The American Journal of Geriatric Cardiology, 2006
OBJECTIVES: To examine epidemiological and clinical data of individuals aged 65 and older with in... more OBJECTIVES: To examine epidemiological and clinical data of individuals aged 65 and older with influenza virus A (H1N1) admitted to the intensive care unit (ICU) and to identify independent predictors of ICU mortality. DESIGN: Prospective, observational, multicenter study to determine prognostic factors in individuals infected with influenza A (H1N1) admitted to the ICU. SETTING: One hundred forty-eight Spanish ICUs. PARTICIPANTS: Individuals with influenza A (H1N1) confirmed using real-time polymerase chain reaction from April 2009 to July 2011. MEASUREMENTS: Individuals aged 65 and older were compared with younger individuals. A multivariate analysis was conducted to determine independent predictors of mortality in this population. RESULTS: One thousand one hundred twenty individuals (129 (11.5%) aged 65) were included. Prevalence of chronic diseases was more common in older individuals. Viral pneumonitis was more frequent in individuals younger than 65 (70.5% vs 54.3%, P < .001). In older individuals, Acute Physiology and Chronic Health Evaluation II score (odds ratio (OR) = 1.11, 95% confidence interval (CI) = 1.11-1.20, P = .002), immunosuppression (OR = 3.66, 95% CI, 1.33-10.03, P = .01) and oseltamivir therapy initiated after 48 hours (OR = 3.32, 95% CI = 1.02-10.8, P = .04) were identified as independent variables associated with mortality. Corticosteroid use was associated with a trend toward greater mortality (OR = 2.39, 95% CI = 0.98-5.91, P = .06). CONCLUSION: Individuals aged 65 and older with influenza A (H1N1) admitted to the ICU have a higher incidence of underlying diseases than younger individuals and differences in clinical presentation. Early oseltamivir therapy is associated with better outcomes in elderly adults.
The American Journal of Geriatric Cardiology, 2006
OBJECTIVES: To examine epidemiological and clinical data of individuals aged 65 and older with in... more OBJECTIVES: To examine epidemiological and clinical data of individuals aged 65 and older with influenza virus A (H1N1) admitted to the intensive care unit (ICU) and to identify independent predictors of ICU mortality. DESIGN: Prospective, observational, multicenter study to determine prognostic factors in individuals infected with influenza A (H1N1) admitted to the ICU. SETTING: One hundred forty-eight Spanish ICUs. PARTICIPANTS: Individuals with influenza A (H1N1) confirmed using real-time polymerase chain reaction from April 2009 to July 2011. MEASUREMENTS: Individuals aged 65 and older were compared with younger individuals. A multivariate analysis was conducted to determine independent predictors of mortality in this population. RESULTS: One thousand one hundred twenty individuals (129 (11.5%) aged 65) were included. Prevalence of chronic diseases was more common in older individuals. Viral pneumonitis was more frequent in individuals younger than 65 (70.5% vs 54.3%, P < .001). In older individuals, Acute Physiology and Chronic Health Evaluation II score (odds ratio (OR) = 1.11, 95% confidence interval (CI) = 1.11-1.20, P = .002), immunosuppression (OR = 3.66, 95% CI, 1.33-10.03, P = .01) and oseltamivir therapy initiated after 48 hours (OR = 3.32, 95% CI = 1.02-10.8, P = .04) were identified as independent variables associated with mortality. Corticosteroid use was associated with a trend toward greater mortality (OR = 2.39, 95% CI = 0.98-5.91, P = .06). CONCLUSION: Individuals aged 65 and older with influenza A (H1N1) admitted to the ICU have a higher incidence of underlying diseases than younger individuals and differences in clinical presentation. Early oseltamivir therapy is associated with better outcomes in elderly adults.
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Papers by Sergio Santana