The effect of sowing time on germination of S. cumini seeds revealed that different treatments ha... more The effect of sowing time on germination of S. cumini seeds revealed that different treatments had a significant influence on seed germination, duration of germination, height and diameter of seedling, number of leaves, seedling survival, transplanting success and buddable seedling per cent. The highest percentage of germination was recorded on 30 th July sown seeds. Seed germination started in 12 days after sowing and completed in 15 days. The minimum duration for germination was recorded when the sowing of seeds was done on 15 th and 30 th July. Height and diameter of seedling varied significantly with sowing time and maximum height and diameter of seedling were noted in 30 th June sown seeds. Number of leaves per seedling also influenced by sowing time and maximum (25.92) number of leaves per seedling was recorded in 15 th July sown seeds. Sowing time greatly influenced the seedling survival in nursery. Maximum (98.60%) seedling survival was obtained, when seeds were sown on 30 th September. The transplanting success ranged between 94.38 and 99.61 per cent and highest transplanting success was noted in 15 th July sown seeds. However, highest percentage (90.86) of buddable seedlings was obtained with 30 th June sown seeds.
Cape gooseberry (Physalis peruviana L.) is a tropical fruit from the solanaceae family, which com... more Cape gooseberry (Physalis peruviana L.) is a tropical fruit from the solanaceae family, which comprises many agriculturally important crops including potato, tomato, pepper, eggplant and tobacco (Knapp, 2001). The cape gooseberry fruit contains high levels of vitamin A, C and B-complex as well as compounds of anti-inflammatory and antioxidant properties (Ramadan, 2011). Epidemiological studies indicate that increased consumption of fruit of cape gooseberry could lead to lower risk of chronic degenerative diseases (Reddy et al., 2010).
With advantage of a quick relief allopathic drugs are causing for serious disease with long or sh... more With advantage of a quick relief allopathic drugs are causing for serious disease with long or short term relief. To avoid these side effects, its need to move towards the Ayurvedic treatment by natural products. Previous studies showing use of many natural product against the lethal diseases. Diabetes is also a such type of emerging disease, needs to be cured by allopathic as well as ayurvedic drugs. Present study aimed to compare the effectiveness of herbal drug Eclipta alba with an allopathic drug metformin against the diabetes. Key-word: Eclipta alba, metformin, Ayurveda, Allopathic, Diabetes.
2016 IEEE International Conference on Recent Trends in Electronics, Information & Communication Technology (RTEICT), 2016
FinFET is the dominating technology for short-channel devices due to its better gate control over... more FinFET is the dominating technology for short-channel devices due to its better gate control over the flow of electrons. In this work, the temperature dependence of drain current (ID) and short channel effects of Bulk FinFET is observed. The FinFET showed ID variation with respect to temperature. The drain current and short channel effects like subthreshold swing (SS), drain induced barrier lowering (DIBL) were investigated with temperature as an input parameter. It was observed that device behaves differently under different mobility models like Lombardi and analytical mobility model. FinFET shows optimum results of on-current, off-current, SS and DIBL at about 250 K Temperature.
International journal of scientific research, 2015
Biostatistics is the application of statistics to a wide range of topics in biology . Statisti... more Biostatistics is the application of statistics to a wide range of topics in biology . Statistics is basically a way of thinking about data that are variable. Biostatistics encompasses the design of biological experiments , especially in medicine , pharmacy , agriculture and fishery ; the collection summarization, and analysis of data from those experiments; and the interpretation of, and inference from, the results. More students are entering college having completed a statistics class, and more students are studying statistics at the research level. There is growing demand for a variety of strong research level programs in statistics to help prepare the next generation of students to make sense of the information around them. This review article deals with basic biostatistical concepts and their application to enable postgraduate medical and allied science students to analyze and interpret their study data and to critically interpret published literature.
Mucuna pruriens, belonging to the family Fabaceae, has been used in traditional Ayurvedic Indian ... more Mucuna pruriens, belonging to the family Fabaceae, has been used in traditional Ayurvedic Indian Medicine for various ailments. In the present study, we investigated the analgesic activity of the Mucuna pruriens extract was evaluated for its in-vivo analgesic activity by using the Eddy’s Hot plate method in mice. Three doses of Mucuna pruriens (100, 200, 400 mg/kg, p.o.) and standard dose of tramadol (25 mg/kg, i.p.) were used for treatment. Swiss albino mice weighing between 20-30 g using oral feeding tube were evaluated for analgesic activity at different time interval such as 0, 30, 60, 90, 120 and 150 minutes against standard and control group. Results indicate that the extracts could possess analgesic activity.
