Cytokeratin 19 was highly significantly upregulated in urine of women with endometriosis compar... more Cytokeratin 19 was highly significantly upregulated in urine of women with endometriosis compared with women without endometriosis. Cytokeratin 19 could be a valuable urinary biomarker in diagnosing women with endometriosis. Further work is in progress to develop an ELISA assay for the detection of this biomarker in urine.
Objective: To investigate whether proteins secreted in urine differ between women with and withou... more Objective: To investigate whether proteins secreted in urine differ between women with and without endometriosis. Design: Laboratory study using human urine. Setting: University-based laboratory. Patient(s): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. Intervention(s): Urine collection from women with and without endometriosis. Main Outcome Measure(s): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. Result(s): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. Conclusion(s): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis. (Fertil Steril Ò 2011;95: 46-9. Ó2011 by American Society for Reproductive Medicine.
Cytokeratin 19 was highly significantly upregulated in urine of women with endometriosis compar... more Cytokeratin 19 was highly significantly upregulated in urine of women with endometriosis compared with women without endometriosis. Cytokeratin 19 could be a valuable urinary biomarker in diagnosing women with endometriosis. Further work is in progress to develop an ELISA assay for the detection of this biomarker in urine.
Objective: To investigate whether proteins secreted in urine differ between women with and withou... more Objective: To investigate whether proteins secreted in urine differ between women with and without endometriosis. Design: Laboratory study using human urine. Setting: University-based laboratory. Patient(s): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage. Intervention(s): Urine collection from women with and without endometriosis. Main Outcome Measure(s): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis. Result(s): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis. Conclusion(s): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis. (Fertil Steril Ò 2011;95: 46-9. Ó2011 by American Society for Reproductive Medicine.
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