Akademisk avhandling som med tillstånd av Kungliga Tekniska högskolan i Stockholm framlägges till... more Akademisk avhandling som med tillstånd av Kungliga Tekniska högskolan i Stockholm framlägges till offentlig granskning för avläggande av teknologie doktorsexamen i kemi med inrikting mot organisk kemi, fredagen den 13 april 2007 kl 10.15 i sal F3, KTH, Lindstedsvägen 26, Stockholm. Avhandlingen försvaras på engelska. Opponent är Professor Ben Feringa,
Confirmation of target engagement in relevant physiological environment ensures successful drug d... more Confirmation of target engagement in relevant physiological environment ensures successful drug discovery and the right project prioritization. The Cellular Thermal Shift Assay (CETSA) offers a robust label-free method for studying protein− compound interactions in a cellular environment. This Viewpoint covers the broad applicability of CETSA in lead generation. The method can be used for deconvolution studies, target validation, screening of compound libraries, and hit confirmation. Moreover, the method is well suited for generation of relevant structure− activity relationship (SAR) data, enabling optimal compound design.
The syntheses of a series of 4-monosubstituted pyridylamides and a resin-supported pyridylamide a... more The syntheses of a series of 4-monosubstituted pyridylamides and a resin-supported pyridylamide are described. The ligands were evaluated in the microwave-accelerated molybdenum-catalyzed asymmetric allylic alkylation. The reaction afforded the product in high yield and with high regio-and enantioselectivity. The heterogeneous ligand could be reused several times with no change in the reaction outcome. The asymmetric allylic alkylation was employed as the key step in the enantioselective synthesis of (R)-baclofen.
... No fulltext in DiVA. Create reference ». Author: Wingstrand, Erica (KTH, School of Chemical S... more ... No fulltext in DiVA. Create reference ». Author: Wingstrand, Erica (KTH, School of Chemical Science and Engineering (CHE), Chemistry ... Hult, Karl (KTH, School of Biotechnology (BIO), Biochemistry). Moberg, Christina (KTH, School of Chemical Science and Engineering (CHE ...
... reference ». Author: Moberg, Christina (KTH, School of Chemical Science and Engineering (CHE)... more ... reference ». Author: Moberg, Christina (KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry). Wingstrand, Erica. Lundgren, Stina. Hamberg, Anders. Penhoat, Mael. Engstrom, Kann. Hult, Karl (KTH, School of Biotechnology (BIO), Biochemistry ...
... Analyst, 126 (2001), pp. 24–27. MC Mitchell, V. Spikmans, A. Manz and AJ de Mello. J. Chem. S... more ... Analyst, 126 (2001), pp. 24–27. MC Mitchell, V. Spikmans, A. Manz and AJ de Mello. J. Chem. Soc., Perkin Trans. 1, 5 (2001), pp. 514–518. M. Sands, SJ Haswell, SM Kelly, V. Skelton, DO Morgan, P. Styring and B. Warrington. Lab on a chip, 1 (2001), pp. 64–65. ...
Aldehyde derivatives Aldehyde derivatives Q 0340 Polymer-Supported Pyridine-Bis(oxazoline). Appli... more Aldehyde derivatives Aldehyde derivatives Q 0340 Polymer-Supported Pyridine-Bis(oxazoline). Application to Ytterbium-Catalyzed Silylcyanation of Benzaldehyde.-The preparation of two polymer supported chiral pybox derivatives and their application in the ytterbium catalyzed silylcyanation of benzaldehyde is reported. The polymeric ligands exhibit as high reactivity as their homogeneous analogues, yielding products with only marginally lower enantioselectivity. The ligands could be easily recovered and reused more than 30 times without any loss in selectivity or activity. The metal complexes could also be recovered and reused at least four times, although with slightly decreasing activity.-(LUNDGREN, S.;
Akademisk avhandling som med tillstånd av Kungl Tekniska Högskolan i Stockholm framlägges till of... more Akademisk avhandling som med tillstånd av Kungl Tekniska Högskolan i Stockholm framlägges till offentlig granskning för avläggande av filosofie doktorsexamen i kemi med inriktning mot organisk kemi fredagen den 8 maj kl 10.00 i sal F3, KTH, Lindstedtsvägen 26, Stockholm. Avhandlingen försvaras på engelska. Opponent är Professor Benjamin List, Max-Planck-Institut für Kohlenforschung, Tyskland.
A pyridine-bis(oxazoline) ligand was efficiently immobilized by copper(I)-catalyzed azidealkyne c... more A pyridine-bis(oxazoline) ligand was efficiently immobilized by copper(I)-catalyzed azidealkyne cycloaddition onto a polystyrene resin. The so obtained click-pybox resin 1a was associated with various metal salts (YbCl 3 , LuCl 3 , CuOTf) and the resulting resin-bound catalysts were explored in ring-opening of cyclohexene oxide, silylcyanation of benzaldehyde and alkynylation of imines. These new polymer-supported catalysts exhibit good to excellent performances in terms of catalytic activity, enantioselectivity and recyclability.
