Papers by Tali Bdolah-abram
Research Square (Research Square), Nov 19, 2021
Background-Right heart catheterization (RHC) and echocardiography are both routinely used for pul... more Background-Right heart catheterization (RHC) and echocardiography are both routinely used for pulmonary artery systolic pressure (PASP) assessment in lung transplantation (LT) candidates, although this is not mandated by current guidelines. We aimed to explore the correlation between PASP estimated by echocardiography to that measured by RHC, in this population in order to assess the necessity of RHC. Methods-From a retrospective registry of 393 LT candidates undergoing RHC and echocardiography during 2015-2019, patients were assessed for the presence of pulmonary hypertension (PH), de ned as mean pulmonary artery pressure (mPAP) above 20 mmHg, according to two methodsechocardiography and RHC. The primary outcome was the correlation between the PASP estimated by echocardiography to that measured by RHC. Secondary outcomes were the prediction value of the echocardiographic evaluation and its accuracy. Results-The mean value of PASP estimated by echocardiography was 49.5±20.0 mmHg, compared to 42.5±18.0 mmHg measured by RHC. The correlation between the two measurements was moderate (Pearson's correlation: r=0.609, p<0.01). Echocardiography PASP measurements were moderately discriminative to diagnose PH, with an area under the curve (AUC) of 0.72 (95% CI 0.66-0.76). Echocardiographic overestimation of PASP of more than 10 mmHg was found in 35.0% of the patients, and underestimation was found in 11.6% of the patients. Conclusion-In the pre-surgical evaluation of LT candidates, echocardiographic estimation of PASP had moderate correlation and limited accuracy compared to the PASP measured by RHC. We thus recommend performing routine RHC to all LT candidates, regardless of the echocardiographic estimation of PASP.
Gynecologic and Obstetric Investigation, Jul 18, 2017
Introduction: In this study we evaluated the associations between fetal urinary production rate (... more Introduction: In this study we evaluated the associations between fetal urinary production rate (FUPR), measured by ultrasound, and adverse neonatal outcome in women with preterm premature rupture of membranes (PPROM). Material and Methods: We conducted a prospective cohort of singleton pregnancies complicated by PPROM occurring at gestational week 24 or later in a single center. Women with PPROM and conservative management until spontaneous labor (after 48 hours of admission), chorioamnionitis, or induction by protocol at 35+0 weeks. FUPR was evaluated by 2D sonography at admission, and corrected for gestational age. Attending physicians were blinded to FUPR results. The main neonatal outcome measures were chorioamnionitis, placental inflammatory grading, first neonatal creatinine value, first neonatal dextrose value, length of neonatal intensive care unit (NICU) stay, necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH) (grades I-IV), blood transfusions, reduced neonatal urine production rate (<4mL/kg/h), and early neonatal sepsis. Samples of maternal (at admission) and umbilical cord blood were analyzed for interleukin-6 (IL-6) level. Results: The study included 38 women. Low FUPR was associated with chorioamnionitis, longer NICU hospitalization (p=0.01), and higher rates of NEC or IVH (p=0.008), and blood transfusion (p=0.004). There were no significant associations between antenatal FUPR and placental histologic inflammation grading, neonatal creatinine, neonatal dextrose, or early neonatal sepsis. IL-6 levels did not correlate with chorioamnionitis, FUPR, or early sepsis. Conclusion: A finding of FUPR on in utero ultrasound examination in pregnancies complicated by PPROM may be indicative of an inflammatory process and predictive of adverse neonatal outcome. Key message Low fetal urine production rate in utero evaluated by 2D sonography at admission for preterm premature rupture of membranes is associated with increased risk of chorioamnionitis and adverse neonatal outcome.
