Papers by Uday Sanglodkar
Journal of clinical and experimental hepatology, Jul 1, 2018
Background and Aims: The diagnosis of 'cirrhosis' carries higher morbidity, mortality and increas... more Background and Aims: The diagnosis of 'cirrhosis' carries higher morbidity, mortality and increased risk of liver cancer irrespective of its aetiology. Liver biopsy is considered 'gold standard'. However, it is invasive, not readily accepted by patients and can rarely, lead to serious complications. Non-invasive markers of liver fibrosis are increasingly developed because of convenient sampling, more practical, reproducible and cost effective. We aim to evaluate the performance of direct serum markers Hyaluronic acid (HA), Procollagen type III amino-terminal peptide (PIIINP), Collagen Type IV (CIV), Laminin (LN) and Cholyclycine (CG) in cirrhotic patients. Methods: Serum samples from cirrhotic patients and those with no liver disease (controls) were tested for HA, PIIINP, CIV, MN and CG using Maglumi fully-automated chemiluminescence immunoassay (CLIA) (SNIBE laboratories, China). Sensitivity, specificity, PPV, NPV and AUROC scores were calculated. Results: Serum samples of 197 (76 cirrhotics and 121 controls) were tested for the above non-invasive markers. Sixty-one male (80%) and 52% male in the cirrhotic and the control group. Serum levels of HA, PIIINP, CIV, MN and CG were significantly higher in cirrhotics (Table 1). Sensitivity, specificity, PPV, NPV and AUROC scores are showed in Table 2. Conclusions: Non-invasive markers (HA, PIIINP, CIV, LN, CG) readily identifies cirrhotics. More data is required to differentiate the degree of fibrosis.
Gastroenterology, hepatology and endoscopy practice, 2023
Gastroenterology, hepatology and endoscopy practice, 2023
Journal of clinical and experimental hepatology, 2023
Journal of clinical and experimental hepatology, 2023
Journal of clinical and experimental hepatology, 2023
Journal of clinical and experimental hepatology, 2023
Journal of clinical and experimental hepatology, May 1, 2021
On July 8, 2020, a 51-year-old diabetic gentleman presented to his local hospital with fever, cou... more On July 8, 2020, a 51-year-old diabetic gentleman presented to his local hospital with fever, cough, and myalgia for 6 days. An RT-PCR of his nasopharyngeal swab was positive for SARS-CoV-2. At that point, his respiratory rate was 22/min, BP 130/70, pulse oximetry saturation 97% on air, and heart rate 110/min. His CT chest revealed a bilateral peripheral ground-glass appearance. His blood tests revealed haemoglobin 13.2 g%, white cell count 6430 cells/mm, neutrophils 5640 cells/mm, lymphocytes 720 cells/mm, platelet 236 10/L, creatinine 0.7 mg/dl, albumin 3.5 g/dl, bilirubin 0.9 mg/dl, aspartate aminotransferase (AST) 63 U/L, alanine aminotransferase (ALT) 41 U/L, alkaline phosphatase (ALP) 132 U/L, gamma-glutamyl transferase (GGT) 37 U/L, and prothrombin time (PT) 12.2 s, International normalized ratio (INR) 1.10. His CRP was 15 mg/dl and ferritin 324 ng/ml. He received vitamin C, zinc supplements, esomeprazole, intravenous methylprednisolone, and subcutaneous enoxaparin for 3
Journal of clinical and experimental hepatology, Jul 1, 2017
Figure 1. Flowchart depicting the vitamin D levels at different time points and modification of t... more Figure 1. Flowchart depicting the vitamin D levels at different time points and modification of therapy accordingly.
