This study aimed to determine the effects of cooking on the dietary fiber and phenolic contents o... more This study aimed to determine the effects of cooking on the dietary fiber and phenolic contents of chickpea (Cicer arietinum L), kidney bean (Phaseolus vulgaris L), mung bean (Vigna radiata L. R. Wilczek) and its combinations. The beans were cooked using an automatic rice cooker and combinations of beans were done by mixing each of the homogenized beans flour in the ratio of 1:1 (w/w) and 1:1:1 (w/w/w). Resulted showed cooking affects the dietary fiber and total phenolic content (TPC) of beans and its combinations to various extents. Comparing with the raw form, cooking significantly reduced (p<0.05) the insoluble dietary fiber (IDF) of mung bean and chickpea. Combinations of cooked kidney bean, mung bean and chickpea (KMC) resulted in a significantly higher (P<0.05) yield of IDF than all individual beans studied. Cooking causes a reduction or increment in the phenolic contents of beans and its combinations. This study suggests the possibility of using the beans combinations m...
Metabolic reprogramming is widely known as a hallmark of cancer cells to allow adaptation of cell... more Metabolic reprogramming is widely known as a hallmark of cancer cells to allow adaptation of cells to sustain survival signals. In this report, we describe a novel oncogenic signaling pathway exclusively acting in mutated epidermal growth factor receptor (EGFR) non-small cell lung cancer (NSCLC) with acquired tyrosine kinase inhibitor (TKI) resistance. Mutated EGFR mediates TKI resistance through regulation of the fatty acid synthase (FASN), which produces 16-C saturated fatty acid palmitate. Our work shows that the persistent signaling by mutated EGFR in TKI-resistant tumor cells relies on EGFR palmitoylation and can be targeted by Orlistat, an FDA-approved anti-obesity drug. Inhibition of FASN with Orlistat induces EGFR ubiquitination and abrogates EGFR mutant signaling, and reduces tumor growths both in culture systems andTogether, our data provide compelling evidence on the functional interrelationship between mutated EGFR and FASN and that the fatty acid metabolism pathway is a...
The Malaysian journal of medical sciences : MJMS, 2017
Epilepsy surgery has been performed by a few centres in Malaysia, including Hospital Universiti S... more Epilepsy surgery has been performed by a few centres in Malaysia, including Hospital Universiti Sains Malaysia (HUSM). To date, a total of 15 patients have undergone epilepsy surgery in HUSM. The epilepsy surgery included anterior temporal lobectomy (ATL) with amygdalohippocampectomy (AH) and Vagal nerve stimulation (VNS). The surgical outcomes of the patients were assessed using the International League Against Epilepsy (ILAE) outcome scale. The ILAE scores for patients who underwent ATL with AH were comparatively better than those who underwent VNS. One of the patient who underwent ATL with AH and frontal lesionectomy was found to have psychosis during follow up. Epilepsy surgery has proven to be an important treatment for medically resistant epilepsy. Thus it is important to raise public awareness regarding epilepsy and its treatment.
A. Deep brain stimulation (DBS) for movement disorders: an experience in Hospital Universiti Sain... more A. Deep brain stimulation (DBS) for movement disorders: an experience in Hospital Universiti Sains Malaysia (HUSM) involving 12 patients.
