Periodontitis and all periodontal diseases are bacterial infections that destroy the attachment f... more Periodontitis and all periodontal diseases are bacterial infections that destroy the attachment fi bers and supporting bone. Left untreated, these diseases can lead to tooth loss. The main cause of periodontal disease is a bacterial plaque, many options are available to treat this disease including non-surgical, surgical, and recent regenerative materials. Growth factors (GFs) are natural biological mediators that regulate key cellular events that are part of the process of tissue repair and regeneration. Recent advances in the areas of cellular and molecular biology allowed better understanding of the functions of GFs and their participation in the different phases of wound healing. In vitro and in vivo studies have confi rmed that GFs can enhance the capacity of tissues to regenerate by regulating cell chemo attraction, differentiation and proliferation. This review focuses on fi ve GF families that have potential for inducing periodontal regeneration based on their ability to stimulate osteoblast and periodontal ligament cells in vivo and vitro.
Periodontitis and all periodontal diseases are bacterial infections that destroy the attachment f... more Periodontitis and all periodontal diseases are bacterial infections that destroy the attachment fi bers and supporting bone. Left untreated, these diseases can lead to tooth loss. The main cause of periodontal disease is a bacterial plaque, many options are available to treat this disease including non-surgical, surgical, and recent regenerative materials. Growth factors (GFs) are natural biological mediators that regulate key cellular events that are part of the process of tissue repair and regeneration. Recent advances in the areas of cellular and molecular biology allowed better understanding of the functions of GFs and their participation in the different phases of wound healing. In vitro and in vivo studies have confi rmed that GFs can enhance the capacity of tissues to regenerate by regulating cell chemo attraction, differentiation and proliferation. This review focuses on fi ve GF families that have potential for inducing periodontal regeneration based on their ability to stimulate osteoblast and periodontal ligament cells in vivo and vitro.
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