Abstract Inflammatory bowel disease (IBD) has affected an increasing number of people worldwide w... more Abstract Inflammatory bowel disease (IBD) has affected an increasing number of people worldwide while alliin has antibiotic effects and is able to alleviate inflammation. We aim to figure out whether pre-consumption of alliin prevents IBD and better understand the mechanism. Rats were orally administrated with alliin prior to the dextran sulfate sodium (DSS)-induced colitis. The inflammatory status, profiles of gut microbial communities and colonic epithelial cells (CECs) gene expressions were also examined. Our results showed that alliin mitigated the inflammation symptom including colon shrinkage prevention, and leukocyte and neutrophil infiltration attenuation by preserving expression of 23 genes in CECs rather than altering gut microbiota. DSS induced the differentially expressed genes related to rodent immune system, while alliin obviate the DSS-induced pathological change through other systems rather than the immune one. The value and prospect of alliin as a prevention for colitis and the potential gene targets for treating IBD are discussed.
Garlic (Allium sativum) is a commonly used culinary spice. It is widely distributed worldwide and... more Garlic (Allium sativum) is a commonly used culinary spice. It is widely distributed worldwide and is used as a medicinal plant by different cultures (Trio et al., 2014). Garlic simultaneously has a pungent smell and a spicy taste because of its organosulfur compounds (OSCs). The OSCs in garlic have been extensively investigated for their therapeutic applications (
Applied microbiology and biotechnology, Jan 2, 2018
The specialty of gastroenterology will be affected profoundly by the ability to modify the gastro... more The specialty of gastroenterology will be affected profoundly by the ability to modify the gastrointestinal microbiota through the use of antibiotics. This study investigated the in vivo effect of roxithromycin on gut bacteria and gene expression of colonic epithelial cells (CECs) using microbial 16S rDNA and colonic epithelial cell RNA sequencing, respectively. The results showed that roxithromycin distinctly lowered the microbial diversity in both the small intestine and cecum and altered the compositions of bacteria at both the phylum and genus levels, including the reduction of some bacteria beneficial to the hosts' health. Eight decreased and 8 increased genera in the small intestine and 17 decreased and 4 increased genera of bacteria in the cecum were most affected by roxithromycin consumption. This consumption further altered the CECs' expression of multiple genes. Thirty-one genes, which were significantly enriched in seven KEGG pathways and related to immune respons...
Abstract Inflammatory bowel disease (IBD) has affected an increasing number of people worldwide w... more Abstract Inflammatory bowel disease (IBD) has affected an increasing number of people worldwide while alliin has antibiotic effects and is able to alleviate inflammation. We aim to figure out whether pre-consumption of alliin prevents IBD and better understand the mechanism. Rats were orally administrated with alliin prior to the dextran sulfate sodium (DSS)-induced colitis. The inflammatory status, profiles of gut microbial communities and colonic epithelial cells (CECs) gene expressions were also examined. Our results showed that alliin mitigated the inflammation symptom including colon shrinkage prevention, and leukocyte and neutrophil infiltration attenuation by preserving expression of 23 genes in CECs rather than altering gut microbiota. DSS induced the differentially expressed genes related to rodent immune system, while alliin obviate the DSS-induced pathological change through other systems rather than the immune one. The value and prospect of alliin as a prevention for colitis and the potential gene targets for treating IBD are discussed.
Garlic (Allium sativum) is a commonly used culinary spice. It is widely distributed worldwide and... more Garlic (Allium sativum) is a commonly used culinary spice. It is widely distributed worldwide and is used as a medicinal plant by different cultures (Trio et al., 2014). Garlic simultaneously has a pungent smell and a spicy taste because of its organosulfur compounds (OSCs). The OSCs in garlic have been extensively investigated for their therapeutic applications (
Applied microbiology and biotechnology, Jan 2, 2018
The specialty of gastroenterology will be affected profoundly by the ability to modify the gastro... more The specialty of gastroenterology will be affected profoundly by the ability to modify the gastrointestinal microbiota through the use of antibiotics. This study investigated the in vivo effect of roxithromycin on gut bacteria and gene expression of colonic epithelial cells (CECs) using microbial 16S rDNA and colonic epithelial cell RNA sequencing, respectively. The results showed that roxithromycin distinctly lowered the microbial diversity in both the small intestine and cecum and altered the compositions of bacteria at both the phylum and genus levels, including the reduction of some bacteria beneficial to the hosts' health. Eight decreased and 8 increased genera in the small intestine and 17 decreased and 4 increased genera of bacteria in the cecum were most affected by roxithromycin consumption. This consumption further altered the CECs' expression of multiple genes. Thirty-one genes, which were significantly enriched in seven KEGG pathways and related to immune respons...
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Papers by Xuanwei Li