Papers by Satish Sarankar
GSC Biological and Pharmaceutical Sciences
Phenolic compounds, abundant in nature and a diverse group of natural plant-derived chemicals, ha... more Phenolic compounds, abundant in nature and a diverse group of natural plant-derived chemicals, have garnered significant attention due to their diverse range of biological activities and potential applications in drug design and medicine. These compounds exhibit a myriad of biological activities, including antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. This review delves into the remarkable contributions of phenolic compounds to modern medicine, exploring their mechanisms of action and highlighting recent advancements in their utilization.
Eurasian Journal of Medicine and Oncology
International Journal of Frontiers in Biology and Pharmacy Research
The aim of present investigation is to formulate floating tablet to increase duration of action o... more The aim of present investigation is to formulate floating tablet to increase duration of action of ranitidine. Floating tablet of ranitidine has long duration of action as compare to its sustained release formulation, Floating tablet has double duration of action than sustained release formulation. Floating tablet is developed by using various polymers like HPMC (15000) and few grades of carbopol, citric acid and sodium bicarbonate were added for effervescence. Tablets were prepared by wet granulation technique by using single operation punch machine in different formulation with polymers, also included testing of some physical parameters like swelling index , hardness and weight variations. In vitro buoyancy evaluation was carried-out and in vitro release of drug was also performed. Increase in quantity of effervescence did not affect buoyancy while facilitating the release of drug. In-Vitro drug release increased when increased quantity of polymers like HPMC and carbopol.
International Journal of Advances in Pharmaceutical Sciences, 2010
Benzo[b]thienyl hydroxamic acids, a novel class of histone deacetylase (HDAC) inhibitors, were id... more Benzo[b]thienyl hydroxamic acids, a novel class of histone deacetylase (HDAC) inhibitors, were identified via a targeted screen of small molecule hydroxamic acids. Quantitative structure activity relationship (QSAR) analysis was performed on a series of Benzo[b]thiophene-based histone deacetylase inhibitors for their anticancer activity by using VLife MDS software. QSAR models were generated based on various statistical methods like Multiple Regression, Principal Component Regression, Partial Least Squares Regression etc. QSAR study revealed that steric, electrostatic interactions, electro-topological parameters, estate numbers and alignment independent descriptors are primarily responsible for anticancer activity. QSAR model demonstrated that anticancer activity is correlated with some of the parameters viz. T_2_N_1, PolarSurfaceAreaIncluding P and S, T_2_S_7, T_C_C_4, T_C_N_4, SaaCHE-Index, T_N_S_4, and SaasCE-Index etc. The best model showed r2 value = 0.9412 and this model was o...
Prospects in Pharmaceutical Sciences
The importance of medicinal plants in traditional medicinal practices and their contribution to b... more The importance of medicinal plants in traditional medicinal practices and their contribution to biodiversity preservation is now widely acknowledged. It is well recognized that the traditional application of medicinal plants in medicinal operations offers guidance for brand-new study areas. Ethnopharmacological studies are very helpful in the creation of herbal medications. One of the primary goals of these studies, which provide scientific documentation for medicinal plants used for specific therapeutic purposes, is the development of superior preparations for use by peoples. It is now commonly recognized how crucial the traditional medicinal uses of plants are for opening up new research areas. It is essential to preserve the traditional knowledge of ethnomedicine. Economic factors are significant, but traditional techniques also have appeal for social, cultural, and medicinal reasons. Madhuca longifolia has pharmaceutical, ethnomedicinal and ethnopharmacological values. The parts...
Saudi Journal of Medical and Pharmaceutical Sciences
Neural tube defects (NTDs) are general complex congenital malformations consequential from failur... more Neural tube defects (NTDs) are general complex congenital malformations consequential from failure of the neural tube closure during embryogenesis. It is recognized that folic acid supplementation decreases the predominance of NTDs, which has led to national public health policies regarding folic acid. To build your healthful pregnancy the choice diet includes a variety of nutrient-packed foods from the following groups: Fruits, Vegetables, Dairy foods, Protein, Whole grains etc. The present review focus on the some of the folic acid rich supplement food which helps to healthful pregnancy and lower the risk of congenital birth defect (NTDs).
Saudi Journal of Medical and Pharmaceutical Sciences
Neural tube defects (NTDs) are general complex congenital malformations consequential from failur... more Neural tube defects (NTDs) are general complex congenital malformations consequential from failure of the neural tube closure during embryogenesis. It is recognized that folic acid supplementation decreases the predominance of NTDs, which has led to national public health policies regarding folic acid. To build your healthful pregnancy the choice diet includes a variety of nutrient-packed foods from the following groups: Fruits, Vegetables, Dairy foods, Protein, Whole grains etc. The present review focus on the some of the folic acid rich supplement food which helps to healthful pregnancy and lower the risk of congenital birth defect (NTDs).
International Journal of …, 2011
... QSAR Study of Novel Benzothiophene Derivatives as Potent Anticancer Agent Satish K. Sarankar1... more ... QSAR Study of Novel Benzothiophene Derivatives as Potent Anticancer Agent Satish K. Sarankar1*, Kalpna Tomar1, Jitendra Bajaj2, Parul Mehta1, AK Pathak1, Mukul Tailang3 ISSN: 0976-1055 ... 19. Kumar A, Ahmad P, Maurya RA, Singh AB and Srivastava AK. ...
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Papers by Satish Sarankar