The primary objective of the CLIPPCAIR study is to construct and validate a new algorithm for pre... more The primary objective of the CLIPPCAIR study is to construct and validate a new algorithm for predicting post-operative forced expiratory volume in 1 second (FEV1) values for lung resection candidates; this new model will be based on data derived from a thoracic CT scan with injection of contrast media. This registration includes information contained in the eCRF.
Additional file 3. Definition of the Central Sleep Apnea Group, the Obstructive Sleep Apnea group... more Additional file 3. Definition of the Central Sleep Apnea Group, the Obstructive Sleep Apnea group, and the Treatment Emergent Central Sleep Apnea Group.
Additional file 1: Supplemental Digital Content – Table 1. Definition of hospital stays in resusc... more Additional file 1: Supplemental Digital Content – Table 1. Definition of hospital stays in resuscitation / ICUs for COPD exacerbation based on ICD-10 codes.
Additional file 4: Supplemental Digital Content – Table 4. PDs of deceased patients in the propen... more Additional file 4: Supplemental Digital Content – Table 4. PDs of deceased patients in the propensity score groups.
Additional file 5: Supplemental - Table 5. Practice Survey among intensivists about their use of ... more Additional file 5: Supplemental - Table 5. Practice Survey among intensivists about their use of bronchoscopy during an acute exacerbation of COPD.
Additional file 3: Supplemental Digital Content – Table 3. PDs of patients in the groups derived ... more Additional file 3: Supplemental Digital Content – Table 3. PDs of patients in the groups derived from propensity scoring.
Additional file 5. Date of the last cardiological consultation depending on the year of ASV initi... more Additional file 5. Date of the last cardiological consultation depending on the year of ASV initiation (pâ =â 0.19).
Sperm count is an important quality assessment tool in farming programs and stock improvement in ... more Sperm count is an important quality assessment tool in farming programs and stock improvement in crustaceans. However, this procedure is still little used in caridean shrimps and standardization of appropriate techniques for the group is lacking. In this study, we propose a simple protocol adapted to determine sperm count in carideans using as model the Amazon River prawn Macrobrachium amazonicum. Males of dominant morphotypes (GC1 and GC2) of this species with amphidromous and hololimnetic life cycles were collected and carefully dissected. The ejaculatory duct was removed from the vas deferens and dissociated in a solution of distilled water (9 μl) and methylene blue (1 μl). Subsequently, 1 μl of this new solution was added to distilled water (9 μl), and then 1 μl was pipetted and quantified in a Neubauer chamber. The feasibility of this technique was also evaluated in animals preserved (5-480 days) in 70% ethanol from collections and the structural morphology of spermatozoa (spz) was examined. Despite morphometric differences observed between different types of males, the mean sperm count was similar for the species. In amphidromous animals, 60,258 spz/μl were registered for GC1 and 65,308 spz/μl for GC2, while in hololimnetic prawns, 48,950 spz/μl were registered in GC1 and 53,850 spz/μl in GC2. The variation in sperm count among animals preserved for different periods of time was small and very similar to those of fresh animals. Also, no microscopic changes in the structures of spz were observed. This technique can be applied to obtain a spermiogram in fresh as well as preserved animals, being especially important in studies with animals examined in population studies and deposited in collections or laboratories. This protocol can be used as a general model for spermiogram in caridean shrimps due to the great similarity of male reproductive systems within the group.
ObjectivesPresently, those outcomes that should be prioritised for chronic obstructive pulmonary ... more ObjectivesPresently, those outcomes that should be prioritised for chronic obstructive pulmonary disease (COPD) exacerbation studies remain unclear. In order to coordinate multicentre studies on eosinophilia-driven corticosteroid therapy for patients hospitalised for acute exacerbation of COPD (AECOPD), we aimed to find consensus among experts in the domain regarding the prioritisation of outcomes.DesignA modified Delphi study was proposed to recognised COPD experts. Two brainstorming questionnaires were used to collect potential outcomes. Four subsequent rounds of questionnaires were used to rank items according to a six-point Likert scale for their importance in the protocol, as well as for being the primary outcome. Priority outcome criteria were predefined as those for which ≥70% of experts indicated that the outcome was essential for interpreting study results.SettingCOPD exacerbation management in France.Participants34 experts recommended by the French Language Pulmonology Soc...