Scheme 1. Dual Lewis acid-Lewis base Catalyzed Addition of Acetyl Cyanide to Benzaldehyde Scheme ... more Scheme 1. Dual Lewis acid-Lewis base Catalyzed Addition of Acetyl Cyanide to Benzaldehyde Scheme 2. One-Pot Step-by-Step Analysis of Unreacted Benzaldehyde (a), (S)-O-Acetylated Cyanohydrin (b), and (R)-O-Acetylated Cyanohydrin (c)
Akademisk avhandling som med tillstånd av Kungliga Tekniska högskolan i Stockholm framlägges till... more Akademisk avhandling som med tillstånd av Kungliga Tekniska högskolan i Stockholm framlägges till offentlig granskning för avläggande av teknologie doktorsexamen i kemi med inrikting mot organisk kemi, fredagen den 13 april 2007 kl 10.15 i sal F3, KTH, Lindstedsvägen 26, Stockholm. Avhandlingen försvaras på engelska. Opponent är Professor Ben Feringa,
Confirmation of target engagement in relevant physiological environment ensures successful drug d... more Confirmation of target engagement in relevant physiological environment ensures successful drug discovery and the right project prioritization. The Cellular Thermal Shift Assay (CETSA) offers a robust label-free method for studying protein− compound interactions in a cellular environment. This Viewpoint covers the broad applicability of CETSA in lead generation. The method can be used for deconvolution studies, target validation, screening of compound libraries, and hit confirmation. Moreover, the method is well suited for generation of relevant structure− activity relationship (SAR) data, enabling optimal compound design.
The syntheses of a series of 4-monosubstituted pyridylamides and a resin-supported pyridylamide a... more The syntheses of a series of 4-monosubstituted pyridylamides and a resin-supported pyridylamide are described. The ligands were evaluated in the microwave-accelerated molybdenum-catalyzed asymmetric allylic alkylation. The reaction afforded the product in high yield and with high regio-and enantioselectivity. The heterogeneous ligand could be reused several times with no change in the reaction outcome. The asymmetric allylic alkylation was employed as the key step in the enantioselective synthesis of (R)-baclofen.
... No fulltext in DiVA. Create reference ». Author: Wingstrand, Erica (KTH, School of Chemical S... more ... No fulltext in DiVA. Create reference ». Author: Wingstrand, Erica (KTH, School of Chemical Science and Engineering (CHE), Chemistry ... Hult, Karl (KTH, School of Biotechnology (BIO), Biochemistry). Moberg, Christina (KTH, School of Chemical Science and Engineering (CHE ...
... reference ». Author: Moberg, Christina (KTH, School of Chemical Science and Engineering (CHE)... more ... reference ». Author: Moberg, Christina (KTH, School of Chemical Science and Engineering (CHE), Chemistry, Organic Chemistry). Wingstrand, Erica. Lundgren, Stina. Hamberg, Anders. Penhoat, Mael. Engstrom, Kann. Hult, Karl (KTH, School of Biotechnology (BIO), Biochemistry ...
... Analyst, 126 (2001), pp. 24–27. MC Mitchell, V. Spikmans, A. Manz and AJ de Mello. J. Chem. S... more ... Analyst, 126 (2001), pp. 24–27. MC Mitchell, V. Spikmans, A. Manz and AJ de Mello. J. Chem. Soc., Perkin Trans. 1, 5 (2001), pp. 514–518. M. Sands, SJ Haswell, SM Kelly, V. Skelton, DO Morgan, P. Styring and B. Warrington. Lab on a chip, 1 (2001), pp. 64–65. ...
Aldehyde derivatives Aldehyde derivatives Q 0340 Polymer-Supported Pyridine-Bis(oxazoline). Appli... more Aldehyde derivatives Aldehyde derivatives Q 0340 Polymer-Supported Pyridine-Bis(oxazoline). Application to Ytterbium-Catalyzed Silylcyanation of Benzaldehyde.-The preparation of two polymer supported chiral pybox derivatives and their application in the ytterbium catalyzed silylcyanation of benzaldehyde is reported. The polymeric ligands exhibit as high reactivity as their homogeneous analogues, yielding products with only marginally lower enantioselectivity. The ligands could be easily recovered and reused more than 30 times without any loss in selectivity or activity. The metal complexes could also be recovered and reused at least four times, although with slightly decreasing activity.-(LUNDGREN, S.;
Akademisk avhandling som med tillstånd av Kungl Tekniska Högskolan i Stockholm framlägges till of... more Akademisk avhandling som med tillstånd av Kungl Tekniska Högskolan i Stockholm framlägges till offentlig granskning för avläggande av filosofie doktorsexamen i kemi med inriktning mot organisk kemi fredagen den 8 maj kl 10.00 i sal F3, KTH, Lindstedtsvägen 26, Stockholm. Avhandlingen försvaras på engelska. Opponent är Professor Benjamin List, Max-Planck-Institut für Kohlenforschung, Tyskland.
A pyridine-bis(oxazoline) ligand was efficiently immobilized by copper(I)-catalyzed azidealkyne c... more A pyridine-bis(oxazoline) ligand was efficiently immobilized by copper(I)-catalyzed azidealkyne cycloaddition onto a polystyrene resin. The so obtained click-pybox resin 1a was associated with various metal salts (YbCl 3 , LuCl 3 , CuOTf) and the resulting resin-bound catalysts were explored in ring-opening of cyclohexene oxide, silylcyanation of benzaldehyde and alkynylation of imines. These new polymer-supported catalysts exhibit good to excellent performances in terms of catalytic activity, enantioselectivity and recyclability.
Scheme 1. Dual Lewis acid-Lewis base Catalyzed Addition of Acetyl Cyanide to Benzaldehyde Scheme ... more Scheme 1. Dual Lewis acid-Lewis base Catalyzed Addition of Acetyl Cyanide to Benzaldehyde Scheme 2. One-Pot Step-by-Step Analysis of Unreacted Benzaldehyde (a), (S)-O-Acetylated Cyanohydrin (b), and (R)-O-Acetylated Cyanohydrin (c)
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