Papers by Sri Purnama Rgg
Bali Medical Journal, 2020
Buletin Farmatera, 2020
Atopic dermatitis (AD) is a multifactorial disease that belongs to the "burden disease" in childh... more Atopic dermatitis (AD) is a multifactorial disease that belongs to the "burden disease" in childhood. It needs to be prevented to reach their optimal growth. Exclusive breastfeeding given during the first six months of life provides nutritional benefits and is thought to protect children from allergic or infectious diseases, such as AD. This study aims to determine the relationship between breastfeeding and the onset of atopic dermatitis. This was an observational analytic study using a cross-sectional method. Samples were taken consecutively at the Dermatovenereology Polyclinic of referral hospital and Puskesmas in Medan. This study included all pediatric patients aged 6 months to <18 years diagnosed with AD and was interviewed with informed consent. Children who didn't get breastmilk were excluded. The result was a significant relationship between breastfeeding (exclusively to partially) and AD onset. There was no relationship between breastfeeding (exclusively to pre-lacteally) and AD onset. Polyunsaturated fatty acids, sIgA, and TGF-β2 in the breast milk of mothers with atopy are lower than mothers without atopy. Breastfeeding exclusively has a protective effect on AD. Further research is needed to analyzes various factors by comparing genetic predisposition.
Open Access Macedonian Journal of Medical Sciences, 2017
BACKGROUND: One of the treatments for leukaemia is chemotherapy. Side effects and toxicity of thi... more BACKGROUND: One of the treatments for leukaemia is chemotherapy. Side effects and toxicity of this treatment can be seen on the skin, adnexal, and mucous membranes. They might increase potential hydrogen (pH) value on the skin surface, therefore, disrupting epidermal barrier defences.AIM: To describe the pH of the skin in children with leukaemia who received chemotherapy.SUBJECT AND METHOD: This study was an observational descriptive, cross-sectional study, conducted from March until December 2016 with 32 children with leukaemia who treated at Haji Adam Malik General Hospital, Medan as subjects. Skin pH was measured by a pH meter.RESULT: We found mean skin pH in ALL (6.28 ± 0.58), CML (5.9 ± 0) and AML (6.5 ± 0.50). The mean skin pH after 1-5 weeks of chemotherapy was 6.13 ± 0.49, at 6-10 weeks (6.32 ± 0.51), and at 11-15 weeks (7.12 ± 0.36). The mean skin pH of patients with two drugs (5.98 ± 0.44), four drugs (6.28 ± 0.55), and six drugs (6.63 ± 0.56).CONCLUSION: The highest mean ...
International Journal of Research in Medical Sciences, 2019
Background: Acute leukemia is a hematopoietic stem cell malignant disease, with abnormal prolifer... more Background: Acute leukemia is a hematopoietic stem cell malignant disease, with abnormal proliferation of leukemic and immature cells that suppress the production of normal blood cell and extensively invade peripheral tissues organs including skin. Homeostatic abnormalities that occur in leukemia e.g. thrombocytopenia and neutropenia. Various cutaneous manifestations can be observed in leukemia but the etiology is usually unknown, because many factors are responsible for this cutaneous manifestation. The aim of the present study was to determine association between thrombocyte and neutrophyl count with cutaneous manifestations in children with Acute Lymphocytic Leukemia (ALL) and Acute Myelocytic Leukemia (AML).Methods: This is an observational analytical cross-sectional study involving 51 children with acute leukemia (ALL and AML) were hospitalized in H. Adam Malik General Hospital Medan during April – September 2018. Interview, dermatology examination and recording thrombocyte and...
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Papers by Sri Purnama Rgg