Background Whereas telemedicine usage is growing, the only clinical algorithm for Continuous Posi... more Background Whereas telemedicine usage is growing, the only clinical algorithm for Continuous Positive Airway Pressure (CPAP) adherence management is that stipulated by the 2013 American Thoracic Society (ATS). The capacity of the latter to predict non-adherence in long-term CPAP-treated patients has not been validated. Methods Patients from the prospective real-life InterfaceVent study (NCT03013283, study conducted in an adult cohort undergoing at least 3 months of CPAP) and eligible for ATS algorithm usage were analysed. The residual device Apnea–Hypopnea-Index (AHIflow) and High Large Leak (HLL) thresholds proposed in the ATS algorithm were evaluated for predicting adherence (i.e. AHIflow > 10/h, HLLs 95th > 24 L/min for ResMed® devices and ResMed® nasal mask, HLLs 95th > 36 l/min for ResMed® devices and ResMed® oronasal masks, HLLs > 1 h for Philips® devices and HHLs > 60 l/min for Fisher & Paykel® devices). Adherence was defined according to the 2013 ATS algorithm...
American Journal of Respiratory and Critical Care Medicine, 2019
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.
Pulmonary arterial hypertension (PAH) is a rare and life-threatening disease well-marked by under... more Pulmonary arterial hypertension (PAH) is a rare and life-threatening disease well-marked by under diagnosis, delayed diagnosis and atypical treatments. Few data are available on the quality of life (QoL) and psychosocial characteristics of patients with PAH. Our aim is to describe the impact of psychological factors on the health-related quality of life (HRQoL) of treated PAH patients in a cross-sectional study. Consecutive patients presenting at our Competency Centre for PAH were recruited. The aetiology, New York Heart Association (NYHA) stage, haemodynamics, 6-min walk distance (6MWD), delta SPO2 (Pulse oximeter oxygen saturation; baseline lowest value during 6-min walk test (6MWT), current treatments and psychological history were recorded. HRQoL, anxiety, depression and coping strategies were explored using self-administered questionnaires (SF-36, HADS, STAI-Y, CHIP and WCC). A total of 55 patients were included. The HRQoL of PAH patients was poor with altered results on severa...
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Introduction: The causative role of new hydroxyethyl starch (HES 130/0.4) in renal dysfunction fr... more Introduction: The causative role of new hydroxyethyl starch (HES 130/0.4) in renal dysfunction frequency (a > 50% increase in serum creatinine or need for renal replacement therapy (RRT)) remains debated. Using the database of a multicenter study focusing on patients with severe sepsis and septic shock, the present study aimed at identifying factors associated with the occurrence of renal dysfunction. Methods: Among the 435 patients in a multicenter study of patients with severe sepsis and septic shock in 15 Southern French ICUs, 388 patients surviving after 24 hour, without a history of renal failure were included. Factors associated with renal dysfunction and RRT were isolated using a multivariate analysis with logistic regression. Results: Renal dysfunction was reported in 117 (33%) patients. Ninety patients required RRT. Among study participants, 379 (98%) were administered fluids in the first 24 hours of management: HES 130/0.4 only (n = 39), crystalloids only (n = 63), or both HES 130/0.4 and crystalloids (n = 276). RRT was independently associated with the need for vasopressors and the baseline value of serum creatinine in the first 24 hours. Multivariate analysis indicated that male gender, SAPS II score, being a surgical patient, lack of decrease in SOFA score during the first 24 hours, and the interventional period of the study were independently associated with renal dysfunction. Mortality increased in the presence of renal dysfunction (48% versus 24%, P < 0.01). Conclusions: Despite being used in more than 80% of patients with severe sepsis and/or septic shock, the administration of HES 130/0.4 in the first 24 hours of management was not associated with the occurrence of renal dysfunction.
Background Predicting fluid responsiveness remains a difficult question in hemodynamically unstab... more Background Predicting fluid responsiveness remains a difficult question in hemodynamically unstable patients. The author's objective was to test whether noninvasive assessment by transthoracic echocardiography of subaortic velocity time index (VTI) variation after a low volume of fluid infusion (100 ml hydroxyethyl starch) can predict fluid responsiveness. Methods Thirty-nine critically ill ventilated and sedated patients with acute circulatory failure were prospectively studied. Subaortic VTI was measured by transthoracic echocardiography before fluid infusion (baseline), after 100 ml hydroxyethyl starch infusion over 1 min, and after an additional infusion of 400 ml hydroxyethyl starch over 14 min. The authors measured the variation of VTI after 100 ml fluid (ΔVTI 100) for each patient. Receiver operating characteristic curves were generated for (ΔVTI 100). When available, receiver operating characteristic curves also were generated for pulse pressure variation and central ven...