Abstract Background Anti-TB drugs are most common cause of idiosyncratic hepatotoxicity worldwide... more Abstract Background Anti-TB drugs are most common cause of idiosyncratic hepatotoxicity worldwide. Reactive metabolite formed during drug metabolism has been involved in a clinical toxicity are described as ‘idiosyncratic’ drug induce liver injury (DILI). We have observed the distribution of glutathione S -transferase (GST) gene polymorphism & its association with drug-induced liver injury in patients taking anti-tubercular treatment. Methods A prospective observational study including 96 patients receiving anti-tubercular treatment. Blood sample was collected for LFT and gene extraction after ruling out other cause of liver injury. DNA extraction for GST gene was done follow by polymerase chain reaction to identify homozygous null mutation at GSTM1 and GSTT1 loci. Association of GSTM1 and GSTT1 gene with DILI was seen. Results Out of 96 tubercular patients under treatment, drug induced liver injury was found in 21 (21.9%) patients and 75 does not develop DILI, GST M1 gene null mutation was observed in 14 (66.7%), GST T1 gene null mutation was observed in 9 (42.9%), Both GST gene null mutation was observed in 8 (38.1%) in DILI group. Conclusion The GSTM1 gene null mutation and both GSTM1 and T1 gene null mutation were a risk factor for the development of DILI. But there is no significant association between GSTT1 gene null mutation and DILI in TB patients.
with duration of one year. It was conducted on 36 healthy adult male Wistar albino rats, weighing... more with duration of one year. It was conducted on 36 healthy adult male Wistar albino rats, weighing between 150-250 gm after being approved by the Institutional Animal Ethics Committee (IAEC Ref. No. 67/IAH/Pharma-14). Animals were housed in Institutional Animal House Facility under standard laboratory conditions of temperature (25±2°C), humidity (55±5%) and 12 hours light-dark cycle controlled environment. Rats were provided pellet food and water ad libitum. Rats were divided into six groups containing six rats in each group. Group I served as arthritis control, Group II and III received WS in dose of 500 mg/kg and 1000 mg/kg respectively [8]. WS were procured from Himalaya Healthcare Co, India. Group IV received Omega-3 polyunsaturated fatty acids in dose of 100 mg/kg [9]. Capsules of Omega-3 polyunsaturated fatty acid were purchased from Merck Germany. The combination of WS (1000 mg/kg) and Omega-3 polyunsaturated fatty acids (100 mg/kg) was given to rats of group V. Group VI served as standard treatment group and received Indomethacin 3 mg/kg. Indomethacin obtained from Jagsonpal Pharmaceuticals India.
This study was carried out to investigate the effect of sodium hypochlorite (NaClO), hydrogen per... more This study was carried out to investigate the effect of sodium hypochlorite (NaClO), hydrogen peroxide (H2O2) and soaking time on vitamin C, carotenoid, antioxidant activity and total phenolic content for optimizing the pre-treatment for minimal processing of bitter melon slices and to evaluate its shelf life at different storage conditions. Fresh-cut bitter melon slices were given post-cutting treatment of wash solution containing NaClO(25-500ppm) and H2O2 (1-5%) solution for different time intervals (10-120 minutes). The treated samples were analyzed for Vitamin C content, carotenoid, DPPH inhibition activity, ABTS inhibition activity and total phenolic content (TPC) using Central Composite Rotatable Design (CCRD). The optimum condition for soaking achieved by CCRD was NaClO (25 ppm), H2O2 (1%) and soaking time (56.32 min). The minimally processed bitter melon at optimized wash water treatment was packed in LDPE pouch of 0.1 mm thickness and were evaluated for shelf-life under mod...
