Hemochromatosis is a disease caused by extraordinary iron deposition in parenchymal cells leading... more Hemochromatosis is a disease caused by extraordinary iron deposition in parenchymal cells leading to cellular damage and organ dysfunction.β-thalassemia major is one of the causes of secondary hemochromatosis due to regular transfusional treatment for maintaining adequate levels of hemoglobin. Hypogonadism is one of the potential complications of hemochromatosis, usually seen in patients with a severe iron overload, and it shows an association with diabetes and cirrhosis in adult patients. We describe a patient with mild transfusional hemochromatosis due toβ-thalassemia major, presenting with central hypogonadism in the absence of cirrhosis or diabetes. Our case showed an atypical presentation with hypogonadotropic hypogonadism without severe hyperferritinemia, cirrhosis, or diabetes. With this case, we aim to raise awareness of hypogonadotropic hypogonadism in patients with intensive transfused thalassemia major even if not severe hemochromatosis so that hypogonadism related compli...
Background: The aim of this study was to determine the levels of lipid peroxidation (MDA) and ant... more Background: The aim of this study was to determine the levels of lipid peroxidation (MDA) and antioxidants such as reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in the blood serum of patients with cirrhosis and liver transplantation. Methods: In this study, serum malondialdehyde acid (MDA) levels, superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT) activities were measured spectrophotometrically and compared to the results of the healthy control group. Results: SOD, CAT and GSH activities were significantly decreased in the patient groups compared to the healthy control group (p<0.05). MDA levels were significantly higher in the patient group compared to the healthy control group (p <0.05). Conclusions: In conclusion, this study demonstrated that oxidative stress may play an important role in the development of liver cirrhosis and in liver transplantation. This study is the first one to show how MDA, SOD, CAT and GSH levels chan...
Background Compassion satisfaction and fear of compassion affect the mental health of professiona... more Background Compassion satisfaction and fear of compassion affect the mental health of professionals who work with people. In addition, each of these two variables can be important indicators of the quality of the services such professionals provide. Methods This study examines compassion as a source of satisfaction and fear among 293 professionals work with people, including 158 teachers, 57 police officers, 45 nurses and 44 imams. A personal information form, the Fear of Compassion Scale, and the Compassion Satisfaction Scale were used as data collection tools. Results Neither fear of compassion nor compassion satisfaction varied significantly according to the sampled professionals’ genders, educational levels, monthly incomes or area of residence. However, both these measures did exhibit statistically significant variation by the respondents’ professional roles, ages, numbers of children and marital statuses. A significant negative relationship between the participants’ fear of co...
Anatomic alterations due to the hepatobiliary system pathologies such as stenosis, dilatation, st... more Anatomic alterations due to the hepatobiliary system pathologies such as stenosis, dilatation, stone, and tumor can be suspected by clinical symptoms, laboratory tests and eventually confirmed by imaging methods. Both Magnetic Resonance Colangiopathy (MRCP) and Endoscopic Ultrasonography (EUS) are diagnostic tools for etiologic assessment of extrahepatic cholestasis. We aimed to compare MRCP and EUS, about the superiority in diagnostic terms, in our patient group with hepatobiliary system disorders. The results of 135 patients who underwent both MRCP and EUS in the Hospital Gastroenterology Clinic of Mersin University Medical Faculty between 2010-2018 were included in the study. After reviewing the MRCP and EUS reports; stone, tumor and pancreatitis were evaluated and analyzed. Of the patients, 71 (52.6%) were male and 64 (47.4%) were female. The mean age of males was 60.5 ± 15.49 years and that of females was 61.2 ± 14.25. The age spectrum was 23-91 years. In 97 (71.9%) of patients, MRCP and EUS were reported in the same way and both imaging methods led to the correct diagnosis. There were 38 (28.14%) patients with different diagnoses and the total cases with stone, tumor and pancreatitis were evaluated and compared. The sensitivity of EUS for the stone was 88.9% and that of MRCP was 81.5%. The sensitivity of EUS was 92.5% and that of MRI was 66%, in the diagnosis of the tumor and IPMN. In pancreatitis, the sensitivity of EUS was 89.7% and MRCP was 72.4%. EUS is a better diagnostic tool for the diagnosis of choledocholithiasis, tumor and pancreatitis than MRCP.