Background: The neuroprotective role of minocycline in the treatment of brachial plexus injury is... more Background: The neuroprotective role of minocycline in the treatment of brachial plexus injury is controversial. Objective: To study the neuroprotective effect of minocycline via different routes in adult Sprague Dawley rats with brachial plexus injury. Methods: The C7 nerve roots of the animals were avulsed via an anterior extravertebral approach. Traction force was used to transect the ventral motor nerve roots at the preganglionic level. Intraperitoneal and intrathecal minocycline (50 mg/kg for the first week and 25 mg/kg for the second week) were administered to promote motor healing. The spinal cord was harvested six weeks after the injury, and structural changes following the avulsion injury and pharmacological intervention were analysed. Results: Motor neuron death and microglial proliferation were observed after the administration of minocycline via two different routes (intraperitoneal and intrathecal) following traumatic avulsion injury of the ventral nerve root. The administration of intraperitoneal minocycline reduced the microglia count but increased the motor neuron count. Intrathecal minocycline also reduced the microglial count, with a greater reduction than in the intraperitoneal group, but it decreased the motor neuron count. Conclusions: Intraperitoneal minocycline increased motor neuron survival by inhibiting microglial proliferation following traumatic avulsion injury of the nerve root. The inhibitory effect was augmented by the use of intrathecal minocycline, in which the targeted drug delivery method increased the bioavailability of the therapeutic agent. However, motor neuron survival was impaired at a higher concentration of minocycline via the intrathecal route due to the more efficient method of drug delivery. Microglial suppression via minocycline can have both beneficial and damaging effects, with a moderate dose being beneficial as regards motor neuron survival but a higher dose proving neurotoxic due to impairment of the glial response and Wallerian degeneration, which is a prerequisite for regeneration.
Non-bacterial thrombotic endocarditis (NBTE) classically presents in the context of pancreatic ad... more Non-bacterial thrombotic endocarditis (NBTE) classically presents in the context of pancreatic adenocarcinomas. Echocardiography is useful to investigate for valvular vegetations, and institution of early treatment is crucial as this can be complicated by multiple systemic emboli, leading to significant morbidity or mortality in serious cases. Treatment options involve anticoagulation with unfractionated heparin, and the role of surgical intervention is unclear. In this report, we describe a classical case of a middle-aged lady with unresectable pancreatic adenocarcinoma who developed NBTE complicated by multiple systemic emboli. She eventually succumbed from poor neurological status from multiple cerebral emboli. Awareness of this condition is required by clinicians for early diagnosis and prompt treatment.
Purpose of ReviewReconstruction of head and neck defects that cannot be closed primarily often re... more Purpose of ReviewReconstruction of head and neck defects that cannot be closed primarily often requires the use of complex locoregional, pedicled, or microvascular flaps. Success of the reconstruction relies on the vascular supply of these flaps to prevent major and sometimes life-threatening wound complications. Intraoperative fluorescence angiography is an emerging aspect of the field that can be used as an adjunct to other methods to identify vascular compromise before, during, and after reconstruction.Recent FindingsLaser-assisted near-infrared angiography with intravenous indocyanine green (ICG) dye has been used to perform optical angiography in plastic surgery to help determine the recipient tissue perfusion at the defect site as well as the perfusion of the tissue used for reconstruction. This method allows for quantification of perfusion in skin and soft tissue reconstruction.SummaryLaser-assisted near-infrared angiography with intravenous ICG dye is fast, reliable, safe and can have many uses in head and neck reconstruction including the ability to quantitatively assess perfusion in perforators and angiosomes in flap design, prior to completion of harvest, during, and after the microvascular anastomosis, and in the distal edges of rotational and pedicled flaps. It can also be used to objectively view the native tissue prior to reconstruction, especially in patients with a history of radiation or chemotherapy.
The tumour-initiating cell (TIC) model accounts for phenotypic and functional heterogeneity among... more The tumour-initiating cell (TIC) model accounts for phenotypic and functional heterogeneity among tumour cells. MicroRNAs (miRNAs) are regulatory molecules frequently aberrantly expressed in cancers, and may contribute towards tumour heterogeneity and TIC behaviour. More recent efforts have focused on miRNAs as diagnostic or therapeutic targets. Here, we identified the TIC-specific miRNAs, miR-1246 and miR-1290, as crucial drivers for tumour initiation and cancer progression in human non-small cell lung cancer. The loss of either miRNA impacted the tumour-initiating potential of TICs and their ability to metastasize. Longitudinal analyses of serum miR-1246 and miR-1290 levels across time correlate their circulating levels to the clinical response of lung cancer patients who were receiving ongoing anti-neoplastic therapies. Functionally, direct inhibition of either miRNA with locked nucleic acid administered systemically, can arrest the growth of established patient-derived xenograft...
