsi örneğinin mikrobiyolojik ve histopatolojik incelemeleri yapıldı. Biyopsi örneklerinde H. pylori varlığı; kültür, histoloji ve HÜT testleri ile araştırıldı. İzolatların; amoksisilin, klaritromisin, levofloksasin ve metronidazole karşı antimikrobiyal dirençleri antibiyotik gradyan yöntemiyle tespit edildi. Kültür altın standard yöntem olarak belirlendi ve histoloji ve HÜT için duyarlılık ve özgüllük hesaplandı. Ayrıca histoloji ve HÜT'ün birlikte pozitifliği altın standard kriteri kabul edilerek kültür için duyarlılık ve özgüllük oranları hesaplandı. Bulgular: Çalışmada, H. pylori pozitifliği; 278 hastanın 140'ında kültür, 174'ünde histoloji ve 191'nde HÜT ile belirlendi. Kültür, histoloji ve HÜT yöntemlerinin duyarlılık oranları %76.5 ve %88.3, %87.8 ve özgüllükleri %63, %94.2 ve %57.2 olarak tespit edildi. Kültürden izole edilen 140 H. pylori suşunda antibiyotik gradyan yöntemiyle antibiyotik direnci araştırıldı; amoksisilin, klaritromisin, levofloksasin ve metronidazole karşı direnç oranları sırasıyla 9 (%6.4), 22 (%15.7), 17 (%12.1), 57 (%40.7) olarak tespit edildi. Sonuçlar: Çalışmada; kültür, HÜT ve histoloji yöntemleri arasında en duyarlı testin HÜT olduğu görüldü. Kültür yönteminin özgüllüğünü yüksek olarak tespit etmemize rağmen, duyarlılığı diğer yöntemlere göre oldukça düşüktü. H. pylori kültürünün duyarlılığının düşük olması; bakterinin nazlı, güç üreyen bir mikroorganizma olması, klinik örneğin alınması ve transport koşullarının izolasyon şansını doğrudan etkilemesi gibi faktörlerden kaynaklanabilir. Anahtar Kelimeler: H. pylori, histopatoloji, hızlı üreaz testi, kültür, antimikrobiyal direnç Bu çalışma Creative Commons Atıf-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Bir pulmoner hyalinize granüloma (PHG) olgusunu sunmak. Olgu Sunumu: 48 yafl›nda kad›n hastan›n t... more Bir pulmoner hyalinize granüloma (PHG) olgusunu sunmak. Olgu Sunumu: 48 yafl›nda kad›n hastan›n tesadüfen çekilen direkt akci¤er grafisinde bilateral kitle gölgeleri izlendi. Hastada klinik bulgu yoktu. Aç›k akci¤er biyopsisi ile ç›kar›lan iki nodülün kesit yüzeyleri homojendi. Hyalinize kollajen demetler ve kronik inflamatuar hücre infiltrasyonunun varl›¤› ile olguya histopatolojik olarak pulmoner hyalinize granüloma tan›s› kondu. Sonuç: Nadir görülen bu benign hastal›¤›n multipl pulmoner nodüllerin ay›r›c› tan›s›nda hat›rlanmas›na dikkat çekmek amac›yla olgu sunuldu.
OBJECTIVE To evaluate ectopic adrenal cortical tissue (EACT) and identify clinical, pathological ... more OBJECTIVE To evaluate ectopic adrenal cortical tissue (EACT) and identify clinical, pathological and radiological aspects. STUDY DESIGN Retrospective review of pathology reports in a single tertiary institution between 2010 and 2020 was conducted. Patients diagnosed with EACT were included for analysis. Demographic characteristics, accompanying pathologies and clinicopathological and radiological findings of these patients were analyzed. RESULTS There was a total of 17 patients in the cohort. Fifteen were boys and 2 were adults (1 male). The mean diameter of the EACT nodule was 0.25 cm (range 0.2-0.5 cm). All EACTs were incidentally diagnosed. Seven EACTs were diagnosed during an inguinal hernia repair, 6 during orchidopexy, 1 during partial orchiectomy, 2 during orchiectomy and 1 during hysterectomy and bilateral salpingoophorectomy due to uterine prolapse. DISCUSSION EACT is a rare entity that is mostly found incidentally during inguinoscrotal interventions. Radiological discrimination of EACT may not be easy and thus, not detected prior to surgery. Clinical significance of EACT is not very well understood, however it tends to be a benign pathology. Although it is more commonly found in children, adults may present with EACT, as well. CONCLUSION A tiny yellowish nodule detected in the inguinoscrotal region should be suspected for EACT by pediatric urologists, surgeons, and pathologists.