The aim of using oral and sublingual immunotherapy with food allergies is to enable the safe cons... more The aim of using oral and sublingual immunotherapy with food allergies is to enable the safe consumption of foods containing these allergens in patients with food allergies. In the present study, a systematic review of intervention studies was undertaken; this involved the searching of eleven international databases for controlled clinical trials. We identified 1152 potentially relevant papers, from which we selected twenty-two reports of twenty-one eligible trials (i.e. eighteen randomised controlled trials and three controlled clinical trials). The meta-analysis revealed a substantially lower risk of reactions to the relevant food allergen in those receiving orally administered immunotherapy (risk ratios (RR) 0·21, 95 % CI 0·12, 0·38). The meta-analysis of immunological data demonstrated that skin prick test responses to the relevant food allergen significantly decreased with immunotherapy (mean difference − 2·96 mm, 95 % CI − 4·48, − 1·45), while allergen-specific IgG4 levels inc...
Disseminated Intravascular Coagulation (DIC) is a systemic syndrome that causes thrombosis in sma... more Disseminated Intravascular Coagulation (DIC) is a systemic syndrome that causes thrombosis in small and mediumdiameter vessels as a result of disruption of hemostatic balance by several reasons, and progresses with the consumption of thrombocyte and coagulation factors, severe hemorrhage and impaired organ perfusion as a result of ac tivation of disseminated intravascular coagulation mechanism. DIC is always a complication that occurs together with some diseases and various secondary pathological conditions. The tissue factor which occurs as a result of tissue factor firstly activates the coagulation cascade; and overproduction of thrombin forms the basis of pathogenesis of DIC. The clinical course of DIC is generally under the influence of the underlying etiologic factor. There is not a laboratory test diagnosing DIC alone; however, the laboratory findings are indispensable for diagnosis. Treating the disease causing DIC and predominant signs of bleeding or thrombosis in clinical table, and conducting prophylaxis for preventing repetitions in chronic DIC cases are the main steps of treatment.
Hemochromatosis is a disease caused by extraordinary iron deposition in parenchymal cells leading... more Hemochromatosis is a disease caused by extraordinary iron deposition in parenchymal cells leading to cellular damage and organ dysfunction.β-thalassemia major is one of the causes of secondary hemochromatosis due to regular transfusional treatment for maintaining adequate levels of hemoglobin. Hypogonadism is one of the potential complications of hemochromatosis, usually seen in patients with a severe iron overload, and it shows an association with diabetes and cirrhosis in adult patients. We describe a patient with mild transfusional hemochromatosis due toβ-thalassemia major, presenting with central hypogonadism in the absence of cirrhosis or diabetes. Our case showed an atypical presentation with hypogonadotropic hypogonadism without severe hyperferritinemia, cirrhosis, or diabetes. With this case, we aim to raise awareness of hypogonadotropic hypogonadism in patients with intensive transfused thalassemia major even if not severe hemochromatosis so that hypogonadism related compli...
Background: The aim of this study was to determine the levels of lipid peroxidation (MDA) and ant... more Background: The aim of this study was to determine the levels of lipid peroxidation (MDA) and antioxidants such as reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in the blood serum of patients with cirrhosis and liver transplantation. Methods: In this study, serum malondialdehyde acid (MDA) levels, superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT) activities were measured spectrophotometrically and compared to the results of the healthy control group. Results: SOD, CAT and GSH activities were significantly decreased in the patient groups compared to the healthy control group (p<0.05). MDA levels were significantly higher in the patient group compared to the healthy control group (p <0.05). Conclusions: In conclusion, this study demonstrated that oxidative stress may play an important role in the development of liver cirrhosis and in liver transplantation. This study is the first one to show how MDA, SOD, CAT and GSH levels chan...