The primary objective of the CLIPPCAIR study is to construct and validate a new algorithm for pre... more The primary objective of the CLIPPCAIR study is to construct and validate a new algorithm for predicting post-operative forced expiratory volume in 1 second (FEV1) values for lung resection candidates; this new model will be based on data derived from a thoracic CT scan with injection of contrast media. This registration includes information contained in the eCRF.
Additional file 3. Definition of the Central Sleep Apnea Group, the Obstructive Sleep Apnea group... more Additional file 3. Definition of the Central Sleep Apnea Group, the Obstructive Sleep Apnea group, and the Treatment Emergent Central Sleep Apnea Group.
Additional file 1: Supplemental Digital Content – Table 1. Definition of hospital stays in resusc... more Additional file 1: Supplemental Digital Content – Table 1. Definition of hospital stays in resuscitation / ICUs for COPD exacerbation based on ICD-10 codes.
Additional file 4: Supplemental Digital Content – Table 4. PDs of deceased patients in the propen... more Additional file 4: Supplemental Digital Content – Table 4. PDs of deceased patients in the propensity score groups.
Additional file 5: Supplemental - Table 5. Practice Survey among intensivists about their use of ... more Additional file 5: Supplemental - Table 5. Practice Survey among intensivists about their use of bronchoscopy during an acute exacerbation of COPD.
Additional file 3: Supplemental Digital Content – Table 3. PDs of patients in the groups derived ... more Additional file 3: Supplemental Digital Content – Table 3. PDs of patients in the groups derived from propensity scoring.
Additional file 5. Date of the last cardiological consultation depending on the year of ASV initi... more Additional file 5. Date of the last cardiological consultation depending on the year of ASV initiation (pâ =â 0.19).
Sperm count is an important quality assessment tool in farming programs and stock improvement in ... more Sperm count is an important quality assessment tool in farming programs and stock improvement in crustaceans. However, this procedure is still little used in caridean shrimps and standardization of appropriate techniques for the group is lacking. In this study, we propose a simple protocol adapted to determine sperm count in carideans using as model the Amazon River prawn Macrobrachium amazonicum. Males of dominant morphotypes (GC1 and GC2) of this species with amphidromous and hololimnetic life cycles were collected and carefully dissected. The ejaculatory duct was removed from the vas deferens and dissociated in a solution of distilled water (9 μl) and methylene blue (1 μl). Subsequently, 1 μl of this new solution was added to distilled water (9 μl), and then 1 μl was pipetted and quantified in a Neubauer chamber. The feasibility of this technique was also evaluated in animals preserved (5-480 days) in 70% ethanol from collections and the structural morphology of spermatozoa (spz) was examined. Despite morphometric differences observed between different types of males, the mean sperm count was similar for the species. In amphidromous animals, 60,258 spz/μl were registered for GC1 and 65,308 spz/μl for GC2, while in hololimnetic prawns, 48,950 spz/μl were registered in GC1 and 53,850 spz/μl in GC2. The variation in sperm count among animals preserved for different periods of time was small and very similar to those of fresh animals. Also, no microscopic changes in the structures of spz were observed. This technique can be applied to obtain a spermiogram in fresh as well as preserved animals, being especially important in studies with animals examined in population studies and deposited in collections or laboratories. This protocol can be used as a general model for spermiogram in caridean shrimps due to the great similarity of male reproductive systems within the group.
ObjectivesPresently, those outcomes that should be prioritised for chronic obstructive pulmonary ... more ObjectivesPresently, those outcomes that should be prioritised for chronic obstructive pulmonary disease (COPD) exacerbation studies remain unclear. In order to coordinate multicentre studies on eosinophilia-driven corticosteroid therapy for patients hospitalised for acute exacerbation of COPD (AECOPD), we aimed to find consensus among experts in the domain regarding the prioritisation of outcomes.DesignA modified Delphi study was proposed to recognised COPD experts. Two brainstorming questionnaires were used to collect potential outcomes. Four subsequent rounds of questionnaires were used to rank items according to a six-point Likert scale for their importance in the protocol, as well as for being the primary outcome. Priority outcome criteria were predefined as those for which ≥70% of experts indicated that the outcome was essential for interpreting study results.SettingCOPD exacerbation management in France.Participants34 experts recommended by the French Language Pulmonology Soc...