Israel Journal of Veterinary Medicine, 2009
Dental diseases are common in dogs. Oral diseases which are chronic bacterial infections found in... more Dental diseases are common in dogs. Oral diseases which are chronic bacterial infections found in dogs, resulting as tooth decay, gingivitis, periodontal diseases and malodor. Salivary bacteria and the formation of dental biofilms on teeth are predominant factors in the etiology of those diseases. In this study we compared the distribution of supragingival oral bacteria of dogs from different habitats: municipal shelter dogs, Israel Defense Forces (IDF) and client owned dogs. Salivary samples from each dog were examined for total supragingival bacteria, lactobacilli and mutans streptococci bacteria. Our results show that the IDF dogs had significantly lower number of total oral supragingival bacteria as well as mutans streptococci bacteria compared to dogs from the municipal shelter and/or client owned dogs. Dogs from the municipal shelter had a significantly higher number of lactobacilli than both IDF and client owned dogs. A significantly higher mean count of total supragingival bacteria was found in mixed breed dogs compared to pure breed dogs. A comparison of the influence of the commercial dried dog food vs. the commercial dried dog food and human food leftovers on the mean general bacteria count and mutans streptococci revealed significantly lower counts in dogs that were fed only commercial dried food as opposed to dogs that ate dried food and human food leftovers. This study showed that the quantity of caries causing bacteria and the quantity of total supragingival bacteria are related to the environment in which the dogs were kept.
Purpose: To evaluate the thickness of the ellipsoid zone (EZ) layer and its correlation with visu... more Purpose: To evaluate the thickness of the ellipsoid zone (EZ) layer and its correlation with visual acuity and the disease stage in eyes with Adult-onset foveomacular vitelliform dystrophy (AFVD).Materials and Methods: Ninety-two eyes of 57 patients with AFVD were evaluated. Four consecutive spectral-domain optical coherence tomography (SD-OCT) scans from each study eye were analyzed. Retinal layers were segmented, and the EZ layer thickness was measure in two areas of the macula: at the center of fovea (CF) and at the foveal avascular zone edge (FE).Results: The mean±SD EZ thickness for was 16.5±9.6 microns at the center of fovea (CF) and 17± 9.8 microns at the edge of foveal avascular zone (FE; p=0.006, t-test). Compared to 30 healthy eyes, the EZ was thicker at the vitelliform stage in both CF and FE (p<0.001 in both points, t-test), and during the pseudohypopyon or vitelliruptive stages in CF (p=0.007, t test), but not in edge of the fovea (p=0.15, t test). Visual acuity was ...
Survival rates of Hodgkin's lymphoma (HL) patients and non-Hodgkin's lymphoma (NHL) are increasin... more Survival rates of Hodgkin's lymphoma (HL) patients and non-Hodgkin's lymphoma (NHL) are increasing. Therefore, the number of patients who are interested in fertility preservation prior to chemotherapy treatment is steadily increasing. It is well known that conventional chemotherapy treatments may significantly reduce sperm quality (Van Der Kaaij et al., 2009). Moreover, several studies have shown that sperm quality in lymphoma patients may be reduced even prior to initiation of chemotherapy (Hallak, Mahran, & Agarwal, 2000; Rueffer et al., 2001). Many parameters were investigated in order to identify factors related to impaired sperm quality prior to chemotherapy. Factors that were investigated include advanced tumour spread (
Journal of the American Society of Echocardiography, 2019
Background: Calcific aortic stenosis (AS) is a progressive disease, and once moderate AS is prese... more Background: Calcific aortic stenosis (AS) is a progressive disease, and once moderate AS is present, the likelihood of symptom onset within 5 years is significant. The aim of this study was to determine the incremental value of global longitudinal strain (GLS) and basal longitudinal strain (BLS) at rest and during exercise on outcomes among asymptomatic patients' with moderate and severe AS. Methods: Seventy-five patients with isolated, asymptomatic AS and preserved left ventricular function were retrospectively enrolled and underwent symptom-limited exercise echocardiography. Clinical and echocardiographic data, including GLS and BLS at rest and during exercise, were assessed. Occurrence of ASrelated cardiovascular events was recorded. Results: The mean age was 71 6 10 years, and 63% were men. The mean aortic valve gradient was 30 6 11 mm Hg, and the mean aortic valve area was 0.98 6 0.21 cm 2. Resting GLS and BLS were À16.5 6 4% and À16.9 6 3.6%, respectively. Exercise stress test results were positive in 27 patients (36%). Mean exercise GLS was À17.8 6 3.5%, and mean exercise BLS was À17.9 6 4%. During mean follow-up of 34.5 6 3.5 months, cardiovascular events were observed in 45 patients. In multivariate analysis, aortic valve mean gradient (HR, 1.073; 95% CI, 1.032-1.115; P < .001) and peak exercise BLS (HR, 1.177; 95% CI, 1.07-1.295; P = .001) were associated with cardiac events during follow-up. Conclusions: Reduced exercise BLS is associated with future cardiovascular events in patients' with asymptomatic AS, independently of clinical factors and conventional echocardiographic parameters. Detection of postexercise myocardial dysfunction in patients with asymptomatic AS with preserved left ventricular function can aid in risk assessment of these patients.