Hypomagnesemia is a common side effect of treatment with epidermal growth factor receptor inhibit... more Hypomagnesemia is a common side effect of treatment with epidermal growth factor receptor inhibitor. Guidelines recommend intravenous magnesium replacement to treat this toxicity; however, our systematic review has found little evidence to support this approach. Prospective studies are needed to define the best strategy to manage epidermal growth factor receptor inhibitor-induced hypomagnesemia. Background: Despite occurring in 30% of patients, there are no evidence-based guidelines on the management of epidermal growth factor receptor inhibitor (EGFRI)-induced hypomagnesemia. Based on expert opinion, severe hypomagnesemia should be treated by intravenous magnesium replacement. A systematic review of published data of intervention on EGFRI-induced hypomagnesemia was performed. Methods: Articles from 1960 to March 2015 were identified from Medline, Embase, Cochrane Central Register of Controlled Trials, and PubMed using a peer-reviewed systematic search strategy. Eligible studies included randomized controlled trials or observational studies that evaluated management of hypomagnesemia in adult patients treated with EGFRIs. Risk factors for severe hypomagnesemia were also assessed. The quality of included studies was rated using Jadad scores. Results: A total of 1327 references were identified, and 6 studies, involving 486 patients, met inclusion criteria for analysis. There were no randomized controlled trials, and all included studies were of poor quality. From the studies included in this review, severity of EGFRI-induced hypomagnesemia was associated with length of EGFRI treatment, concomitant platinum chemotherapy, increasing age, and baseline magnesium concentration. In most patients with grade 3 or 4 hypomagnesemia, high-dose intravenous magnesium replacement did not achieve sustainable magnesium repletion beyond 72 hours. Oral magnesium supplementation was not effective or tolerable. Severe hypomagnesemia has been associated with tachycardia and mental alteration. After discontinuation of EGFRI therapy, hypomagnesemia generally resolves within weeks to months. Conclusions: There is an absence of high-quality evidence for the management of EGFRI-induced hypomagnesemia. As hypomagnesemia is often refractory to frequent intravenous or oral replacement, there is a need for prospective trials of new interventions for this common toxicity.
The NF-κB pathway is overexpressed in non-small cell lung cancers (NSCLC) and contributes to the ... more The NF-κB pathway is overexpressed in non-small cell lung cancers (NSCLC) and contributes to the poor prognosis and high mortality characterizing this malignancy. Silencing the p50 and p65 NF-κB subunits in the NSCLC H1299 cell line led to profound loss in cell viability and downregulated anti-apoptotic proteins survivin and Mcl1. We also showed that a survivin suppressant, the dioxonaphthoimidazolium YM155, and its structural analog AB1 arrested the growth of H1299 cells at nanomolar concentrations. Both compounds were apoptogenic and suppressed survivin and other anti-apoptotic proteins (Mcl1, Bcl-2, Bcl-xl) in a dose- and/or time-dependent manner. YM155 and AB1 did not affect the expression of key proteins (IκBα, p65, p50) involved in NF-κB signaling. Stable IκBα levels suggest that the NF-κB/IκB complex and proteins upstream of IκBα, were not targeted. Neither did the compounds intercept the nuclear translocation of the p50 and p65 subunits. On the other hand, YM155 and AB1 supp...
