Papers by Sravanthi Vemula
International Journal of Veterinary Sciences and Animal Husbandry
The livestock sector provides a consistent income to the farmer and acts as a backbone of the nat... more The livestock sector provides a consistent income to the farmer and acts as a backbone of the national economy along with agriculture and in the near future, this sector will become the major source to provide nutritional security (meat and milk) for the growing population. But the changing climate scenario and global warming are increasing the effect of Heat stress (HS) on animals and it becomes a severe threat to sustainable livestock production. HS compromises the growth, production, and reproduction efficiency of dairy cattle and will cause severe economic losses to the dairy farmer. The adverse effects of HS can be minimized by three types of interventions including genetic manipulation, nutritional interventions, and management practices that help the dairy cow to sustain production and reproduction in hot weather. Among these, nutritional strategies are simple and cost-effective in preventing the adverse effects of HS. This article will discuss various nutritional strategies such as the provision of ad libitum cold water, quality protein, fat, minerals, vitamins, and other feed additives necessary for dairy cows to cope with HS and sustain productivity in dairy cows.
Journal of advances in biology & biotechnology, Jun 20, 2024
Nearly all types of cells release exosomes (30-120 nm, nanosized vesicles), both in diseased and ... more Nearly all types of cells release exosomes (30-120 nm, nanosized vesicles), both in diseased and healthy physiological situations. Initially, it was believed that they acted just as "Cellular vacuoles" allowing cells to expel undesired components. Exosome composition and function have been the subject of extensive research since 2007. They are expelled from the majority of cell types and are present in the majority of bodily fluids, such as blood, urine, saliva, breast milk, semen, ascitic fluid, and cell culture media. The study has shown that the exosomal miRNA (MicroRNA) and lncRNA (Long non-coding RNA) content in diseased patients and healthy persons varies. Scientists have successfully discovered in several studies on disease cells that they work as biomarkers, having particular proteins connected to sick pathology. This is due to their role in expressing RNAs, DNAs, and proteins from cell to cell and their presence in most bodily fluids. Exosome-based diagnostic procedures are now being used for the early diagnosis of cancer, diabetes, neurological illnesses, and other conditions. Exosomes have the ability to traverse the blood-brain barrier and may be utilised to deliver therapeutic agents such as proteins, small compounds, viral gene therapy, RNA treatments, and CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene editing. The aim is to use exosomes as therapeutic drug delivery or carriers as it is much more compatible with the patient's body. Also, it can easily carry the disease information during diagnosis. Our review focuses on two key areas: a) identifying exosomal content from cancer cells as potential diagnostic tools, and b) exploring the possibility of customizing exosomes with therapeutic agents for treatment advantages.
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Papers by Sravanthi Vemula