Israel Journal of Veterinary Medicine, 2008
Two approaches to the synthesis of biotinylated derivatives of the stress-activated protein kinas... more Two approaches to the synthesis of biotinylated derivatives of the stress-activated protein kinase (SAPK) pathway activator anisomycin have been investigated. Attachment of the biotin moiety to the central core was achieved either through the use of a classical displacement reaction on a.-halo carbonyl derivatives of biotin or through a copper(I)-catalyzed 1,3-dipolar Huisgen cycloaddition ("click") coupling of biotinylated azides to propargyl-marked analogues of anisomycin. In each case, the resultant N-linked molecular probes were found to be active in SAPK pathway immunoblot assays, while their O-linked counterparts were inactive. However, in sharp contrast to the classical coupling approach which results in low coupling yields, the aqueous "click" coupling process was found to deliver high yields of biotinylated probes, making it the conjugation method of choice. A survey of the available methods for the addition of a propargyl marker onto a range of chemical functionalities strongly suggests that this copper(I)-catalyzed 1,3-dipolar Huisgen cycloaddition approach to biotinylation may be generally applied.
Techniques in Coloproctology, Apr 26, 2021
Postoperative ileus is a common condition following abdominal surgery. Previous studies have show... more Postoperative ileus is a common condition following abdominal surgery. Previous studies have shown the positive effects of coffee on gastrointestinal motility. The aim of this study was to assess whether caffeine is the stimulatory agent in coffee that triggers bowel motility and thus may reduce the duration of postoperative ileus. This was a single-centered, prospective, randomized controlled, double-blinded clinical trial. Patients scheduled to undergo elective laparoscopic colectomy between November 2017 and March 2019 were randomly assigned to receive either oral caffeine (100 mg three times daily) or placebo following the procedure. Primary endpoints were time to first flatus and time to first bowel movement. Secondary endpoints were time to tolerate a solid, low-residue diet and length of hospital stay. Registration number: NCT03097900. Seventy patients were included, [35 males, median age 56 years (range 19–79 years)]. After the exclusion of 12 patients, there were 30 patients in the caffeine group and 28 patients in the placebo group. The first passage of stool in the caffeine group occurred 18 h earlier than in the placebo group (p = 0.012); other endpoints did not reach statistical significance. No caffeine-related adverse events were observed. Caffeine consumption following colectomy is safe, leads to a significantly shorter time to first bowel movement, and may thus potentially lead to a shorter postoperative hospital stay.
Journal of Anesthesia, Analgesia and Critical Care, Dec 21, 2022
Background: Intellectually disabled (ID) patients present unique therapeutic challenges. We aimed... more Background: Intellectually disabled (ID) patients present unique therapeutic challenges. We aimed to describe the characteristics of ID patients admitted to a general intensive care unit (ICU). Results: We conducted a retrospective cohort study comparing critically ill adult ID patients to matched patients without ID (1:2 ratio) in a single ICU (2010-2020). The main outcome measure was mortality. Secondary outcomes included complications during admission and characteristics of weaning from mechanical ventilation. The study and control groups were randomly selected based on similar age and sex. ID patients nonetheless had an average APACHE score of 18.5 ± 8.7 vs. 13.4 ± 8.5 in controls (p < 0.001). ID patients had more hematological (p = 0.04), endocrinological (p < 0.001) and neurological (p = 0.004) comorbidities and used more psychiatric medication before admission. No difference was found in mortality rates. Differences were found as there were more secondary complications, such as pulmonary and sepsis (p < 0.03), frequent requirement of vasopressors (p = 0.001), significantly higher intubation rates with more weaning attempts, tracheostomies and longer ICU and hospital admissions (p < 0.019). Conclusions: Critically ill adult ID may have more comorbidities and be sicker at the time of admission compared to their age-and sex-matched counterparts. They require more supportive treatment and their weaning from mechanical ventilation may be more challenging.