International Journal of Applied and Basic Medical Research, 2019
Context: The worldwide prevalence of rheumatoid arthritis (RA) is about 1%, whereas in India, it ... more Context: The worldwide prevalence of rheumatoid arthritis (RA) is about 1%, whereas in India, it is approximately 0.75%. The current therapy for RA includes nonsteroidal anti-inflammatory drugs corticosteroids, disease-modifying anti-rheumatic drugs and some recently developed biologic agents, but all of these are associated with adverse effects. Some herbal drugs, such as Boswellia serrata, have been reported to possess anti-inflammatory activity. Aims: The aim of this study is to evaluate the anti-arthritic activity of Boswellia serrata extract (BSE) in complete Freund's adjuvant (CFA)-induced arthritis in rats. Materials and Methods: Thirty-six Wistar rats were divided into six equal groups. RA was induced by intradermal injection of 0.1 ml CFA in hind paw. Body weight, ankle diameter, paw volume, arthritic index, tumor necrosis factor-α (TNF-α), and histopathological examination were assessed. The experimental data were statistically assessed by one-way analysis of variance (ANOVA). Statistical Analysis Used: The recorded data were analyzed using paired t-test and ANOVA test using SPSS. The data were analyzed and represented as mean difference. Value of P < 0.05 was considered statistically significant. Results: BSE at dose 180 mg/kg showed statistically significant improvement in body weight and decrease in ankle diameter and arthritic index (P < 0.05); however, there was insignificant change in paw volume (P = 0.056). This improvement was comparable with Indomethacin. The level of TNF-α did not show any statistically significant change (P = 0.076). Histopathological results also exhibited a reduction in inflammatory parameters. Conclusions: BSE might have usefulness as an adjunct to conventional therapy of RA.
A study was conducted to evaluate the different guava cultivars for their physico-chemical compos... more A study was conducted to evaluate the different guava cultivars for their physico-chemical composition and organoleptic assessment during the year 2012-2013. Results of study indicated that Gorakh Bilas Pasand cultivar proved to be superior on the basis of physical characters (Length-7.64 cm, Breadth-7.79 cm , Weight-240.60 g, Number of seeds per fruit-251 etc.) followed by Lucknow-49. However, Lucknow-49 was found noteworthy in respect of chemical composition (TSS-13.00 oBrix, Acidity-0.50%, pH-5.86, Vitamin C-300.36 mg/100g etc). In organoleptic assessment, it was found that ‘liked very much’ rating was provided by consumer to Lucknow-49. On the basis of overall findings, it was concluded that ‘Lucknow-49’ was superior in most of characters studied and might be one of the promising cultivars for quality fruits under eastern Uttar Pradesh conditions.
International Journal of Research in Medical Sciences, 2018
Background: DPCO (Drugs Prices Control Order) price list is issued by NPPA (National Pharmaceutic... more Background: DPCO (Drugs Prices Control Order) price list is issued by NPPA (National Pharmaceutical Pricing Authority) each year to guide the pharmaceuticals companies for controlling the prices in India. Some drugs cost more than the DPCO list. As antihypertensive drugs are taken lifelong once diagnosis is made, price variation and costing above prescribed price cause a huge economic burden on such patients. This study was undertaken to know the number of antihypertensive drugs brands with price above the recommended DPCO price list 2017.Methods: Authors have collected the data from website medguideindia.com, CIMS (current index of medical specialties), Drug Today, and compared the listed antihypertensive drugs of various available brands in India with DPCO price list 2017. Data was entered in Microsoft excel 2010. Percentage of selling price above the DPCO price list was calculated for each drug.Results: The data of 30 formulations of 16 antihypertensive drugs was analysed. The to...