Microcrystalline silicon thin films have been prepared through a mixture of silane and hydrogen g... more Microcrystalline silicon thin films have been prepared through a mixture of silane and hydrogen gases using an excitation frequency of 40.68 MHz. For more cost reduction of solar cells, higher module efficiencies and deposition rates are required. This study tried to develop the low temperature processes of silicon thin film for solar cell deposition with a range of crystalline volume
Research is an essential guide to improve and develop new inventions in the health system 1 so th... more Research is an essential guide to improve and develop new inventions in the health system 1 so that we are able to meet the challenges in the health system. There are constantly new discoveries and inventions in the medical sciences and doctors need to keep up to date with the recent developments
Myeloid sarcoma (MS) is a rare extramedullary myeloid tumour. It has been reported in various sit... more Myeloid sarcoma (MS) is a rare extramedullary myeloid tumour. It has been reported in various sites, including lymph node, bone, skin, soft tissue, various organs and the CNS. It may precede or occur concurrently with acute myeloid leukemia. Urinary bladder involvement is extremely uncommon. We report a 70-year-old female who had MS of the urinary bladder, presented with frank and persistent hematuria associated with lower abdominal pain. She subsequently had tumour seeding in the abdominal skin via percutaneous suprapubic catheter. Tumours from both the urinary bladder and skin showed immature cells that were immunoreactive toward LCA (focal), MPO (strong), CD99 (weak) and CD117 (weak). Summary of cases in the literature is presented. The potential of its misdiagnosis and the useful markers for the diagnosis of MS are discussed.
17th IEEE International Conference on Tools with Artificial Intelligence (ICTAI'05), 2005
A RWA linear programming formulation was formulated and ILP solver was used along with good appro... more A RWA linear programming formulation was formulated and ILP solver was used along with good approximation techniques (heuristic) to solve the static RWA problem The objective was to maximize the one hop traffic, given a set of lightpath requests/traffic demand. However, the proposed heuristic has the limitation of stagnation. Thus we applied Ant Colony Optimization (ACO) combined with heuristic algorithm to solve the assignment problem to obtain best assignment with highest objective value. The ACO based algorithm can outperform the comparison scheme and provide a better performance and more reliable than the proposed heuristic and ILP solver. The claim made in the paper for the proposed new heuristic and ACO are supported by experimental results.
We read with great interest the recent article by Arcila and colleagues (1). We present a case of... more We read with great interest the recent article by Arcila and colleagues (1). We present a case of exon 20 insertion mutation (A763_764insFQEA), with documented clinical and radiologic response to EGF receptor (EGFR) tyrosine kinase inhibitor (TKI). To our knowledge, this is the first report of response to erlotinib monotherapy with this particular solitary mutation (1, 2). The patient, a 75-year-old Chinese male ex-smoker (40 pack-years), was diagnosed with metastatic non-small cell lung carcinoma in November 2010. Fine needle aspiration
Ninth International Workshop on Frontiers in Handwriting Recognition
In automatic word recognition, location-scale-rotation invariant features are important. We will ... more In automatic word recognition, location-scale-rotation invariant features are important. We will consider rotation invariant moments of 2-D imagery. Two new series of invariant moments are derived by Lie theory of the orthogonal transformation group. The infinite series are expressed in terms of regular moments.
The paper presents the results of numerical simulation of crack of mild steel under compression l... more The paper presents the results of numerical simulation of crack of mild steel under compression load. The work is performed with the use of CASCA and FRANC2D/L for modeling and simulating the stress distribution of crack under compression radial load. The aims were to develop a finite element model and to simulate the crack propagation in steel plate under compression load. The simulation results were compared with experimental results for verification. The obtained results will provide a prediction of physical behaviour of the structure with failure direction of the crack path.
2010 IEEE 24th International Conference on Advanced Information Networking and Applications Workshops, 2010
Abstract Packet contention is a major issue in optical packet switching network. To resolve cont... more Abstract Packet contention is a major issue in optical packet switching network. To resolve contention, optical buffering approach is used using Fiber Delay Lines (FDLs). Yet there is a heavy packet loss rate due to unavailability of output-port and free FDLs. This paper ...
2010 Second International Conference on Computer Research and Development, 2010
Page 1. Performance Analysis of Selective Minimum Delay Value (SMDV) Algorithm for Packet Content... more Page 1. Performance Analysis of Selective Minimum Delay Value (SMDV) Algorithm for Packet Contention Resolution of Optical Packet Switch Ahmed Galib Reza Faculty of Information Technology Multimedia University 63100 Cyberjaya, Malaysia [email protected] ...
