Papers by Sulaiman Sani Kankara
UMYU Journal of Microbiology Research (UJMR)
Momordica balsamina L. commonly known as African pumpkin or Balsam apple (Cucurbitaceae) is used ... more Momordica balsamina L. commonly known as African pumpkin or Balsam apple (Cucurbitaceae) is used as vegetable in many African countries and traditionally in the treatment of skin diseases. In this study, phytochemical prospective and antimicrobial activities of its leaf extracts were evaluated with the view to validating its medicinal potentials. Acetone, ethanol and water were used as the extracting solvents. Presence of various secondary metabolites as tannins, flavonoids, proanthocyanidins, alkaloids and saponins were observed. Acetone extract indicated a significant inhibition in all the bacterial isolate (Escherichia coli, Staphylococcus aureus, and Salmonella typhi) tested at 100 mg/ml (P<0.05) followed by ethanol extract which inhibited the growth of E. coli and S. aureus. The water extract showed a significant (P<0.05) inhibition on the growth of E. coli and Sa. typhi. The result of antifungal assay showed that acetone extract suppressed the growth of Aspergillus niger...
Ethnobotany Research and Applications, Jul 12, 2022
Background: Medicinal plants are widely used for the management of many diseases including HIV / ... more Background: Medicinal plants are widely used for the management of many diseases including HIV / AIDS opportunistic infections in Katsina State, Northwestern part of Nigeria. The usage of those plants is, however, poorly documented. Method: An ethnobotanical study was conducted to document medicinal plants used for the management of HIV / AIDS opportunistic infections in three Local Government Areas (one from each Senatorial Zone) of Katsina State, Nigeria. Information was obtained through a semi-structured questionnaire administered to 150 respondents comprising traditional healers, herbalists, farmers and HIV / AIDS patients. Results: The survey revealed 48 plant species distributed among 44 genera and 28 families. The highest Relative Frequency of Citation was observed in Anogeissus leiocarpa (DC.) Guill. and Perr (0.75). Fabaceae represented by 11 species appeared to be the most utilised family. Highest Informant Consensus factor was observed in abnormal vaginal discharge and genital ulcer. Most of the cited species are trees that are sourced from the wild and majority of medications are prepared in the form of decoction which is taken orally. The most used plant parts were leaves (40%). Ethnobotany Research and Applications 2 Conclusion: The study revealed substantial numbers and knowledge of medicinal plants used for the treatment of HIV / AIDS related infections in Katsina State, Nigeria. Further investigations to establish the pharmacological potentials of the cited species with regard to the treatment of HIV / AIDS are highly recommended.
Advances in Traditional Medicine
This study was conducted to validate the folkloric use of Acacia nilotica pods as wound healing a... more This study was conducted to validate the folkloric use of Acacia nilotica pods as wound healing agent. Full thickness excision wounds of 6mm diameter were created on Sprague-Dawley rats. Prior to the wound healing assessment, the antioxidant activity of the extract was determined in vitro using 2,2ꞌ- diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. Six groups of 6 wounded rats were formed. In each group, the wounds were topically treated with either petroleum jelly (vehicle control), silver sulfadiazine (positive control), 0.5%, 1% or 2% Acacia nilotica cream (treatment groups) prepared by mixing appropriate quantity of A. nilotica pods’ aqueous extract with petroleum jelly. The negative control group received no treatment. The wound healing parameters assessed include wound contraction rate, level of pro-inflammatory cytokines Interleukin1β (IL-1 β) and Tumor Necrosis Factor-α (TNF- α) and histopathological analysis of the wound area. Wounds were assessed on 7th and 14...
Moringa plant parts could be exploited to make the greatest nutraceuticals contribution amongst i... more Moringa plant parts could be exploited to make the greatest nutraceuticals contribution amongst impoverished communities globally.Considering the many cases of malnutrition related deaths in especially many regions of Africa, the current research effort was conceived with the objective of appraising the nutritive potential of Moringa oleifera L. plant through the evaluation of proper agronomic practice that will enhance its nutritive potential. Measured quantity of dried roots, stem, and leaves portions of 5 months old Moringa oleifera L. seedlings, grown under various applied phosphorus (P) and potassium (K) rates were analysed for essential and non-essential amino acids content, secondary metabolites (phenolics and flavonoids), total antioxidants, and mineral nutrient elements. The high-performance liquid chromatography (HPLC) analysis revealed the presence of 9 essential and 7 non-essential amino acids, with a range of 4.24 to 10.04 gkg-1 recorded for leucine, threonine, histidin...