Background: It has been hypothesized that IL-18 (pro-) and IL-10 (anti-) inflammatory genetic var... more Background: It has been hypothesized that IL-18 (pro-) and IL-10 (anti-) inflammatory genetic variants at-607 C/A-137G/C and-819C/T,-592C/A, respectively, may generate susceptibility and severity risk with various modes of tobacco exposure in prostate carcinoma (PCa) patients. IL-18 is a pro-inflammatory cytokine expressed on various cells including prostate gland elements, and is a key mediator of immune responses with anti-cancerous properties. IL-10 is an anti-inflammatory cytokine that is associated with tumour malignancy which causes immune escape. Materials and Methods: The present study was conducted with 540 subjects, comprising 269 prostate carcinoma patients and 271 controls. Genotyping was performed by PCR-RFLP and confirmed by real time PCR probe-based methods. Results: The findings indicated that the mutant heterozygous and homozygous genotype CC and GC+CC showed significant negative associations (p=0.01, OR=0.21; 95% CI: 0.08-0.51 and p=0.011, OR=0.43; 95% CI: 0.22-0.81, respectively) thus, less chance to be diagnosed as cancer against GG genotype of tobacco smoking patients. In addition, a heterozygous GC genotype at the same locus of IL-18 pro-inflammatory cytokine may aggravate the severity (OR=2.82; 95%CI 1.09-7.29 :p=001) so that patients are more likely to be diagnosed in advanced stage than with the GG wild homozygous genotype. Our results also illustrated that anti-inflammatory cytokine (IL-10) genetic variants, although showing no significant association with susceptibility to cancer of the prostate, may gave profound effects on severity of the disease, as-819 TC (OR=4.60; 95%CI 1.35-15.73), and-592 AC (OR=5.04; 95%CI 1.08-25.43) of IL-10 in tobacco chewers and combined users (both chewers and smokers) respectively, are associated with diagnosis in more advanced stage than with other variants. Conclusions: We conclude that promoter genetic variants of IL-18 and IL-10 with various modes of tobacco exposure may affect not only susceptibility risk but also severity in prostate cancer.
International Journal of Research in Ayurveda & Pharmacy, 2015
Diabetes is going to be most dreadful life style disorder as it is spreading to most of the count... more Diabetes is going to be most dreadful life style disorder as it is spreading to most of the countries. If not controlled/managed, leads to energy starvation and deleterious effects on multiple organs like kidney, heart, eyes or nerves and 50% of the diabetic people show such complications at some later stages of chronic metabolic disorder. People are managing diabetes by different available therapies but some are also controlling by dietary life style modification. This study to compare the effectiveness of the Eclipta alba as well as the dietary life style modification against the diabetes.
Azole Schiff bases 2a-f are annulated diastereoselectively with glycine and acetic anhydride, und... more Azole Schiff bases 2a-f are annulated diastereoselectively with glycine and acetic anhydride, under microwave irradiation and solvent-free conditions, to yield 6,7-dihydro-5H-1,3,4oxa(thia)diazolo[3,2-a]pyrimidin-5-ones 4a-f in a one-pot procedure.
The effect of sowing time on germination of S. cumini seeds revealed that different treatments ha... more The effect of sowing time on germination of S. cumini seeds revealed that different treatments had a significant influence on seed germination, duration of germination, height and diameter of seedling, number of leaves, seedling survival, transplanting success and buddable seedling per cent. The highest percentage of germination was recorded on 30 th July sown seeds. Seed germination started in 12 days after sowing and completed in 15 days. The minimum duration for germination was recorded when the sowing of seeds was done on 15 th and 30 th July. Height and diameter of seedling varied significantly with sowing time and maximum height and diameter of seedling were noted in 30 th June sown seeds. Number of leaves per seedling also influenced by sowing time and maximum (25.92) number of leaves per seedling was recorded in 15 th July sown seeds. Sowing time greatly influenced the seedling survival in nursery. Maximum (98.60%) seedling survival was obtained, when seeds were sown on 30 th September. The transplanting success ranged between 94.38 and 99.61 per cent and highest transplanting success was noted in 15 th July sown seeds. However, highest percentage (90.86) of buddable seedlings was obtained with 30 th June sown seeds.
Cape gooseberry (Physalis peruviana L.) is a tropical fruit from the solanaceae family, which com... more Cape gooseberry (Physalis peruviana L.) is a tropical fruit from the solanaceae family, which comprises many agriculturally important crops including potato, tomato, pepper, eggplant and tobacco (Knapp, 2001). The cape gooseberry fruit contains high levels of vitamin A, C and B-complex as well as compounds of anti-inflammatory and antioxidant properties (Ramadan, 2011). Epidemiological studies indicate that increased consumption of fruit of cape gooseberry could lead to lower risk of chronic degenerative diseases (Reddy et al., 2010).
With advantage of a quick relief allopathic drugs are causing for serious disease with long or sh... more With advantage of a quick relief allopathic drugs are causing for serious disease with long or short term relief. To avoid these side effects, its need to move towards the Ayurvedic treatment by natural products. Previous studies showing use of many natural product against the lethal diseases. Diabetes is also a such type of emerging disease, needs to be cured by allopathic as well as ayurvedic drugs. Present study aimed to compare the effectiveness of herbal drug Eclipta alba with an allopathic drug metformin against the diabetes. Key-word: Eclipta alba, metformin, Ayurveda, Allopathic, Diabetes.