Clinical & Experimental Hepatology, 2018
Introduction: Cirrhosis of the liver predisposes patients to serious bacterial infections includi... more Introduction: Cirrhosis of the liver predisposes patients to serious bacterial infections including cellulitis. The aim of the study was to determine the clinical and bacteriological profile of cellulitis in patients with liver cirrhosis. Material and methods: In this prospective study, consecutive cirrhotic patients hospitalized between February and September 2017 were enrolled. Data retrieved included demographics, aetiology, co-morbidity, cirrhosisrelated complications, site of cellulitis, baseline investigations, and wound and blood culture. Results: Three hundred and thirty-eight patients were admitted, of whom 25 had cellulitis (mean age 52.8 ± 10.4 years, men 88.0%, median MELD [model of end-stage liver disease] 18.8 ± 10.4). Non-alcoholic steatohepatitis and alcohol were each the cause of cirrhosis in 40% of cases. Nine patients (36%) had diabetes mellitus. Cultures were positive in 13 cases (52%; 1-blood, 11-wound, 1-both blood and skin). The majority of the cultures showed monomicrobial growth (9; 70%). Escherichia coli was the commonest isolate (6/13), followed by Klebsiella (4). 61% of isolates had multidrug resistant organisms. The outcome was favourable. Conclusions: Prevalence of cellulitis was 7.4% in hospitalised cirrhotics. Culture positivity was 52%. Escherichia coli and Klebsiella were the most common isolates and three fifths of isolates were multidrug resistant.
Indian Journal of Gastroenterology, Aug 1, 2020
Background There is scarce data from the Indian subcontinent on the outcomes following spontaneou... more Background There is scarce data from the Indian subcontinent on the outcomes following spontaneous bacterial peritonitis (SBP). Aim To study the immediate (within 30 days) and short-term mortality (31-90 days) associated with SBP and to determine the predictors of the same. Methods This prospective observational study was done among patients with liver cirrhosis who underwent paracentesis. Patient data included age, gender, co-morbidity, cirrhosis-related complications, model of end-stage liver disease (MELD), and Child-Turcotte-Pugh (CTP) scores. SBP was diagnosed based on ascitic fluid polymorphonuclear leukocyte count > 250/mm 3 with or without ascitic fluid culture positivity. Results Of the 870 patients with cirrhosis and ascites registered during the study period, 610 fulfilled the criteria for inclusion. Altogether, 122 patients with SBP were identified: 52 (42.6%) died, 40 (32.8%) survived without liver transplant, and 30 (24.6%) underwent liver transplantation within 3 months. Thirty-two patients (26.2%) were blood culture posi tive for bacteria and 7 (5.7%) demonstrable bacterial growth in ascitic fluid. Blood culture positivity was significantly higher in the group with immediate mortality (p < 0.0001) and was also significantly associated (p 0.005) with mortality at 3 months. Conclusion Nearly two-fifths (42.6%) of the study cohort died within 3 months of an episode of SBP. Four-fifths of these patients died within 30 days. Blood culture positivity was significantly associated with immediate and short-term mortality.
Clinical & Experimental Hepatology, 2018
Rebleeding after initially successful endoscopic variceal ligation (EVL) occurs in 20-60% of pati... more Rebleeding after initially successful endoscopic variceal ligation (EVL) occurs in 20-60% of patients, most commonly from band ulcers, and is associated with 20-50% mortality. Although band ulcer bleeding has been treated in a number of different ways, no single therapeutic intervention has shown a clear benefit. Hemospray (Cook Medical, Winston-Salem, North Carolina, USA) is a relatively new non-contact hemostatic modality used in the management of bleeding peptic ulcers. It is a nano-powder that can be sprayed over a larger mucosal area. Here we describe a patient with end stage liver disease who presented with recurrent bleeding from a deep esophageal ulcer following band ligation and sclerotherapy, effectively managed with multiple sessions of Hemospray.
Journal of clinical and experimental hepatology, May 1, 2019
Journal of Clinical and Experimental Hepatology
Journal of Clinical and Experimental Hepatology
Journal of Clinical and Experimental Hepatology
Journal of Clinical and Experimental Hepatology
Journal of Clinical and Experimental Hepatology
Gastroenterology, hepatology and endoscopy practice, 2023
Gastroenterology, Hepatology and Endoscopy Practice
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Papers by Uday Sanglodkar