Aim: Our study aims to find the relationship between the degree of GATA-3 expression in breast ca... more Aim: Our study aims to find the relationship between the degree of GATA-3 expression in breast cancer and other prognostic factors such as ER, PR, HER-2, Ki67, and axillary metastasis. Materials and Methods: The cases in which GATA-3 immunohistochemical staining was applied to breast cancer tissues between 2018 and 2020 were detected. Immunohistochemically stained preparations of ER, PRG, GATA-3, Ki-67, and HER-2 of these cases were obtained from the hospital archive and evaluated by two pathologists. Results: As a result, GATA-3 was directly proportional to PR and ER and inversely proportional to Ki 67. GATA-3 expression was associated with a higher Ki-67 mitotic index compared to the percentage of ER and PR expression. Conclusion: According to the results of our study, indicating GATA-3 positivity and negativity as well as the degree of expression in the pathology reports of breast tumors will help the clinician in terms of differentiation and prognosis of the tumor. Finally, brea...
Objective: This study aimed to find out valuable parameters that predict the nature of breast pap... more Objective: This study aimed to find out valuable parameters that predict the nature of breast papillary lesions before excision, and we compared our results with those in the literature. Materials and Methods: We reviewed the medical records and pathology slides of patients diagnosed with papillary neoplasm after undergoing a coreneedle biopsy between 2010 and 2020, who, subsequently, underwent surgical excision in a single tertiary care institution. The core biopsy results and pathology results of excision materials were compared with the radiological, pathological, and demographic findings. Results: A total of 51 patients were included in the study. According to the excision results, the patients were divided into two groups: the atypical group, which included 20 patients (39.3%), and the benign group, which included 31 patients (61.7%). The results of the core biopsy showed that the loss of myoepithelial cell layer was identified in 18 patients in the atypical group, while it was present in all patients in the benign group. Tumor sizes were larger and patient ages were older in the atypical group compared with the benign group. No significant difference was found between atypical and benign groups in terms of breast imaging-reporting and data system (BI-RADS) classification and location (right vs left; central vs peripheral). The upgrade rate was between 0% and 16% in literature, while it was 4% in our study. Conclusion: There is no consensus on whether patients diagnosed with papillary neoplasia as a result of core biopsy will undergo excision. According to our results, patients with following criteria should have their lesions excised: those who are advanced in age, those who are diagnosed with a papillary lesion as a result of core biopsies with loss of myoepithelial cell layer, and those who are diagnosed with large-sized lesions without loss of myoepithelial cell layer. Patients diagnosed with small-sized lesions without loss of myoepithelial cell layer and who are young in age are to be followed up without the need for lesion excision. The lesions should be adequately sampled.
Amac: Karin ici basinc (KIB) artisi ile Abdominal Kompartman Sendromu (AKS) arasindaki iliskiyi m... more Amac: Karin ici basinc (KIB) artisi ile Abdominal Kompartman Sendromu (AKS) arasindaki iliskiyi mesane ici basincini olcerek incelemek. Gerec ve Yontem: Bu calismada Selcuk Universitesi Meram Tip Fakultesi Acil Servisi’ne akut batin nedeniyle muracaat eden 61 olgu kullanildi. Olgulardan 25’i ileus, 13’u akut pankreatit, 11’i mezenter iskemi ve 12’si gastrointestinal perforasyon tanisi aldi. Olgularin tamaminda mesaneye yerlestirilen bir sonda araciligiyla karin ici basincinin bir gostergesi olan mesane ici basinci olculdu. Bu olcumle es zamanli olarak arteriyel ve venoz kanda pH, PaCO2, PaO2, SGOT, SGPT, ure ve kreatinin degerlerine bakildi. Ilk basvuru aninda yapilan bu islemler, 24, 48 ve 72. saatlerde tekrar edildi. KIB artisi ile kan degerleri arasindaki iliski incelendi Bulgular: Calismamizda KIB artisinin bobrekler, solunum sistemi ve karaciger uzerinde birtakim degisikliklere yol actigi izlendi. KIB 10 cm H2O’yu gecince bobrek fonksiyonlarinin bozulmaya basladigi, 20 cm H2O b...