This study aimed to determine the effects of cooking on the dietary fiber and phenolic contents o... more This study aimed to determine the effects of cooking on the dietary fiber and phenolic contents of chickpea (Cicer arietinum L), kidney bean (Phaseolus vulgaris L), mung bean (Vigna radiata L. R. Wilczek) and its combinations. The beans were cooked using an automatic rice cooker and combinations of beans were done by mixing each of the homogenized beans flour in the ratio of 1:1 (w/w) and 1:1:1 (w/w/w). Resulted showed cooking affects the dietary fiber and total phenolic content (TPC) of beans and its combinations to various extents. Comparing with the raw form, cooking significantly reduced (p<0.05) the insoluble dietary fiber (IDF) of mung bean and chickpea. Combinations of cooked kidney bean, mung bean and chickpea (KMC) resulted in a significantly higher (P<0.05) yield of IDF than all individual beans studied. Cooking causes a reduction or increment in the phenolic contents of beans and its combinations. This study suggests the possibility of using the beans combinations m...
Metabolic reprogramming is widely known as a hallmark of cancer cells to allow adaptation of cell... more Metabolic reprogramming is widely known as a hallmark of cancer cells to allow adaptation of cells to sustain survival signals. In this report, we describe a novel oncogenic signaling pathway exclusively acting in mutated epidermal growth factor receptor (EGFR) non-small cell lung cancer (NSCLC) with acquired tyrosine kinase inhibitor (TKI) resistance. Mutated EGFR mediates TKI resistance through regulation of the fatty acid synthase (FASN), which produces 16-C saturated fatty acid palmitate. Our work shows that the persistent signaling by mutated EGFR in TKI-resistant tumor cells relies on EGFR palmitoylation and can be targeted by Orlistat, an FDA-approved anti-obesity drug. Inhibition of FASN with Orlistat induces EGFR ubiquitination and abrogates EGFR mutant signaling, and reduces tumor growths both in culture systems andTogether, our data provide compelling evidence on the functional interrelationship between mutated EGFR and FASN and that the fatty acid metabolism pathway is a...
The Malaysian journal of medical sciences : MJMS, 2017
Epilepsy surgery has been performed by a few centres in Malaysia, including Hospital Universiti S... more Epilepsy surgery has been performed by a few centres in Malaysia, including Hospital Universiti Sains Malaysia (HUSM). To date, a total of 15 patients have undergone epilepsy surgery in HUSM. The epilepsy surgery included anterior temporal lobectomy (ATL) with amygdalohippocampectomy (AH) and Vagal nerve stimulation (VNS). The surgical outcomes of the patients were assessed using the International League Against Epilepsy (ILAE) outcome scale. The ILAE scores for patients who underwent ATL with AH were comparatively better than those who underwent VNS. One of the patient who underwent ATL with AH and frontal lesionectomy was found to have psychosis during follow up. Epilepsy surgery has proven to be an important treatment for medically resistant epilepsy. Thus it is important to raise public awareness regarding epilepsy and its treatment.
A. Deep brain stimulation (DBS) for movement disorders: an experience in Hospital Universiti Sain... more A. Deep brain stimulation (DBS) for movement disorders: an experience in Hospital Universiti Sains Malaysia (HUSM) involving 12 patients.
