Papers by Georgios Stamatas
International Journal of Dermatology
BACKGROUND AND OBJECTIVE Infant human immunodeficiency virus (HIV) infection remains a problem in... more BACKGROUND AND OBJECTIVE Infant human immunodeficiency virus (HIV) infection remains a problem in different parts of the world. Early signs of disease manifestation often involve infant skin. This study compared the skin barrier properties of HIV infected with uninfected infants. METHODS A cross-sectional descriptive study was undertaken with HIV positive and HIV negative unexposed African infants (6 weeks-12 months). Both had normal birth weight for age, no pre-existing dermatoses or co-infections, and received all their vaccinations timeously. The HIV positive infants were on antiretroviral (ARV) therapy. The skin barrier quality was assessed by measuring the transepidermal water loss (TEWL) and skin surface hydration (SSH) on the dorsal arm (1) and the inner forearm (2). RESULTS Eighty-six HIV negative and 43 HIV positive African children were recruited. There were significant differences between the two groups based on the presence of HIV infection. In both sites, measured TEWL rates were significantly higher for the HIV positive children. There was a nonsignificant difference between the SSH values for site 1 and a marginally significant difference for site 2, with the average values higher in the HIV positive group. In both groups, TEWL rates and SSH values were significantly lower on site 1 compared to site 2. CONCLUSION Differences in skin barrier properties of HIV infected and uninfected children may exist. The altered skin barrier in infected children may be one of the factors that predisposes them to various inflammatory and infectious dermatoses. Improving the skin barrier may assist in preventing these conditions.
Proceedings of the 17th Southern Biomedical Engineering Conference
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ACS Symposium Series, 2000
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Biophotonics 2007: Optics in Life Science, 2007
A rotationally invariant algorithm was developed to evaluate the orientation direction and orient... more A rotationally invariant algorithm was developed to evaluate the orientation direction and orientation coherence of features in a two-dimensional image. The algorithm was validated on test images and was applied on in vivo confocal microscopy images to extract information on collagen matrix orientation and on skin microrelief images for the calculation of the primary direction of microglyphics.
Optical Biopsy VII, 2010
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Lipids and Skin Health, 2014
Mineral oil in skin care is used as an emollient enhancing moisture retention in the skin. Toxico... more Mineral oil in skin care is used as an emollient enhancing moisture retention in the skin. Toxicological studies in animals and tolerance studies in humans demonstrate the safety profile of pharmaceutical grade mineral oil.
Pediatric Dermatology, 2011
Journal of the American Academy of Dermatology, 2009
Journal of the American Academy of Dermatology, 2011
Journal of the American Academy of Dermatology, 2011
Journal of the American Academy of Dermatology, 2005
Industrial & Engineering Chemistry Research, 1999
For the last 3 decades evidence has been accumulating that some types of mammalian cells respond ... more For the last 3 decades evidence has been accumulating that some types of mammalian cells respond to their mechanically active environment by altering their morphology, growth rate, and metabolism. The study of such responses is very important in understanding physiological and pathological conditions ranging from bone formation to atherosclerosis. Obtaining this knowledge has been the goal for an active research area in bioengineering termed cell mechanotransduction. The advancement of optical methodologies used in cell biology research has given the tools to elucidate cellular mechanisms that would otherwise be impossible to visualize. Combined with molecular biology techniques, they give engineers invaluable tools in understanding the chemical pathways involved in mechanotransduction. Herein we briefly review the current knowledge on mechanical signal transduction in mammalian cells, focusing on the application of novel optical techniques in the ongoing research.
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Papers by Georgios Stamatas