Cukurova Anestezi ve Cerrahi Bilimler Dergisi, 2020
Çalışmamızın amacı hastanemizde 10 yıllık sürede myelolipom tanısı alan hastaların klinik ve pato... more Çalışmamızın amacı hastanemizde 10 yıllık sürede myelolipom tanısı alan hastaların klinik ve patolojik özelliklerini ortaya koymaktır. Gereç ve yöntem: Nisan 2009-Nisan 2019 tarihleri arasında Konya Eğitim ve Araştırma Hastanesi'nde myelolipom tanısı alan olgular retrospektif olarak incelendi. Bulgular: 10 yıllık sürede hastanemizde 7 olgu myelolipom tanısı almıştır. Olguların ortanca yaşı 33 ortanca tümör çapı 13 cm'dir. Olguların beşi kadın, ikisi erkektir. Tümörlerin altısı adrenal bezde, biri karaciğerde lokalizedir. Adrenal yerleşimli tümörlerin tamamı sağ tarafta lokalizedir. Olguların beşi sağ üst kadranda ağrı şikâyeti ile başvurmuştur, iki olguda ise tümör insidental olarak saptanmıştır. Adrenal kaynaklı 6 myelolipom değişen sürelerde takip edildikten sonra cerrahi olarak rezeke edilmiştir, karaciğer kaynaklı myelolipom ise klinik olarak takip edilmektedir. Tümörleri cerrahi olarak rezeke edilen olguların cerrahi sonrası takip süreleri 13-123 ay arasında değişmektedir. Olguların hiçbirinde nüks veya metastaz saptanmamıştır. Sonuç: Myelolipomlar yağ doku ve kemik iliği elemanlarından oluşan nadir görülen benign tümörlerdir. En sık adrenal bezde görülür. Adrenal myelolipomlar adrenal korteksin ikinci sık tümörüdür. Sıklıkla kadınlarda, sağ tarafta ve 5-7. dekatlarda izlenir. Ortalama 5 cm çaplı tümörler olup 31 cm çaplı myelolipomlar da bildirilmiştir. Çoğu asemtomatik olup insidental olarak saptanır, büyük tümörler semptomatik olabilir. Myelolipomlar klinik olarak takip edilebilir, büyük ve semptomatik tümörler cerrahi olarak rezeke edilebilir. Prognoz çok iyidir, malign transformasyon bildirilmemiştir.
Thymolipoma is a rare and benign lesion originating from the anterior mediastinum. Thymolipoma is... more Thymolipoma is a rare and benign lesion originating from the anterior mediastinum. Thymolipoma is mostly diagnosed incidentally. However, cough, dyspnea and chest pain can be seen. A 35-year-old male patient presented to our hospital with the complaint of shortness of breath lasting for one month. The physical examination revealed a massive pleural effusion on the right. In computed tomography (CT) imaging of the thorax, a soft tissue density of 7.5x5x5 cm in size, containing calcifications were observed in the anterior mediastinum. A right thoracotomy was performed for the treatment and to make a definite diagnosis. The histopathological examination resulted in the diagnosis of a thymolipoma. We presented our case with its differential diagnosis because of its rarity.
The aim of this study was to evaluate the diagnostic performance of two-dimensional shear wave el... more The aim of this study was to evaluate the diagnostic performance of two-dimensional shear wave elastography in the differentiation of malignant and benign breast lesions. Material and Methods: A total of 83 breast lesions in 76 patients were prospectively investigated with B-mode ultrasonography and two-dimensional shear wave elastography techniques. B-mode ultrasonography findings were classified based on BI-RADS lexicon 5th edition. The mean elasticity and the standard deviation of speed mode (m/s) and elasticity mode (kPa) were calculated for all breast lesions. Diagnostic performances of each quantitative parameters were compared. Results: Of 83 breast lesions, 45 (54.2%) were benign and 38 (45.7%) were malignant. Among the all shear wave elastography parameters, the standard deviation (E SD) of the shear wave speed (m/s) had the highest AUROC (0.953) value. When a cutoff value of 0.85 m/s was used for E SD of speed mode, sensitivity, specificity, accuracy, PPV, and NPV were detected as 94.7%, 88.8%, 91.5%, 87.8%, and 95.2%, respectively. Conclusions: Two-dimensional shear wave elastography has excellent diagnostic performance in the differentiation of benign and malignant breast lesions. The standard deviation (E SD) of speed modehad the best diagnostic performance when compared other quantitative parameters.
Background/aim: To evaluate the diagnostic performance of strain elastography (SE) combined with ... more Background/aim: To evaluate the diagnostic performance of strain elastography (SE) combined with B-mode ultrasound in distinguishing between idiopathic granulomatous mastitis (IGM) and malignant breast lesions. Materials and methods: Seventy-seven malignant breast lesions and 36 IGM were assessed using B-mode ultrasound and SE. Ultrasonographic findings for all the breast lesions were classified based on the 2013 American College of Radiology Breast Imaging Reporting and Data System (BI-RADS-US), and the SE findings were evaluated based on the strain ratio and a five-point scale. The diagnostic performances of B-mode ultrasonography, SE, and the combination of both methods were compared. Results: Significant differences in strain ratio and elastography scores were found between IGM and malignant breast lesions. When the lesions were assessed with B-mode ultrasound alone, in order to distinguish between IGM and malignant breast lesions, sensitivity, specificity, positive predictive v...
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