Open Journal of Veterinary Medicine, 2012
This is the first reported study in which various cytological and microbial components of the ear... more This is the first reported study in which various cytological and microbial components of the ear canal of wild jackals (Canis aureus) were examined and compared with those of domesticated dogs (C. domesticus). It is proposed that the differences between them might be attributable to domestication. The normal cytology of the jackals' ears includes cerumen, keratinous debris, coccoid bacteria and yeast-like organisms similar to domesticated dogs, but the frequencies of these findings differed significantly between the two species. In the jackals the incidences of ceruminous debris and yeasts were significantly lower (p < 0.001, p = 0.004 respectively), while keratinous debris and coccoid bacteria were significantly higher (p < 0.001). During domestication some changes have probably occurred in the dogs' lifestyle that predisposed them to the growth of yeasts in their ears but less to bacterial growth. It is possible that the higher numbers of bacteria might be a result of environmental contamination, because some of the jackals lived near urban centers and feed on garbage.
Theriogenology, Apr 1, 2012
Bovine necrotic vulvovaginitis (BNVV) is a syndrome unique to Israel characterized by necrotic le... more Bovine necrotic vulvovaginitis (BNVV) is a syndrome unique to Israel characterized by necrotic lesion in the caudal vagina mainly in first calf heifers after calving, associated with Porphyromonas levii. The objectives of this study were to analyze the impact of BNVV on reproductive performance, milk production and survival in the heard of first calf dairy heifers in affected farms, and to verify if the effects of BNVV are severity-dependent. For assessment of the severity level a scale of 4 degrees was formed, and cows were scored 4 to 6 d after calving. Data were obtained from two dairy farms during 2006-07, consisting of 603 lactations. The incidence and the severity of BNVV declined between 2006 and 2007, and severe BNVV tended to be more prevalent in the summer. The odds to conceive in the first artificial insemination of BNVV cow tended to be lower than healthy cows (OR ϭ 0.676, P ϭ 0.052). Cows with BNVV had longer empty period (145.8 d vs. 135.1 d of healthy cows, P ϭ 0.031), but only severe BNVV had a negative effect on the odds of the cow to be empty at 150 d in milk (DIM) (OR ϭ 2.05, P ϭ 0.052). Severe BNVV also affected the mean survival time to conception (155.9 d vs. 142.3 d, P ϭ 0.042). All BNVV severity degrees had a negative effect on milk production. The effect on milk production was not limited only to the beginning of the lactation, cows with BNVV produced 338.1 kg milk less than healthy cows (P ϭ 0.016) in 305 d corrected lactation. The effect on milk production was not severity depended. No effect on survival time in the herd was demonstrated.
Journal of Dual Diagnosis, May 12, 2019
Objective: A significant proportion of patients with severe mental illness also experience substa... more Objective: A significant proportion of patients with severe mental illness also experience substance use disorder. For these dual diagnosis (DD) patients, treatment is more complicated and prognosis is worse. Despite the introduction of the Community Rehabilitation of Persons With Mental Health Disability Law in 2000 and ongoing national mental health reforms, psychiatric services in Israel are not meeting the needs of an increasing number of DD patients. This study examines, for the first time in Israel, the prevalence of DD and patterns of psychiatric hospitalizations of chronic psychotic disorder patients with and without substance use disorder. Methods: The National Psychiatric Case Registry provided data on 18,684 persons with schizophrenia/schizoaffective disorders, aged 18-65, with a psychiatric hospitalization during the period 1963-2016 (with at least one hospitalization in 2010-15). Patients were considered as having DD if their substance use disorder was indicated in at least two, or 20%, of hospitalizations. Regression modeling predicted hospitalization measures (number of hospitalizations, total days hospitalized, length of stay). Results were also analyzed by legal status of admission (voluntary or involuntary; psychiatrist-ordered and court-ordered). Results: One-third of patients with chronic psychotic disorder met DD criteria, with a threefold higher rate among males (37.1%) than females (12.8%). Particularly high rates of DD (nearly 50%) were noted among male immigrants from Ethiopia. Compared with non-substance use disorder patients, DD patients had a significantly younger mean age at first hospitalization and shorter average length of stay per hospitalization but a greater number of hospitalizations and total hospital days (p < .0001 for all comparisons). The associations between DD status and hospitalization characteristics remained significant even after accounting for the effects of confounding factors. Hospitalization characteristics were also associated significantly with sex, population group, age, age at first hospitalization, and country of origin. The rate of court-ordered observation or hospitalization was threefold higher in the DD group. Conclusions: These findings, which broadly align with other countries, reflect a scarcity of outpatient services for DD patients with schizophrenia/ schizoaffective disorder and substance use disorder. To achieve long-term mental health improvements, an expansion of community-based integrative treatment and rehabilitation services is needed in Israel.
