Tuberous sclerosis is a rare dominant autosomal disorder in which neurological involvement manife... more Tuberous sclerosis is a rare dominant autosomal disorder in which neurological involvement manifests itself in the form of seizures,mental retardation affective and behavioral derangement.We report a case whose main presenting feature was major depression,not mentioned in previous literature.
Background: The association between gallstones and abnormal lipids and later increase in risk of ... more Background: The association between gallstones and abnormal lipids and later increase in risk of coronary artery disease and stroke has been shown in many studies. The aim of study is to elucidate the association of dyslipidaemia with Cholilithiasis and effect of Cholecystectomy on the same. Methods: 73 patients with symptomatic gallstones were studied prospectively. Plasma concentration of cholesterol, triglycerides, LDL, HDL was analysed preoperatively and postoperatively on day 3 and after 6 months of Cholecystectomy. None of the patients received any lipid lowering drug or dietary restriction. Results were analysed and compared. Results: 36 (80%) of the female patients and 20 (71.42%) of male patients had one or other abnormality in their lipid profile preoperatively Plasma concentration of total cholesterol, triglycerides, and LDL cholesterol were significantly reduced in patients on day 3 of surgery and 6 months thereafter. There was no significant increase/decrease in HDL cholesterol in 6 months after Cholecystectomy. Conclusion: There was a significant decrease in plasma concentration of lipids in Cholecystectomy patients postoperatively. These changes in plasma lipids are likely to have significant effect in the development of coronary artery diseases in patients with Cholecystectomy.
Reninoma, a renin-secreting tumor of the juxta-glomerular cells of the kidney, is a rare but surg... more Reninoma, a renin-secreting tumor of the juxta-glomerular cells of the kidney, is a rare but surgically treatable cause of secondary hypertension in children. We report a case of reninoma presenting as cardiac syncope with long QTc on electrocardiogram due to hypokalemia.
This syndrome is characterized by the presence of hypothyroidism with myxoedema, muscle stiffness... more This syndrome is characterized by the presence of hypothyroidism with myxoedema, muscle stiffness and pseudo hypertrophy. We describe the disorder in a 21 year old male, who got admitted with complaints of generalized weakness, cold intolerance, constipation, and hoarse ...
Objective: We report a very rare case of Hoffmann’s syndrome with musclehypertrophy complicating ... more Objective: We report a very rare case of Hoffmann’s syndrome with musclehypertrophy complicating hypothyroidism. Clinical Presentation: A 24-year-old man presented with a 2-year history of forgetfulness, swelling in his face, shoulder and calf, and motor weakness in his lower extremities. His calf and shoulder muscles were hypertrophic. Neurological examination revealed hoarseness of the voice, proximal muscle weakness, reduced deep tendon reflexes and a mildly ataxic gait. Laboratory tests indicated markedly elevated serum muscle enzymes and lipids, a high thyroid-stimulating hormone level and low free triiodothyronine and free thyroxine levels. Electromyographic evaluation showed myopathy. Intervention: Oral L-thyroxine treatment was started and at a 1-month follow-up examination, mental status and physical performance were improved. Conclusion: This report shows that in the differential diagnosis of myopathy with pseudohypertrophy, Hoffmann’s syndrome should be considered.
Tuberous sclerosis is a rare dominant autosomal disorder in which neurological involvement manife... more Tuberous sclerosis is a rare dominant autosomal disorder in which neurological involvement manifests itself in the form of seizures,mental retardation affective and behavioral derangement.We report a case whose main presenting feature was major depression,not mentioned in previous literature.
Background: The association between gallstones and abnormal lipids and later increase in risk of ... more Background: The association between gallstones and abnormal lipids and later increase in risk of coronary artery disease and stroke has been shown in many studies. The aim of study is to elucidate the association of dyslipidaemia with Cholilithiasis and effect of Cholecystectomy on the same. Methods: 73 patients with symptomatic gallstones were studied prospectively. Plasma concentration of cholesterol, triglycerides, LDL, HDL was analysed preoperatively and postoperatively on day 3 and after 6 months of Cholecystectomy. None of the patients received any lipid lowering drug or dietary restriction. Results were analysed and compared. Results: 36 (80%) of the female patients and 20 (71.42%) of male patients had one or other abnormality in their lipid profile preoperatively Plasma concentration of total cholesterol, triglycerides, and LDL cholesterol were significantly reduced in patients on day 3 of surgery and 6 months thereafter. There was no significant increase/decrease in HDL cholesterol in 6 months after Cholecystectomy. Conclusion: There was a significant decrease in plasma concentration of lipids in Cholecystectomy patients postoperatively. These changes in plasma lipids are likely to have significant effect in the development of coronary artery diseases in patients with Cholecystectomy.
Reninoma, a renin-secreting tumor of the juxta-glomerular cells of the kidney, is a rare but surg... more Reninoma, a renin-secreting tumor of the juxta-glomerular cells of the kidney, is a rare but surgically treatable cause of secondary hypertension in children. We report a case of reninoma presenting as cardiac syncope with long QTc on electrocardiogram due to hypokalemia.
This syndrome is characterized by the presence of hypothyroidism with myxoedema, muscle stiffness... more This syndrome is characterized by the presence of hypothyroidism with myxoedema, muscle stiffness and pseudo hypertrophy. We describe the disorder in a 21 year old male, who got admitted with complaints of generalized weakness, cold intolerance, constipation, and hoarse ...
Objective: We report a very rare case of Hoffmann’s syndrome with musclehypertrophy complicating ... more Objective: We report a very rare case of Hoffmann’s syndrome with musclehypertrophy complicating hypothyroidism. Clinical Presentation: A 24-year-old man presented with a 2-year history of forgetfulness, swelling in his face, shoulder and calf, and motor weakness in his lower extremities. His calf and shoulder muscles were hypertrophic. Neurological examination revealed hoarseness of the voice, proximal muscle weakness, reduced deep tendon reflexes and a mildly ataxic gait. Laboratory tests indicated markedly elevated serum muscle enzymes and lipids, a high thyroid-stimulating hormone level and low free triiodothyronine and free thyroxine levels. Electromyographic evaluation showed myopathy. Intervention: Oral L-thyroxine treatment was started and at a 1-month follow-up examination, mental status and physical performance were improved. Conclusion: This report shows that in the differential diagnosis of myopathy with pseudohypertrophy, Hoffmann’s syndrome should be considered.
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