Background Whereas telemedicine usage is growing, the only clinical algorithm for Continuous Posi... more Background Whereas telemedicine usage is growing, the only clinical algorithm for Continuous Positive Airway Pressure (CPAP) adherence management is that stipulated by the 2013 American Thoracic Society (ATS). The capacity of the latter to predict non-adherence in long-term CPAP-treated patients has not been validated. Methods Patients from the prospective real-life InterfaceVent study (NCT03013283, study conducted in an adult cohort undergoing at least 3 months of CPAP) and eligible for ATS algorithm usage were analysed. The residual device Apnea–Hypopnea-Index (AHIflow) and High Large Leak (HLL) thresholds proposed in the ATS algorithm were evaluated for predicting adherence (i.e. AHIflow > 10/h, HLLs 95th > 24 L/min for ResMed® devices and ResMed® nasal mask, HLLs 95th > 36 l/min for ResMed® devices and ResMed® oronasal masks, HLLs > 1 h for Philips® devices and HHLs > 60 l/min for Fisher & Paykel® devices). Adherence was defined according to the 2013 ATS algorithm...
American Journal of Respiratory and Critical Care Medicine, 2019
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers.
Pulmonary arterial hypertension (PAH) is a rare and life-threatening disease well-marked by under... more Pulmonary arterial hypertension (PAH) is a rare and life-threatening disease well-marked by under diagnosis, delayed diagnosis and atypical treatments. Few data are available on the quality of life (QoL) and psychosocial characteristics of patients with PAH. Our aim is to describe the impact of psychological factors on the health-related quality of life (HRQoL) of treated PAH patients in a cross-sectional study. Consecutive patients presenting at our Competency Centre for PAH were recruited. The aetiology, New York Heart Association (NYHA) stage, haemodynamics, 6-min walk distance (6MWD), delta SPO2 (Pulse oximeter oxygen saturation; baseline lowest value during 6-min walk test (6MWT), current treatments and psychological history were recorded. HRQoL, anxiety, depression and coping strategies were explored using self-administered questionnaires (SF-36, HADS, STAI-Y, CHIP and WCC). A total of 55 patients were included. The HRQoL of PAH patients was poor with altered results on severa...
HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific re... more HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
Introduction: The causative role of new hydroxyethyl starch (HES 130/0.4) in renal dysfunction fr... more Introduction: The causative role of new hydroxyethyl starch (HES 130/0.4) in renal dysfunction frequency (a > 50% increase in serum creatinine or need for renal replacement therapy (RRT)) remains debated. Using the database of a multicenter study focusing on patients with severe sepsis and septic shock, the present study aimed at identifying factors associated with the occurrence of renal dysfunction. Methods: Among the 435 patients in a multicenter study of patients with severe sepsis and septic shock in 15 Southern French ICUs, 388 patients surviving after 24 hour, without a history of renal failure were included. Factors associated with renal dysfunction and RRT were isolated using a multivariate analysis with logistic regression. Results: Renal dysfunction was reported in 117 (33%) patients. Ninety patients required RRT. Among study participants, 379 (98%) were administered fluids in the first 24 hours of management: HES 130/0.4 only (n = 39), crystalloids only (n = 63), or both HES 130/0.4 and crystalloids (n = 276). RRT was independently associated with the need for vasopressors and the baseline value of serum creatinine in the first 24 hours. Multivariate analysis indicated that male gender, SAPS II score, being a surgical patient, lack of decrease in SOFA score during the first 24 hours, and the interventional period of the study were independently associated with renal dysfunction. Mortality increased in the presence of renal dysfunction (48% versus 24%, P < 0.01). Conclusions: Despite being used in more than 80% of patients with severe sepsis and/or septic shock, the administration of HES 130/0.4 in the first 24 hours of management was not associated with the occurrence of renal dysfunction.
Background Predicting fluid responsiveness remains a difficult question in hemodynamically unstab... more Background Predicting fluid responsiveness remains a difficult question in hemodynamically unstable patients. The author's objective was to test whether noninvasive assessment by transthoracic echocardiography of subaortic velocity time index (VTI) variation after a low volume of fluid infusion (100 ml hydroxyethyl starch) can predict fluid responsiveness. Methods Thirty-nine critically ill ventilated and sedated patients with acute circulatory failure were prospectively studied. Subaortic VTI was measured by transthoracic echocardiography before fluid infusion (baseline), after 100 ml hydroxyethyl starch infusion over 1 min, and after an additional infusion of 400 ml hydroxyethyl starch over 14 min. The authors measured the variation of VTI after 100 ml fluid (ΔVTI 100) for each patient. Receiver operating characteristic curves were generated for (ΔVTI 100). When available, receiver operating characteristic curves also were generated for pulse pressure variation and central ven...
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