2016 IEEE International Conference on Recent Trends in Electronics, Information & Communication Technology (RTEICT), 2016
FinFET is the dominating technology for short-channel devices due to its better gate control over... more FinFET is the dominating technology for short-channel devices due to its better gate control over the flow of electrons. In this work, the temperature dependence of drain current (ID) and short channel effects of Bulk FinFET is observed. The FinFET showed ID variation with respect to temperature. The drain current and short channel effects like subthreshold swing (SS), drain induced barrier lowering (DIBL) were investigated with temperature as an input parameter. It was observed that device behaves differently under different mobility models like Lombardi and analytical mobility model. FinFET shows optimum results of on-current, off-current, SS and DIBL at about 250 K Temperature.
International journal of scientific research, 2015
Biostatistics is the application of statistics to a wide range of topics in biology . Statisti... more Biostatistics is the application of statistics to a wide range of topics in biology . Statistics is basically a way of thinking about data that are variable. Biostatistics encompasses the design of biological experiments , especially in medicine , pharmacy , agriculture and fishery ; the collection summarization, and analysis of data from those experiments; and the interpretation of, and inference from, the results. More students are entering college having completed a statistics class, and more students are studying statistics at the research level. There is growing demand for a variety of strong research level programs in statistics to help prepare the next generation of students to make sense of the information around them. This review article deals with basic biostatistical concepts and their application to enable postgraduate medical and allied science students to analyze and interpret their study data and to critically interpret published literature.
Mucuna pruriens, belonging to the family Fabaceae, has been used in traditional Ayurvedic Indian ... more Mucuna pruriens, belonging to the family Fabaceae, has been used in traditional Ayurvedic Indian Medicine for various ailments. In the present study, we investigated the analgesic activity of the Mucuna pruriens extract was evaluated for its in-vivo analgesic activity by using the Eddy’s Hot plate method in mice. Three doses of Mucuna pruriens (100, 200, 400 mg/kg, p.o.) and standard dose of tramadol (25 mg/kg, i.p.) were used for treatment. Swiss albino mice weighing between 20-30 g using oral feeding tube were evaluated for analgesic activity at different time interval such as 0, 30, 60, 90, 120 and 150 minutes against standard and control group. Results indicate that the extracts could possess analgesic activity.
Abstract Background Anti-TB drugs are most common cause of idiosyncratic hepatotoxicity worldwide... more Abstract Background Anti-TB drugs are most common cause of idiosyncratic hepatotoxicity worldwide. Reactive metabolite formed during drug metabolism has been involved in a clinical toxicity are described as ‘idiosyncratic’ drug induce liver injury (DILI). We have observed the distribution of glutathione S -transferase (GST) gene polymorphism & its association with drug-induced liver injury in patients taking anti-tubercular treatment. Methods A prospective observational study including 96 patients receiving anti-tubercular treatment. Blood sample was collected for LFT and gene extraction after ruling out other cause of liver injury. DNA extraction for GST gene was done follow by polymerase chain reaction to identify homozygous null mutation at GSTM1 and GSTT1 loci. Association of GSTM1 and GSTT1 gene with DILI was seen. Results Out of 96 tubercular patients under treatment, drug induced liver injury was found in 21 (21.9%) patients and 75 does not develop DILI, GST M1 gene null mutation was observed in 14 (66.7%), GST T1 gene null mutation was observed in 9 (42.9%), Both GST gene null mutation was observed in 8 (38.1%) in DILI group. Conclusion The GSTM1 gene null mutation and both GSTM1 and T1 gene null mutation were a risk factor for the development of DILI. But there is no significant association between GSTT1 gene null mutation and DILI in TB patients.