Background: The neuroprotective role of minocycline in the treatment of brachial plexus injury is... more Background: The neuroprotective role of minocycline in the treatment of brachial plexus injury is controversial. Objective: To study the neuroprotective effect of minocycline via different routes in adult Sprague Dawley rats with brachial plexus injury. Methods: The C7 nerve roots of the animals were avulsed via an anterior extravertebral approach. Traction force was used to transect the ventral motor nerve roots at the preganglionic level. Intraperitoneal and intrathecal minocycline (50 mg/kg for the first week and 25 mg/kg for the second week) were administered to promote motor healing. The spinal cord was harvested six weeks after the injury, and structural changes following the avulsion injury and pharmacological intervention were analysed. Results: Motor neuron death and microglial proliferation were observed after the administration of minocycline via two different routes (intraperitoneal and intrathecal) following traumatic avulsion injury of the ventral nerve root. The administration of intraperitoneal minocycline reduced the microglia count but increased the motor neuron count. Intrathecal minocycline also reduced the microglial count, with a greater reduction than in the intraperitoneal group, but it decreased the motor neuron count. Conclusions: Intraperitoneal minocycline increased motor neuron survival by inhibiting microglial proliferation following traumatic avulsion injury of the nerve root. The inhibitory effect was augmented by the use of intrathecal minocycline, in which the targeted drug delivery method increased the bioavailability of the therapeutic agent. However, motor neuron survival was impaired at a higher concentration of minocycline via the intrathecal route due to the more efficient method of drug delivery. Microglial suppression via minocycline can have both beneficial and damaging effects, with a moderate dose being beneficial as regards motor neuron survival but a higher dose proving neurotoxic due to impairment of the glial response and Wallerian degeneration, which is a prerequisite for regeneration.
Non-bacterial thrombotic endocarditis (NBTE) classically presents in the context of pancreatic ad... more Non-bacterial thrombotic endocarditis (NBTE) classically presents in the context of pancreatic adenocarcinomas. Echocardiography is useful to investigate for valvular vegetations, and institution of early treatment is crucial as this can be complicated by multiple systemic emboli, leading to significant morbidity or mortality in serious cases. Treatment options involve anticoagulation with unfractionated heparin, and the role of surgical intervention is unclear. In this report, we describe a classical case of a middle-aged lady with unresectable pancreatic adenocarcinoma who developed NBTE complicated by multiple systemic emboli. She eventually succumbed from poor neurological status from multiple cerebral emboli. Awareness of this condition is required by clinicians for early diagnosis and prompt treatment.
Purpose of ReviewReconstruction of head and neck defects that cannot be closed primarily often re... more Purpose of ReviewReconstruction of head and neck defects that cannot be closed primarily often requires the use of complex locoregional, pedicled, or microvascular flaps. Success of the reconstruction relies on the vascular supply of these flaps to prevent major and sometimes life-threatening wound complications. Intraoperative fluorescence angiography is an emerging aspect of the field that can be used as an adjunct to other methods to identify vascular compromise before, during, and after reconstruction.Recent FindingsLaser-assisted near-infrared angiography with intravenous indocyanine green (ICG) dye has been used to perform optical angiography in plastic surgery to help determine the recipient tissue perfusion at the defect site as well as the perfusion of the tissue used for reconstruction. This method allows for quantification of perfusion in skin and soft tissue reconstruction.SummaryLaser-assisted near-infrared angiography with intravenous ICG dye is fast, reliable, safe and can have many uses in head and neck reconstruction including the ability to quantitatively assess perfusion in perforators and angiosomes in flap design, prior to completion of harvest, during, and after the microvascular anastomosis, and in the distal edges of rotational and pedicled flaps. It can also be used to objectively view the native tissue prior to reconstruction, especially in patients with a history of radiation or chemotherapy.
The tumour-initiating cell (TIC) model accounts for phenotypic and functional heterogeneity among... more The tumour-initiating cell (TIC) model accounts for phenotypic and functional heterogeneity among tumour cells. MicroRNAs (miRNAs) are regulatory molecules frequently aberrantly expressed in cancers, and may contribute towards tumour heterogeneity and TIC behaviour. More recent efforts have focused on miRNAs as diagnostic or therapeutic targets. Here, we identified the TIC-specific miRNAs, miR-1246 and miR-1290, as crucial drivers for tumour initiation and cancer progression in human non-small cell lung cancer. The loss of either miRNA impacted the tumour-initiating potential of TICs and their ability to metastasize. Longitudinal analyses of serum miR-1246 and miR-1290 levels across time correlate their circulating levels to the clinical response of lung cancer patients who were receiving ongoing anti-neoplastic therapies. Functionally, direct inhibition of either miRNA with locked nucleic acid administered systemically, can arrest the growth of established patient-derived xenograft...