Journal of Clinical Ultrasound, Jul 18, 2023
BackgroundThe presentation of the patient with acute cholangitis (AC) ranges from mild illness to... more BackgroundThe presentation of the patient with acute cholangitis (AC) ranges from mild illness to life‐threatening shock. Therefore, prompt diagnosis and treatment are critical. Abdominal ultrasound (US) is the imaging of choice to locate bile duct dilatation. Other modalities include abdominal computed tomography (CT) or endoscopic retrograde cholangiopancreatography (ERCP).ObjectivesTo determine whether sonographic common bile duct dilatation in emergency department (ED) patients with AC predicts outcomes including sepsis, hospital length of stay (LOS), admission to the intensive care unit (ICU), time to ERCP, and mortality.MethodsElectronic medical records of all patients hospitalized in a tertiary care medical center between July 2012–February 2021 with a discharge diagnosis of cholangitis were assessed. Patients were dichotomously classified as CBD dilated or CBD non‐dilated based on ultrasound. Dilation was defined as CBD larger than 6 mm in patients younger than 60 or larger than 6 mm + 1 mm per decade in patients over 60.ResultsThe study included 271 patients‐ 172 with CBD dilation versus 99 without. Mean LOS was 9.92 days for those with a dilated CBD versus 13.4 days without. The mean time to ERCP was 4.26 days for those with a dilated CBD versus 6.56 days without. Sepsis, mortality, and ICU admission were scarce and there was no statistically significant difference between the cohorts.ConclusionPatients with a dilated CBD per the abdominal US performed during the patient's ED stay, underwent ERCP earlier, and were hospitalized fewer days than patients without CBD dilation.
Research Square (Research Square), Dec 1, 2022
Background: CRP is increasingly used as in ammatory marker in sepsis. Aim of study: Assessment of... more Background: CRP is increasingly used as in ammatory marker in sepsis. Aim of study: Assessment of the cost-effectiveness of CRP in the treatment of patients with bacteremia. Methods: This was a retrospective study of two patient cohorts, one in 2015 (cohort A) and the other in 2018 (cohort B), each included 200 consecutively diagnosed patients with proven bacteremia. We assessed the following outcome markers: antibiotic use, duration of admission and in-hospital mortality. Results: Baseline demographic and clinical data of the cohorts were similar. In cohort A, a single CRP test was obtained from 5% of the patients, while in cohort B, 95% of patients had CRP tests with a mean of 5.7 tests/person. Empiric, appropriate antibiotic treatment, increased from 72% in cohort A to 75% in cohort B (NS). Duration of antibiotic treatment did not change (10±8 days). The in-hospital mortality rate decreased from 38.5% in cohort A to 30.5% in cohort B (NS), as did mortality <7 days after diagnosis of bacteremia, from 17.5% to 14% respectively)(NS). Conclusion: We found statistically insigni cant differences between the cohorts. It is di cult to establish a causal relationship between the described changes and the widespread use of serial CRP tests. There is currently no evidence that supports serial use of CRP tests in the treatment of patients with bacteremia.