Background Compassion satisfaction and fear of compassion affect the mental health of professiona... more Background Compassion satisfaction and fear of compassion affect the mental health of professionals who work with people. In addition, each of these two variables can be important indicators of the quality of the services such professionals provide. Methods This study examines compassion as a source of satisfaction and fear among 293 professionals work with people, including 158 teachers, 57 police officers, 45 nurses and 44 imams. A personal information form, the Fear of Compassion Scale, and the Compassion Satisfaction Scale were used as data collection tools. Results Neither fear of compassion nor compassion satisfaction varied significantly according to the sampled professionals’ genders, educational levels, monthly incomes or area of residence. However, both these measures did exhibit statistically significant variation by the respondents’ professional roles, ages, numbers of children and marital statuses. A significant negative relationship between the participants’ fear of co...
Anatomic alterations due to the hepatobiliary system pathologies such as stenosis, dilatation, st... more Anatomic alterations due to the hepatobiliary system pathologies such as stenosis, dilatation, stone, and tumor can be suspected by clinical symptoms, laboratory tests and eventually confirmed by imaging methods. Both Magnetic Resonance Colangiopathy (MRCP) and Endoscopic Ultrasonography (EUS) are diagnostic tools for etiologic assessment of extrahepatic cholestasis. We aimed to compare MRCP and EUS, about the superiority in diagnostic terms, in our patient group with hepatobiliary system disorders. The results of 135 patients who underwent both MRCP and EUS in the Hospital Gastroenterology Clinic of Mersin University Medical Faculty between 2010-2018 were included in the study. After reviewing the MRCP and EUS reports; stone, tumor and pancreatitis were evaluated and analyzed. Of the patients, 71 (52.6%) were male and 64 (47.4%) were female. The mean age of males was 60.5 ± 15.49 years and that of females was 61.2 ± 14.25. The age spectrum was 23-91 years. In 97 (71.9%) of patients, MRCP and EUS were reported in the same way and both imaging methods led to the correct diagnosis. There were 38 (28.14%) patients with different diagnoses and the total cases with stone, tumor and pancreatitis were evaluated and compared. The sensitivity of EUS for the stone was 88.9% and that of MRCP was 81.5%. The sensitivity of EUS was 92.5% and that of MRI was 66%, in the diagnosis of the tumor and IPMN. In pancreatitis, the sensitivity of EUS was 89.7% and MRCP was 72.4%. EUS is a better diagnostic tool for the diagnosis of choledocholithiasis, tumor and pancreatitis than MRCP.
The aim of using oral and sublingual immunotherapy with food allergies is to enable the safe cons... more The aim of using oral and sublingual immunotherapy with food allergies is to enable the safe consumption of foods containing these allergens in patients with food allergies. In the present study, a systematic review of intervention studies was undertaken; this involved the searching of eleven international databases for controlled clinical trials. We identified 1152 potentially relevant papers, from which we selected twenty-two reports of twenty-one eligible trials (i.e. eighteen randomised controlled trials and three controlled clinical trials). The meta-analysis revealed a substantially lower risk of reactions to the relevant food allergen in those receiving orally administered immunotherapy (risk ratios (RR) 0·21, 95 % CI 0·12, 0·38). The meta-analysis of immunological data demonstrated that skin prick test responses to the relevant food allergen significantly decreased with immunotherapy (mean difference − 2·96 mm, 95 % CI − 4·48, − 1·45), while allergen-specific IgG4 levels inc...
Disseminated Intravascular Coagulation (DIC) is a systemic syndrome that causes thrombosis in sma... more Disseminated Intravascular Coagulation (DIC) is a systemic syndrome that causes thrombosis in small and mediumdiameter vessels as a result of disruption of hemostatic balance by several reasons, and progresses with the consumption of thrombocyte and coagulation factors, severe hemorrhage and impaired organ perfusion as a result of ac tivation of disseminated intravascular coagulation mechanism. DIC is always a complication that occurs together with some diseases and various secondary pathological conditions. The tissue factor which occurs as a result of tissue factor firstly activates the coagulation cascade; and overproduction of thrombin forms the basis of pathogenesis of DIC. The clinical course of DIC is generally under the influence of the underlying etiologic factor. There is not a laboratory test diagnosing DIC alone; however, the laboratory findings are indispensable for diagnosis. Treating the disease causing DIC and predominant signs of bleeding or thrombosis in clinical table, and conducting prophylaxis for preventing repetitions in chronic DIC cases are the main steps of treatment.
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Papers by Yaren Dirik