with duration of one year. It was conducted on 36 healthy adult male Wistar albino rats, weighing... more with duration of one year. It was conducted on 36 healthy adult male Wistar albino rats, weighing between 150-250 gm after being approved by the Institutional Animal Ethics Committee (IAEC Ref. No. 67/IAH/Pharma-14). Animals were housed in Institutional Animal House Facility under standard laboratory conditions of temperature (25±2°C), humidity (55±5%) and 12 hours light-dark cycle controlled environment. Rats were provided pellet food and water ad libitum. Rats were divided into six groups containing six rats in each group. Group I served as arthritis control, Group II and III received WS in dose of 500 mg/kg and 1000 mg/kg respectively [8]. WS were procured from Himalaya Healthcare Co, India. Group IV received Omega-3 polyunsaturated fatty acids in dose of 100 mg/kg [9]. Capsules of Omega-3 polyunsaturated fatty acid were purchased from Merck Germany. The combination of WS (1000 mg/kg) and Omega-3 polyunsaturated fatty acids (100 mg/kg) was given to rats of group V. Group VI served as standard treatment group and received Indomethacin 3 mg/kg. Indomethacin obtained from Jagsonpal Pharmaceuticals India.
This study was carried out to investigate the effect of sodium hypochlorite (NaClO), hydrogen per... more This study was carried out to investigate the effect of sodium hypochlorite (NaClO), hydrogen peroxide (H2O2) and soaking time on vitamin C, carotenoid, antioxidant activity and total phenolic content for optimizing the pre-treatment for minimal processing of bitter melon slices and to evaluate its shelf life at different storage conditions. Fresh-cut bitter melon slices were given post-cutting treatment of wash solution containing NaClO(25-500ppm) and H2O2 (1-5%) solution for different time intervals (10-120 minutes). The treated samples were analyzed for Vitamin C content, carotenoid, DPPH inhibition activity, ABTS inhibition activity and total phenolic content (TPC) using Central Composite Rotatable Design (CCRD). The optimum condition for soaking achieved by CCRD was NaClO (25 ppm), H2O2 (1%) and soaking time (56.32 min). The minimally processed bitter melon at optimized wash water treatment was packed in LDPE pouch of 0.1 mm thickness and were evaluated for shelf-life under mod...
International Journal of Applied and Basic Medical Research, 2019
Context: The worldwide prevalence of rheumatoid arthritis (RA) is about 1%, whereas in India, it ... more Context: The worldwide prevalence of rheumatoid arthritis (RA) is about 1%, whereas in India, it is approximately 0.75%. The current therapy for RA includes nonsteroidal anti-inflammatory drugs corticosteroids, disease-modifying anti-rheumatic drugs and some recently developed biologic agents, but all of these are associated with adverse effects. Some herbal drugs, such as Boswellia serrata, have been reported to possess anti-inflammatory activity. Aims: The aim of this study is to evaluate the anti-arthritic activity of Boswellia serrata extract (BSE) in complete Freund's adjuvant (CFA)-induced arthritis in rats. Materials and Methods: Thirty-six Wistar rats were divided into six equal groups. RA was induced by intradermal injection of 0.1 ml CFA in hind paw. Body weight, ankle diameter, paw volume, arthritic index, tumor necrosis factor-α (TNF-α), and histopathological examination were assessed. The experimental data were statistically assessed by one-way analysis of variance (ANOVA). Statistical Analysis Used: The recorded data were analyzed using paired t-test and ANOVA test using SPSS. The data were analyzed and represented as mean difference. Value of P < 0.05 was considered statistically significant. Results: BSE at dose 180 mg/kg showed statistically significant improvement in body weight and decrease in ankle diameter and arthritic index (P < 0.05); however, there was insignificant change in paw volume (P = 0.056). This improvement was comparable with Indomethacin. The level of TNF-α did not show any statistically significant change (P = 0.076). Histopathological results also exhibited a reduction in inflammatory parameters. Conclusions: BSE might have usefulness as an adjunct to conventional therapy of RA.
A study was conducted to evaluate the different guava cultivars for their physico-chemical compos... more A study was conducted to evaluate the different guava cultivars for their physico-chemical composition and organoleptic assessment during the year 2012-2013. Results of study indicated that Gorakh Bilas Pasand cultivar proved to be superior on the basis of physical characters (Length-7.64 cm, Breadth-7.79 cm , Weight-240.60 g, Number of seeds per fruit-251 etc.) followed by Lucknow-49. However, Lucknow-49 was found noteworthy in respect of chemical composition (TSS-13.00 oBrix, Acidity-0.50%, pH-5.86, Vitamin C-300.36 mg/100g etc). In organoleptic assessment, it was found that ‘liked very much’ rating was provided by consumer to Lucknow-49. On the basis of overall findings, it was concluded that ‘Lucknow-49’ was superior in most of characters studied and might be one of the promising cultivars for quality fruits under eastern Uttar Pradesh conditions.