Hypomagnesemia is a common side effect of treatment with epidermal growth factor receptor inhibit... more Hypomagnesemia is a common side effect of treatment with epidermal growth factor receptor inhibitor. Guidelines recommend intravenous magnesium replacement to treat this toxicity; however, our systematic review has found little evidence to support this approach. Prospective studies are needed to define the best strategy to manage epidermal growth factor receptor inhibitor-induced hypomagnesemia. Background: Despite occurring in 30% of patients, there are no evidence-based guidelines on the management of epidermal growth factor receptor inhibitor (EGFRI)-induced hypomagnesemia. Based on expert opinion, severe hypomagnesemia should be treated by intravenous magnesium replacement. A systematic review of published data of intervention on EGFRI-induced hypomagnesemia was performed. Methods: Articles from 1960 to March 2015 were identified from Medline, Embase, Cochrane Central Register of Controlled Trials, and PubMed using a peer-reviewed systematic search strategy. Eligible studies included randomized controlled trials or observational studies that evaluated management of hypomagnesemia in adult patients treated with EGFRIs. Risk factors for severe hypomagnesemia were also assessed. The quality of included studies was rated using Jadad scores. Results: A total of 1327 references were identified, and 6 studies, involving 486 patients, met inclusion criteria for analysis. There were no randomized controlled trials, and all included studies were of poor quality. From the studies included in this review, severity of EGFRI-induced hypomagnesemia was associated with length of EGFRI treatment, concomitant platinum chemotherapy, increasing age, and baseline magnesium concentration. In most patients with grade 3 or 4 hypomagnesemia, high-dose intravenous magnesium replacement did not achieve sustainable magnesium repletion beyond 72 hours. Oral magnesium supplementation was not effective or tolerable. Severe hypomagnesemia has been associated with tachycardia and mental alteration. After discontinuation of EGFRI therapy, hypomagnesemia generally resolves within weeks to months. Conclusions: There is an absence of high-quality evidence for the management of EGFRI-induced hypomagnesemia. As hypomagnesemia is often refractory to frequent intravenous or oral replacement, there is a need for prospective trials of new interventions for this common toxicity.
The NF-κB pathway is overexpressed in non-small cell lung cancers (NSCLC) and contributes to the ... more The NF-κB pathway is overexpressed in non-small cell lung cancers (NSCLC) and contributes to the poor prognosis and high mortality characterizing this malignancy. Silencing the p50 and p65 NF-κB subunits in the NSCLC H1299 cell line led to profound loss in cell viability and downregulated anti-apoptotic proteins survivin and Mcl1. We also showed that a survivin suppressant, the dioxonaphthoimidazolium YM155, and its structural analog AB1 arrested the growth of H1299 cells at nanomolar concentrations. Both compounds were apoptogenic and suppressed survivin and other anti-apoptotic proteins (Mcl1, Bcl-2, Bcl-xl) in a dose- and/or time-dependent manner. YM155 and AB1 did not affect the expression of key proteins (IκBα, p65, p50) involved in NF-κB signaling. Stable IκBα levels suggest that the NF-κB/IκB complex and proteins upstream of IκBα, were not targeted. Neither did the compounds intercept the nuclear translocation of the p50 and p65 subunits. On the other hand, YM155 and AB1 supp...
