Papers by Suneeta Sonawane
Current Drug Therapy, 2009
Nanotechnology, for the past few years, has evolved as a new era of drug delivery for many drug s... more Nanotechnology, for the past few years, has evolved as a new era of drug delivery for many drug systems. Transdermal drug delivery is one of the few systems which have been a major area of research these days. Transdermal Drug Delivery System (TDDS) offers many advantages as compared to traditional drug delivery systems. However TDDS has limited market success due to the barrier properties of the Stratum Corneum. Introduction of ethosomes, which are soft, malleable vesicular carriers containing ethanol tailored for enhanced delivery of active agents, has initiated a new area on vesicular research for transdermal drug delivery. Different reports show a promising future of ethosomes in making transdermal delivery of various agents more effective. Ethosomes also offer a good opportunity for the non-invasive delivery of small, medium, and large sized drug molecules. Preparation of ethosomes is easy with no complicated equipment involved and therefore can be scaled up to industrial level. This review includes introduction to ethosomes, composition and methods of preparation, evaluation and effectiveness in skin permeation. The review also highlights use of ethosomes in transdermal drug delivery in terms of quantity and depth than either liposomes or hydroalcoholic solutions.
AAPS PharmSciTech, 2009
The effect of complexation of irbesartan (IRB), a practically water-insoluble drug, with cyclodex... more The effect of complexation of irbesartan (IRB), a practically water-insoluble drug, with cyclodextrins in presence of different concentrations of water-soluble polymers (PEG 4000 and PVP K-90) on the dissolution rate of the drug has been investigated. Phase solubility studies were carried out to evaluate the solubilizing power of βCD in association with water-soluble polymers towards IRB and to determine the apparent stability constant (K S) of the complexes. Improvement in K S value for ternary complexes (IRB-βCD-polymers) clearly proved the benefit on the addition of water-soluble polymer to increase complexation efficiency. The dissolution rate of the drug from ternary systems containing PEG 4000 and PVP K-90 was higher as compared to the binary system. An optimum increase in the dissolution rate of the drug was observed at a polymer concentration of 5% w/w for PVP K-90 and 10% w/w for PEG 4000. DSC, FTIR, SEM, and XRD studies were carried out to characterize the complexes.
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Papers by Suneeta Sonawane