Infection, Dec 28, 2012
The objective of this study was to evaluate the mortality of and risk factors for bacteriuria due... more The objective of this study was to evaluate the mortality of and risk factors for bacteriuria due to carbapenem-resistant Klebsiella pneumoniae (CRKp) versus carbapenem-susceptible K. pneumoniae (CSKp) producing extended spectrum β lactamase (ESBL). This was a retrospective case-control study in which 135 case-patients with bacteriuria due to CRKp were compared with 127 control patients with CSKp producing ESBL. In a first step, multivariate Cox regression and Kaplan-Meier survival analysis models were used to determine the difference in mortality between the two groups and risk factors for mortality. In a second step, a univariate analysis was used to identify risk factors for CRKp colonization. There were no significant demographic or clinical differences between the groups. In-hospital mortality in the study and control groups was 29 and 25 %, respectively (non-significant difference). Multivariate analysis revealed that the most important risk factor for mortality in both groups was being bed ridden [hazard ratio 2.2, 95 % confidence interval (CI) 1.23-3.93; P = 0.008]. Patients with CRKp bacteriuria had a longer hospitalization time with a mean ± standard deviation of 28 ± 33 days compared to 22 ± 28 days in the control group (P &lt; 0.05). Several univariate risk factors for acquiring CRKp bacteriuria were identified: antibiotic use [odds ratio (OR) 1.93, 95 % CI 1.18-3.17, p = 0.008], especially colistin (OR 2.04, 95 % CI 1.04-4.02; P = 0.036), presence of a urinary catheter (OR 2.09, 95 % CI 1.2-3.63; P = 0.008), surgery (OR 3.94, 95 % CI 1.85-8.37; P = 0.0002), invasive procedures (OR 3.06, 95 % CI 1.61-5.8; P = 0.0004), and intensive care unit admission (OR 2.49, 95 % CI 1.18-5.37; P = 0.015). Bacteriuria caused by CRKp as compared that caused by CSKp was not found to be a risk factor for death.
BMC Cardiovascular Disorders, Feb 16, 2022
Background: Right heart catheterization (RHC) and echocardiography are both routinely used for pu... more Background: Right heart catheterization (RHC) and echocardiography are both routinely used for pulmonary artery systolic pressure (PASP) assessment in lung transplantation (LT) candidates, although this is not mandated by current guidelines. We aimed to explore the performance of echocardiographic PASP as an indicator of pulmonary hypertension in LT candidates, in order to assess the necessity of RHC. Methods: From a retrospective registry of 393 LT candidates undergoing RHC and echocardiography during 2015-2019, patients were assessed for the presence of pulmonary hypertension (PH), defined as mean pulmonary artery pressure (mPAP) above 20 mmHg, according to two methods-echocardiography and RHC. The primary outcome was the correlation between the PASP estimated by echocardiography to that measured by RHC. Secondary outcomes were the prediction value of the echocardiographic evaluation and its accuracy. Results: The mean value of PASP estimated by echocardiography was 49.5 ± 20.0 mmHg, compared to 42.5 ± 18.0 mmHg measured by RHC. The correlation between the two measurements was moderate (Pearson's correlation: r = 0.609, p < 0.01). Echocardiography PASP measurements were moderately discriminative to diagnose PH, with an area under the curve (AUC) of 0.72 (95% CI 0.66-0.77). Echocardiographic overestimation of PASP of more than 10 mmHg was found in 35.0% of the patients, and underestimation was found in 11.6% of the patients. Conclusion: In the pre-surgical evaluation of LT candidates, echocardiographic estimation of PASP had moderate correlation and limited accuracy compared to the PASP measured by RHC. We thus recommend performing routine RHC to all LT candidates, regardless of the echocardiographic estimation of PASP.
