Papers by Thomas Lundeberg
Acupuncture and Related Therapies, 2015
Revista Internacional De Acupuntura, Oct 1, 2014
Autonomic Neuroscience Basic Clinical, Dec 1, 2000
Interleukin-1b (IL-1b) is an important mediator of fever and illness. Recent studies have demonst... more Interleukin-1b (IL-1b) is an important mediator of fever and illness. Recent studies have demonstrated that IL-1b (2 mg kg) increases gastric vagal afferent activity. The peripheral mechanisms of the action of lower doses were studied by recording the mass efferent and afferent activity of the gastric branch of the ventral vagal nerve in anesthetized rats. Twenty min after i.v. administration of 21 IL-1b (1 mg kg) the efferent activity of the vagal nerve was decreased to 6266% in totally but not in partly vagotomized rats. 21 21 Preadministration of indomethacin (5 mg kg) 30 min before IL-1b blocked this reduction. Administration of 1 mg kg of IL-1b had no effect on the afferent activity of the gastric branch of the vagal nerve. The present results suggest that the subdiaphragmatic vagal afferents modulate the parasympathetic efferent outflow in response to IL-1b partly through prostaglandin dependent mechanisms and that supradiaphragmatic afferents or central sites are more sensitive to the low doses of IL-1b which becomes evident after elimination of the subdiaphragmatic vagal input.
Revista Internacional De Acupuntura, Nov 28, 2014
Journal of Pain Research, 2016
Endometriosis is a multifactorial, estrogen-dependent, inflammatory gynecological condition-often... more Endometriosis is a multifactorial, estrogen-dependent, inflammatory gynecological condition-often with long-lasting visceral pelvic pain of different origin, and infertility among women. Current management options for patients' are often inadequate, with side effects for many for whom acupuncture techniques could be an alternative. Earlier studies have discussed the efficacy of acupuncture, but not its methodological aspects. Objectives: To summarize the documented clinical effects of acupuncture on rated visceral pelvic endometriosis-related pain, and associated variables among individuals, within and between studied groups, and to discuss the methodological treatment aspects. Methods: Published full text clinical studies, case reports, and observational studies with abstracts written in English were searched by using the keywords "Acupuncture and Endometriosis" in databases such as PubMed, Web of Science, and CINAHL. The reporting guidelines, Standards for Reporting Interventions in Clinical Trials of Acupuncture was used for the methodological report. Results: Three studies were found including 99 women, 13-40 years old, with diagnosed endometriosis. The studies were different in research design, needle stimulation techniques, and evaluation instruments. Methodological similarities were seven to12 needle insertions per subject/session, and 15-25 minutes of needle retention time. The needles were placed in lower back/pelvic-abdominal area, in the shank, feet, and hands. Treatment numbers varied from nine to 16 and patients received one to two treatments per week. Similarity in reported treatment effects in the quoted studies, irrespective of research design or treatment technique, was reported decrease of rated pain intensity. Discussion: Meta-analysis is the standard procedure for the evaluation of evidence of treatment effects, ie, on a group level, usually without analysis of the individual responses even with obvious spread in the results leading to lack of guidance for treatment of the individual patient. By conceptualizing pain as subjective, the individual aspect should serve as the basis for the analysis to allow clinical recommendations. From a physiological and a western medical perspective, acupuncture can be regarded as a type of sensory stimulation that induces changes in the function of the central nervous system that partly can explain the decrease of perceived pain in response to acupuncture treatment irrespective of the technique. Conclusion: Endometriosis is often painful, although with various origin, where standard treatments may be insufficient or involve side effects. Based on the reported studies, acupuncture could be tried as a complement as it is an overall safe treatment. In the future, studies designed for evaluating effectiveness between treatment strategies rather than efficacy design would be preferred as the analyses of treatment effects in the individual patients.
Revista Internacional De Acupuntura, Oct 1, 2014
Inflammation, 1997
In the present study the content of substance P (SP)-, neurokinin A (NKA)-, calcitonin gene-relat... more In the present study the content of substance P (SP)-, neurokinin A (NKA)-, calcitonin gene-related peptide (CGRP)-and neuropeptide Y (NPY)-like immunoreactivity (-L1) was measured in rats cerebrospinal fluid (CSF), plasma and perfusates (PF) from both elbow enthesis during acute inflammation. Either substance P, SP, (10-5 M, 0.01 ml) or human recombinant interleukin-1 a (hrll-l a, 0.01 ml) were injected into the right enthesis of the extensor carpi radial is brevis (ECRB). The left ECRB and both ECRBs of control rats, were injected with 0.01 ml saline. Samples of CSF, plasma and PF from both ECRBs were obtained at 2, 6, and 24 h following injection and neuropeptide-LI was analysed by specific radioimmunoassays. Neuropeptide-LI was compared with control values and between the treated groups. In both treated groups NKA-and CGRP-LI was increased in CSF and NKA-LI decreased in plasma, while CGRP-and NPY-LI were raised to a similarly significant degree in the enthesis of the ECRB. SP-LI was increased in ECRB PF in comparison with controls and NKA-LI levels were higher in the hrll-l a group both in comparison with controls and between treated groups. In summary an unilateral injection of either SP or hrll-1 a into the enthesis of the ECRB of the rat showed a similar influence at 2, 6, and 24 h following injection. The most pronounced changes in neuropeptide-LI occurred in the ECRB PF of both treated groups.
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Papers by Thomas Lundeberg