International Journal of Research in Medical Sciences, 2018
Background: DPCO (Drugs Prices Control Order) price list is issued by NPPA (National Pharmaceutic... more Background: DPCO (Drugs Prices Control Order) price list is issued by NPPA (National Pharmaceutical Pricing Authority) each year to guide the pharmaceuticals companies for controlling the prices in India. Some drugs cost more than the DPCO list. As antihypertensive drugs are taken lifelong once diagnosis is made, price variation and costing above prescribed price cause a huge economic burden on such patients. This study was undertaken to know the number of antihypertensive drugs brands with price above the recommended DPCO price list 2017.Methods: Authors have collected the data from website medguideindia.com, CIMS (current index of medical specialties), Drug Today, and compared the listed antihypertensive drugs of various available brands in India with DPCO price list 2017. Data was entered in Microsoft excel 2010. Percentage of selling price above the DPCO price list was calculated for each drug.Results: The data of 30 formulations of 16 antihypertensive drugs was analysed. The to...
Background: It has been hypothesized that IL-18 (pro-) and IL-10 (anti-) inflammatory genetic var... more Background: It has been hypothesized that IL-18 (pro-) and IL-10 (anti-) inflammatory genetic variants at-607 C/A-137G/C and-819C/T,-592C/A, respectively, may generate susceptibility and severity risk with various modes of tobacco exposure in prostate carcinoma (PCa) patients. IL-18 is a pro-inflammatory cytokine expressed on various cells including prostate gland elements, and is a key mediator of immune responses with anti-cancerous properties. IL-10 is an anti-inflammatory cytokine that is associated with tumour malignancy which causes immune escape. Materials and Methods: The present study was conducted with 540 subjects, comprising 269 prostate carcinoma patients and 271 controls. Genotyping was performed by PCR-RFLP and confirmed by real time PCR probe-based methods. Results: The findings indicated that the mutant heterozygous and homozygous genotype CC and GC+CC showed significant negative associations (p=0.01, OR=0.21; 95% CI: 0.08-0.51 and p=0.011, OR=0.43; 95% CI: 0.22-0.81, respectively) thus, less chance to be diagnosed as cancer against GG genotype of tobacco smoking patients. In addition, a heterozygous GC genotype at the same locus of IL-18 pro-inflammatory cytokine may aggravate the severity (OR=2.82; 95%CI 1.09-7.29 :p=001) so that patients are more likely to be diagnosed in advanced stage than with the GG wild homozygous genotype. Our results also illustrated that anti-inflammatory cytokine (IL-10) genetic variants, although showing no significant association with susceptibility to cancer of the prostate, may gave profound effects on severity of the disease, as-819 TC (OR=4.60; 95%CI 1.35-15.73), and-592 AC (OR=5.04; 95%CI 1.08-25.43) of IL-10 in tobacco chewers and combined users (both chewers and smokers) respectively, are associated with diagnosis in more advanced stage than with other variants. Conclusions: We conclude that promoter genetic variants of IL-18 and IL-10 with various modes of tobacco exposure may affect not only susceptibility risk but also severity in prostate cancer.
International Journal of Research in Ayurveda & Pharmacy, 2015
Diabetes is going to be most dreadful life style disorder as it is spreading to most of the count... more Diabetes is going to be most dreadful life style disorder as it is spreading to most of the countries. If not controlled/managed, leads to energy starvation and deleterious effects on multiple organs like kidney, heart, eyes or nerves and 50% of the diabetic people show such complications at some later stages of chronic metabolic disorder. People are managing diabetes by different available therapies but some are also controlling by dietary life style modification. This study to compare the effectiveness of the Eclipta alba as well as the dietary life style modification against the diabetes.
Azole Schiff bases 2a-f are annulated diastereoselectively with glycine and acetic anhydride, und... more Azole Schiff bases 2a-f are annulated diastereoselectively with glycine and acetic anhydride, under microwave irradiation and solvent-free conditions, to yield 6,7-dihydro-5H-1,3,4oxa(thia)diazolo[3,2-a]pyrimidin-5-ones 4a-f in a one-pot procedure.
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Papers by Sarvesh Singh