Nigerian Journal of Scientific Research, Apr 15, 2017
European Journal of Integrative Medicine, 2022
international food research journal, 2018
Taking into account the many cases of malnutrition related deaths in especially sub-Saharan Afric... more Taking into account the many cases of malnutrition related deaths in especially sub-Saharan Africa, the current research effort was conceived with the objective of appraising the nutritive potential of Moringa oleifera L. plant through the evaluation of proper agronomic practice that will enhance its nutritive potential. Measured quantity of dried roots, stem, and leaves portions of 5 months old Moringa oleifera L. seedlings, grown under various applied phosphorus (P) and potassium (K) rates were analysed for essential and non-essential amino acids content, total antioxidants, secondary metabolites (phenolics and flavonoids), and mineral nutrient elements. The high-performance liquid chromatography (HPLC) analysis revealed the presence of 9 essential and 7 non-essential amino acids, with a range of 4.24 to 10.04 gkg-1 recorded for leucine, threonine, histidine, glutamic acid, aspartic acid, and glycine. The 2,2ꞌ- diphenyl-1-picrylhydrazyl (DPPH) and the ferric reducing antioxidant p...
Journal of Medicinal Plants Research, 2018
Malaria is a major debilitating disease caused by Plasmodium species and spread by female Anophel... more Malaria is a major debilitating disease caused by Plasmodium species and spread by female Anopheles mosquitoes. This research was conducted to determine the efficacy of ethanolic leaf extracts of Ricinus communis L. against Plasmodium berghei (NK65) infection in mice. Phytochemical components of the extract were analyzed and elucidated in order to reveal the constituents with antimalarial potentials. The safety of the extract in the experimental mice was ascertained by determining the median lethal dose (LD 50). Result of the phytochemical screening revealed the presence of compounds notable for antimalarial effects such as alkaloids, flavonoids and anthraquinones. From the findings, it was established that a dosage of 141.42 mg/kg of the extract represents the acute lethal dose (LD 50) in mice. Hence, three separate doses of the extract (10, 20 and 40 mg/kg) were prepared for the curative test. All the three doses portrayed a remarkable antimalarial activity as compared to the standard reference drug (chloroquine, 5 mg/kg). The extract dosage of 20 mg/kg showed the highest average suppression of 81.6% among the treatments. No significant differences were however observed among the treated groups (P>0.05). On the other hand, a highly significant difference was observed between the treated and control groups (P≤0.001). The leaf extracts of R. communis thus possess antimalarial properties and is therefore recommended as a new candidate for antimalarial drug development.
Bothalia, 2019
Background: The loss of biodiversity in Nigeria is escalating alarmingly. However, there is gener... more Background: The loss of biodiversity in Nigeria is escalating alarmingly. However, there is generally a paucity of information as to what taxa are endangered because of a dearth of functioning conservation agencies in Nigeria.Objectives: The aim of this research is to record the endangered medicinal and other economic plant species in the Sudan Savanna vegetation in Katsina and to provide an assessment of the various threats faced by these plants.Method: Medicinal plants were identified through oral interviews with traditional medical practitioners within the study area. Conservation statuses were assessed using a bespoke data collection and assessment form; the data were then evaluated using the International Union for the Conservation of Nature Red List categories and criteria.Results: A total of 169 species belonging to 62 families were recorded. Of these, 43 taxa were reported to be used for ethnomedicinal practices. It was found that more than half (108) of the 169 species were...
Hot water extract of Guiera senegalensis leaves is used traditionally by women in Katsina State, ... more Hot water extract of Guiera senegalensis leaves is used traditionally by women in Katsina State, Nigeria during postpartum period for general wellbeing. However the preparation of this beverage has not been optimized so far, which may underestimate its health benefit potentials. In this study, the effects of drying methods (air, oven and sun), solid-solvent ratio (1:10-1:30), extraction time (30-180 min) and extraction temperature (25-85°C) on phenolic antioxidants and antioxidant activity of G. senegalensis were studied using Single Factor Experiment (SFE). Total Phenolic Content (TPC) and Total Flavonoid Content (TFC) assays were used to determine the phenolic antioxidants. Antioxidant activity was evaluated by measuring scavenging effect on 2,2ꞌdiphenyl-1-picrylhydrazyl (DPPH) radical, Ferric Reducing Antioxidant Power (FRAP) and Total Antioxidant Capacity (TAC) using phosphomolybdate assay. Results showed that extraction conditions significantly (P<0.05) affect phenolic antioxidants extraction and antioxidant properties of G. senegalensis leaves water extract. The optimal conditions were air drying using 1:10 solidsolvent ratio for 60 minutes at 40°C with values of 2720.37 mg QE/g DW for TFC, 1431.74mg GAE/100g DW for TPC, 96.73% for DPPH scavenging, 2797.04mg AAE/100g DW for FRAP and 1144.49mg AAE/100g DW for TAC. TFC was found to be significantly correlated with TAC (r2= 0.851; P<0.01) and TPC with DPPH (r2= 0.732: P<0.05) under the influence of drying methods. TFC was also significantly correlated with TAC (r2= 0.683; P<0.01) and DPPH (r2= 0.538; P<0.01) under the effect of solid-solvent ratio. Negative significant correlations were found between TFC and FRAP (r2=-0.369; P<0.01), DPPH and FRAP (r2=-0.591; P<0.01) under the influence of extraction temperature. However, poor correlations were observed among all variables under the influence of extraction time.
