Papers by Shivlok Narayan
Panacea Journal of Medical Sciences, 2020
The significant dose-related as well as idiosyncratic drug toxicity are encountered in pediatric ... more The significant dose-related as well as idiosyncratic drug toxicity are encountered in pediatric practice occasionally due to the zero order pharmacokinetics and narrow therapeutic margin of phenytoin. Among uncommon side effects reported in patients with phenytoin exposure are cerebellar atrophy and at times its clinical presentation is masquerading as acute encephalitis. An unusual presentation of phenytoin toxicity in a 15-year-old girl suffering from multiple tubercular with seizure who developed bilateral cerebellar atrophy besides other features of Phenytoin toxicity over 3 years of drug use has been reported here along with possible approaches to minimize the possibility of dosing error in its prescription.
Background:Osteoporosis (OP) is being increasingly recognized in inflammatory rheumatic diseases ... more Background:Osteoporosis (OP) is being increasingly recognized in inflammatory rheumatic diseases like rheumatoid arthritis (RA), characterized mainly by low bone mass, reduced bone strength, and an increased risk of fractures affecting bone metabolism influencing bone mineral density (BMD) and fracture risk.Results :Women in the RA with PRED group did not show lower BMD values than those in the RA without PRED group at baseline, in both lumbar spine L1-L4 (P=0.691), in femoral neck (P=0.332), in radius total (P=0.564) and radius UD (P=0.941). Women in the RA without PRED group had lower T score (Radius UD) (P=0.015) value than those in the RA with PRED group. However, during 12 months follow ups there was no statistically significant difference between the two groups in the change in BMD or projection area in the lumbar spine, femoral neck and radius UD.Conclusion: Premenopausal RA women with or without prednisolone treatment lost their bone mass statistically similar. Study as...
Annals of Saudi Medicine, 2014
Uploads
Papers by Shivlok Narayan