Microcrystalline silicon thin films have been prepared through a mixture of silane and hydrogen g... more Microcrystalline silicon thin films have been prepared through a mixture of silane and hydrogen gases using an excitation frequency of 40.68 MHz. For more cost reduction of solar cells, higher module efficiencies and deposition rates are required. This study tried to develop the low temperature processes of silicon thin film for solar cell deposition with a range of crystalline volume
Research is an essential guide to improve and develop new inventions in the health system 1 so th... more Research is an essential guide to improve and develop new inventions in the health system 1 so that we are able to meet the challenges in the health system. There are constantly new discoveries and inventions in the medical sciences and doctors need to keep up to date with the recent developments
Myeloid sarcoma (MS) is a rare extramedullary myeloid tumour. It has been reported in various sit... more Myeloid sarcoma (MS) is a rare extramedullary myeloid tumour. It has been reported in various sites, including lymph node, bone, skin, soft tissue, various organs and the CNS. It may precede or occur concurrently with acute myeloid leukemia. Urinary bladder involvement is extremely uncommon. We report a 70-year-old female who had MS of the urinary bladder, presented with frank and persistent hematuria associated with lower abdominal pain. She subsequently had tumour seeding in the abdominal skin via percutaneous suprapubic catheter. Tumours from both the urinary bladder and skin showed immature cells that were immunoreactive toward LCA (focal), MPO (strong), CD99 (weak) and CD117 (weak). Summary of cases in the literature is presented. The potential of its misdiagnosis and the useful markers for the diagnosis of MS are discussed.
17th IEEE International Conference on Tools with Artificial Intelligence (ICTAI'05), 2005
A RWA linear programming formulation was formulated and ILP solver was used along with good appro... more A RWA linear programming formulation was formulated and ILP solver was used along with good approximation techniques (heuristic) to solve the static RWA problem The objective was to maximize the one hop traffic, given a set of lightpath requests/traffic demand. However, the proposed heuristic has the limitation of stagnation. Thus we applied Ant Colony Optimization (ACO) combined with heuristic algorithm to solve the assignment problem to obtain best assignment with highest objective value. The ACO based algorithm can outperform the comparison scheme and provide a better performance and more reliable than the proposed heuristic and ILP solver. The claim made in the paper for the proposed new heuristic and ACO are supported by experimental results.
We read with great interest the recent article by Arcila and colleagues (1). We present a case of... more We read with great interest the recent article by Arcila and colleagues (1). We present a case of exon 20 insertion mutation (A763_764insFQEA), with documented clinical and radiologic response to EGF receptor (EGFR) tyrosine kinase inhibitor (TKI). To our knowledge, this is the first report of response to erlotinib monotherapy with this particular solitary mutation (1, 2). The patient, a 75-year-old Chinese male ex-smoker (40 pack-years), was diagnosed with metastatic non-small cell lung carcinoma in November 2010. Fine needle aspiration
Ninth International Workshop on Frontiers in Handwriting Recognition
In automatic word recognition, location-scale-rotation invariant features are important. We will ... more In automatic word recognition, location-scale-rotation invariant features are important. We will consider rotation invariant moments of 2-D imagery. Two new series of invariant moments are derived by Lie theory of the orthogonal transformation group. The infinite series are expressed in terms of regular moments.
The paper presents the results of numerical simulation of crack of mild steel under compression l... more The paper presents the results of numerical simulation of crack of mild steel under compression load. The work is performed with the use of CASCA and FRANC2D/L for modeling and simulating the stress distribution of crack under compression radial load. The aims were to develop a finite element model and to simulate the crack propagation in steel plate under compression load. The simulation results were compared with experimental results for verification. The obtained results will provide a prediction of physical behaviour of the structure with failure direction of the crack path.
2010 IEEE 24th International Conference on Advanced Information Networking and Applications Workshops, 2010
Abstract Packet contention is a major issue in optical packet switching network. To resolve cont... more Abstract Packet contention is a major issue in optical packet switching network. To resolve contention, optical buffering approach is used using Fiber Delay Lines (FDLs). Yet there is a heavy packet loss rate due to unavailability of output-port and free FDLs. This paper ...
2010 Second International Conference on Computer Research and Development, 2010
Page 1. Performance Analysis of Selective Minimum Delay Value (SMDV) Algorithm for Packet Content... more Page 1. Performance Analysis of Selective Minimum Delay Value (SMDV) Algorithm for Packet Contention Resolution of Optical Packet Switch Ahmed Galib Reza Faculty of Information Technology Multimedia University 63100 Cyberjaya, Malaysia [email protected] ...
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