Sains Malaysiana, 2019
Scurrula ferruginea is a type of mistletoe from the Loranthaceae family found in Southeast Asia a... more Scurrula ferruginea is a type of mistletoe from the Loranthaceae family found in Southeast Asia and distributed in tropical regions, is known to have healing effects for many disorders. Preservation of the bioactive metabolites is dependent on the sample preparation and drying methods as well as extraction solvents used. Thus, the present study was carried out to investigate the effect of different drying methods and extraction solvents on the total phenolic and the antioxidant activities of S. ferruginea leaves. The leaves of S. ferruginea were air and oven (60°C) dried and extracted with aqueous, organic and aqueous-organic solvents. The total phenolic content (TPC) and total flavonoid content (TFC) were used to gauge the phenolic antioxidants extracted, while the antioxidant activity was evaluated by measuring the scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and via the ferric reducing antioxidant power (FRAP) assay. The optimum conditions obtained were oven drying, 80% acetone with values of 3.47 mg/10 g DW (extract yield), 171.29 mg GAE/1 g DW (TPC), 31.91 mg QE/1 g DW (TFC), 93.2% (DPPH), 26.41 mg TE/1 g DW (FRAP) and 7.41 µg/mL (IC 50). The present findings suggested that sample preparation variability using different drying methods and solvents for extraction play a crucial role in enhancing the efficiency of extraction and efficacy of the antioxidant compounds in S. ferruginea leaf extracts.
Journal of Medicinal Plants Research
People in Katsina State, Nigeria have been using medicinal plants to cure several ailments associ... more People in Katsina State, Nigeria have been using medicinal plants to cure several ailments associated with liver since time immemorial; however the use of such plants was never documented. In this study, an ethnobotanical survey was conducted to document the medicinal plants used for the management of hepatic ailments in Katsina State, Nigeria. A semi-structured questionnaire method was adopted to interview 150 respondents (50 respondents from 1 Local Government Area of each of the three Senatorial Zones of the State) comprising herbalist, farmers, house wives, and others. A total of 62 plant species belonging to 57 genera distributed among 34 families were documented. Most of the reported plants belong to the Fabaceae (24.19%), Moraceae (6.45%), followed by Anacardiaceae, Euphorbiaceae and Asteraceae (each with 4.84%). Senna occidentalis L., Ficus thonningii Bl., and Moringa oleifera Lam. had the highest relative frequency of citation (RFC) of 0.75, 0.64, and 0.53 respectively. Majority (38.71%) of the reported plants were trees and about 79.03% of the surveyed plants are sourced from wild. Leaves were the most frequently used (45.16%) plants part. Most of the herbal medicines (80.65%) were prepared in form of decoction and all the medicines were administered orally. This is the first ethnobotanical study on hepatic ailments in the study area. Results of the study could serve as baseline data based on which further ethnopharmacological investigations would be carried out. Further researches aimed at conserving as well as validating the folkloric use of the surveyed plants would be ideal.
In Katsina State, Northern Nigeria, medicinal plants are widely used for the management of many m... more In Katsina State, Northern Nigeria, medicinal plants are widely used for the management of many medical conditions including maternal health since time immemorial. In this study, an ethnobotanical survey was conducted using semistructured questionnaire method to obtain information on the use of medicinal plants for traditional maternal healthcare in the study area. The respondents comprised of herbalists, traditional birth attendants (TBAs), traditional medical practitioners (TMPs), housewives, farmers and others. 111 medicinal plants belonging to 101 genera, distributed across 50 families were documented. Acacia nilotica (L) Delile and Guiera senegalensis J.F Gmel had the highest Relative Frequency of Citations (RFC) and Fidelity Levels (FL). 22.52% of the cited species belong to Fabaceae family followed by Asteraceae (7.21%), Malvaceae (5.41%) and Anacardiaceae (4.51%). 25.23% of the cited species are used for general wellbeing during and after pregnancy. 68.47% of the cited speci...
Uploads
Papers by Sulaiman Sani Kankara