VetPharma, 2013
THE ASSOCIATION BETWEEN THE SIGNALMENT, COMMON CAUSES OF CANINE OTITIS EXTERNA AND PATHOGENS Ключ... more THE ASSOCIATION BETWEEN THE SIGNALMENT, COMMON CAUSES OF CANINE OTITIS EXTERNA AND PATHOGENS Ключевые слова: наружный отит у собак, аллергия, структурные изменения в слуховом канале, предрасполагающие факторы Key words: canine otitis externa, allergies, conformational abnormalities, predisposing factors Аннотация ЦЕЛЬ: определить, существует ли взаимосвязь между болезнетворными микроорганизмами, аллергией, анатомическими особенностями, эндокринными нарушениями и проявлением наружного отита у собак (НО). МЕТОДЫ: проведён ретроспективный анализ и статистическая обработка 149 случаев наружного отита у собак. РЕЗУЛЬТАТЫ: были выявлены некоторые породные особенности НО у наиболее часто поступающих в ветеринарные клиники собак (шар-пей, немецкая овчарка, кокер-спаниель и др.) с высокой степенью достоверности (р˂0, 001). По статистике, немецкие овчарки и кокер-спаниели более склонны к бактериальной инфекции, вызванной палочками, а у лабрадор-ретриверов, напротив, причиной НО палочки являются реже, чем у всех других пород (р=0,034). Почти у всех собак в возрасте старше пяти лет при НО присутствуют и кокки (р=0,01), и палочки (р=0,028). Отиты, вызванные палочками, встречались чаще при эндокринных нарушениях (р=0,004), в то время как тенденция к отитам, связанных с Malassezia spp. выявлена при аллергиях (р=0,098). Эндокринные патологии могут способствовать более тяжёлому течению НО, и, в связи с этим, у пожилых собак наружный отит может труднее поддаваться лечению. Между другими рассмотренными параметрами не было выявлено статистически значимых взаимосвязей.
Diseases of The Esophagus, Jul 7, 2022
Summary Esophageal strictures in children may cause dysphagia, choking during feeds, and failure ... more Summary Esophageal strictures in children may cause dysphagia, choking during feeds, and failure to thrive. They can be treated by balloon dilatations, either under endoscopic or fluoroscopic guidance; there is no literature comparing the methods. Retrospective review of the medical records of children (0–18 years) who were treated with balloon dilatations between 2010 and 2020. The primary outcome was the number of dilatation sessions required until clinical success after 3 months. Secondary outcomes were long-term success at 12 months, and complications of bleeding and perforation. Forty-six patients underwent 174 dilatation sessions. Success rates in the endoscopy and fluoroscopy groups were similar: 62% versus 67% (p = 0.454) at 3 months and 57% versus 67% (p = 0.721) at 12 months. Complication rate was lower in the endoscopy group (0% vs. 15%, p &lt; 0.001). Both endoscopic and radiologic-guided balloon dilatations were shown to be equally effective, but endoscopic guidance had fewer complications.
Administration and Policy in Mental Health, Aug 11, 2020
The co-occurrence of schizophrenia and substance use disorder (SUD) is clinically challenging and... more The co-occurrence of schizophrenia and substance use disorder (SUD) is clinically challenging and increasingly prevalent. This study compares trends in hospitalization characteristics of chronic psychotic patients with and without SUD in Israel, before and after introduction of the Community Rehabilitation of Persons with Mental Disability Law in 2000. The National Psychiatric Case Registry provided data on 18,684 adults with schizophrenia/schizoaffective disorders, hospitalized in 1991-2016 (at least once in 2010-2015). Repeated-measures ANOVA was used to measure the effect (and interactions) of group (patients with and without co-occurring disorders (COD)), time-period (
Journal of Veterinary Pharmacology and Therapeutics, Sep 28, 2015
Therapeutic soft contact lenses (TSCLs) are frequently used to support or protect the cornea duri... more Therapeutic soft contact lenses (TSCLs) are frequently used to support or protect the cornea during healing. Our aim was to quantitatively evaluate the efficacy of topical medications in TSCL-fitted dogs and determine whether it is affected by the presence of TSCLs. In Phase I, pupil diameter was measured in eyes treated with tropicamide and in eyes covered with TSCLs and then treated with tropicamide, with 1-week intervals between sessions. In Phase II, intraocular pressure (IOP) was measured in uncovered and TSCL-covered eyes treated with latanoprost, with 1-week intervals between sessions. Tropicamide caused significant mydriasis in both uncovered and TSCL-covered eyes (P = 0.005). On the other hand, latanoprost caused a significant decrease in IOP when applied to uncovered eyes (P = 0.002), but had no significant effect on IOP when applied to TSCL-covered eyes (P = 0.7). As we used the same dogs and identical TSCLs throughout the study, we conclude that the different outcomes of the two drugs are due to properties of the drugs themselves, or their formulations, affecting their interaction with the TSCLs. The clinical efficacy of topical drugs applied to TSCL-covered eyes may have to be determined for each drug and/or formulation.
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Papers by Tali Bdolah-abram